{"id":"https://openalex.org/W4401211705","doi":"https://doi.org/10.1016/j.biopha.2024.117209","title":"AD16 attenuates neuroinflammation induced by cerebral ischemia through down-regulating astrocytes A1 polarization","display_name":"AD16 attenuates neuroinflammation induced by cerebral ischemia through down-regulating astrocytes A1 polarization","publication_year":2024,"publication_date":"2024-08-01","ids":{"openalex":"https://openalex.org/W4401211705","doi":"https://doi.org/10.1016/j.biopha.2024.117209","pmid":"https://pubmed.ncbi.nlm.nih.gov/39094544"},"language":"en","primary_location":{"id":"doi:10.1016/j.biopha.2024.117209","doi":"https://doi.org/10.1016/j.biopha.2024.117209","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2024.117209","pdf_url":null,"source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & Pharmacotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.biopha.2024.117209","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100415164","display_name":"Limei Zhang","orcid":"https://orcid.org/0000-0002-7383-8475","observed_orcids":["https://orcid.org/0000-0002-7383-8475"]},"institutions":[{"id":"https://openalex.org/I4210113195","display_name":"Gannan Medical University","ror":"https://ror.org/01tjgw469","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113195"]},{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Limei Zhang","raw_affiliation_strings":["Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, Ganzhou Key Laboratory of Neuroinflammation Research, School of Basic Medicine Sciences, Gannan Medical University, Ganzhou 341000, China; School of Basic Medical Sciences, China Medical University,\u00a0Shengyang 110122, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, Ganzhou Key Laboratory of Neuroinflammation Research, School of Basic Medicine Sciences, Gannan Medical University, Ganzhou 341000, China; School of Basic Medical Sciences, China Medical University,\u00a0Shengyang 110122, China","institution_ids":["https://openalex.org/I4210113195","https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074635548","display_name":"Guojian Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113195","display_name":"Gannan Medical University","ror":"https://ror.org/01tjgw469","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113195"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guojian Zhao","raw_affiliation_strings":["Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, Ganzhou Key Laboratory of Neuroinflammation Research, School of Basic Medicine Sciences, Gannan Medical University, Ganzhou 341000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, Ganzhou Key Laboratory of Neuroinflammation Research, School of Basic Medicine Sciences, Gannan Medical University, Ganzhou 341000, China","institution_ids":["https://openalex.org/I4210113195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114210210","display_name":"Zhengwei Luo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Zhengwei Luo","raw_affiliation_strings":["Department of Physiology, Temerty Faculty of Medicine, University of Toronto,\u00a0Toronto, ON M5S 1A8, Canada; Department of Surgery, Temerty Faculty of Medicine, University of Toronto,\u00a0Toronto, ON M5S 1A8, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Temerty Faculty of Medicine, University of Toronto,\u00a0Toronto, ON M5S 1A8, Canada; Department of Surgery, Temerty Faculty of Medicine, University of Toronto,\u00a0Toronto, ON M5S 1A8, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043738489","display_name":"Zining Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113195","display_name":"Gannan Medical University","ror":"https://ror.org/01tjgw469","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113195"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zining Yu","raw_affiliation_strings":["Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, Ganzhou Key Laboratory of Neuroinflammation Research, School of Basic Medicine Sciences, Gannan Medical University, Ganzhou 341000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, Ganzhou Key Laboratory of Neuroinflammation Research, School of Basic Medicine Sciences, Gannan Medical University, Ganzhou 341000, China","institution_ids":["https://openalex.org/I4210113195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084734548","display_name":"Gaigai Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113195","display_name":"Gannan Medical University","ror":"https://ror.org/01tjgw469","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113195"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gaigai Liu","raw_affiliation_strings":["Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, Ganzhou Key Laboratory of Neuroinflammation Research, School of Basic Medicine Sciences, Gannan Medical University, Ganzhou 341000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, Ganzhou Key Laboratory of Neuroinflammation Research, School of Basic Medicine Sciences, Gannan Medical University, Ganzhou 341000, China","institution_ids":["https://openalex.org/I4210113195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008695184","display_name":"Guangjun