{"id":"https://openalex.org/W4401046002","doi":"https://doi.org/10.1038/s41467-024-50466-y","title":"Adenosine triggers early astrocyte reactivity that provokes microglial responses and drives the pathogenesis of sepsis-associated encephalopathy in mice","display_name":"Adenosine triggers early astrocyte reactivity that provokes microglial responses and drives the pathogenesis of sepsis-associated encephalopathy in mice","publication_year":2024,"publication_date":"2024-07-27","ids":{"openalex":"https://openalex.org/W4401046002","doi":"https://doi.org/10.1038/s41467-024-50466-y","pmid":"https://pubmed.ncbi.nlm.nih.gov/39068155","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11283516"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-024-50466-y","doi":"https://doi.org/10.1038/s41467-024-50466-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-024-50466-y","pdf_url":"https://www.nature.com/articles/s41467-024-50466-y.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-024-50466-y.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087349417","display_name":"Qilin Guo","orcid":"https://orcid.org/0000-0002-7531-0818","observed_orcids":["https://orcid.org/0000-0002-7531-0818"]},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Qilin Guo","raw_affiliation_strings":["Center for Gender-specific Biology and Medicine (CGBM), University of Saarland, 66421, Homburg, Germany","Molecular Physiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), University of Saarland, 66421, Homburg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-7531-0818","affiliations":[{"raw_affiliation_string":"Center for Gender-specific Biology and Medicine (CGBM), University of Saarland, 66421, Homburg, Germany","institution_ids":["https://openalex.org/I91712215"]},{"raw_affiliation_string":"Molecular Physiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), University of Saarland, 66421, Homburg, Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077838902","display_name":"Davide Gobbo","orcid":"https://orcid.org/0000-0002-4076-2697","observed_orcids":["https://orcid.org/0000-0002-4076-2697"]},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Davide Gobbo","raw_affiliation_strings":["Molecular Physiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), University of Saarland, 66421, Homburg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-4076-2697","affiliations":[{"raw_affiliation_string":"Molecular Physiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), University of Saarland, 66421, Homburg, Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070460690","display_name":"Na Zhao","orcid":"https://orcid.org/0000-0003-1780-7700","observed_orcids":["https://orcid.org/0000-0003-1780-7700"]},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Na Zhao","raw_affiliation_strings":["Institute of Anatomy and Cell Biology, University of Saarland, 66421, Homburg, Germany","Molecular Physiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), University of Saarland, 66421, Homburg, Germany"],"raw_orcid":"https://orcid.org/0000-0003-1780-7700","affiliations":[{"raw_affiliation_string":"Institute of Anatomy and Cell Biology, University of Saarland, 66421, Homburg, Germany","institution_ids":["https://openalex.org/I91712215"]},{"raw_affiliation_string":"Molecular Physiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), University of Saarland, 66421, Homburg, Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113387773","display_name":"Hong Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hong Zhang","raw_affiliation_strings":["Biophysics, CIPMM, University of Saarland, 66421, Homburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biophysics, CIPMM, University of Saarland, 66421, Homburg, Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105911648","display_name":"Nana-Oye Awuku","orcid":"https://orcid.org/0000-0002-9593-568X","observed_orcids":["https://orcid.org/0000-0002-9593-568X"]},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nana-Oye Awuku","raw_affiliation_strings":["Molecular Neurophysiology, CIPMM, University of Saarland, 66421, Homburg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-9593-568X","affiliations":[{"raw_affiliation_string":"Molecular Neurophysiology, CIPMM, University of Saarland, 66421, Homburg, Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021133690","display_name":"Qing Liu","orcid":"https://orcid.org/0000-0002-5245-1474","observed_orcids":["https://orcid.org/0000-0002-5245-1474"]},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Qing Liu","raw_affiliation_strings":["Molecular Physiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), University of Saarland, 66421, Homburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Physiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), University of Saarland, 66421, Homburg, Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006134721","display_name":"Li\u2010Pao Fang","orcid":"https://orcid.org/0000-0002-7973-9523","observed_orcids":["https://orcid.org/0000-0002-7973-9523"]},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Li-Pao Fang","raw_affiliation_strings":["Center for Gender-specific Biology and Medicine (CGBM), University of Saarland, 66421, Homburg, Germany","Molecular Physiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), University of Saarland, 66421, Homburg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-7973-9523","affiliations":[{"raw_affiliation_string":"Center for Gender-specific Biology and Medicine (CGBM), University of Saarland, 66421, Homburg, Germany","institution_ids":["https://openalex.org/I91712215"]},{"raw_affiliation_string":"Molecular Physiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), University of Saarland, 66421, Homburg, Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087166832","display_name":"Tanja M. Gampfer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tanja M. Gampfer","raw_affiliation_strings":["Department of Experimental and Clinical Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, Center for Molecular Signaling (PZMS), University of Saarland, 66421, Homburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, Center for Molecular Signaling (PZMS), University of Saarland, 66421, Homburg, Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005967499","display_name":"Markus Robert Meyer","orcid":"https://orcid.org/0000-0003-4377-6784","observed_orcids":["https://orcid.org/0000-0003-4377-6784"]},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Markus R. Meyer","raw_affiliation_strings":["Department of Experimental and Clinical Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, Center for Molecular Signaling (PZMS), University of Saarland, 66421, Homburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, Center for Molecular Signaling (PZMS), University of Saarland, 66421, Homburg, Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019037779","display_name":"Renping Zhao","orcid":"https://orcid.org/0000-0001-8964-2058","observed_orcids":["https://orcid.org/0000-0001-8964-2058"]},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Renping Zhao","raw_affiliation_strings":["Biophysics, CIPMM, University of Saarland, 66421, Homburg, Germany"],"raw_orcid":"https://orcid.org/0000-0001-8964-2058","affiliations":[{"raw_affiliation_string":"Biophysics, CIPMM, University of Saarland, 66421, Homburg, Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008417603","display_name":"Xianshu Bai","orcid":"https://orcid.org/0000-0002-4758-1645","observed_orcids":["https://orcid.org/0000-0002-4758-1645"]},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Xianshu Bai","raw_affiliation_strings":["Center for Gender-specific Biology and Medicine (CGBM), University of Saarland, 66421, Homburg, Germany","Molecular Physiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), University of Saarland, 66421, Homburg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-4758-1645","affiliations":[{"raw_affiliation_string":"Center for Gender-specific Biology and Medicine (CGBM), University of Saarland, 66421, Homburg, Germany","institution_ids":["https://openalex.org/I91712215"]},{"raw_affiliation_string":"Molecular Physiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), University of Saarland, 66421, Homburg, Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040217973","display_name":"Shan Bian","orcid":"https://orcid.org/0000-0003-4507-3003","observed_orcids":["https://orcid.org/0000-0003-4507-3003"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210128175","display_name":"Shanghai East Hospital","ror":"https://ror.org/038xmzj21","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128175"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shan Bian","raw_affiliation_strings":["Institute for Regenerative Medicine, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, 200092, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Regenerative Medicine, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, 200092, Shanghai, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210128175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074956035","display_name":"Anja Scheller","orcid":"https://orcid.org/0000-0001-8955-2634","observed_orcids":["https://orcid.org/0000-0001-8955-2634"]},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anja Scheller","raw_affiliation_strings":["Center for Gender-specific Biology and Medicine (CGBM), University of Saarland, 66421, Homburg, Germany","Molecular Physiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), University of Saarland, 66421, Homburg, Germany"],"raw_orcid":"https://orcid.org/0000-0001-8955-2634","affiliations":[{"raw_affiliation_string":"Center for Gender-specific Biology and Medicine (CGBM), University of Saarland, 66421, Homburg, Germany","institution_ids":["https://openalex.org/I91712215"]},{"raw_affiliation_string":"Molecular Physiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), University of Saarland, 66421, Homburg, Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009493618","display_name":"Frank Kirchhoff","orcid":"https://orcid.org/0000-0002-2324-2761","observed_orcids":["https://orcid.org/0000-0002-2324-2761"]},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Frank Kirchhoff","raw_affiliation_strings":["Center for Gender-specific Biology and Medicine (CGBM), University of Saarland, 