{"id":"https://openalex.org/W4410769198","doi":"https://doi.org/10.18632/aging.206259","title":"Methods for joint modeling of longitudinal omics data and time-to-event outcomes: applications to lysophosphatidylcholines in connection to aging and mortality in the Long Life Family Study","display_name":"Methods for joint modeling of longitudinal omics data and time-to-event outcomes: applications to lysophosphatidylcholines in connection to aging and mortality in the Long Life Family Study","publication_year":2025,"publication_date":"2025-05-27","ids":{"openalex":"https://openalex.org/W4410769198","doi":"https://doi.org/10.18632/aging.206259","pmid":"https://pubmed.ncbi.nlm.nih.gov/39132492","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11312646"},"language":"en","primary_location":{"id":"doi:10.18632/aging.206259","doi":"https://doi.org/10.18632/aging.206259","is_oa":true,"landing_page_url":"https://doi.org/10.18632/aging.206259","pdf_url":"https://www.aging-us.com/article/206259/pdf","source":{"id":"https://openalex.org/S4210231119","display_name":"Aging","issn_l":"1945-4589","issn":["1945-4589"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.aging-us.com/article/206259/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051786764","display_name":"Konstantin G. Arbeev","orcid":"https://orcid.org/0000-0002-4195-7832","observed_orcids":["https://orcid.org/0000-0002-4195-7832"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Konstantin G. Arbeev","raw_affiliation_strings":["Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina 27708, USA","Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC 27708, USA"],"raw_orcid":"https://orcid.org/0000-0002-4195-7832","affiliations":[{"raw_affiliation_string":"Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina 27708, USA","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC 27708, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077207464","display_name":"Olivia Bagley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olivia Bagley","raw_affiliation_strings":["Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina 27708, USA","Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC 27708, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina 27708, USA","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC 27708, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018208097","display_name":"Svetlana V. Ukraintseva","orcid":"https://orcid.org/0000-0002-0079-5494","observed_orcids":["https://orcid.org/0000-0002-0079-5494"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Svetlana V. Ukraintseva","raw_affiliation_strings":["Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina 27708, USA","Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC 27708, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina 27708, USA","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC 27708, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017898754","display_name":"Alexander M. Kulminski","orcid":"https://orcid.org/0000-0002-0205-8228","observed_orcids":["https://orcid.org/0000-0002-0205-8228"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Kulminski","raw_affiliation_strings":["Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina 27708, USA","Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC 27708, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina 27708, USA","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC 27708, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018020035","display_name":"Eric Stallard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Stallard","raw_affiliation_strings":["Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina 27708, USA","Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC 27708, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina 27708, USA","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC 27708, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085399017","display_name":"Michaela Schwaiger-Haber","orcid":"https://orcid.org/0000-0002-2715-753X","observed_orcids":["https://orcid.org/0000-0002-2715-753X"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michaela Schwaiger-Haber","raw_affiliation_strings":["Center for Metabolomics and Isotope Tracing at Washington University in St. Louis, St. Louis, Missouri 63130, United States","Department of Chemistry, Washington University in St. Louis, St. Louis, Missouri 63130, United States","Department of Medicine, Washington University in St. Louis, St. Louis, Missouri 63130, United States","Center for Metabolomics and Isotope Tracing at Washington University in St. Louis, St. Louis, MO 63130, USA","Department of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA","Department of Medicine, Washington University in St. Louis, St. Louis, MO 63130, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Metabolomics and Isotope Tracing at Washington University in St. Louis, St. Louis, Missouri 63130, United States","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Chemistry, Washington University in St. Louis, St. Louis, Missouri 63130, United States","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Medicine, Washington University in St. Louis, St. Louis, Missouri 63130, United States","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Center for Metabolomics and Isotope Tracing at Washington University in St. Louis, St. Louis, MO 63130, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Medicine, Washington