{"id":"https://openalex.org/W4401200845","doi":"https://doi.org/10.15698/mic2024.07.832","title":"Promoter methylation and increased expression of PD-L1 in patients with active tuberculosis","display_name":"Promoter methylation and increased expression of PD-L1 in patients with active tuberculosis","publication_year":2024,"publication_date":"2024-07-29","ids":{"openalex":"https://openalex.org/W4401200845","doi":"https://doi.org/10.15698/mic2024.07.832","pmid":"https://pubmed.ncbi.nlm.nih.gov/39081906","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11287217"},"language":"en","primary_location":{"id":"doi:10.15698/mic2024.07.832","doi":"https://doi.org/10.15698/mic2024.07.832","is_oa":true,"landing_page_url":"https://doi.org/10.15698/mic2024.07.832","pdf_url":"http://microbialcell.com/wordpress/wp-content/uploads/2024a-tseng-microbial-cell.pdf","source":{"id":"https://openalex.org/S2765077297","display_name":"Microbial Cell","issn_l":"2311-2638","issn":["2311-2638"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317901","host_organization_name":"Shared Science Publishers OG","host_organization_lineage":["https://openalex.org/P4310317901"],"host_organization_lineage_names":["Shared Science Publishers OG"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbial Cell","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://microbialcell.com/wordpress/wp-content/uploads/2024a-tseng-microbial-cell.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102710225","display_name":"Yen-Han Tseng","orcid":"https://orcid.org/0000-0002-7504-0678","observed_orcids":["https://orcid.org/0000-0002-7504-0678"]},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]},{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yen-Han Tseng","raw_affiliation_strings":["Department of Chest Medicine, Taipei Veterans General Hospital Taipei, 112 Taiwan","School of Medicine, National Yang Ming Chiao Tung University Taipei, 112 Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chest Medicine, Taipei Veterans General Hospital Taipei, 112 Taiwan","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"School of Medicine, National Yang Ming Chiao Tung University Taipei, 112 Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019535625","display_name":"Sheng\u2010Wei Pan","orcid":"https://orcid.org/0000-0002-7400-6996","observed_orcids":["https://orcid.org/0000-0002-7400-6996"]},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]},{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Sheng-Wei Pan","raw_affiliation_strings":["Department of Chest Medicine, Taipei Veterans General Hospital Taipei, 112 Taiwan","Institute of Public Health, National Yang Ming Chiao Tung University Taipei, 112 Taiwan","School of Medicine, National Yang Ming Chiao Tung University Taipei, 112 Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chest Medicine, Taipei Veterans General Hospital Taipei, 112 Taiwan","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"Institute of Public Health, National Yang Ming Chiao Tung University Taipei, 112 Taiwan","institution_ids":["https://openalex.org/I148366613"]},{"raw_affiliation_string":"School of Medicine, National Yang Ming Chiao Tung University Taipei, 112 Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035065966","display_name":"Jhong-Ru Huang","orcid":"https://orcid.org/0000-0002-3820-6966","observed_orcids":["https://orcid.org/0000-0002-3820-6966"]},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]},{"id":"https://openalex.org/I4210121532","display_name":"Ministry of Health and Welfare","ror":"https://ror.org/024w0ge69","country_code":"TW","type":"government","lineage":["https://openalex.org/I4210121532","https://openalex.org/I4405257903"]},{"id":"https://openalex.org/I4210129936","display_name":"Taichung Hospital","ror":"https://ror.org/03ky42c33","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210129936"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jhong-Ru Huang","raw_affiliation_strings":["Division of Chest Medicine, Department of Internal Medicine, Taichung Hospital, Ministry of Health and Welfare Taichung Taiwan","School of Medicine, National Yang Ming Chiao Tung University Taipei, 112 Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Chest Medicine, Department of Internal Medicine, Taichung Hospital, Ministry of Health and Welfare Taichung Taiwan","institution_ids":["https://openalex.org/I4210121532","https://openalex.org/I4210129936"]},{"raw_affiliation_string":"School of Medicine, National Yang Ming Chiao Tung University Taipei, 112 Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011078468","display_name":"Chang-Ching Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chang-Ching Lee","raw_affiliation_strings":["Department of Chest Medicine, Taipei Veterans General Hospital Taipei, 112 Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chest Medicine, Taipei Veterans General Hospital Taipei, 112 