{"id":"https://openalex.org/W4401101771","doi":"https://doi.org/10.3389/fphar.2024.1424219","title":"Protective effect of andrographolide against ulcerative colitis by activating Nrf2/HO-1 mediated antioxidant response","display_name":"Protective effect of andrographolide against ulcerative colitis by activating Nrf2/HO-1 mediated antioxidant response","publication_year":2024,"publication_date":"2024-07-29","ids":{"openalex":"https://openalex.org/W4401101771","doi":"https://doi.org/10.3389/fphar.2024.1424219","pmid":"https://pubmed.ncbi.nlm.nih.gov/39135804","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11317410"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2024.1424219","doi":"https://doi.org/10.3389/fphar.2024.1424219","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2024.1424219","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1424219/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1424219/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027847977","display_name":"Long Shu","orcid":"https://orcid.org/0000-0002-6560-9808","observed_orcids":["https://orcid.org/0000-0002-6560-9808"]},"institutions":[{"id":"https://openalex.org/I4210119853","display_name":"Zhejiang Hospital","ror":"https://ror.org/02kzr5g33","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119853"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Long Shu","raw_affiliation_strings":["Department of Clinical Nutrition, Zhejiang Hospital, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Nutrition, Zhejiang Hospital, Hangzhou, China","institution_ids":["https://openalex.org/I4210119853"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038211091","display_name":"Hangjie Fu","orcid":"https://orcid.org/0000-0001-8857-5295","observed_orcids":["https://orcid.org/0000-0001-8857-5295"]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hangjie Fu","raw_affiliation_strings":["School of Public Health, Zhejiang Chinese Medical University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Zhejiang Chinese Medical University, Hangzhou, China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104076820","display_name":"Aiwen Pi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Aiwen Pi","raw_affiliation_strings":["School of Public Health, Zhejiang Chinese Medical University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Zhejiang Chinese Medical University, Hangzhou, China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115589415","display_name":"Yuliang Feng","orcid":"https://orcid.org/0009-0002-9227-9717","observed_orcids":["https://orcid.org/0009-0002-9227-9717"]},"institutions":[{"id":"https://openalex.org/I4210119853","display_name":"Zhejiang Hospital","ror":"https://ror.org/02kzr5g33","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119853"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuliang Feng","raw_affiliation_strings":["Department of Digestion, Zhejiang Hospital, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Digestion, Zhejiang Hospital, Hangzhou, China","institution_ids":["https://openalex.org/I4210119853"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100389342","display_name":"Hui Dong","orcid":"https://orcid.org/0000-0001-5021-1349","observed_orcids":["https://orcid.org/0000-0001-5021-1349"]},"institutions":[{"id":"https://openalex.org/I4210119853","display_name":"Zhejiang Hospital","ror":"https://ror.org/02kzr5g33","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119853"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Dong","raw_affiliation_strings":["Department of Digestion, Zhejiang Hospital, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Digestion, Zhejiang Hospital, Hangzhou, China","institution_ids":["https://openalex.org/I4210119853"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090566987","display_name":"Caijuan Si","orcid":"https://orcid.org/0000-0003-3289-8807","observed_orcids":["https://orcid.org/0000-0003-3289-8807"]},"institutions":[{"id":"https://openalex.org/I4210119853","display_name":"Zhejiang Hospital","ror":"https://ror.org/02kzr5g33","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119853"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Caijuan Si","raw_affiliation_strings":["Department of Clinical Nutrition, Zhejiang Hospital, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Nutrition, Zhejiang Hospital, Hangzhou, China","institution_ids":["https://openalex.org/I4210119853"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100713509","display_name":"Songtao Li","orcid":"https://orcid.org/0000-0002-2926-673X","observed_orcids":["https://orcid.org/0000-0002-2926-673X","https://orcid.org/0009-0008-8036-9380"]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]},{"id":"https://openalex.org/I4210119853","display_name":"Zhejiang Hospital","ror":"https://ror.org/02kzr5g33","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119853"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Songtao Li","raw_affiliation_strings":["Department of Clinical Nutrition, Zhejiang Hospital, Hangzhou, China","School of Public Health, Zhejiang Chinese Medical University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Nutrition, Zhejiang Hospital, Hangzhou, China","institution_ids":["https://openalex.org/I4210119853"]},{"raw_affiliation_string":"School of Public Health, Zhejiang Chinese Medical