{"id":"https://openalex.org/W4401101136","doi":"https://doi.org/10.1002/pul2.12403","title":"Selexipag in patients with pulmonary arterial hypertension associated with connective tissue disease (PAH\u2010CTD): Real\u2010world experience from EXPOSURE","display_name":"Selexipag in patients with pulmonary arterial hypertension associated with connective tissue disease (PAH\u2010CTD): Real\u2010world experience from EXPOSURE","publication_year":2024,"publication_date":"2024-07-01","ids":{"openalex":"https://openalex.org/W4401101136","doi":"https://doi.org/10.1002/pul2.12403","pmid":"https://pubmed.ncbi.nlm.nih.gov/39076250","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11284239"},"language":"en","primary_location":{"id":"doi:10.1002/pul2.12403","doi":"https://doi.org/10.1002/pul2.12403","is_oa":true,"landing_page_url":"https://doi.org/10.1002/pul2.12403","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pul2.12403","source":{"id":"https://openalex.org/S2764573606","display_name":"Pulmonary Circulation","issn_l":"2045-8932","issn":["2045-8932","2045-8940"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pulmonary Circulation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pul2.12403","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070548054","display_name":"Se\u00e1n Gaine","orcid":"https://orcid.org/0000-0002-5941-684X","observed_orcids":["https://orcid.org/0000-0002-5941-684X"]},"institutions":[{"id":"https://openalex.org/I2803071314","display_name":"Mater Misericordiae University Hospital","ror":"https://ror.org/040hqpc16","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2803071314"]}],"countries":["IE"],"is_corresponding":true,"raw_author_name":"Sean Gaine","raw_affiliation_strings":["National Pulmonary Hypertension Unit, Mater Misericordiae University Hospital, Dublin, Ireland"],"raw_orcid":"https://orcid.org/0000-0002-5941-684X","affiliations":[{"raw_affiliation_string":"National Pulmonary Hypertension Unit, Mater Misericordiae University Hospital, Dublin, Ireland","institution_ids":["https://openalex.org/I2803071314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072002848","display_name":"Pilar Escribano Sub\u00edas","orcid":"https://orcid.org/0000-0002-6640-4839","observed_orcids":["https://orcid.org/0000-0002-6640-4839"]},"institutions":[{"id":"https://openalex.org/I4210095014","display_name":"Centro de Investigaci\u00f3n en Red en Enfermedades Cardiovasculares","ror":"https://ror.org/00s29fn93","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210095014"]},{"id":"https://openalex.org/I4210101691","display_name":"Hospital Universitario 12 De Octubre","ror":"https://ror.org/00qyh5r35","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210101691","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Pilar Escribano\u2010Subias","raw_affiliation_strings":["Pulmonary Hypertension Unit, Cardiology Department, CIBERCV, Hospital 12 de Octubre, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary Hypertension Unit, Cardiology Department, CIBERCV, Hospital 12 de Octubre, Madrid, Spain","institution_ids":["https://openalex.org/I4210095014","https://openalex.org/I4210101691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002294585","display_name":"Audrey Muller","orcid":"https://orcid.org/0009-0008-9438-539X","observed_orcids":["https://orcid.org/0009-0008-9438-539X"]},"institutions":[{"id":"https://openalex.org/I95056601","display_name":"Actelion (Switzerland)","ror":"https://ror.org/001yedb91","country_code":"CH","type":"company","lineage":["https://openalex.org/I95056601"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Audrey Muller","raw_affiliation_strings":["Actelion Pharmaceuticals Ltd, a Johnson & Johnson Company, Global Epidemiology Allschwil Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Actelion Pharmaceuticals Ltd, a Johnson & Johnson Company, Global Epidemiology Allschwil Switzerland","institution_ids":["https://openalex.org/I95056601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029176115","display_name":"Catarina Fernandes","orcid":"https://orcid.org/0000-0002-6649-4889","observed_orcids":["https://orcid.org/0000-0002-6649-4889"]},"institutions":[{"id":"https://openalex.org/I95056601","display_name":"Actelion (Switzerland)","ror":"https://ror.org/001yedb91","country_code":"CH","type":"company","lineage":["https://openalex.org/I95056601"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Catarina