Taiwan","institution_ids":["https://openalex.org/I2803004286"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112736465","display_name":"Jung\u2010Jyh Hung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]},{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jung-Jyh Hung","raw_affiliation_strings":["Division of Thoracic Surgery, Department of Surgery, Taipei Veterans General Hospital Taipei, 112 Taiwain","School of Medicine, National Yang Ming Chiao Tung University Taipei, 112 Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Thoracic Surgery, Department of Surgery, Taipei Veterans General Hospital Taipei, 112 Taiwain","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"School of Medicine, National Yang Ming Chiao Tung University Taipei, 112 Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055464489","display_name":"Po\u2010Kuei Hsu","orcid":"https://orcid.org/0000-0003-1790-0227","observed_orcids":["https://orcid.org/0000-0003-1790-0227"]},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]},{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Po-Kuei Hsu","raw_affiliation_strings":["Division of Thoracic Surgery, Department of Surgery, Taipei Veterans General Hospital Taipei, 112 Taiwain","School of Medicine, National Yang Ming Chiao Tung University Taipei, 112 Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Thoracic Surgery, Department of Surgery, Taipei Veterans General Hospital Taipei, 112 Taiwain","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"School of Medicine, National Yang Ming Chiao Tung University Taipei, 112 Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062516508","display_name":"Nien\u2010Jung Chen","orcid":"https://orcid.org/0000-0002-9441-4049","observed_orcids":["https://orcid.org/0000-0002-9441-4049"]},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Nien-Jung Chen","raw_affiliation_strings":["Institute of Microbiology and Immunology, School of Life Sciences, National Yang Ming Chiao Tung University Taipei, 112 Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microbiology and Immunology, School of Life Sciences, National Yang Ming Chiao Tung University Taipei, 112 Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057571010","display_name":"Wei\u2010Juin Su","orcid":"https://orcid.org/0000-0001-9581-6472","observed_orcids":["https://orcid.org/0000-0001-9581-6472"]},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]},{"id":"https://openalex.org/I4210126829","display_name":"China Medical University Hospital","ror":"https://ror.org/0368s4g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210126829"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Wei-Juin Su","raw_affiliation_strings":["Division of Chest Medicine, China Medical University Hospital, Taipei Branch Taipei, 114 Taiwan","School of Medicine, National Yang Ming Chiao Tung University Taipei, 112 Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Chest Medicine, China Medical University Hospital, Taipei Branch Taipei, 114 Taiwan","institution_ids":["https://openalex.org/I4210126829"]},{"raw_affiliation_string":"School of Medicine, National Yang Ming Chiao Tung University Taipei, 112 Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028055906","display_name":"Yuh\u2010Min Chen","orcid":"https://orcid.org/0000-0003-0585-8463","observed_orcids":["https://orcid.org/0000-0003-0585-8463"]},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]},{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yuh-Min Chen","raw_affiliation_strings":["Department of Chest Medicine, Taipei Veterans General Hospital Taipei, 112 Taiwan","School of Medicine, National Yang Ming Chiao Tung University Taipei, 112 Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chest Medicine, Taipei Veterans General Hospital Taipei, 112 Taiwan","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"School of Medicine, National Yang Ming Chiao Tung University Taipei, 112 Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017489241","display_name":"Jia\u2010Yih Feng","orcid":"https://orcid.org/0000-0001-8840-8112","observed_orcids":["https://orcid.org/0000-0001-8840-8112"]},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]},{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jia-Yih Feng","raw_affiliation_strings":["Department of Chest Medicine, Taipei Veterans General Hospital Taipei, 112 Taiwan","Institute of Emergency and Critical Care Medicine, National Yang Ming Chiao Tung University Taipei, 112 Taiwan","School of Medicine, National Yang Ming Chiao Tung University Taipei, 112 Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chest Medicine, Taipei Veterans General Hospital Taipei, 112 Taiwan","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"Institute of Emergency and Critical Care Medicine, National Yang Ming Chiao Tung University Taipei, 112 Taiwan","institution_ids":["https://openalex.org/I148366613"]},{"raw_affiliation_string":"School of Medicine, National Yang Ming Chiao Tung University Taipei, 112 