{"id":"https://openalex.org/W4401115671","doi":"https://doi.org/10.1016/j.heliyon.2024.e35158","title":"Analysis of the interlink between glucose-6-phosphate dehydrogenase (G6PD) and lung cancer through multi-omics databases","display_name":"Analysis of the interlink between glucose-6-phosphate dehydrogenase (G6PD) and lung cancer through multi-omics databases","publication_year":2024,"publication_date":"2024-07-29","ids":{"openalex":"https://openalex.org/W4401115671","doi":"https://doi.org/10.1016/j.heliyon.2024.e35158","pmid":"https://pubmed.ncbi.nlm.nih.gov/39165939","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11334843"},"language":"en","primary_location":{"id":"doi:10.1016/j.heliyon.2024.e35158","doi":"https://doi.org/10.1016/j.heliyon.2024.e35158","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.heliyon.2024.e35158","pdf_url":null,"source":{"id":"https://openalex.org/S2898612692","display_name":"Heliyon","issn_l":"2405-8440","issn":["2405-8440"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.heliyon.2024.e35158","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084915366","display_name":"Parth Thakor","orcid":"https://orcid.org/0000-0002-7477-0177","observed_orcids":["https://orcid.org/0000-0002-7477-0177"]},"institutions":[{"id":"https://openalex.org/I107949126","display_name":"University of Lethbridge","ror":"https://ror.org/044j76961","country_code":"CA","type":"education","lineage":["https://openalex.org/I107949126"]},{"id":"https://openalex.org/I33459947","display_name":"Charotar University of Science and Technology","ror":"https://ror.org/0442pkv24","country_code":"IN","type":"education","lineage":["https://openalex.org/I33459947"]}],"countries":["CA","IN"],"is_corresponding":true,"raw_author_name":"Parth Thakor","raw_affiliation_strings":["Bapubhai Desaibhai Patel Institute of Paramedical Sciences, Charotar University of Science and Technology, CHARUSAT Campus, Changa, Gujarat, India","Department of Chemistry and Biochemistry, Alberta RNA Research and Training Institute, University of Lethbridge, Lethbridge, AB, T1K 2E1, Canada"],"raw_orcid":"https://orcid.org/0000-0002-7477-0177","affiliations":[{"raw_affiliation_string":"Bapubhai Desaibhai Patel Institute of Paramedical Sciences, Charotar University of Science and Technology, CHARUSAT Campus, Changa, Gujarat, India","institution_ids":["https://openalex.org/I33459947"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Alberta RNA Research and Training Institute, University of Lethbridge, Lethbridge, AB, T1K 2E1, Canada","institution_ids":["https://openalex.org/I107949126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049023461","display_name":"Mohammad Quadir Siddiqui","orcid":"https://orcid.org/0000-0003-0891-3122","observed_orcids":["https://orcid.org/0000-0003-0891-3122"]},"institutions":[{"id":"https://openalex.org/I107949126","display_name":"University of Lethbridge","ror":"https://ror.org/044j76961","country_code":"CA","type":"education","lineage":["https://openalex.org/I107949126"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"M. Quadir Siddiqui","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Alberta RNA Research and Training Institute, University of Lethbridge, Lethbridge, AB, T1K 2E1, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Alberta RNA Research and Training Institute, University of Lethbridge, Lethbridge, AB, T1K 2E1, Canada","institution_ids":["https://openalex.org/I107949126"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081132440","display_name":"Trushar R. Patel","orcid":"https://orcid.org/0000-0003-0627-2923","observed_orcids":["https://orcid.org/0000-0003-0627-2923"]},"institutions":[{"id":"https://openalex.org/I107949126","display_name":"University of Lethbridge","ror":"https://ror.org/044j76961","country_code":"CA","type":"education","lineage":["https://openalex.org/I107949126"]},{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]},{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Trushar R. Patel","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Alberta RNA Research and Training Institute, University of Lethbridge, Lethbridge, AB, T1K 2E1, Canada","Department of Microbiology, Immunology & Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, T2N 4N1, Canada","Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB, T6G 2E1, Canada"],"raw_orcid":"https://orcid.org/0000-0003-0627-2923","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Alberta RNA Research and Training