Su","orcid":"https://orcid.org/0000-0001-5396-4426","observed_orcids":["https://orcid.org/0000-0001-5396-4426"]},"institutions":[{"id":"https://openalex.org/I4210113195","display_name":"Gannan Medical University","ror":"https://ror.org/01tjgw469","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113195"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guangjun Su","raw_affiliation_strings":["Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, Ganzhou Key Laboratory of Neuroinflammation Research, School of Basic Medicine Sciences, Gannan Medical University, Ganzhou 341000, China"],"raw_orcid":"https://orcid.org/0000-0001-5396-4426","affiliations":[{"raw_affiliation_string":"Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, Ganzhou Key Laboratory of Neuroinflammation Research, School of Basic Medicine Sciences, Gannan Medical University, Ganzhou 341000, China","institution_ids":["https://openalex.org/I4210113195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032801850","display_name":"Xiaolu Tang","orcid":"https://orcid.org/0000-0002-7737-5092","observed_orcids":["https://orcid.org/0000-0002-7737-5092"]},"institutions":[{"id":"https://openalex.org/I4210113195","display_name":"Gannan Medical University","ror":"https://ror.org/01tjgw469","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113195"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaolu Tang","raw_affiliation_strings":["Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, Ganzhou Key Laboratory of Neuroinflammation Research, School of Basic Medicine Sciences, Gannan Medical University, Ganzhou 341000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, Ganzhou Key Laboratory of Neuroinflammation Research, School of Basic Medicine Sciences, Gannan Medical University, Ganzhou 341000, China","institution_ids":["https://openalex.org/I4210113195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102881157","display_name":"Zhidong Yuan","orcid":"https://orcid.org/0000-0001-5670-2560","observed_orcids":["https://orcid.org/0000-0001-5670-2560"]},"institutions":[{"id":"https://openalex.org/I4210113195","display_name":"Gannan Medical University","ror":"https://ror.org/01tjgw469","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113195"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhidong Yuan","raw_affiliation_strings":["Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, Ganzhou Key Laboratory of Neuroinflammation Research, School of Basic Medicine Sciences, Gannan Medical University, Ganzhou 341000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, Ganzhou Key Laboratory of Neuroinflammation Research, School of Basic Medicine Sciences, Gannan Medical University, Ganzhou 341000, China","institution_ids":["https://openalex.org/I4210113195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030949828","display_name":"Cheng Huang","orcid":"https://orcid.org/0000-0001-8220-1815","observed_orcids":["https://orcid.org/0000-0001-8220-1815"]},"institutions":[{"id":"https://openalex.org/I4210113195","display_name":"Gannan Medical University","ror":"https://ror.org/01tjgw469","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113195"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cheng Huang","raw_affiliation_strings":["Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, Ganzhou Key Laboratory of Neuroinflammation Research, School of Basic Medicine Sciences, Gannan Medical University, Ganzhou 341000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, Ganzhou Key Laboratory of Neuroinflammation Research, School of Basic Medicine Sciences, Gannan Medical University, Ganzhou 341000, China","institution_ids":["https://openalex.org/I4210113195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054420556","display_name":"Hong\u2010Shuo Sun","orcid":"https://orcid.org/0000-0001-5142-1874","observed_orcids":["https://orcid.org/0000-0001-5142-1874"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Hong-Shuo Sun","raw_affiliation_strings":["Department of Physiology, Temerty Faculty of Medicine, University of Toronto,\u00a0Toronto, ON M5S 1A8, Canada; Department of Surgery, Temerty Faculty of Medicine, University of Toronto,\u00a0Toronto, ON M5S 1A8, Canada. Electronic address: hss.sun@utoronto.ca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Temerty Faculty of Medicine, University of Toronto,\u00a0Toronto, ON M5S 1A8, Canada; Department of Surgery, Temerty Faculty of Medicine, University of Toronto,\u00a0Toronto, ON M5S 1A8, Canada. Electronic address: hss.sun@utoronto.ca","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071323598","display_name":"Zhong\u2010Ping Feng","orcid":"https://orcid.org/0000-0002-2454-4462","observed_orcids":["https://orcid.org/0000-0002-2454-4462"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Zhong-Ping Feng","raw_affiliation_strings":["Department of Physiology, Temerty Faculty of Medicine, University of Toronto,\u00a0Toronto, ON M5S 1A8, Canada. Electronic address: zp.feng@utoronto.ca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Temerty Faculty of Medicine, University of Toronto,\u00a0Toronto, ON M5S 1A8, Canada. Electronic address: zp.feng@utoronto.ca","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063926096","display_name":"Zhihua