Taiwan","institution_ids":["https://openalex.org/I148366613"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1190,"currency":"EUR","value_usd":1283},"apc_paid":{"value":1190,"currency":"EUR","value_usd":1283},"fwci":2.0436,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.85199714,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"11","issue":null,"first_page":"278","last_page":"278"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.9010000228881836},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.8169999718666077},{"id":"https://openalex.org/keywords/promoter-methylation","display_name":"promoter methylation","score":0.9169999957084656},{"id":"https://openalex.org/keywords/active-tuberculosis","display_name":"active tuberculosis","score":0.8980000019073486},{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.9369999766349792},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8700000047683716},{"id":"https://openalex.org/keywords/tet1","display_name":"TET1","score":0.890999972820282},{"id":"https://openalex.org/keywords/dnmt3b","display_name":"DNMT3B","score":0.9110000133514404},{"id":"https://openalex.org/keywords/dnmt1","display_name":"DNMT1","score":0.9789999723434448},{"id":"https://openalex.org/keywords/dnmt-inhibition","display_name":"DNMT inhibition","score":0.8450000286102295},{"id":"https://openalex.org/keywords/pd-1-pd-l1-pathway","display_name":"PD-1/PD-L1 pathway","score":0.906000018119812},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.781000018119812},{"id":"https://openalex.org/keywords/treatment-outcomes","display_name":"treatment outcomes","score":0.5109999775886536},{"id":"https://openalex.org/keywords/lung-tissue","display_name":"lung tissue","score":0.32899999618530273}],"concepts":[{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.6595886945724487},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.6465118527412415},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.49948644638061523},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37096261978149414},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3618777394294739},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3580027222633362},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3544843792915344},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3296721577644348},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3210071325302124},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.28334566950798035},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.17522385716438293},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15926653146743774}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.15698/mic2024.07.832","doi":"https://doi.org/10.15698/mic2024.07.832","is_oa":true,"landing_page_url":"https://doi.org/10.15698/mic2024.07.832","pdf_url":"http://microbialcell.com/wordpress/wp-content/uploads/2024a-tseng-microbial-cell.pdf","source":{"id":"https://openalex.org/S2765077297","display_name":"Microbial Cell","issn_l":"2311-2638","issn":["2311-2638"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317901","host_organization_name":"Shared Science Publishers OG","host_organization_lineage":["https://openalex.org/P4310317901"],"host_organization_lineage_names":["Shared Science Publishers OG"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbial Cell","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11287217","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11287217","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11287217/pdf/mic-11-278.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microb Cell","raw_type":"Text"},{"id":"pmid:39081906","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39081906","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbial cell (Graz, Austria)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:0d13d1073e114f1b828ead3170573d78","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/0d13d1073e114f1b828ead3170573d78","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Microbial Cell, Vol 11, p 278 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.15698/mic2024.07.832","doi":"https://doi.org/10.15698/mic2024.07.832","is_oa":true,"landing_page_url":"https://doi.org/10.15698/mic2024.07.832","pdf_url":"http://microbialcell.com/wordpress/wp-content/uploads/2024a-tseng-microbial-cell.pdf","source":{"id":"https://openalex.org/S2765077297","display_name":"Microbial Cell","issn_l":"2311-2638","issn":["2311-2638"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317901","host_organization_name":"Shared Science Publishers OG","host_organization_lineage":["https://openalex.org/P4310317901"],"host_organization_lineage_names":["Shared Science Publishers OG"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbial Cell","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1462995560","display_name":null,"funder_award_id":"V111C-037","funder_id":"https://openalex.org/F4320327358","funder_display_name":"Taipei