University in St. Louis, St. Louis, MO 63130, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027513211","display_name":"Gary J. Patti","orcid":"https://orcid.org/0000-0002-3748-6193","observed_orcids":["https://orcid.org/0000-0002-3748-6193"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary J. Patti","raw_affiliation_strings":["Center for Metabolomics and Isotope Tracing at Washington University in St. Louis, St. Louis, Missouri 63130, United States","Department of Chemistry, Washington University in St. Louis, St. Louis, Missouri 63130, United States","Department of Medicine, Washington University in St. Louis, St. Louis, Missouri 63130, United States","Center for Metabolomics and Isotope Tracing at Washington University in St. Louis, St. Louis, MO 63130, USA","Department of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA","Department of Medicine, Washington University in St. Louis, St. Louis, MO 63130, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Metabolomics and Isotope Tracing at Washington University in St. Louis, St. Louis, Missouri 63130, United States","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Chemistry, Washington University in St. Louis, St. Louis, Missouri 63130, United States","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Medicine, Washington University in St. Louis, St. Louis, Missouri 63130, United States","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Center for Metabolomics and Isotope Tracing at Washington University in St. Louis, St. Louis, MO 63130, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Medicine, Washington University in St. Louis, St. Louis, MO 63130, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047887049","display_name":"Yian Gu","orcid":"https://orcid.org/0000-0002-4297-1548","observed_orcids":["https://orcid.org/0000-0002-4297-1548"]},"institutions":[{"id":"https://openalex.org/I1340179700","display_name":"NewYork\u2013Presbyterian Hospital","ror":"https://ror.org/03gzbrs57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1340179700"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yian Gu","raw_affiliation_strings":["Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York 10032, USA","Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, and the New York Presbyterian Hospital, New York, New York 10032, USA","G.H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA","Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA","Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA","Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, and the New York Presbyterian Hospital, New York, NY 10032, USA","G.H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA","Taub Institute for Research on Alzheimer\u2019s Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York 10032, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, and the New York Presbyterian Hospital, New York, New York 10032, USA","institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I78577930"]},{"raw_affiliation_string":"G.H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, and the New York Presbyterian Hospital, New York, NY 10032, USA","institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I78577930"]},{"raw_affiliation_string":"G.H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Taub Institute for Research on Alzheimer\u2019s Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085542503","display_name":"Anatoliy I. Yashin","orcid":"https://orcid.org/0000-0003-4262-8894","observed_orcids":["https://orcid.org/0000-0003-4262-8894"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anatoliy I. Yashin","raw_affiliation_strings":["Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina 27708, USA","Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC 27708, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina 27708, USA","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC 27708, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004832167","display_name":"Michael A. Province","orcid":"https://orcid.org/0000-0001-6102-774X","observed_orcids":["https://orcid.org/0000-0001-6102-774X"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A. Province","raw_affiliation_strings":["Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri 63110, USA","Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri 63110, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5051786764"],"corresponding_institution_ids":["https://openalex.org/I170897317"],"apc_list":null,"apc_paid":null,"fwci":1.3809,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.79007373,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"17","issue":"5","first_page":"1221","last_page":"1260"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.8964999914169312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.8964999914169312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10243","display_name":"Statistical Methods and Bayesian Inference","score":0.013799999840557575,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14393","display_name":"Health, Environment, Cognitive Aging","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lysophosphatidylcholine","display_name":"lysophosphatidylcholine","score":0.9909999966621399},{"id":"https://openalex.org/keywords/joint-modeling","display_name":"joint modeling","score":0.7139999866485596},{"id":"https://openalex.org/keywords/stochastic-modeling","display_name":"stochastic