{"id":"https://openalex.org/W4401189784","doi":"https://doi.org/10.4014/jmb.2402.02035","title":"Anti-Menopausal Effect of Heat-Killed Bifidobacterium breve HDB7040 via Estrogen Receptor-Selective Modulation in MCF-7 Cells and Ovariectomized Rats","display_name":"Anti-Menopausal Effect of Heat-Killed Bifidobacterium breve HDB7040 via Estrogen Receptor-Selective Modulation in MCF-7 Cells and Ovariectomized Rats","publication_year":2024,"publication_date":"2024-06-17","ids":{"openalex":"https://openalex.org/W4401189784","doi":"https://doi.org/10.4014/jmb.2402.02035","pmid":"https://pubmed.ncbi.nlm.nih.gov/39081245","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11380510"},"language":"en","primary_location":{"id":"doi:10.4014/jmb.2402.02035","doi":"https://doi.org/10.4014/jmb.2402.02035","is_oa":true,"landing_page_url":"https://doi.org/10.4014/jmb.2402.02035","pdf_url":"https://www.jmb.or.kr/journal/download_pdf.php?doi=10.4014/jmb.2402.02035","source":{"id":"https://openalex.org/S70307536","display_name":"Journal of Microbiology and Biotechnology","issn_l":"1017-7825","issn":["1017-7825","1738-8872"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","kci-registered","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Microbiology and Biotechnology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jmb.or.kr/journal/download_pdf.php?doi=10.4014/jmb.2402.02035","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100775576","display_name":"Hyeon Jeong Kim","orcid":"https://orcid.org/0000-0001-5217-5580","observed_orcids":["https://orcid.org/0000-0001-5217-5580"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hyeon Jeong Kim","raw_affiliation_strings":["Biohealthcare R&D Center, HYUNDAI BIOLAND Co., Ltd., Ansan 15407, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biohealthcare R&D Center, HYUNDAI BIOLAND Co., Ltd., Ansan 15407, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100332057","display_name":"Kyung Min Kim","orcid":"https://orcid.org/0000-0002-0261-1687","observed_orcids":["https://orcid.org/0000-0002-0261-1687"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kyung Min Kim","raw_affiliation_strings":["Biohealthcare R&D Center, HYUNDAI BIOLAND Co., Ltd., Ansan 15407, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biohealthcare R&D Center, HYUNDAI BIOLAND Co., Ltd., Ansan 15407, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054868291","display_name":"Min\u2010Kyu Yun","orcid":"https://orcid.org/0000-0002-5874-0728","observed_orcids":["https://orcid.org/0000-0002-5874-0728"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Min-Kyu Yun","raw_affiliation_strings":["Biohealthcare R&D Center, HYUNDAI BIOLAND Co., Ltd., Ansan 15407, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biohealthcare R&D Center, HYUNDAI BIOLAND Co., Ltd., Ansan 15407, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016553462","display_name":"Duseong Kim","orcid":"https://orcid.org/0009-0009-2419-0818","observed_orcids":["https://orcid.org/0009-0009-2419-0818"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Duseong Kim","raw_affiliation_strings":["Biohealthcare R&D Center, HYUNDAI BIOLAND Co., Ltd., Ansan 15407, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biohealthcare R&D Center, HYUNDAI BIOLAND Co., Ltd., Ansan 15407, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101654893","display_name":"Johann Sohn","orcid":"https://orcid.org/0000-0002-4449-9910","observed_orcids":["https://orcid.org/0000-0002-4449-9910"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Johann Sohn","raw_affiliation_strings":["Biohealthcare R&D Center, HYUNDAI BIOLAND Co., Ltd., Ansan 15407, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biohealthcare R&D Center, HYUNDAI BIOLAND Co., Ltd., Ansan 15407, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101039508","display_name":"Ji-Won Song","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ji-Won Song","raw_affiliation_strings":["Biohealthcare R&D Center, HYUNDAI BIOLAND Co., Ltd., Ansan 15407, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biohealthcare R&D Center, HYUNDAI BIOLAND Co., Ltd., Ansan 15407, Republic of Korea","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108713087","display_name":"Seunghun Lee","orcid":"https://orcid.org/0009-0002-8125-8240","observed_orcids":["https://orcid.org/0009-0002-8125-8240"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Seunghun Lee","raw_affiliation_strings":["Biohealthcare R&D Center, HYUNDAI BIOLAND Co., Ltd., Ansan 15407, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biohealthcare R&D Center, HYUNDAI BIOLAND Co., Ltd., Ansan 15407, Republic of Korea","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5108713087"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4973,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.57696549,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"34","issue":"8","first_page":"1580","last_page":"1591"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.5741999745368958,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.5741999745368958,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.19179999828338623,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.13169999420642853,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bifidobacterium-breve","display_name":"Bifidobacterium breve","score":0.8299999833106995},{"id":"https://openalex.org/keywords/heat-killed-bacteria","display_name":"heat-killed bacteria","score":0.7990000247955322},{"id":"https://openalex.org/keywords/menopausal-syndrome","display_name":"menopausal syndrome","score":0.8859999775886536},{"id":"https://openalex.org/keywords/estrogen-receptor-beta","display_name":"estrogen receptor beta","score":0.9700000286102295},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.8679999709129333},{"id":"https://openalex.org/keywords/ovariectomized-rats","display_name":"ovariectomized