66421, Homburg, Germany. frank.kirchhoff@uks.eu","Molecular Physiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), University of Saarland, 66421, Homburg, Germany. frank.kirchhoff@uks.eu","Center for Gender-specific Biology and Medicine (CGBM), University of Saarland, 66421, Homburg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-2324-2761","affiliations":[{"raw_affiliation_string":"Center for Gender-specific Biology and Medicine (CGBM), University of Saarland, 66421, Homburg, Germany. frank.kirchhoff@uks.eu","institution_ids":["https://openalex.org/I91712215"]},{"raw_affiliation_string":"Molecular Physiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), University of Saarland, 66421, Homburg, Germany. frank.kirchhoff@uks.eu","institution_ids":["https://openalex.org/I91712215"]},{"raw_affiliation_string":"Center for Gender-specific Biology and Medicine (CGBM), University of Saarland, 66421, Homburg, Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069678891","display_name":"Wenhui Huang","orcid":"https://orcid.org/0000-0001-9865-0375","observed_orcids":["https://orcid.org/0000-0001-9865-0375"]},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Wenhui Huang","raw_affiliation_strings":["Center for Gender-specific Biology and Medicine (CGBM), University of Saarland, 66421, Homburg, Germany. wenhui.huang@uks.eu","Molecular Physiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), University of Saarland, 66421, Homburg, Germany. wenhui.huang@uks.eu","Center for Gender-specific Biology and Medicine (CGBM), University of Saarland, 66421, Homburg, Germany"],"raw_orcid":"https://orcid.org/0000-0001-9865-0375","affiliations":[{"raw_affiliation_string":"Center for Gender-specific Biology and Medicine (CGBM), University of Saarland, 66421, Homburg, Germany. wenhui.huang@uks.eu","institution_ids":["https://openalex.org/I91712215"]},{"raw_affiliation_string":"Molecular Physiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), University of Saarland, 66421, Homburg, Germany. wenhui.huang@uks.eu","institution_ids":["https://openalex.org/I91712215"]},{"raw_affiliation_string":"Center for Gender-specific Biology and Medicine (CGBM), University of Saarland, 66421, Homburg, Germany","institution_ids":["https://openalex.org/I91712215"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5009493618","https://openalex.org/A5069678891"],"corresponding_institution_ids":["https://openalex.org/I91712215"],"apc_list":{"value":6790,"currency":"USD","value_usd":6790},"apc_paid":{"value":5374,"currency":"EUR","value_usd":5795},"fwci":13.4865,"has_fulltext":true,"cited_by_count":89,"citation_normalized_percentile":{"value":0.99503465,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"15","issue":"1","first_page":"6340","last_page":"6340"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9063000082969666,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9063000082969666,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.0608999989926815,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.00930000003427267,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sepsis-associated-encephalopathy","display_name":"sepsis-associated encephalopathy","score":0.9750000238418579},{"id":"https://openalex.org/keywords/adenosine","display_name":"adenosine","score":0.9819999933242798},{"id":"https://openalex.org/keywords/adenosine-a1-receptor","display_name":"adenosine A1 receptor","score":0.9079999923706055},{"id":"https://openalex.org/keywords/astrocyte-activation","display_name":"astrocyte activation","score":0.9800000190734863},{"id":"https://openalex.org/keywords/microglial-activation","display_name":"microglial activation","score":0.8679999709129333},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9629999995231628},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9440000057220459},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.9309999942779541},{"id":"https://openalex.org/keywords/blood-brain-barrier-disruption","display_name":"blood-brain barrier disruption","score":0.9610000252723694},{"id":"https://openalex.org/keywords/chemogenetic-stimulation","display_name":"chemogenetic stimulation","score":0.5809999704360962},{"id":"https://openalex.org/keywords/depression-like-behavior","display_name":"depression-like behavior","score":0.753000020980835},{"id":"https://openalex.org/keywords/gi-protein-signaling","display_name":"Gi protein signaling","score":0.6060000061988831},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.628000020980835},{"id":"https://openalex.org/keywords/ccl5","display_name":"RANTES","score":0.9769999980926514},{"id":"https://openalex.org/keywords/cxcl1","display_name":"CXCL1","score":1.0}],"concepts":[{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.8056055903434753},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.7809067964553833},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.651370644569397},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.5898261666297913},{"id":"https://openalex.org/C2778621155","wikidata":"https://www.wikidata.org/wiki/Q576349","display_name":"Encephalopathy","level":2,"score":0.5890737771987915},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5448378324508667},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.5144177079200745},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4898199737071991},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.45457857847213745},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3674187958240509},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3228321671485901},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2054465115070343},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13884922862052917}],"mesh":[{"descriptor_ui":"D000090862","descriptor_name":"Neuroinflammatory Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D043682","descriptor_name":"Receptor, Adenosine