Institute, University of Lethbridge, Lethbridge, AB, T1K 2E1, Canada","institution_ids":["https://openalex.org/I107949126"]},{"raw_affiliation_string":"Department of Microbiology, Immunology & Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, T2N 4N1, Canada","institution_ids":["https://openalex.org/I168635309"]},{"raw_affiliation_string":"Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB, T6G 2E1, Canada","institution_ids":["https://openalex.org/I154425047"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5081132440","https://openalex.org/A5084915366"],"corresponding_institution_ids":["https://openalex.org/I107949126","https://openalex.org/I154425047","https://openalex.org/I168635309","https://openalex.org/I33459947"],"apc_list":{"value":2100,"currency":"USD","value_usd":2100},"apc_paid":{"value":2100,"currency":"USD","value_usd":2100},"fwci":1.6313,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.82872366,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"10","issue":"15","first_page":"e35158","last_page":"e35158"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.6762999892234802,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.6762999892234802,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.052400000393390656,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.03660000115633011,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucose-6-phosphate-dehydrogenase","display_name":"glucose-6-phosphate dehydrogenase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.9470000267028809},{"id":"https://openalex.org/keywords/pentose-phosphate-pathway","display_name":"pentose phosphate pathway","score":0.9929999709129333},{"id":"https://openalex.org/keywords/promoter-methylation","display_name":"promoter methylation","score":0.8489999771118164},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.9240000247955322},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7269999980926514},{"id":"https://openalex.org/keywords/tumour-immune-infiltration","display_name":"tumour immune infiltration","score":0.7519999742507935},{"id":"https://openalex.org/keywords/tumor-mutational-burden","display_name":"tumor mutational burden","score":0.9049999713897705},{"id":"https://openalex.org/keywords/microsatellite-instability","display_name":"microsatellite instability","score":0.9580000042915344},{"id":"https://openalex.org/keywords/immune-checkpoint-genes","display_name":"immune checkpoint genes","score":0.7559999823570251},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7860000133514404},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7950000166893005},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.6930000185966492},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.8659999966621399},{"id":"https://openalex.org/keywords/hypoxia-inducible-factor-1","display_name":"HIF-1","score":0.7570000290870667},{"id":"https://openalex.org/keywords/kras","display_name":"KRAS","score":0.6050000190734863},{"id":"https://openalex.org/keywords/lag-3","display_name":"LAG-3","score":0.9819999933242798}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7636175155639648},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6148245334625244},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5731094479560852},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5376722812652588},{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.5299065113067627},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.4591587781906128},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.4278280735015869},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.3732674717903137},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3143109083175659},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.25231388211250305},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22275182604789734},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.1870446503162384},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13398221135139465}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.heliyon.2024.e35158","doi":"https://doi.org/10.1016/j.heliyon.2024.e35158","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.heliyon.2024.e35158","pdf_url":null,"source":{"id":"https://openalex.org/S2898612692","display_name":"Heliyon","issn_l":"2405-8440","issn":["2405-8440"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11334843","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11334843","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11334843/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"Text"},{"id":"pmid:39165939","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39165939","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:da0b645fe28e4ad3836cf6b5c9410475","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/da0b645fe28e4ad3836cf6b5c9410475","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Heliyon, Vol 