{"id":"https://openalex.org/W4401197832","doi":"https://doi.org/10.25100/cm.v39i2.supl.2.584","title":"Microsatellite instability analysis using BAT-26 marker in patients with gastric or colorectal cancer diagnosed at Hospital Universitario de Santander.","display_name":"Microsatellite instability analysis using BAT-26 marker in patients with gastric or colorectal cancer diagnosed at Hospital Universitario de Santander.","publication_year":2008,"publication_date":"2008-06-30","ids":{"openalex":"https://openalex.org/W4401197832","doi":"https://doi.org/10.25100/cm.v39i2.supl.2.584","mag":"2112209117"},"language":"en","primary_location":{"id":"doi:10.25100/cm.v39i2.supl.2.584","doi":"https://doi.org/10.25100/cm.v39i2.supl.2.584","is_oa":true,"landing_page_url":"http://dx.doi.org/10.25100/cm.v39i2.supl.2.584","pdf_url":"https://colombiamedica.univalle.edu.co/index.php/comedica/article/download/584/602","source":{"id":"https://openalex.org/S1041805121","display_name":"Colombia medica","issn_l":"0120-8322","issn":["0120-8322","1657-9534"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","latindex","medline","poland-40","publindex-a2","russia-white-list-2","scielo"],"host_organization":"https://openalex.org/P4310318840","host_organization_name":"University of Valle","host_organization_lineage":["https://openalex.org/P4310318840"],"host_organization_lineage_names":["University of Valle"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Colombia Medica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://colombiamedica.univalle.edu.co/index.php/comedica/article/download/584/602","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079830408","display_name":"Wilmer C\u00e1rdenas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115684694","display_name":"Universidad Industrial de Santander","ror":"https://ror.org/00xc1d948","country_code":"CO","type":"education","lineage":["https://openalex.org/I115684694"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Wilmer C\u00e1rdenas","raw_affiliation_strings":["Universidad Industrial de Santander"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad Industrial de Santander","institution_ids":["https://openalex.org/I115684694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111765335","display_name":"Adriana Castillo","orcid":"https://orcid.org/0000-0002-7292-8401","observed_orcids":["https://orcid.org/0000-0002-7292-8401"]},"institutions":[{"id":"https://openalex.org/I115684694","display_name":"Universidad Industrial de Santander","ror":"https://ror.org/00xc1d948","country_code":"CO","type":"education","lineage":["https://openalex.org/I115684694"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Adriana Castillo","raw_affiliation_strings":["Universidad Industrial de Santander"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad Industrial de Santander","institution_ids":["https://openalex.org/I115684694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102146707","display_name":"Clara In\u00e9s Vargas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115684694","display_name":"Universidad Industrial de Santander","ror":"https://ror.org/00xc1d948","country_code":"CO","type":"education","lineage":["https://openalex.org/I115684694"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Clara Vargas","raw_affiliation_strings":["Universidad Industrial de Santander"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad Industrial de Santander","institution_ids":["https://openalex.org/I115684694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113894252","display_name":"Olga Mar\u00eda Moreno","orcid":"https://orcid.org/0000-0002-0826-6191","observed_orcids":["https://orcid.org/0000-0002-0826-6191"]},"institutions":[{"id":"https://openalex.org/I115684694","display_name":"Universidad Industrial de Santander","ror":"https://ror.org/00xc1d948","country_code":"CO","type":"education","lineage":["https://openalex.org/I115684694"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Olga Moreno","raw_affiliation_strings":["Universidad Industrial de Santander"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad Industrial de Santander","institution_ids":["https://openalex.org/I115684694"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049214996","display_name":"Jes\u00fas Insuasty","orcid":"https://orcid.org/0000-0002-6535-4657","observed_orcids":["https://orcid.org/0000-0002-6535-4657"]},"institutions":[{"id":"https://openalex.org/I115684694","display_name":"Universidad Industrial de Santander","ror":"https://ror.org/00xc1d948","country_code":"CO","type":"education","lineage":["https://openalex.org/I115684694"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Jes\u00fas Insuasty","raw_affiliation_strings":["Universidad Industrial de Santander"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad Industrial de