Veterans General Hospital"},{"id":"https://openalex.org/G3453617484","display_name":"Epigenetic Control of Immune Checkpoint Molecules in Mycobacterial Infection- Human and Mouse Model Study","funder_award_id":"MOST111-2314-B075-058","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G6425181458","display_name":null,"funder_award_id":"V112C-181","funder_id":"https://openalex.org/F4320327358","funder_display_name":"Taipei Veterans General Hospital"}],"funders":[{"id":"https://openalex.org/F4320322795","display_name":"Ministry of Science and Technology, Taiwan","ror":"https://ror.org/02kv4zf79"},{"id":"https://openalex.org/F4320327358","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76"},{"id":"https://openalex.org/F4320331164","display_name":"National Science and Technology Council","ror":"https://ror.org/00wnb9798"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4401200845.pdf","grobid_xml":"https://content.openalex.org/works/W4401200845.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1827923022","https://openalex.org/W1993263603","https://openalex.org/W2028165539","https://openalex.org/W2097855813","https://openalex.org/W2153745676","https://openalex.org/W2464452428","https://openalex.org/W2547156322","https://openalex.org/W2550560229","https://openalex.org/W2553022605","https://openalex.org/W2553733474","https://openalex.org/W2559827530","https://openalex.org/W2589528213","https://openalex.org/W2760106390","https://openalex.org/W2761172458","https://openalex.org/W2761586559","https://openalex.org/W2793615081","https://openalex.org/W2794763378","https://openalex.org/W2889554021","https://openalex.org/W2902493397","https://openalex.org/W2910861679","https://openalex.org/W2915174466","https://openalex.org/W2977648831","https://openalex.org/W2980869578","https://openalex.org/W2985205513","https://openalex.org/W3117999696","https://openalex.org/W4210534310","https://openalex.org/W4224219866","https://openalex.org/W4287308120","https://openalex.org/W4312065543"],"related_works":["https://openalex.org/W4312229431","https://openalex.org/W4210534310","https://openalex.org/W2559827530","https://openalex.org/W2529584041","https://openalex.org/W2889554021","https://openalex.org/W2045323799","https://openalex.org/W1988916904","https://openalex.org/W2564748283","https://openalex.org/W2354917776","https://openalex.org/W1968218641"],"abstract_inverted_index":{"Abstract":[0],"The":[1,59,169],"PD-1/PD-L1":[2],"pathway":[3],"plays":[4],"a":[5,26],"pivotal":[6],"role":[7],"in":[8,15,32,41,66,108,116,136,165,196,202,215,229,244,248],"T":[9],"cell":[10,118,205],"activity":[11],"and":[12,56,63,74,80,96,105,115,130,156,173,181,185,193,201,212,219,234],"is":[13,25,227,235,242],"involved":[14,243],"the":[16,137,166,189],"pathophysiology":[17],"of":[18,61,147,159,171,191],"Mycobacterium":[19],"tuberculosis":[20,54],"(MTB)":[21],"infection.":[22],"DNA":[23,240],"methylation":[24,87,241],"mechanism":[27],"that":[28,164],"modulates":[29],"PD-L1":[30,39,62,85,148,172,221,225,246],"expression":[31,40,60,146,158,170,226,247],"cancer":[33],"cells.":[34],"However,":[35],"its":[36],"effect":[37],"on":[38],"macrophages":[42,195,217],"after":[43,207],"MTB":[44],"infection":[45],"remains":[46],"unknown.":[47],"We":[48],"prospectively":[49],"enrolled":[50,135],"patients":[51,112,126,197,230],"with":[52,77,113,120,127,140,178,198,231,237],"active":[53,128,141,232],"(TB)":[55],"non-TB":[57,132,167],"subjects.":[58,168],"methylation-related":[64],"genes":[65],"peripheral":[67],"blood":[68],"mononuclear":[69],"cells":[70,107],"(PBMCs)":[71],"were":[72,83,100,134],"investigated":[73],"their":[75],"correlation":[76],"disease":[78],"severity":[79],"treatment":[81,238],"outcomes":[82],"examined.":[84],"promoter":[86],"status":[88],"was":[89,175],"evaluated":[90],"using":[91],"bisulfite":[92],"sequencing.":[93],"Immunohistochemistry":[94],"(IHC)":[95],"immunofluorescence":[97],"(IF)":[98],"staining":[99,187],"used":[101],"to":[102,163],"visualize":[103],"PD-L1-":[104,192],"TET-1-expressing":[106,194],"lung":[109],"tissues":[110],"from":[111],"TB":[114,129,142,200,233],"macrophage":[117,204],"lines":[119,206],"MTB-related":[121,208],"stimulation.":[122,209],"In":[123],"total,":[124],"80":[125],"40":[131],"subjects":[133],"analysis.":[138],"Patients":[139],"had":[143],"significantly":[144,176],"higher":[145],",":[149,151,153,155,161],"DNMT3b":[150],"TET1":[152],"TET2":[154],"lower":[157],"DNMT1":[160],"compared":[162],"TET-1":[174,213],"associated":[177],"1-month":[179],"smear":[180],"culture":[182],"non-conversion.":[183],"IHC":[184],"IF":[186],"demonstrated":[188],"co-localization":[190],"pulmonary":[199],"human":[203,216,249],"DNMT":[210],"inhibition":[211],"knockdown":[214],"increased":[218,228],"decreased":[220],"expression,":[222],"respectively.":[223],"Overall,":[224],"correlated":[236],"outcomes.":[239],"modulating":[245],"macrophages.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-08-01T00:00:00"}