10, Iss 15, Pp e35158- (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.heliyon.2024.e35158","doi":"https://doi.org/10.1016/j.heliyon.2024.e35158","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.heliyon.2024.e35158","pdf_url":null,"source":{"id":"https://openalex.org/S2898612692","display_name":"Heliyon","issn_l":"2405-8440","issn":["2405-8440"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6641478441","display_name":null,"funder_award_id":"SIR/2022/000968","funder_id":"https://openalex.org/F4320334771","funder_display_name":"Science and Engineering Research Board"}],"funders":[{"id":"https://openalex.org/F4320310768","display_name":"University of Lethbridge","ror":"https://ror.org/044j76961"},{"id":"https://openalex.org/F4320320994","display_name":"Canada Research Chairs","ror":"https://ror.org/0517h6h17"},{"id":"https://openalex.org/F4320326160","display_name":"Charotar University of Science and Technology","ror":"https://ror.org/0442pkv24"},{"id":"https://openalex.org/F4320334771","display_name":"Science and Engineering Research Board","ror":"https://ror.org/03ffdsr55"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4401115671.pdf","grobid_xml":"https://content.openalex.org/works/W4401115671.grobid-xml"},"referenced_works_count":108,"referenced_works":["https://openalex.org/W1766114318","https://openalex.org/W1966969388","https://openalex.org/W1973287822","https://openalex.org/W1979840121","https://openalex.org/W2000412712","https://openalex.org/W2006044886","https://openalex.org/W2022338332","https://openalex.org/W2024492396","https://openalex.org/W2039220817","https://openalex.org/W2040127137","https://openalex.org/W2041663954","https://openalex.org/W2041757368","https://openalex.org/W2046100445","https://openalex.org/W2050658928","https://openalex.org/W2058386734","https://openalex.org/W2070923004","https://openalex.org/W2072451938","https://openalex.org/W2073157961","https://openalex.org/W2076477755","https://openalex.org/W2100148709","https://openalex.org/W2110511887","https://openalex.org/W2112912738","https://openalex.org/W2114970231","https://openalex.org/W2117692326","https://openalex.org/W2121236281","https://openalex.org/W2158485828","https://openalex.org/W2161081593","https://openalex.org/W2165907830","https://openalex.org/W2179504521","https://openalex.org/W2272037513","https://openalex.org/W2275174502","https://openalex.org/W2314597046","https://openalex.org/W2329659234","https://openalex.org/W2341157401","https://openalex.org/W2345968067","https://openalex.org/W2416096426","https://openalex.org/W2422429083","https://openalex.org/W2443643663","https://openalex.org/W2508590965","https://openalex.org/W2513566326","https://openalex.org/W2546736978","https://openalex.org/W2567668099","https://openalex.org/W2578618235","https://openalex.org/W2591755009","https://openalex.org/W2612952548","https://openalex.org/W2618719143","https://openalex.org/W2736386702","https://openalex.org/W2753678520","https://openalex.org/W2760942750","https://openalex.org/W2763880575","https://openalex.org/W2767526093","https://openalex.org/W2782873773","https://openalex.org/W2790164909","https://openalex.org/W2796207838","https://openalex.org/W2802518194","https://openalex.org/W2807541399","https://openalex.org/W2809203760","https://openalex.org/W2810016861","https://openalex.org/W2810358408","https://openalex.org/W2884610229","https://openalex.org/W2900569176","https://openalex.org/W2910183000","https://openalex.org/W2911745809","https://openalex.org/W2917254076","https://openalex.org/W2937441321","https://openalex.org/W2945858728","https://openalex.org/W2946550388","https://openalex.org/W2946657092","https://openalex.org/W2969333588","https://openalex.org/W2971580085","https://openalex.org/W2979026278","https://openalex.org/W2999626196","https://openalex.org/W3027286012","https://openalex.org/W3028304854","https://openalex.org/W3044486631","https://openalex.org/W3047748656","https://openalex.org/W3082631559","https://openalex.org/W3087553737","https://openalex.org/W3092751535","https://openalex.org/W3120340770","https