C. Fernandes","raw_affiliation_strings":["Actelion Pharmaceuticals Ltd, a Johnson & Johnson Company, Global Medical Affairs Allschwil Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Actelion Pharmaceuticals Ltd, a Johnson & Johnson Company, Global Medical Affairs Allschwil Switzerland","institution_ids":["https://openalex.org/I95056601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078003419","display_name":"Martina Fontana","orcid":"https://orcid.org/0000-0002-3999-6170","observed_orcids":["https://orcid.org/0000-0002-3999-6170"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martina Fontana","raw_affiliation_strings":["Janssen\u2010Cilag S.p.A, a Johnson & Johnson Company, Statistics and Decision Sciences Milan Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen\u2010Cilag S.p.A, a Johnson & Johnson Company, Statistics and Decision Sciences Milan Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060969252","display_name":"Tatiana Reme\u0148ov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95056601","display_name":"Actelion (Switzerland)","ror":"https://ror.org/001yedb91","country_code":"CH","type":"company","lineage":["https://openalex.org/I95056601"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Tatiana Remenova","raw_affiliation_strings":["Actelion Pharmaceuticals Ltd, a Johnson & Johnson Company, Global Medical Safety Allschwil Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Actelion Pharmaceuticals Ltd, a Johnson & Johnson Company, Global Medical Safety Allschwil Switzerland","institution_ids":["https://openalex.org/I95056601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046487380","display_name":"Stefan S\u00f6derberg","orcid":"https://orcid.org/0000-0001-9225-1306","observed_orcids":["https://orcid.org/0000-0001-9225-1306"]},"institutions":[{"id":"https://openalex.org/I90267481","display_name":"Ume\u00e5 University","ror":"https://ror.org/05kb8h459","country_code":"SE","type":"education","lineage":["https://openalex.org/I90267481"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Stefan S\u00f6derberg","raw_affiliation_strings":["Department of Public Health and Clinical Medicine, Cardiology and Heart Centre Ume\u00e5 University Ume\u00e5 Sweden"],"raw_orcid":"https://orcid.org/0000-0001-9225-1306","affiliations":[{"raw_affiliation_string":"Department of Public Health and Clinical Medicine, Cardiology and Heart Centre Ume\u00e5 University Ume\u00e5 Sweden","institution_ids":["https://openalex.org/I90267481"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012428965","display_name":"Tobias J. Lange","orcid":"https://orcid.org/0000-0002-2897-8145","observed_orcids":["https://orcid.org/0000-0002-2897-8145"]},"institutions":[{"id":"https://openalex.org/I4210152055","display_name":"Klinik Bad Reichenhall","ror":"https://ror.org/03ytm9f32","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210152055"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tobias J. Lange","raw_affiliation_strings":["Department Internal Medicine II, Faculty of Medicine, Regensburg University, Regensburg, Germany","Department of Pulmonology, Kreisklinik Bad Reichenhall, Bad Reichenhall, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Internal Medicine II, Faculty of Medicine, Regensburg University, Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]},{"raw_affiliation_string":"Department of Pulmonology, Kreisklinik Bad Reichenhall, Bad Reichenhall, Germany","institution_ids":["https://openalex.org/I4210152055"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5070548054"],"corresponding_institution_ids":["https://openalex.org/I2803071314"],"apc_list":{"value":2310,"currency":"USD","value_usd":2310},"apc_paid":{"value":2310,"currency":"USD","value_usd":2310},"fwci":3.6197,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.93460758,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"14","issue":"3","first_page":"e12403","last_page":"e12403"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12199","display_name":"Vascular Anomalies and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/selexipag","display_name":"selexipag","score":1.0},{"id":"https://openalex.org/keywords/pulmonary-arterial-hypertension","display_name":"pulmonary arterial hypertension","score":0.9919999837875366},{"id":"https://openalex.org/keywords/connective-tissue-diseases","display_name":"connective