A1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065166","descriptor_name":"Sepsis-Associated Encephalopathy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1038/s41467-024-50466-y","doi":"https://doi.org/10.1038/s41467-024-50466-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-024-50466-y","pdf_url":"https://www.nature.com/articles/s41467-024-50466-y.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"doi:10.1101/2023.10.30.563169","doi":"https://doi.org/10.1101/2023.10.30.563169","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2023.10.30.563169","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/11/10/2023.10.30.563169.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:11283516","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11283516","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11283516/pdf/41467_2024_Article_50466.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:39068155","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39068155","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-50466-y","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-024-50466-y","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:2954b4389bb94dc5b10dbce4a62930e7","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/2954b4389bb94dc5b10dbce4a62930e7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41467-024-50466-y","doi":"https://doi.org/10.1038/s41467-024-50466-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-024-50466-y","pdf_url":"https://www.nature.com/articles/s41467-024-50466-y.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1171311887","display_name":null,"funder_award_id":"SFB 894","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G1278710292","display_name":null,"funder_award_id":"EC-H2020 FET ProAct Neurofibres","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G1547223429","display_name":null,"funder_award_id":"SFB-1158","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G1734823010","display_name":null,"funder_award_id":"KI 503/14-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G1818335800","display_name":null,"funder_award_id":"INST 256/423-1 FUGG","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G3412159837","display_name":null,"funder_award_id":"10.21.1.021MN","funder_id":"https://openalex.org/F4320321876","funder_display_name":"Fritz Thyssen Stiftung"},{"id":"https://openalex.org/G4937468798","display_name":null,"funder_award_id":"H2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G509498957","display_name":null,"funder_award_id":"SPP-1757","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G5133108855","display_name":null,"funder_award_id":"HU 2614/1-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G7123683057","display_name":null,"funder_award_id":"H2020 FET","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G7520756090","display_name":null,"funder_award_id":"KI 503/14","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G7578079922","display_name":null,"funder_award_id":"/14-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G7755227777","display_name":"Die Rolle der AdenosinSignalgebung f\u00fcr OligodendrozytenRegeneration und Remyelinisierung","funder_award_id":"462650276","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320320881","display_name":"Universit\u00e4t Heidelberg","ror":"https://ror.org/038t36y30"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"},{"id":"https://openalex.org/F4320321876","display_name":"Fritz Thyssen Stiftung","ror":"https://ror.org/00f3sc705"},{"id":"https://openalex.org/F4320323326","display_name":"Medizinischen Hochschule Hannover","ror":"https://ror.org/00f2yqf98"},{"id":"https://openalex.org/F4320324787","display_name":"Peking University","ror":"https://ror.org/02v51f717"},{"id":"https://openalex.org/F4320332999","display_name":"Horizon 2020 Framework