://openalex.org/W3125090642","https://openalex.org/W3128646645","https://openalex.org/W3159454489","https://openalex.org/W3171675220","https://openalex.org/W3197015296","https://openalex.org/W3201087911","https://openalex.org/W3201872536","https://openalex.org/W3202853415","https://openalex.org/W4205771466","https://openalex.org/W4206349208","https://openalex.org/W4206841660","https://openalex.org/W4206965224","https://openalex.org/W4213131590","https://openalex.org/W4220915443","https://openalex.org/W4226075561","https://openalex.org/W4281550843","https://openalex.org/W4283015173","https://openalex.org/W4367055460","https://openalex.org/W4380992572","https://openalex.org/W4390605960","https://openalex.org/W4391116558","https://openalex.org/W6633658626","https://openalex.org/W6641792293","https://openalex.org/W6725325408","https://openalex.org/W6744687619","https://openalex.org/W6752707835","https://openalex.org/W6753476606","https://openalex.org/W6790598159"],"related_works":["https://openalex.org/W4381163894","https://openalex.org/W4403739130","https://openalex.org/W4376872449","https://openalex.org/W4385520576","https://openalex.org/W4206048695","https://openalex.org/W4226440407","https://openalex.org/W4390673543","https://openalex.org/W2802518194","https://openalex.org/W4412111271","https://openalex.org/W3091820504"],"abstract_inverted_index":{"Glucose-6-Phosphate":[0],"Dehydrogenase":[1],"(G6PD)":[2],"is":[3,24],"a":[4,229,241],"crucial":[5],"enzyme":[6],"that":[7,116,209],"executes":[8],"the":[9,20,71,82,117,123,142,153,162,174,193],"pentose":[10],"phosphate":[11],"pathway.":[12],"Due":[13],"to":[14,80,170],"its":[15,35,86],"critical":[16],"nodal":[17],"position":[18],"in":[19,41,213,235],"metabolic":[21],"network,":[22],"it":[23],"associated":[25,52],"with":[26,53,92,122,180],"different":[27],"forms":[28],"of":[29,59,84,126,145,159,164,232],"cancer":[30,43,128],"tumorigeneses":[31],"and":[32,38,55,70,107,137,198,206],"progression.":[33],"Nonetheless,":[34],"functional":[36],"role":[37],"molecular":[39],"mechanism":[40],"lung":[42,127,236],"remain":[44],"unknown.":[45],"The":[46,75,112,189],"present":[47,113],"study":[48,114],"provides":[49,228],"intricate":[50],"information":[51],"G6PD":[54,118,146,210],"Lung":[56],"Cancer.":[57],"Varieties":[58],"public":[60],"datasets":[61],"were":[62,78],"retrieved":[63],"by":[64,151],"us,":[65],"including":[66,129],"UALCAN,":[67],"TCGA,":[68],"cBioPortal,":[69],"UCSC":[72],"Xena":[73],"browser.":[74],"data":[76],"obtained":[77],"used":[79],"assess":[81],"expression":[83,119,143,163],"G6PD,":[85],"clinical":[87,124],"features,":[88],"epigenetic":[89,149],"regulation,":[90],"relationship":[91],"tumour":[93,95,100],"infiltration,":[94],"mutation":[96],"burden,":[97],"microsatellite":[98],"instability,":[99],"microenvironment,":[101],"immune":[102,175],"checkpoint":[103],"genes,":[104],"genomic":[105],"alteration,":[106],"patient's":[108,194],"overall":[109,195],"survival":[110,196],"rate.":[111],"revealed":[115],"was":[120],"correlated":[121],"features":[125],"disease":[130],"stage,":[131],"race,":[132],"sex,":[133],"age,":[134],"smoking":[135],"habits,":[136],"lymph":[138],"node":[139],"metastasis.":[140],"Moreover,":[141],"profile":[144],"also":[147],"imparts":[148],"changes":[150,161],"modulating":[152],"DNA":[154],"promoter":[155],"methylation":[156],"activity.":[157],"Methylation":[158],"promoters":[160],"various":[165],"transcription":[166],"factors,":[167],"genes":[168],"leading":[169],"an":[171],"influence":[172],"on":[173],"system.":[176],"These":[177],"events":[178],"linked":[179],"G6PD-related":[181],"mutational":[182],"gene":[183],"alterations":[184],"(FAM3A,":[185],"LAG3,":[186],"p53,":[187,221],"KRAS).":[188],"entire":[190],"circumstance":[191],"influences":[192],"rate":[197],"poor":[199],"prognosis.":[200],"Functional":[201],"investigation":[202],"using":[203],"STRING,":[204],"GO,":[205],"KEGG":[207],"found":[208],"primarily":[211],"engages":[212],"hallmark":[214],"functions":[215],"(metabolism,":[216],"immunological":[217],"responses,":[218],"proliferation,":[219],"apoptosis,":[220],"HIF-1,":[222],"FOXO,":[223],"PI3K-AKT":[224],"signaling).":[225],"This":[226],"work":[227],"wide":[230],"knowledge":[231],"G6PD's":[233],"function":[234],"cancer,":[237],"as":[238,240],"well":[239],"theoretical":[242],"foundation":[243],"for":[244],"possible":[245],"prognostic":[246],"therapeutic":[247],"markers.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2024-07-31T00:00:00"}
