{"id":"https://openalex.org/W4401211005","doi":"https://doi.org/10.1038/s41698-024-00658-y","title":"XRCC2 driven homologous recombination subtypes and therapeutic targeting in lung adenocarcinoma metastasis","display_name":"XRCC2 driven homologous recombination subtypes and therapeutic targeting in lung adenocarcinoma metastasis","publication_year":2024,"publication_date":"2024-08-01","ids":{"openalex":"https://openalex.org/W4401211005","doi":"https://doi.org/10.1038/s41698-024-00658-y","pmid":"https://pubmed.ncbi.nlm.nih.gov/39090304","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11294482"},"language":"en","primary_location":{"id":"doi:10.1038/s41698-024-00658-y","doi":"https://doi.org/10.1038/s41698-024-00658-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41698-024-00658-y","pdf_url":"https://www.nature.com/articles/s41698-024-00658-y.pdf","source":{"id":"https://openalex.org/S4210211538","display_name":"npj Precision Oncology","issn_l":"2397-768X","issn":["2397-768X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Precision Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41698-024-00658-y.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071777836","display_name":"Han Gong","orcid":"https://orcid.org/0000-0001-9835-1551","observed_orcids":["https://orcid.org/0000-0001-9835-1551"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210115624","display_name":"Hunan Cancer Hospital","ror":"https://ror.org/025020z88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115624"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Han Gong","raw_affiliation_strings":["Molecular Biology Research Center and Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China","The 1st Department of Thoracic Surgery of Hunan Cancer Hospital & the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 4100013, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Biology Research Center and Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"The 1st Department of Thoracic Surgery of Hunan Cancer Hospital & the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 4100013, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210115624"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Peihe Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210156904","display_name":"Third Xiangya Hospital","ror":"https://ror.org/05akvb491","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156904"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peihe Zhang","raw_affiliation_strings":["Department of Anesthesiology, The Third Xiangya Hospital, Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, The Third Xiangya Hospital, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210156904","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065339043","display_name":"Qiang Liu","orcid":"https://orcid.org/0000-0003-2268-4717","observed_orcids":["https://orcid.org/0000-0003-2268-4717"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210115624","display_name":"Hunan Cancer Hospital","ror":"https://ror.org/025020z88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115624"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiang Liu","raw_affiliation_strings":["Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China","Institute of Reproductive and Stem Cell Engineering, NHC Key Laboratory of Human Stem Cell and Reproductive Engineering, School of Basic Medical Sciences, Central South University, Changsha, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210115624"]},{"raw_affiliation_string":"Institute of Reproductive and Stem Cell Engineering, NHC Key Laboratory of Human Stem Cell and Reproductive Engineering, School of Basic Medical Sciences, Central South University, Changsha, Hunan, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061117084","display_name":"Yuxuan Tian","orcid":"https://orcid.org/0000-0002-0695-5743","observed_orcids":["https://orcid.org/0000-0002-0695-5743"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuxuan Tian","raw_affiliation_strings":["Department of Histology and Embryology, School of Basic Medical Sciences, Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology and Embryology, School of Basic Medical Sciences, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049470136","display_name":"Fuxin Chen","orcid":"https://orcid.org/0000-0002-5384-7825","observed_orcids":["https://orcid.org/0000-0002-5384-7825"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fuxin Chen","raw_affiliation_strings":["Department of Histology and Embryology, School of Basic Medical Sciences, Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology and Embryology, School of Basic Medical Sciences, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104256307","display_name":"Siyi Qian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Siyi Qian","raw_affiliation_strings":["Department of Histology and Embryology, School of Basic Medical Sciences, Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology and Embryology, School of Basic Medical Sciences, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053957782","display_name":"Chaofeng