Huang","orcid":"https://orcid.org/0000-0002-2610-1999","observed_orcids":["https://orcid.org/0000-0002-2610-1999"]},"institutions":[{"id":"https://openalex.org/I4210113195","display_name":"Gannan Medical University","ror":"https://ror.org/01tjgw469","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113195"]},{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhihua Huang","raw_affiliation_strings":["Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, Ganzhou Key Laboratory of Neuroinflammation Research, School of Basic Medicine Sciences, Gannan Medical University, Ganzhou 341000, China; School of Basic Medical Sciences, China Medical University,\u00a0Shengyang 110122, China. Electronic address: zh.huang@gmu.edu.cn"],"raw_orcid":"https://orcid.org/0000-0002-2610-1999","affiliations":[{"raw_affiliation_string":"Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, Ganzhou Key Laboratory of Neuroinflammation Research, School of Basic Medicine Sciences, Gannan Medical University, Ganzhou 341000, China; School of Basic Medical Sciences, China Medical University,\u00a0Shengyang 110122, China. Electronic address: zh.huang@gmu.edu.cn","institution_ids":["https://openalex.org/I4210113195","https://openalex.org/I91656880"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5054420556","https://openalex.org/A5063926096","https://openalex.org/A5071323598"],"corresponding_institution_ids":["https://openalex.org/I185261750","https://openalex.org/I4210113195","https://openalex.org/I91656880"],"apc_list":{"value":3420,"currency":"USD","value_usd":3420},"apc_paid":{"value":3420,"currency":"USD","value_usd":3420},"fwci":2.6864,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.89986524,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"178","issue":null,"first_page":"117209","last_page":"117209"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.777999997138977},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8740000128746033},{"id":"https://openalex.org/keywords/transient-middle-cerebral-artery-occlusion","display_name":"transient middle cerebral artery occlusion","score":0.9419999718666077},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9390000104904175},{"id":"https://openalex.org/keywords/jak2-stat3-signaling-pathway","display_name":"JAK2/STAT3 signaling","score":0.9980000257492065},{"id":"https://openalex.org/keywords/blood-brain-barrier-permeability","display_name":"blood-brain barrier permeability","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cytokine-cytokine-receptor-interaction","display_name":"cytokine-cytokine receptor interaction","score":0.8410000205039978},{"id":"https://openalex.org/keywords/il-17-signaling","display_name":"IL-17 signaling","score":0.7570000290870667},{"id":"https://openalex.org/keywords/anti-inflammatory-agents","display_name":"anti-inflammatory agents","score":0.4519999921321869},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.652999997138977}],"concepts":[{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.9243143796920776},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.5732272267341614},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5645303726196289},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.4822450578212738},{"id":"https://openalex.org/C205049153","wikidata":"https://www.wikidata.org/wiki/Q2698605","display_name":"Polarization (electrochemistry)","level":2,"score":0.4375036060810089},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4224601984024048},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.4185274839401245},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3301229476928711},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.19801253080368042},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1843617856502533},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15840205550193787},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.1145859956741333},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000090862","descriptor_name":"Neuroinflammatory Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000090862","descriptor_name":"Neuroinflammatory Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020244","descriptor_name":"Infarction, Middle Cerebral Artery","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D020244","descriptor_name":"Infarction, Middle Cerebral Artery","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020244","descriptor_name":"Infarction, Middle Cerebral Artery","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.biopha.2024.117209","doi":"https://doi.org/10.1016/j.biopha.2024.117209","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2024.117209","pdf_url":null,"source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & Pharmacotherapy","raw_type":"journal-article"},{"id":"pmid:39094544","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39094544","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.biopha.2024.117209","doi":"https://doi.org/10.1016/j.biopha.2024.117209","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2024.117209","pdf_url":null,"source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & Pharmacotherapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1445886483","display_name":null,"funder_award_id":"TD2021JC06","funder_id":"https://openalex.org/F4320331101","funder_display_name":"Gannan