tissue diseases","score":0.9480000138282776},{"id":"https://openalex.org/keywords/treatment-patterns","display_name":"treatment patterns","score":0.75},{"id":"https://openalex.org/keywords/drug-tolerability","display_name":"drug tolerability","score":0.8119999766349792},{"id":"https://openalex.org/keywords/hospitalization","display_name":"hospitalization","score":0.718999981880188},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.7900000214576721},{"id":"https://openalex.org/keywords/mortality-risk","display_name":"mortality risk","score":0.5299999713897705},{"id":"https://openalex.org/keywords/who-functional-class","display_name":"WHO functional class","score":0.6179999709129333},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.3109999895095825}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9658055305480957},{"id":"https://openalex.org/C125533998","wikidata":"https://www.wikidata.org/wiki/Q1024499","display_name":"CTD","level":2,"score":0.7359169721603394},{"id":"https://openalex.org/C2776670291","wikidata":"https://www.wikidata.org/wiki/Q1779300","display_name":"Connective tissue disease","level":4,"score":0.6426479816436768},{"id":"https://openalex.org/C2780930700","wikidata":"https://www.wikidata.org/wiki/Q1128595","display_name":"Pulmonary hypertension","level":2,"score":0.6008337736129761},{"id":"https://openalex.org/C518705261","wikidata":"https://www.wikidata.org/wiki/Q25615","display_name":"Connective tissue","level":2,"score":0.5518298745155334},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4823026657104492},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4710148572921753},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40064698457717896},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.39710748195648193},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.09325379133224487},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1002/pul2.12403","doi":"https://doi.org/10.1002/pul2.12403","is_oa":true,"landing_page_url":"https://doi.org/10.1002/pul2.12403","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pul2.12403","source":{"id":"https://openalex.org/S2764573606","display_name":"Pulmonary Circulation","issn_l":"2045-8932","issn":["2045-8932","2045-8940"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pulmonary Circulation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11284239","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11284239","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11284239/pdf/PUL2-14-e12403.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pulm Circ","raw_type":"Text"},{"id":"pmid:39076250","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39076250","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pulmonary circulation","raw_type":"Journal Article"},{"id":"pmh:oai:DiVA.org:umu-228191","doi":null,"is_oa":true,"landing_page_url":"https://umu.diva-portal.org/smash/get/diva2:1887294/FULLTEXT01","pdf_url":null,"source":{"id":"https://openalex.org/S4306400361","display_name":"DiVA at Ume\u00e5 University (Ume\u00e5 University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I90267481","host_organization_name":"Ume\u00e5 University","host_organization_lineage":["https://openalex.org/I90267481"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:42cce7bd102e4cb2b8f3c4abd28d3fa1","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/42cce7bd102e4cb2b8f3c4abd28d3fa1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pulmonary Circulation, Vol 14, Iss 3, Pp n/a-n/a (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/pul2.12403","doi":"https://doi.org/10.1002/pul2.12403","is_oa":true,"landing_page_url":"https://doi.org/10.1002/pul2.12403","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pul2.12403","source":{"id":"https://openalex.org/S2764573606","display_name":"Pulmonary Circulation","issn_l":"2045-8932","issn":["2045-8932","2045-8940"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pulmonary Circulation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320338282","display_name":"Actelion Pharmaceuticals","ror":"https://ror.org/001yedb91"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4401101136.pdf","grobid_xml":"https://content.openalex.org/works/W4401101136.