{"id":"https://openalex.org/W4401188174","doi":"https://doi.org/10.21608/rpbs.2024.294154.1301","title":"A review: Imidazole and its biological activities","display_name":"A review: Imidazole and its biological activities","publication_year":2024,"publication_date":"2024-05-01","ids":{"openalex":"https://openalex.org/W4401188174","doi":"https://doi.org/10.21608/rpbs.2024.294154.1301"},"language":"en","primary_location":{"id":"doi:10.21608/rpbs.2024.294154.1301","doi":"https://doi.org/10.21608/rpbs.2024.294154.1301","is_oa":true,"landing_page_url":"https://doi.org/10.21608/rpbs.2024.294154.1301","pdf_url":null,"source":{"id":"https://openalex.org/S4210233164","display_name":"Records of Pharmaceutical and Biomedical Sciences/Records of Pharmaceutical & Biomedical Sciences","issn_l":"2536-9857","issn":["2536-9857","2535-2091"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Records of Pharmaceutical and Biomedical Sciences","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4401188174"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.21608/rpbs.2024.294154.1301","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108149881","display_name":"sahar abdallah ibrahim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1355163","display_name":"Sinai University","ror":"https://ror.org/01dd13a92","country_code":"EG","type":"education","lineage":["https://openalex.org/I1355163"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"sahar abdallah ibrahim","raw_affiliation_strings":["Department of pharmaceutical chemistry, faculty of pharmacy, Sinai university- Arish branch"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of pharmaceutical chemistry, faculty of pharmacy, Sinai university- Arish branch","institution_ids":["https://openalex.org/I1355163"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026101030","display_name":"Ismail Salama","orcid":"https://orcid.org/0000-0002-1360-0430","observed_orcids":["https://orcid.org/0000-0002-1360-0430"]},"institutions":[{"id":"https://openalex.org/I114794399","display_name":"Suez Canal University","ror":"https://ror.org/02m82p074","country_code":"EG","type":"education","lineage":["https://openalex.org/I114794399"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Ismail Awad Alla salama","raw_affiliation_strings":["Department of Medicinal chemistry, Faculty of Pharmacy, Suez Canal University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal chemistry, Faculty of Pharmacy, Suez Canal University","institution_ids":["https://openalex.org/I114794399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036561963","display_name":"Khaled Mohamed Darwish","orcid":"https://orcid.org/0000-0002-0597-482X","observed_orcids":["https://orcid.org/0000-0002-0597-482X"]},"institutions":[{"id":"https://openalex.org/I114794399","display_name":"Suez Canal University","ror":"https://ror.org/02m82p074","country_code":"EG","type":"education","lineage":["https://openalex.org/I114794399"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Khaled Mohamed Darweesh","raw_affiliation_strings":["Department of Medicinal chemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal chemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt","institution_ids":["https://openalex.org/I114794399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068063379","display_name":"Yasser M. Loksha","orcid":"https://orcid.org/0000-0001-5731-0315","observed_orcids":["https://orcid.org/0000-0001-5731-0315"]},"institutions":[{"id":"https://openalex.org/I1355163","display_name":"Sinai University","ror":"https://ror.org/01dd13a92","country_code":"EG","type":"education","lineage":["https://openalex.org/I1355163"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"yasser mohamed loksha","raw_affiliation_strings":["Department of pharmaceutical chemistry, faculty of pharmacy, Sinai university- Arish branch"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of pharmaceutical chemistry, faculty of pharmacy, Sinai university- Arish branch","institution_ids":["https://openalex.org/I1355163"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079000937","display_name":"Safaa M. Kishk","orcid":"https://orcid.org/0000-0001-5822-0581","observed_orcids":["https://orcid.org/0000-0001-5822-0581"]},"institutions":[{"id":"https://openalex.org/I114794399","display_name":"Suez Canal University","ror":"https://ror.org/02m82p074","country_code":"EG","type":"education","lineage":["https://openalex.org/I114794399"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Safaa Mohamed Kishk","raw_affiliation_strings":["Department of Medicinal chemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal chemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt","institution_ids":["https://openalex.org/I114794399"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":200,"currency":"USD","value_usd":200},"apc_paid":{"value":200,"currency":"USD","value_usd":200},"fwci":0.5497,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.48608205,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"8","issue":"1","first_page":"123","last_page":"129"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.6083999872207642,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.6083999872207642,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14459","display_name":"Synthesis and Reactions of Organic Compounds","score":0.37400001287460327,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/imidazole","display_name":"imidazole","score":0.9879999756813049},{"id":"https://openalex.org/keywords/imidazole-derivatives","display_name":"imidazole derivatives","score":0.9819999933242798},{"id":"https://openalex.org/keywords/bioactivity","display_name":"biological