Programme","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4401046002.pdf","grobid_xml":"https://content.openalex.org/works/W4401046002.grobid-xml"},"referenced_works_count":84,"referenced_works":["https://openalex.org/W64159066","https://openalex.org/W778730798","https://openalex.org/W1485764767","https://openalex.org/W1500415856","https://openalex.org/W1519559613","https://openalex.org/W1551550807","https://openalex.org/W1868995267","https://openalex.org/W1982470063","https://openalex.org/W1983832155","https://openalex.org/W1992457570","https://openalex.org/W1995336204","https://openalex.org/W2005406125","https://openalex.org/W2018160227","https://openalex.org/W2020004768","https://openalex.org/W2035618305","https://openalex.org/W2054226892","https://openalex.org/W2054275187","https://openalex.org/W2062038518","https://openalex.org/W2078065336","https://openalex.org/W2079574859","https://openalex.org/W2096536217","https://openalex.org/W2111199809","https://openalex.org/W2113058827","https://openalex.org/W2126795224","https://openalex.org/W2135640564","https://openalex.org/W2138207763","https://openalex.org/W2146152985","https://openalex.org/W2147809951","https://openalex.org/W2159822844","https://openalex.org/W2161057248","https://openalex.org/W2167158961","https://openalex.org/W2179438025","https://openalex.org/W2206490240","https://openalex.org/W2290031963","https://openalex.org/W2330756578","https://openalex.org/W2400419369","https://openalex.org/W2570076292","https://openalex.org/W2572710398","https://openalex.org/W2591914678","https://openalex.org/W2608823051","https://openalex.org/W2782454362","https://openalex.org/W2793100732","https://openalex.org/W2865698779","https://openalex.org/W2893038030","https://openalex.org/W2894446469","https://openalex.org/W2911862132","https://openalex.org/W2915859536","https://openalex.org/W2928665623","https://openalex.org/W2940727119","https://openalex.org/W2964849163","https://openalex.org/W2975507539","https://openalex.org/W2994871395","https://openalex.org/W3023548531","https://openalex.org/W3048574446","https://openalex.org/W3049429323","https://openalex.org/W3049431618","https://openalex.org/W3080685366","https://openalex.org/W3081624198","https://openalex.org/W3083733923","https://openalex.org/W3092058471","https://openalex.org/W3112296380","https://openalex.org/W3122507014","https://openalex.org/W3126183467","https://openalex.org/W3138364969","https://openalex.org/W3164709643","https://openalex.org/W3170626284","https://openalex.org/W3194004635","https://openalex.org/W3205263478","https://openalex.org/W3205986596","https://openalex.org/W3211181013","https://openalex.org/W3214216551","https://openalex.org/W4200500813","https://openalex.org/W4200596034","https://openalex.org/W4220703941","https://openalex.org/W4220888877","https://openalex.org/W4223411834","https://openalex.org/W4292646793","https://openalex.org/W4295037725","https://openalex.org/W4327677037","https://openalex.org/W4366083479","https://openalex.org/W4380367860","https://openalex.org/W4386497828","https://openalex.org/W4386703669","https://openalex.org/W4389430126"],"related_works":["https://openalex.org/W4391539933","https://openalex.org/W3112296380","https://openalex.org/W3182043589","https://openalex.org/W4406325611","https://openalex.org/W4392308215","https://openalex.org/W3033621934","https://openalex.org/W4402319816","https://openalex.org/W7204856756","https://openalex.org/W4404144277","https://openalex.org/W4414309798"],"abstract_inverted_index":{"Molecular":[0],"pathways":[1],"mediating":[2],"systemic":[3,31],"inflammation":[4,32],"entering":[5],"the":[6,23,35,44,75,105,160],"brain":[7],"parenchyma":[8],"to":[9],"induce":[10],"sepsis-associated":[11],"encephalopathy":[12],"(SAE)":[13],"remain":[14],"elusive.":[15],"Here,":[16],"we":[17],"report":[18],"that":[19],"in":[20,85,104,112],"mice":[21],"during":[22],"first":[24],"6":[25],"hours":[26],"of":[27,38,46,61,77,109,120,137,150,162],"peripheral":[28,95,146],"lipopolysaccharide":[29],"(LPS)-evoked":[30],"(6":[33],"hpi),":[34],"plasma":[36],"level":[37],"adenosine":[39,49,66,151],"quickly":[40],"increased":[41],"and":[42,73,83,101,117,126,147,158],"enhanced":[43],"tone":[45],"central":[47,148],"extracellular":[48],"which":[50],"then":[51],"provoked":[52],"neuroinflammation":[53,125],"by":[54],"triggering":[55],"early":[56,71,135,142],"astrocyte":[57,143],"reactivity.":[58],"Specific":[59],"ablation":[60],"astrocytic":[62],"Gi":[63,110],"protein-coupled":[64],"A1":[65],"receptors":[67],"(A1ARs)":[68],"prevented":[69],"this":[70],"reactivity":[72,144],"reduced":[74],"levels":[76,149],"inflammatory":[78],"factors":[79],"(e.g.,":[80],"CCL2,":[81],"CCL5,":[82],"CXCL1)":[84],"astrocytes,":[86],"thereby":[87],"alleviating":[88],"microglial":[89],"reaction,":[90],"ameliorating":[91],"blood-brain":[92],"barrier":[93],"disruption,":[94],"immune":[96],"cell":[97],"infiltration,":[98],"neuronal":[99],"dysfunction,":[100],"depression-like":[102,127],"behaviour":[103],"mice.":[106],"Chemogenetic":[107],"stimulation":[108],"signaling":[111],"A1AR-deficent":[113],"astrocytes":[114,130],"at":[115],"2":[116],"4":[118],"hpi":[119],"LPS":[121],"injection":[122],"could":[123],"restore":[124],"behaviour,":[128],"highlighting":[129],"rather":[131],"than":[132],"microglia":[133],"as":[134,152],"drivers":[136],"neuroinflammation.":[138],"Our":[139],"results":[140],"identify":[141],"towards":[145],"an":[153],"important":[154],"pathway":[155],"driving":[156],"SAE":[157],"highlight":[159],"potential":[161],"targeting":[163],"A1ARs":[164],"for":[165],"therapeutic":[166],"intervention.":[167]},"counts_by_year":[{"year":2026,"cited_by_count":38},{"year":2025,"cited_by_count":43},{"year":2024,"cited_by_count":7},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-07-31T00:00:00"}