Tu","orcid":"https://orcid.org/0000-0001-5682-8948","observed_orcids":["https://orcid.org/0000-0001-5682-8948"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210102182","display_name":"Reproductive & Genetic Hospital CITIC-Xiangya","ror":"https://ror.org/01ar3e651","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210102182"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chaofeng Tu","raw_affiliation_strings":["Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, Hunan, China","Institute of Reproductive and Stem Cell Engineering, NHC Key Laboratory of Human Stem Cell and Reproductive Engineering, School of Basic Medical Sciences, Central South University, Changsha, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, Hunan, China","institution_ids":["https://openalex.org/I4210102182"]},{"raw_affiliation_string":"Institute of Reproductive and Stem Cell Engineering, NHC Key Laboratory of Human Stem Cell and Reproductive Engineering, School of Basic Medical Sciences, Central South University, Changsha, Hunan, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004909924","display_name":"Yue\u2010Qiu Tan","orcid":"https://orcid.org/0000-0002-8359-4654","observed_orcids":["https://orcid.org/0000-0002-8359-4654"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I173759888","display_name":"Hunan Normal University","ror":"https://ror.org/053w1zy07","country_code":"CN","type":"education","lineage":["https://openalex.org/I173759888"]},{"id":"https://openalex.org/I4210102182","display_name":"Reproductive & Genetic Hospital CITIC-Xiangya","ror":"https://ror.org/01ar3e651","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210102182"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yueqiu Tan","raw_affiliation_strings":["Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, Hunan, China","College of Life Sciences, Hunan Normal University, Changsha, China","Institute of Reproductive and Stem Cell Engineering, NHC Key Laboratory of Human Stem Cell and Reproductive Engineering, School of Basic Medical Sciences, Central South University, Changsha, Hunan, China"],"raw_orcid":"https://orcid.org/0000-0002-8359-4654","affiliations":[{"raw_affiliation_string":"Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, Hunan, China","institution_ids":["https://openalex.org/I4210102182"]},{"raw_affiliation_string":"College of Life Sciences, Hunan Normal University, Changsha, China","institution_ids":["https://openalex.org/I173759888"]},{"raw_affiliation_string":"Institute of Reproductive and Stem Cell Engineering, NHC Key Laboratory of Human Stem Cell and Reproductive Engineering, School of Basic Medical Sciences, Central South University, Changsha, Hunan, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101886475","display_name":"Xingming Hu","orcid":"https://orcid.org/0000-0002-8472-9266","observed_orcids":["https://orcid.org/0000-0002-8472-9266"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210115624","display_name":"Hunan Cancer Hospital","ror":"https://ror.org/025020z88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115624"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xingming Hu","raw_affiliation_strings":["The 1st Department of Thoracic Surgery of Hunan Cancer Hospital & the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 4100013, China. wangzigre@sina.com","The 1st Department of Thoracic Surgery of Hunan Cancer Hospital & the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 4100013, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The 1st Department of Thoracic Surgery of Hunan Cancer Hospital & the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 4100013, China. wangzigre@sina.com","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210115624"]},{"raw_affiliation_string":"The 1st Department of Thoracic Surgery of Hunan Cancer Hospital & the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 4100013, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210115624"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065512778","display_name":"Bin Zhang","orcid":"https://orcid.org/0000-0003-3765-4764","observed_orcids":["https://orcid.org/0000-0003-3765-4764"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210115624","display_name":"Hunan Cancer Hospital","ror":"https://ror.org/025020z88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115624"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bin Zhang","raw_affiliation_strings":["Department of Histology and Embryology, School of Basic Medical Sciences, Central South University, Changsha, China. coolzhangbin22@163.com","The 1st Department of Thoracic Surgery of Hunan Cancer Hospital & the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 4100013, China. coolzhangbin22@163.com","Department of Histology and Embryology, School of Basic Medical Sciences, Central South University, Changsha, China"],"raw_orcid":"https://orcid.org/0000-0003-3765-4764","affiliations":[{"raw_affiliation_string":"Department of Histology and Embryology, School of Basic Medical Sciences, Central South University, Changsha, China. coolzhangbin22@163.com","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"The 1st Department of Thoracic Surgery of Hunan Cancer Hospital & the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 