activity","score":0.7059999704360962},{"id":"https://openalex.org/keywords/heterocyclic-compounds","display_name":"heterocyclic compounds","score":0.906000018119812},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"drug discovery","score":0.6309999823570251},{"id":"https://openalex.org/keywords/imidazole-synthesis","display_name":"imidazole synthesis","score":0.753000020980835},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.6650000214576721},{"id":"https://openalex.org/keywords/solubility","display_name":"solubility","score":0.7099999785423279},{"id":"https://openalex.org/keywords/purines","display_name":"purines","score":0.4519999921321869},{"id":"https://openalex.org/keywords/histidine","display_name":"histidine","score":0.8859999775886536},{"id":"https://openalex.org/keywords/nucleic-acids","display_name":"nucleic acids","score":0.7580000162124634},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.8759999871253967}],"concepts":[{"id":"https://openalex.org/C2780874372","wikidata":"https://www.wikidata.org/wiki/Q328692","display_name":"Imidazole","level":2,"score":0.6286363005638123},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33420079946517944},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2983488440513611},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08561202883720398}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.21608/rpbs.2024.294154.1301","doi":"https://doi.org/10.21608/rpbs.2024.294154.1301","is_oa":true,"landing_page_url":"https://doi.org/10.21608/rpbs.2024.294154.1301","pdf_url":null,"source":{"id":"https://openalex.org/S4210233164","display_name":"Records of Pharmaceutical and Biomedical Sciences/Records of Pharmaceutical & Biomedical Sciences","issn_l":"2536-9857","issn":["2536-9857","2535-2091"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Records of Pharmaceutical and Biomedical Sciences","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:d3ea23906d88492c8250e367eae2566a","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/d3ea23906d88492c8250e367eae2566a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Records of Pharmaceutical & Biomedical Sciences, Vol 8, Iss 1, Pp 123-129 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.21608/rpbs.2024.294154.1301","doi":"https://doi.org/10.21608/rpbs.2024.294154.1301","is_oa":true,"landing_page_url":"https://doi.org/10.21608/rpbs.2024.294154.1301","pdf_url":null,"source":{"id":"https://openalex.org/S4210233164","display_name":"Records of Pharmaceutical and Biomedical Sciences/Records of Pharmaceutical & Biomedical Sciences","issn_l":"2536-9857","issn":["2536-9857","2535-2091"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Records of Pharmaceutical and Biomedical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W70716281","https://openalex.org/W388296777","https://openalex.org/W1709109739","https://openalex.org/W1837692691","https://openalex.org/W1973979839","https://openalex.org/W1980161387","https://openalex.org/W1984484299","https://openalex.org/W2008416074","https://openalex.org/W2012568827","https://openalex.org/W2053331795","https://openalex.org/W2053746762","https://openalex.org/W2070868273","https://openalex.org/W2079011049","https://openalex.org/W2088135043","https://openalex.org/W2098145925","https://openalex.org/W2098387836","https://openalex.org/W2167021504","https://openalex.org/W2603368873","https://openalex.org/W2953001999"],"related_works":["https://openalex.org/W2603368873","https://openalex.org/W2137796142","https://openalex.org/W2768945281","https://openalex.org/W4396862358","https://openalex.org/W2164342962","https://openalex.org/W4377238748","https://openalex.org/W4414534262","https://openalex.org/W6949317948","https://openalex.org/W7160400153","https://openalex.org/W3164205181"],"abstract_inverted_index":{"Imidazole":[0,73],"is":[1,16,26,87],"a":[2,27,57,76],"planner":[3],"heterocyclic":[4],"five-member":[5],"ring":[6,14,25],"with":[7],"3C":[8],"and":[9,12,20,37,42,53,62,123,147],"2N":[10],"atom":[11],"in":[13,18,79,92,131],"N":[15],"present":[17],"1st":[19],"3rd":[21],"positions.":[22],"The":[23,95],"imidazole":[24,85,101,122,151],"constituent":[28],"of":[29,50,65,72,82,99,113,121,134,150],"many":[30],"important":[31,89],"natural":[32],"products,":[33],"including":[34],"purine,":[35],"histidine,":[36],"nucleic":[38],"acid.":[39],"Being":[40],"polar":[41],"ionizable":[43],"aromatic":[44],"compound,":[45],"it":[46],"improves":[47],"pharmacokinetic":[48],"characteristics":[49],"lead":[51,69],"molecules":[52],"thus":[54],"used":[55],"as":[56],"drug":[58,93],"to":[59,109,140],"optimize":[60],"solubility":[61],"bioavailability":[63],"parameters":[64],"proposed":[66],"poorly":[67],"soluble":[68],"molecules.":[70],"Derivatives":[71],"have":[74,104],"occupied":[75],"critical":[77],"place":[78],"the":[80,100,106,119,132,142],"field":[81,133],"medicinal":[83,107,135],"chemistry.":[84,136],"nucleus":[86],"an":[88],"synthetic":[90],"strategy":[91],"discovery.":[94],"high":[96],"therapeutic":[97],"properties":[98],"related":[102],"drugs":[103],"improved":[105],"chemists":[108],"synthesize":[110],"enormous":[111,129],"number":[112],"novel":[114],"chemotherapeutic":[115],"agents.":[116],"Methods":[117],"for":[118],"synthesis":[120],"their":[124,145],"various":[125],"structure":[126],"reactions":[127],"offer":[128],"scope":[130],"This":[137],"article":[138],"seeks":[139],"review":[141],"work":[143],"reported,":[144],"chemistry":[146],"biological":[148],"activities":[149],"during":[152],"past":[153],"years.":[154]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2024-08-01T00:00:00"}