Medical University"}],"funders":[{"id":"https://openalex.org/F4320331101","display_name":"Gannan Medical University","ror":"https://ror.org/01tjgw469"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W1979003573","https://openalex.org/W1983061009","https://openalex.org/W2084566588","https://openalex.org/W2102278945","https://openalex.org/W2108234281","https://openalex.org/W2112505121","https://openalex.org/W2119485597","https://openalex.org/W2138207763","https://openalex.org/W2139884360","https://openalex.org/W2179438025","https://openalex.org/W2497761855","https://openalex.org/W2592609681","https://openalex.org/W2790139801","https://openalex.org/W2808597917","https://openalex.org/W2888938950","https://openalex.org/W2897292622","https://openalex.org/W2939187945","https://openalex.org/W2942349545","https://openalex.org/W2951912016","https://openalex.org/W2969494640","https://openalex.org/W2971470218","https://openalex.org/W2973160898","https://openalex.org/W2980537802","https://openalex.org/W2993239729","https://openalex.org/W3008417101","https://openalex.org/W3086988082","https://openalex.org/W3087903541","https://openalex.org/W3089596350","https://openalex.org/W3093494259","https://openalex.org/W3096853844","https://openalex.org/W3097256238","https://openalex.org/W3127432357","https://openalex.org/W3134875727","https://openalex.org/W3137930015","https://openalex.org/W3141883903","https://openalex.org/W3152985561","https://openalex.org/W3178834492","https://openalex.org/W3185522419","https://openalex.org/W3192607103","https://openalex.org/W3197233575","https://openalex.org/W3200266763","https://openalex.org/W3200709465","https://openalex.org/W3205955396","https://openalex.org/W4200306318","https://openalex.org/W4200316753","https://openalex.org/W4200423719","https://openalex.org/W4207032408","https://openalex.org/W4296642217","https://openalex.org/W4296988791","https://openalex.org/W4310238871","https://openalex.org/W4311448450","https://openalex.org/W4313012431","https://openalex.org/W4313597390","https://openalex.org/W4388943609"],"related_works":["https://openalex.org/W4412664757","https://openalex.org/W4207032408","https://openalex.org/W7223169385","https://openalex.org/W4396700688","https://openalex.org/W3194559415","https://openalex.org/W3086196796","https://openalex.org/W4392608177","https://openalex.org/W2969280964","https://openalex.org/W4410633043","https://openalex.org/W7171861126"],"abstract_inverted_index":{"A1":[0,79,173,195],"polarization":[1,80,171,196],"of":[2,58,124,158,172],"astrocytes":[3],"mediated":[4],"prolonged":[5],"inflammation":[6],"contributing":[7],"to":[8,65,197],"brain":[9,24,75,94,188],"injury":[10,76,189],"in":[11,26,31,43,101,121,135,190],"ischemic":[12,74,191],"stroke.":[13],"We":[14],"have":[15],"previously":[16],"shown":[17],"that":[18,88,108,184,217],"AD16":[19,35,71,89,116,153,165,185,214,218],"protects":[20,72,186],"against":[21,73,187,223],"neonatal":[22],"hypoxic-ischemic":[23],"damage":[25],"vivo":[27],"and":[28,40,81,97,115,126,148,162,174,177,203,215],"oxygen-glucose":[29],"deprivation":[30],"vitro.":[32],"More":[33],"recently,":[34],"has":[36],"demonstrated":[37],"safety,":[38],"tolerability,":[39],"favorable":[41],"pharmacokinetics":[42],"a":[44,55,209],"randomized":[45],"controlled":[46],"phase":[47],"I":[48],"trial.":[49],"In":[50],"this":[51],"study,":[52],"we":[53],"utilized":[54],"rat":[56],"model":[57],"transient":[59],"middle":[60],"cerebral":[61,224],"artery":[62],"occlusion":[63],"(tMCAO)":[64],"explore":[66],"whether":[67],"the":[68,93,112,122,156,159,170],"anti-inflammatory":[69],"compound":[70],"by":[77,193],"regulating":[78],"its":[82],"underlying":[83],"mechanisms.":[84],"Our":[85,206],"results":[86,106],"showed":[87],"treatment":[90,117,154,166],"significantly":[91,168],"reduced":[92,169],"infarcted":[95],"volume":[96],"improved":[98],"neurological":[99],"function":[100],"tMCAO":[102,114],"rats.":[103],"GO":[104],"analysis":[105,132],"show":[107],"differential":[109],"genes":[110],"among":[111],"Sham,":[113],"groups":[118],"are":[119],"involved":[120],"regulation":[123],"cytokine":[125],"inflammatory":[127],"response.":[128],"KEGG":[129],"enrichment":[130],"pathways":[131],"mainly":[133],"enriched":[134],"cytokine-cytokine":[136,143],"receptor":[137],"interaction,":[138],"viral":[139],"protein":[140],"interaction":[141],"with":[142],"receptor,":[144],"TNF,":[145],"chemokine,":[146],"NF-\u03baB":[147,176,202],"IL-17":[149],"signaling":[150,179],"pathway.":[151],"Furthermore,":[152],"decreased":[155],"permeability":[157],"blood-brain":[160],"barrier":[161],"suppressed":[163],"neuroinflammation.":[164],"also":[167],"inhibited":[175],"JAK2/STAT3":[178,204],"pathways.":[180],"This":[181],"study":[182],"demonstrates":[183],"stroke":[192],"reducing":[194],"suppress":[198],"neuroinflammation":[199],"through":[200],"downregulating":[201],"signaling.":[205],"findings":[207],"uncover":[208],"potential":[210,222],"molecular":[211],"mechanism":[212],"for":[213],"suggest":[216],"holds":[219],"promising":[220],"therapeutic":[221],"ischemia.":[225]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2024-08-02T00:00:00"}