rats","score":0.9020000100135803},{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.671999990940094},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C8264082","wikidata":"https://www.wikidata.org/wiki/Q7113259","display_name":"Ovariectomized rat","level":3,"score":0.8699623942375183},{"id":"https://openalex.org/C2778562196","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Menopause","level":2,"score":0.7082899808883667},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.5776691436767578},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.574945330619812},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5322278141975403},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5118757486343384},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5074097514152527},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4396458566188812},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.22431951761245728}],"mesh":[{"descriptor_ui":"D000069984","descriptor_name":"Bifidobacterium breve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000071163","descriptor_name":"Trefoil Factor-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000071163","descriptor_name":"Trefoil Factor-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008593","descriptor_name":"Menopause","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010052","descriptor_name":"Ovariectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011980","descriptor_name":"Receptors, Progesterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014599","descriptor_name":"Uterus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019936","descriptor_name":"Probiotics","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019936","descriptor_name":"Probiotics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047628","descriptor_name":"Estrogen Receptor alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047628","descriptor_name":"Estrogen Receptor alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047629","descriptor_name":"Estrogen Receptor beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D047629","descriptor_name":"Estrogen Receptor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.4014/jmb.2402.02035","doi":"https://doi.org/10.4014/jmb.2402.02035","is_oa":true,"landing_page_url":"https://doi.org/10.4014/jmb.2402.02035","pdf_url":"https://www.jmb.or.kr/journal/download_pdf.php?doi=10.4014/jmb.2402.02035","source":{"id":"https://openalex.org/S70307536","display_name":"Journal of Microbiology and Biotechnology","issn_l":"1017-7825","issn":["1017-7825","1738-8872"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","kci-registered","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Microbiology and Biotechnology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11380510","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11380510","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11380510/pdf/jmb-34-8-1580.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Microbiol Biotechnol","raw_type":"Text"},{"id":"pmid:39081245","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39081245","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of microbiology and biotechnology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4014/jmb.2402.02035","doi":"https://doi.org/10.4014/jmb.2402.02035","is_oa":true,"landing_page_url":"https://doi.org/10.4014/jmb.2402.02035","pdf_url":"https://www.jmb.or.kr/journal/download_pdf.php?doi=10.4014/jmb.2402.02035","source":{"id":"https://openalex.org/S70307536","display_name":"Journal of Microbiology and Biotechnology","issn_l":"1017-7825","issn":["1017-7825","1738-8872"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","kci-registered","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Microbiology and Biotechnology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4401189784.pdf","grobid_xml":"https://content.openalex.org/works/W4401189784.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1760940766","https://openalex.org/W1965632982","https://openalex.org/W1988941884","https://openalex.org/W2018979693","https://openalex.org/W2034329390","https://openalex.org/W2035587817","https://openalex.org/W2059477274","https://openalex.org/W2069183127","https://openalex.org/W2159837057","https://openalex.org/W2165180787","https://openalex.org/W2303286930","https://openalex.org/W2527707651","https://openalex.org/W2613177040","https://openalex.org/W2914371319","https://openalex.org/W2943968638","https://openalex.org/W2946568639","https://openalex.org/W2951936075","https://openalex.org/W2969581479","https://openalex.org/W3000118636","https://openalex.org/W3011987578","https://openalex.org/W3038130097","https://openalex.org/W3059301501","https://openalex.org/W3094559596","https://openalex.org/W3100445942","https://openalex.org/W3147034087","https://openalex.org/W3180157887","https://openalex.org/W3197280431","https://openalex.org/W4213424402","https://openalex.org/W4286001034","https://openalex.org/W4293724043","https://openalex.org/W4296744079","https://openalex.org/W4328047903","https://openalex.org/W4362458708","https://openalex.org/W4387054193","https://openalex.org/W4387880513"],"related_works":["https://openalex.org/W7218185115","https://openalex.org/W6981095745","https://openalex.org/W2049112448","https://openalex.org/W2553778555","https://openalex.org/W2059983415","https://openalex.org/W1983716127","https://openalex.org/W7146035672","https://openalex.org/W2922443668","https://openalex.org/W7052661809","https://openalex.org/W4386426186"],"abstract_inverted_index":{"HDB7040":[0],"exerts":[1],"an":[2],"anti-menopausal":[3],"effect":[4],"via":[5],"the":[6],"specific":[7],"regulation":[8],"of":[9],"ER\u03b2":[10],"in":[11,14],"vitro":[12],"and":[13,25],"vivo,":[15],"suggesting":[16],"its":[17],"potential":[18],"as":[19],"a":[20],"novel":[21],"substance":[22],"for":[23],"improving":[24],"treating":[26],"menopausal":[27],"syndrome.":[28]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-08-01T00:00:00"}