4100013, China. coolzhangbin22@163.com","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210115624"]},{"raw_affiliation_string":"Department of Histology and Embryology, School of Basic Medical Sciences, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5065512778","https://openalex.org/A5101886475"],"corresponding_institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210115624"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":{"value":3790,"currency":"USD","value_usd":3790},"fwci":1.1313,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.78853875,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"8","issue":"1","first_page":"169","last_page":"169"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.7339000105857849,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.7339000105857849,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.13770000636577606,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.026399999856948853,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.9869999885559082},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.8920000195503235},{"id":"https://openalex.org/keywords/homologous-recombination","display_name":"homologous recombination","score":0.9110000133514404},{"id":"https://openalex.org/keywords/xrcc2","display_name":"XRCC2","score":0.9900000095367432},{"id":"https://openalex.org/keywords/rad51","display_name":"RAD51","score":0.9160000085830688},{"id":"https://openalex.org/keywords/brca1","display_name":"BRCA1","score":0.9850000143051147},{"id":"https://openalex.org/keywords/fanca","display_name":"FANCA","score":0.9980000257492065},{"id":"https://openalex.org/keywords/chk1","display_name":"Chk1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9340000152587891},{"id":"https://openalex.org/keywords/immunotherapy-response-prediction","display_name":"immunotherapy response prediction","score":0.902999997138977},{"id":"https://openalex.org/keywords/vimentin","display_name":"vimentin","score":0.7820000052452087},{"id":"https://openalex.org/keywords/deubiquitination","display_name":"deubiquitination","score":0.8820000290870667},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.9750000238418579},{"id":"https://openalex.org/keywords/10058-f4","display_name":"10058-F4","score":0.9190000295639038},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.8830000162124634},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6000000238418579},{"id":"https://openalex.org/keywords/tumor-cell-migration-and-invasion","display_name":"tumor cell migration and invasion","score":0.7210000157356262}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5829274654388428},{"id":"https://openalex.org/C2779012473","wikidata":"https://www.wikidata.org/wiki/Q3235015","display_name":"RAD51","level":4,"score":0.5422940254211426},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.5412319302558899},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.4834069311618805},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.48281630873680115},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.476003497838974},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41567903757095337},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.37688133120536804},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.36594051122665405},{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.354472815990448},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3525334596633911},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24614807963371277},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24224448204040527},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07496005296707153}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1038/s41698-024-00658-y","doi":"https://doi.org/10.1038/s41698-024-00658-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41698-024-00658-y","pdf_url":"https://www.nature.com/articles/s41698-024-00658-y.pdf","source":{"id":"https://openalex.org/S4210211538","display_name":"npj Precision Oncology","issn_l":"2397-768X","issn":["2397-768X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Precision Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11294482","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11294482","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11294482/pdf/41698_2024_Article_658.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ Precis Oncol","raw_type":"Text"},{"id":"pmid:39090304","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39090304","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ precision oncology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:aab5b71e8c774ac4835276ea060d0099","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/aab5b71e8c774ac4835276ea060d0099","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"npj Precision Oncology, Vol 8, Iss 1, Pp 1-14 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41698-024-00658-y","doi":"https://doi.org/10.1038/s41698-024-00658-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41698-024-00658-y","pdf_url":"https://www.nature.com/articles/s41698-024-00658-y.pdf","source":{"id":"https://openalex.org/S4210211538","display_name":"npj Precision Oncology","issn_l":"2397-768X","issn":["2397-768X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Precision Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7373292621","display_name":null,"funder_award_id":"82073099","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4401211005.pdf","grobid_xml":"https://content.openalex.org/works/W4401211005.