Santander","institution_ids":["https://openalex.org/I115684694"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I115684694"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.58173174,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"39","issue":"2.Supl.2","first_page":"41","last_page":"51"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microsatellite-instability","display_name":"microsatellite instability","score":0.9980000257492065},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.7369999885559082},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":1.0},{"id":"https://openalex.org/keywords/hereditary-cancer-syndromes","display_name":"hereditary cancer","score":0.8059999942779541},{"id":"https://openalex.org/keywords/tumor-differentiation","display_name":"tumor differentiation","score":0.7360000014305115},{"id":"https://openalex.org/keywords/histopathological-grade","display_name":"histopathological grade","score":0.6039999723434448},{"id":"https://openalex.org/keywords/proteinase-k-digestion","display_name":"proteinase K digestion","score":0.7630000114440918}],"concepts":[{"id":"https://openalex.org/C2779767149","wikidata":"https://www.wikidata.org/wiki/Q488212","display_name":"Microsatellite instability","level":5,"score":0.8765445947647095},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7800377607345581},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7375401258468628},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.561867356300354},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.556725800037384},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5464533567428589},{"id":"https://openalex.org/C3017595490","wikidata":"https://www.wikidata.org/wiki/Q17006263","display_name":"University hospital","level":2,"score":0.43716612458229065},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4348936676979065},{"id":"https://openalex.org/C61320498","wikidata":"https://www.wikidata.org/wiki/Q265193","display_name":"Microsatellite","level":4,"score":0.2670722007751465},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12329810857772827},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08584576845169067},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.25100/cm.v39i2.supl.2.584","doi":"https://doi.org/10.25100/cm.v39i2.supl.2.584","is_oa":true,"landing_page_url":"http://dx.doi.org/10.25100/cm.v39i2.supl.2.584","pdf_url":"https://colombiamedica.univalle.edu.co/index.php/comedica/article/download/584/602","source":{"id":"https://openalex.org/S1041805121","display_name":"Colombia medica","issn_l":"0120-8322","issn":["0120-8322","1657-9534"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","latindex","medline","poland-40","publindex-a2","russia-white-list-2","scielo"],"host_organization":"https://openalex.org/P4310318840","host_organization_name":"University of Valle","host_organization_lineage":["https://openalex.org/P4310318840"],"host_organization_lineage_names":["University of Valle"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Colombia Medica","raw_type":"journal-article"},{"id":"pmh:oai:bibliotecadigital.univalle.edu.co:10893/4224","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10893/4224","pdf_url":"http://hdl.handle.net/10893/4224","source":{"id":"https://openalex.org/S4377196465","display_name":"Univalle Digital Repository (University of Valle)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I91732220","host_organization_name":"Universidad del Valle","host_organization_lineage":["https://openalex.org/I91732220"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Art\u00edculo de revista"},{"id":"pmh:cria:bioline:rc:rc08041","doi":null,"is_oa":false,"landing_page_url":"http://www.bioline.org.br/abstract?id=rc08041","pdf_url":null,"source":{"id":"https://openalex.org/S4306402188","display_name":"Bioline International (Bioline International)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Revista Colombia M\u00e9dica (ISSN: 0120-8322) Vol 39 Num 2s2","raw_type":"AA"},{"id":"pmh:oai:utoronto.scholaris.ca:1807/60829","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1807/60829","pdf_url":null,"source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"mag:2112209117","doi":null,"is_oa":true,"landing_page_url":"https://biblat.unam.mx/hevila/Colombiamedica/2008/vol39/Supl2delno2/6.