modeling","score":0.8889999985694885},{"id":"https://openalex.org/keywords/longitudinal-metabolomics","display_name":"longitudinal metabolomics","score":0.7379999756813049},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.7730000019073486},{"id":"https://openalex.org/keywords/aging-biomarkers","display_name":"aging biomarkers","score":0.7459999918937683},{"id":"https://openalex.org/keywords/long-life-family-study","display_name":"Long Life Family Study","score":0.8360000252723694},{"id":"https://openalex.org/keywords/biological-robustness","display_name":"biological robustness","score":0.7720000147819519},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.7450000047683716}],"concepts":[{"id":"https://openalex.org/C13355873","wikidata":"https://www.wikidata.org/wiki/Q2920850","display_name":"Connection (principal bundle)","level":2,"score":0.6236730217933655},{"id":"https://openalex.org/C3020672099","wikidata":"https://www.wikidata.org/wiki/Q857354","display_name":"Longitudinal data","level":2,"score":0.6031028032302856},{"id":"https://openalex.org/C2779662365","wikidata":"https://www.wikidata.org/wiki/Q5416694","display_name":"Event (particle physics)","level":2,"score":0.5560368299484253},{"id":"https://openalex.org/C2987896495","wikidata":"https://www.wikidata.org/wiki/Q5416716","display_name":"Event data","level":3,"score":0.4781576097011566},{"id":"https://openalex.org/C18555067","wikidata":"https://www.wikidata.org/wiki/Q8375051","display_name":"Joint (building)","level":2,"score":0.4670846462249756},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.46669676899909973},{"id":"https://openalex.org/C2777895361","wikidata":"https://www.wikidata.org/wiki/Q1758614","display_name":"Longitudinal study","level":2,"score":0.430072546005249},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.34748607873916626},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.33348584175109863},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32286888360977173},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.27420276403427124},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.17618951201438904},{"id":"https://openalex.org/C79158427","wikidata":"https://www.wikidata.org/wiki/Q485396","display_name":"Analytics","level":2,"score":0.07865843176841736},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C66938386","wikidata":"https://www.wikidata.org/wiki/Q633538","display_name":"Structural engineering","level":1,"score":0.0},{"id":"https://openalex.org/C170154142","wikidata":"https://www.wikidata.org/wiki/Q150737","display_name":"Architectural engineering","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":8,"locations":[{"id":"doi:10.18632/aging.206259","doi":"https://doi.org/10.18632/aging.206259","is_oa":true,"landing_page_url":"https://doi.org/10.18632/aging.206259","pdf_url":"https://www.aging-us.com/article/206259/pdf","source":{"id":"https://openalex.org/S4210231119","display_name":"Aging","issn_l":"1945-4589","issn":["1945-4589"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging","raw_type":"journal-article"},{"id":"doi:10.1101/2024.07.29.24311176","doi":"https://doi.org/10.1101/2024.07.29.24311176","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.07.29.24311176","pdf_url":null,"source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},{"id":"pmh:oai:europepmc.org:10964215","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12151508","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12151508","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12151508","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging (Albany NY)","raw_type":"Text"},{"id":"pmid:39132492","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39132492","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"medRxiv : the preprint server for health sciences","raw_type":"Journal Article"},{"id":"pmid:40440492","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40440492","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11312646","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11312646","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11312646/pdf/nihpp-2024.07.29.24311176v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"Text"},{"id":"pmh:oai:digitalcommons.wustl.edu:oa_4-6080","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.wustl.edu/oa_4/5092","pdf_url":null,"source":{"id":"https://openalex.org/S4306400764","display_name":"Digital Commons@Becker (Washington University School of Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204465549","host_organization_name":"Washington University in St. Louis","host_organization_lineage":["https://openalex.org/I204465549"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"2020-Current year OA Pubs","raw_type":"text"}],"best_oa_location":{"id":"doi:10.18632/aging.206259","doi":"https://doi.org/10.18632/aging.206259","is_oa":true,"landing_page_url":"https://doi.org/10.18632/aging.206259","pdf_url":"https://www.aging-us.com/article/206259/pdf","source":{"id":"https://openalex.org/S4210231119","display_name":"Aging","issn_l":"1945-4589","issn":["1945-4589"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000863725","display_name":"The Long Life Family Study","funder_award_id":"U19AG063893","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000868406","display_name":"Washington University Nutrition Obesity Research