University, Hangzhou, China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100529480","display_name":"Feiye Zhu","orcid":"https://orcid.org/0000-0002-9769-2730","observed_orcids":["https://orcid.org/0000-0002-9769-2730"]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Feiye Zhu","raw_affiliation_strings":["Academy of Chinese Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Chinese Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101184599","display_name":"Peifen Zheng","orcid":"https://orcid.org/0000-0003-4127-2259","observed_orcids":["https://orcid.org/0000-0003-4127-2259"]},"institutions":[{"id":"https://openalex.org/I4210119853","display_name":"Zhejiang Hospital","ror":"https://ror.org/02kzr5g33","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119853"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Peifen Zheng","raw_affiliation_strings":["Department of Clinical Nutrition, Zhejiang Hospital, Hangzhou, China","Department of Digestion, Zhejiang Hospital, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Nutrition, Zhejiang Hospital, Hangzhou, China","institution_ids":["https://openalex.org/I4210119853"]},{"raw_affiliation_string":"Department of Digestion, Zhejiang Hospital, Hangzhou, China","institution_ids":["https://openalex.org/I4210119853"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100616633","display_name":"Qin Zhu","orcid":"https://orcid.org/0000-0003-2186-3828","observed_orcids":["https://orcid.org/0000-0003-2186-3828"]},"institutions":[{"id":"https://openalex.org/I4210119853","display_name":"Zhejiang Hospital","ror":"https://ror.org/02kzr5g33","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119853"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qin Zhu","raw_affiliation_strings":["Department of Clinical Nutrition, Zhejiang Hospital, Hangzhou, China","Department of Digestion, Zhejiang Hospital, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Nutrition, Zhejiang Hospital, Hangzhou, China","institution_ids":["https://openalex.org/I4210119853"]},{"raw_affiliation_string":"Department of Digestion, Zhejiang Hospital, Hangzhou, China","institution_ids":["https://openalex.org/I4210119853"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100529480","https://openalex.org/A5100616633","https://openalex.org/A5101184599"],"corresponding_institution_ids":["https://openalex.org/I114539943","https://openalex.org/I4210119853"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":10.2643,"has_fulltext":true,"cited_by_count":39,"citation_normalized_percentile":{"value":0.98810853,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"15","issue":null,"first_page":"1424219","last_page":"1424219"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13281","display_name":"Andrographolide Research and Applications","score":0.02070000022649765,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/andrographolide","display_name":"andrographolide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":1.0},{"id":"https://openalex.org/keywords/nrf2-ho-1-signaling-pathway","display_name":"Nrf2/HO-1 pathway","score":0.9919999837875366},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7960000038146973},{"id":"https://openalex.org/keywords/antioxidant-response","display_name":"antioxidant response","score":0.9190000295639038},{"id":"https://openalex.org/keywords/tight-junctions","display_name":"tight junctions","score":0.7590000033378601},{"id":"https://openalex.org/keywords/intestinal-barrier","display_name":"intestinal barrier","score":0.7129999995231628},{"id":"https://openalex.org/keywords/dss-induced-colitis","display_name":"DSS-induced colitis","score":0.828000009059906},{"id":"https://openalex.org/keywords/ml385","display_name":"ML385","score":0.878000020980835},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.7279999852180481},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C2781357234","wikidata":"https://www.wikidata.org/wiki/Q4759444","display_name":"Andrographolide","level":2,"score":0.9448103904724121},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.7308293581008911},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.7294145822525024},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5542266368865967},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45472896099090576},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44918641448020935},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3330293893814087},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17665699124336243},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16474097967147827},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.06876859068870544}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fphar.2024.1424219","doi":"https://doi.org/10.3389/fphar.2024.1424219","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2024.1424219","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1424219/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11317410","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11317410","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11317410/pdf/fphar-15-1424219.