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S1041805121","display_name":"Colombia medica","issn_l":"0120-8322","issn":["0120-8322","1657-9534"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","latindex","medline","poland-40","publindex-a2","russia-white-list-2","scielo"],"host_organization":"https://openalex.org/P4310318840","host_organization_name":"University of Valle","host_organization_lineage":["https://openalex.org/P4310318840"],"host_organization_lineage_names":["University of Valle"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Colombia medica","raw_type":null}],"best_oa_location":{"id":"doi:10.25100/cm.v39i2.supl.2.584","doi":"https://doi.org/10.25100/cm.v39i2.supl.2.584","is_oa":true,"landing_page_url":"http://dx.doi.org/10.25100/cm.v39i2.supl.2.584","pdf_url":"https://colombiamedica.univalle.edu.co/index.php/comedica/article/download/584/602","source":{"id":"https://openalex.org/S1041805121","display_name":"Colombia medica","issn_l":"0120-8322","issn":["0120-8322","1657-9534"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","latindex","medline","poland-40","publindex-a2","russia-white-list-2","scielo"],"host_organization":"https://openalex.org/P4310318840","host_organization_name":"University of Valle","host_organization_lineage":["https://openalex.org/P4310318840"],"host_organization_lineage_names":["University of Valle"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Colombia Medica","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4401197832.pdf","grobid_xml":"https://content.openalex.org/works/W4401197832.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W149099508","https://openalex.org/W1546598264","https://openalex.org/W1606687529","https://openalex.org/W1903698419","https://openalex.org/W1970625318","https://openalex.org/W2007620902","https://openalex.org/W2018009295","https://openalex.org/W2032131734","https://openalex.org/W2033689666","https://openalex.org/W2049263845","https://openalex.org/W2058680827","https://openalex.org/W2090290891","https://openalex.org/W2097622325","https://openalex.org/W2097639613","https://openalex.org/W2098476483","https://openalex.org/W2136364644","https://openalex.org/W2150172738","https://openalex.org/W2158417496","https://openalex.org/W2162701425","https://openalex.org/W2166803140","https://openalex.org/W2304715284"],"related_works":["https://openalex.org/W2112209117","https://openalex.org/W7133447918","https://openalex.org/W7054598179","https://openalex.org/W10374688","https://openalex.org/W2347173399","https://openalex.org/W3184829983","https://openalex.org/W2081783593","https://openalex.org/W2405088833","https://openalex.org/W2356803357","https://openalex.org/W7133427881"],"abstract_inverted_index":{"Introduction:":[0],"The":[1],"path":[2],"of":[3,12,15,18,51,63,108,113,178,185,229,236,245,255,266],"microsatellite":[4,136,158],"instability":[5,32,38,159],"has":[6],"mainly":[7],"been":[8,82],"found":[9,222],"in":[10,53,66,120,227],"cancers":[11],"digestive":[13],"tracts,":[14],"which":[16,79],"90%":[17],"cases":[19,179,192,230],"are":[20,26],"hereditary":[21,195],"cancer":[22,189,201],"patients":[23,27,67,116],"and":[24,69,88,106,123,129,197,216,258,269],"15%":[25],"with":[28,73,84,168,187,194,199,210,233],"sporadic":[29],"cancer.":[30],"That":[31],"produces":[33],"a":[34,85,153],"phenotype":[35,41,65,148,208,224],"called":[36],"Microsatellite":[37],"(IMI+)":[39,163],"or":[40,164],"by":[42,127,142,241],"replication":[43],"mistake":[44],"(RER+)":[45],"that":[46],"leads":[47],"to":[48,56,91,94,145,251],"the":[49,61,74,95,109,114,121,125,135,157,161,165,211,223,234,242,253],"accumulation":[50],"mutations":[52],"higher":[54],"rates":[55],"normal.":[57],"Objectives:":[58],"To":[59],"identify":[60],"presence":[62,162],"IMI+":[64,147,209],"analyzed":[68],"evaluated":[70],"its":[71],"relationship":[72],"differentiation":[75,217,237],"histopathologic":[76,218,238],"tumor,":[77,239],"because":[78,261],"together":[80],"have":[81],"associated":[83],"better":[86],"prognosis":[87],"improved":[89],"response":[90],"treatment":[92],"given":[93],"patient.":[96],"Methodology:":[97],"DNA":[98],"was":[99,133,140,204],"extracted":[100],"from":[101],"blood":[102],"samples":[103,246],"(normal":[104],"cells)":[105,112],"biopsy":[107],"tumor":[110],"(tumor":[111],"23":[115],"who":[117,139],"were":[118],"included":[119],"study":[122],"through":[124],"amplification":[126],"PCR":[128],"subsequent":[130],"capillary":[131],"electrophoresis":[132],"typified":[134],"mononucleotidic":[137],"BAT-26,":[138],"employed":[141],"his":[143],"sensitivity":[144],"detect":[146],"(95%).":[149],"Finally,":[150],"we":[151],"made":[152],"statistical":[154],"correlation":[155],"between":[156,207],"phenotype,":[160],"absence":[166],"(IMI-),":[167],"histopathological":[169],"findings":[170],"using":[171],"Fisher\u2019s":[172],"exact":[173],"test.":[174],"Results:":[175],"In":[176],"17%":[177,228],"(4":[180],"patients)":[181],"had":[182],"IMI+:":[183],"3":[184],"them":[186],"colorectal":[188],"(CRC)":[190],"-2":[191],"possibly":[193,240],"cancer-":[196],"one":[198],"gastric":[200],"(GC).":[202],"There":[203],"no":[205],"association":[206,232],"pathological":[212],"diagnosis,":[213],"age,":[214],"sex":[215],"tumor.":[219],"Conclusion:":[220],"We":[221],"IMI":[225],"+":[226],"without":[231],"degree":[235],"reduced":[243],"number":[244],"analyzed,":[247],"making":[248],"it":[249],"essential":[250],"review":[252],"methods":[254],"fixation,":[256],"paraffin":[257],"storage":[259],"tissue":[260],"current":[262],"techniques":[263],"hinder":[264],"digestion":[265],"proteinase":[267],"k":[268],"PCR.":[270]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-08-01T00:00:00"}