Center","funder_award_id":"P30DK056341","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4410769198.pdf","grobid_xml":"https://content.openalex.org/works/W4410769198.grobid-xml"},"referenced_works_count":74,"referenced_works":["https://openalex.org/W31659055","https://openalex.org/W1570622790","https://openalex.org/W1846287826","https://openalex.org/W1980405404","https://openalex.org/W1981748148","https://openalex.org/W1988643163","https://openalex.org/W1990667054","https://openalex.org/W1993373433","https://openalex.org/W1994969712","https://openalex.org/W2021229835","https://openalex.org/W2025483550","https://openalex.org/W2034945547","https://openalex.org/W2035459227","https://openalex.org/W2039659882","https://openalex.org/W2039816778","https://openalex.org/W2042276707","https://openalex.org/W2062778025","https://openalex.org/W2065683696","https://openalex.org/W2071271451","https://openalex.org/W2073877542","https://openalex.org/W2081604967","https://openalex.org/W2096468806","https://openalex.org/W2104382557","https://openalex.org/W2105575181","https://openalex.org/W2110921609","https://openalex.org/W2121737643","https://openalex.org/W2124652134","https://openalex.org/W2144494932","https://openalex.org/W2155820566","https://openalex.org/W2288696091","https://openalex.org/W2344242864","https://openalex.org/W2345434628","https://openalex.org/W2470559861","https://openalex.org/W2512685240","https://openalex.org/W2517397596","https://openalex.org/W2703490595","https://openalex.org/W2778438848","https://openalex.org/W2789141562","https://openalex.org/W2809334224","https://openalex.org/W2913413642","https://openalex.org/W2914816103","https://openalex.org/W2919002166","https://openalex.org/W2971373099","https://openalex.org/W3011415530","https://openalex.org/W3014109350","https://openalex.org/W3014674754","https://openalex.org/W3037908215","https://openalex.org/W3045689662","https://openalex.org/W3082593196","https://openalex.org/W3105594762","https://openalex.org/W3111980798","https://openalex.org/W3118553819","https://openalex.org/W3153020845","https://openalex.org/W3158807201","https://openalex.org/W3177725658","https://openalex.org/W3210119926","https://openalex.org/W4213165287","https://openalex.org/W4226151481","https://openalex.org/W4240400659","https://openalex.org/W4245933202","https://openalex.org/W4293425965","https://openalex.org/W4299305591","https://openalex.org/W4308740989","https://openalex.org/W4312082702","https://openalex.org/W4313531093","https://openalex.org/W4320718125","https://openalex.org/W4365443016","https://openalex.org/W4366991544","https://openalex.org/W4380537289","https://openalex.org/W4385294812","https://openalex.org/W4386568869","https://openalex.org/W4386615105","https://openalex.org/W4387329249","https://openalex.org/W4389038571"],"related_works":["https://openalex.org/W4401115111","https://openalex.org/W1965639860","https://openalex.org/W4400183432","https://openalex.org/W2517105567","https://openalex.org/W2747431846","https://openalex.org/W7095231575","https://openalex.org/W2517072927","https://openalex.org/W7075711617","https://openalex.org/W7161553286","https://openalex.org/W2043478295"],"abstract_inverted_index":{"Studying":[0],"relationships":[1],"between":[2,154],"longitudinal":[3,19,36,50],"changes":[4,51],"in":[5,52,67,120,127,149,179,192],"omics":[6],"variables":[7],"and":[8,20,57,151,157,176,181,196],"risks":[9,164],"of":[10,18,49,65,71,82,85,137,174,186,190],"events":[11],"requires":[12],"specific":[13],"methodologies":[14],"for":[15,100,183],"joint":[16],"analyses":[17,77],"time-to-event":[21],"outcomes.":[22],"We":[23],"applied":[24],"two":[25],"such":[26],"approaches":[27],"(joint":[28],"models":[29,33],"[JM],":[30],"stochastic":[31],"process":[32],"[SPM])":[34],"to":[35,112,129,140,142,161,194],"metabolomics":[37],"data":[38],"from":[39,131],"the":[40,83,95,117,155],"Long":[41],"Life":[42],"Family":[43],"Study":[44],"focusing":[45],"on":[46],"understudied":[47],"associations":[48],"lysophosphatidylcholines":[53],"(LPC)":[54],"with":[55,90,94,165],"mortality":[56,92,163,195],"aging-related":[58,124],"outcomes":[59],"(23":[60],"LPC":[61,86,101,113,133,144,170,191],"species,":[62],"5,790":[63],"measurements":[64],"each":[66],"4,011":[68],"participants,":[69],"1,431":[70],"whom":[72],"died":[73],"during":[74],"follow-up).":[75],"JM":[76,121],"found":[78,119],"that":[79],"higher":[80,148],"levels":[81,145,159],"majority":[84],"species":[87],"were":[88],"associated":[89],"lower":[91],"risks,":[93],"largest":[96],"effect":[97],"size":[98],"observed":[99],"15:0/0:0":[102,114],"(hazard":[103],"ratio:":[104],"0.715,":[105],"95%":[106],"CI":[107],"(0.649,":[108],"0.788)).":[109],"SPM":[110],"applications":[111],"revealed":[115],"how":[116],"association":[118],"reflects":[122],"underlying":[123,188],"processes:":[125],"decline":[126,178],"robustness":[128],"deviations":[130],"optimal":[132],"levels,":[134],"better":[135],"ability":[136],"males'":[138],"organisms":[139],"return":[141],"equilibrium":[143,158],"(which":[146],"are":[147],"females),":[150],"increasing":[152],"gaps":[153],"optimum":[156],"leading":[160],"increased":[162],"age.":[166],"Our":[167],"results":[168],"support":[169],"as":[171],"a":[172],"biomarker":[173],"aging":[175],"related":[177],"robustness/resilience,":[180],"call":[182],"further":[184],"exploration":[185],"factors":[187],"age-dynamics":[189],"relation":[193],"diseases.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-05-28T00:00:00"}