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Pharmacol","raw_type":"Text"},{"id":"pmid:39135804","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39135804","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:0f35190589924327b2064cb33623a67c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/0f35190589924327b2064cb33623a67c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 15 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2024.1424219","doi":"https://doi.org/10.3389/fphar.2024.1424219","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2024.1424219","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1424219/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8427297872","display_name":null,"funder_award_id":"82004040","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4401101771.pdf","grobid_xml":"https://content.openalex.org/works/W4401101771.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1034925818","https://openalex.org/W1523693806","https://openalex.org/W1966609569","https://openalex.org/W1976599392","https://openalex.org/W1981336514","https://openalex.org/W2003572076","https://openalex.org/W2006595429","https://openalex.org/W2038468771","https://openalex.org/W2039898654","https://openalex.org/W2053919910","https://openalex.org/W2057400731","https://openalex.org/W2058520274","https://openalex.org/W2069055606","https://openalex.org/W2089097264","https://openalex.org/W2101177775","https://openalex.org/W2117800935","https://openalex.org/W2146558971","https://openalex.org/W2316174071","https://openalex.org/W2340338776","https://openalex.org/W2754373048","https://openalex.org/W2843268874","https://openalex.org/W2890580222","https://openalex.org/W2904443985","https://openalex.org/W2943347926","https://openalex.org/W2957836220","https://openalex.org/W2980799156","https://openalex.org/W3001780488","https://openalex.org/W3087967903","https://openalex.org/W3088062854","https://openalex.org/W3096971374","https://openalex.org/W3105668712","https://openalex.org/W3109059245","https://openalex.org/W3110312428","https://openalex.org/W3113180888","https://openalex.org/W3115914677","https://openalex.org/W3121835129","https://openalex.org/W3130785861","https://openalex.org/W3139516084","https://openalex.org/W3141600959","https://openalex.org/W3173948537","https://openalex.org/W4297312212","https://openalex.org/W4310396520","https://openalex.org/W4313597880","https://openalex.org/W4320731306","https://openalex.org/W4360999657","https://openalex.org/W4362602736","https://openalex.org/W4379472974","https://openalex.org/W4381806330","https://openalex.org/W4385728359","https://openalex.org/W4385800193","https://openalex.org/W4385999933","https://openalex.org/W4386624403","https://openalex.org/W4389201799","https://openalex.org/W6762407331"],"related_works":["https://openalex.org/W4392805154","https://openalex.org/W4407786009","https://openalex.org/W2998473664","https://openalex.org/W4406075432","https://openalex.org/W3197400136","https://openalex.org/W2313687783","https://openalex.org/W2902104141","https://openalex.org/W2803263409","https://openalex.org/W2906883806","https://openalex.org/W2792509463"],"abstract_inverted_index":{"Ulcerative":[0],"colitis":[1],"(UC)":[2],"is":[3],"a":[4,14,29,94,107],"recurring":[5],"inflammatory":[6,81,178],"bowel":[7],"disease,":[8],"in":[9,16,99,117,158,174],"which":[10],"oxidative":[11,142,216],"stress":[12,143,217],"plays":[13],"role":[15],"its":[17,53],"progression,":[18],"and":[19,52,77,126,131,138,144,180,190,218],"regulation":[20],"of":[21,35,39,48,91,128,135,155,172,184,200,207,215],"the":[22,33,45,59,78,88,113,124,133,153,159,182,197,204,213,221],"oxidative/antioxidative":[23],"balance":[24],"has":[25],"been":[26],"suggested":[27],"as":[28],"potential":[30,54,89],"target":[31],"for":[32],"treatment":[34],"UC.":[36],"The":[37,116],"aim":[38],"this":[40],"study":[41],"was":[42,97],"to":[43,86,102,187],"evaluate":[44],"protective":[46,108,205],"effect":[47,109,199,206],"andrographolide":[49,105,122,149,167,208],"against":[50,110,209],"UC":[51,75,111,210],"antioxidant":[55],"properties":[56],"by":[57,148],"modulating":[58],"nuclear":[60],"factor":[61,64],"erythroid":[62],"2-related":[63],"2":[65],"(Nrf2)/heme":[66],"oxygenase-1":[67],"(HO-1)":[68],"pathway.":[69,115,161,192,223],"Dextran":[70],"sulfate":[71],"sodium":[72],"(DSS)":[73],"-induced":[74],"mice":[76,130],"LPS-induced":[79,169],"HT29":[80,175],"cell":[82],"model":[83],"were":[84,146],"established":[85],"uncover":[87],"mechanisms":[90],"andrographolide.":[92,201],"ML385,":[93],"Nrf2":[95],"inhibitor,":[96],"used":[98],"both":[100],"models":[101],"assess":[103],"whether":[104],"exerts":[106],"through":[112],"Nrf2/HO-1":[114,160,191,222],"vivo":[118],"experiment":[119],"showed":[120,165],"that":[121,166],"ameliorated":[123],"symptoms":[125],"histopathology":[127],"DSS-induced":[129,141],"restored":[132],"expressions":[134],"ZO-1,":[136],"Occludin-1":[137],"Claudin-1.":[139],"Meanwhile,":[140],"inflammation":[145,219],"suppressed":[147],"treatment,":[150],"along":[151],"with":[152],"upregulation":[154],"key":[156],"proteins":[157,185],"In":[162,193,202],"vitro":[163],"experiments":[164],"attenuated":[168],"excessive":[170],"generation":[171],"ROS":[173],"cells,":[176],"reduced":[177],"factors,":[179],"upregulated":[181],"expression":[183],"related":[186],"tight":[188],"junctions":[189],"addition,":[194],"ML385":[195],"abolished":[196],"beneficial":[198],"conclusion,":[203],"may":[211],"involve":[212],"suppression":[214],"via":[220]},"counts_by_year":[{"year":2026,"cited_by_count":18},{"year":2025,"cited_by_count":19},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2024-07-31T00:00:00"}