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1954004200","https://openalex.org/W1985526821","https://openalex.org/W2023149067","https://openalex.org/W2073305297","https://openalex.org/W2077418333","https://openalex.org/W2098830214","https://openalex.org/W2106199142","https://openalex.org/W2132078597","https://openalex.org/W2142655452","https://openalex.org/W2158862125","https://openalex.org/W2278696749","https://openalex.org/W2411316627","https://openalex.org/W2736062315","https://openalex.org/W2745759236","https://openalex.org/W2803740985","https://openalex.org/W2999142710","https://openalex.org/W3006390447","https://openalex.org/W3126829642","https://openalex.org/W3130346358","https://openalex.org/W3201735854","https://openalex.org/W3206212741","https://openalex.org/W3210217027","https://openalex.org/W4200622415","https://openalex.org/W4293207258","https://openalex.org/W4293217384","https://openalex.org/W4308708682","https://openalex.org/W4384626874","https://openalex.org/W4390811971"],"related_works":["https://openalex.org/W2745759236","https://openalex.org/W4225325403","https://openalex.org/W4396503426","https://openalex.org/W3092940248","https://openalex.org/W2569832756","https://openalex.org/W4411421009","https://openalex.org/W4410276872","https://openalex.org/W4360612358","https://openalex.org/W4401182168","https://openalex.org/W4404097157"],"abstract_inverted_index":{"Selexipag":[0],"is":[1],"indicated":[2],"for":[3,72,222],"the":[4,23,37,105,132,215,233],"treatment":[5,46],"of":[6,25,36,51,127,148,165,217,235],"pulmonary":[7],"arterial":[8],"hypertension":[9],"(PAH),":[10],"including":[11],"PAH":[12,64],"associated":[13],"with":[14,62,98,191,220,224,239],"connective":[15],"tissue":[16],"disease":[17],"(CTD),":[18],"and":[19,49,97,123,146,202],"further":[20],"insights":[21],"into":[22],"management":[24],"selexipag-treated":[26,77],"PAH-CTD":[27,52,240],"patients":[28,53,65,78,92,116,171,182,210,223,238],"in":[29,56,247],"clinical":[30,250,257],"settings":[31],"are":[32],"needed.":[33],"These":[34,212,226],"analyses":[35,59],"ongoing,":[38],"multicenter,":[39],"prospective":[40],"EXPOSURE":[41],"(EUPAS19085)":[42],"study":[43],"describe":[44,214],"characteristics,":[45],"patterns,":[47],"tolerability,":[48],"outcomes":[50],"initiating":[54],"selexipag":[55,140,162,221,236],"Europe/Canada.":[57],"All":[58],"were":[60,93,114,183],"descriptive,":[61],"idiopathic":[63],"who":[66],"typically":[67],"display":[68],"better":[69],"prognosis":[70],"included":[71],"context.":[73],"Six":[74],"hundred":[75],"ninety-eight":[76],"had":[79,84],"follow-up":[80],"information;":[81],"178":[82],"(26%)":[83],"PAH-CTD.":[85,225],"The":[86],"median":[87,106,160],"age":[88],"was":[89,110,200,206],"68":[90],"years,":[91],"predominantly":[94],"female":[95],"(88%),":[96],"WHO":[99],"functional":[100],"class":[101],"III":[102],"symptoms":[103],"(63%);":[104],"time":[107],"since":[108],"diagnosis":[109],"1.7":[111],"years.":[112],"There":[113],"5%":[115],"at":[117,185,197,203],"low,":[118],"25%":[119],"intermediate-low,":[120],"40%":[121],"intermediate-high,":[122],"30%":[124],"high":[125],"risk":[126,135],"1-year":[128],"mortality,":[129],"according":[130],"to":[131,177,231,249,252,255],"ESC/ERS":[133],"4-strata":[134],"score.":[136],"Most":[137],"(80%)":[138],"initiated":[139],"as":[141],"a":[142,159],"triple":[143,153],"oral":[144],"therapy,":[145],"most":[147],"these":[149],"(62%)":[150],"remained":[151],"on":[152],"therapy":[154,219],"6":[155],"months":[156],"post-baseline.":[157],"Over":[158],"(Q1-Q3)":[161],"exposure":[163],"period":[164],"8.6":[166],"(2.5-17.2)":[167],"months,":[168],"79":[169],"(44%)":[170],"discontinued":[172],"selexipag;":[173],"36":[174],"(20%)":[175],"due":[176],"tolerability/adverse":[178],"events.":[179],"Sixty":[180],"(34%)":[181],"hospitalized":[184],"least":[186],"once;":[187],"120":[188],"hospitalizations":[189],"occurred,":[190],"49":[192],"(48%)":[193],"deemed":[194],"PAH-related.":[195],"Survival":[196],"1":[198],"year":[199],"85%,":[201],"2":[204],"years":[205,246],"71%;":[207],"29":[208],"(16%)":[209],"died.":[211],"results":[213],"use":[216],"combination":[218],"findings":[227],"suggest":[228],"an":[229],"opportunity":[230],"optimize":[232],"benefits":[234],"among":[237],"by":[241],"moving":[242],"from":[243],"escalating":[244,253],"after":[245],"response":[248],"deterioration":[251],"sooner":[254],"prevent":[256],"deterioration.":[258]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2024-07-31T00:00:00"}