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1973268287","https://openalex.org/W1995097523","https://openalex.org/W2023970825","https://openalex.org/W2028598028","https://openalex.org/W2035618305","https://openalex.org/W2050428459","https://openalex.org/W2061096783","https://openalex.org/W2068566366","https://openalex.org/W2070686951","https://openalex.org/W2091503064","https://openalex.org/W2115462905","https://openalex.org/W2130410032","https://openalex.org/W2146042781","https://openalex.org/W2146512944","https://openalex.org/W2151789140","https://openalex.org/W2158485828","https://openalex.org/W2169589032","https://openalex.org/W2170237380","https://openalex.org/W2230320310","https://openalex.org/W2332185934","https://openalex.org/W2587862832","https://openalex.org/W2792396136","https://openalex.org/W2804007674","https://openalex.org/W2896872272","https://openalex.org/W2955620588","https://openalex.org/W3004154864","https://openalex.org/W3008601088","https://openalex.org/W3011978775","https://openalex.org/W3015666203","https://openalex.org/W3080500495","https://openalex.org/W3130102056","https://openalex.org/W3197532732","https://openalex.org/W3197862819","https://openalex.org/W3208047819","https://openalex.org/W3208854942","https://openalex.org/W4200076559","https://openalex.org/W4206675150","https://openalex.org/W4225320848","https://openalex.org/W4280495239","https://openalex.org/W4285611955","https://openalex.org/W4292678705","https://openalex.org/W4295079305","https://openalex.org/W4312096896","https://openalex.org/W4381489574","https://openalex.org/W4385997304","https://openalex.org/W4387246316"],"related_works":["https://openalex.org/W4214920698","https://openalex.org/W4298109935","https://openalex.org/W3199793685","https://openalex.org/W4403077861","https://openalex.org/W7222814021","https://openalex.org/W4296016099","https://openalex.org/W7135077768","https://openalex.org/W7222008312","https://openalex.org/W4312212251","https://openalex.org/W4415666228"],"abstract_inverted_index":{"Lung":[0],"adenocarcinoma":[1],"(LUAD)":[2],"is":[3,41],"a":[4,70,98,137,174,185,193,209,218],"leading":[5],"cause":[6],"of":[7,115,140,161],"cancer":[8,120],"mortality,":[9],"with":[10,18,62,147,168],"many":[11],"patients":[12],"facing":[13],"poor":[14],"prognosis,":[15,181],"particularly":[16],"those":[17],"metastatic":[19],"or":[20],"drug-resistant":[21],"tumors.":[22],"Homologous":[23],"recombination":[24],"genes":[25],"(HRGs)":[26],"are":[27],"crucial":[28,99],"in":[29,39,53,88,101,106,109,117,163],"tumor":[30],"progression":[31],"and":[32,65,78,85,92,108,122,142,152,216],"therapy":[33],"resistance,":[34],"but":[35],"their":[36],"clinical":[37,93,214],"significance":[38],"LUAD":[40,54,180],"not":[42],"well":[43],"understood.":[44],"In":[45],"this":[46],"study,":[47],"we":[48],"systematically":[49],"characterize":[50],"key":[51],"HRGs":[52],"patients,":[55],"identifying":[56,182],"two":[57],"distinct":[58],"HR":[59],"subtypes":[60],"associated":[61],"different":[63],"outcomes":[64,84],"biological":[66],"functions.":[67],"We":[68,133],"establish":[69],"5-gene":[71],"scoring":[72],"system":[73],"(XRCC2,":[74],"RAD51,":[75],"BRCA1,":[76],"FANCA,":[77],"CHEK1)":[79],"that":[80,144],"reliably":[81],"predicts":[82],"patient":[83],"immunotherapy":[86],"responses":[87],"LUAD.":[89,102],"Bioinformatics":[90],"analysis":[91],"validation":[94,215],"highlight":[95],"XRCC2":[96,116,125,141,151,183],"as":[97,136,184,192],"biomarker":[100],"Functional":[103],"investigations":[104],"through":[105,131],"vivo":[107,164],"vitro":[110],"experiments":[111],"reveal":[112],"the":[113,158],"role":[114],"promoting":[118],"lung":[119,199,224],"migration":[121],"invasion.":[123],"Mechanistically,":[124],"stabilizes":[126],"vimentin":[127],"(VIM)":[128],"protein":[129],"expression":[130],"deubiquitylation.":[132],"predict":[134],"c-MYC":[135,146],"potential":[138,175,219],"regulator":[139],"demonstrate":[143],"inhibiting":[145],"compound":[148],"10058-F4":[149,167],"reduces":[150],"VIM":[153],"expression.":[154],"Preclinical":[155],"studies":[156],"show":[157],"synergistic":[159],"inhibition":[160],"metastasis":[162,225],"when":[165],"combining":[166],"doxorubicin":[169],"(Dox).":[170],"Our":[171],"findings":[172],"present":[173],"personalized":[176],"predictive":[177],"tool":[178,211],"for":[179,197,212,222],"critical":[186],"biomarker.":[187],"The":[188],"c-Myc-XRCC2-VIM":[189],"axis":[190],"emerges":[191],"promising":[194],"therapeutic":[195,220],"target":[196],"overcoming":[198],"metastasis.":[200],"This":[201],"study":[202],"provides":[203],"valuable":[204],"insights":[205],"into":[206],"LUAD,":[207],"proposing":[208],"prognostic":[210],"further":[213],"unveiling":[217],"strategy":[221],"combating":[223],"by":[226],"targeting":[227],"c-Myc-XRCC2-VIM.":[228]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2024-08-02T00:00:00"}
