{"id":"https://openalex.org/W4401040902","doi":"https://doi.org/10.17615/3zvt-2r32","title":"Socioeconomic inequalities in early adulthood disrupt the immune transcriptomic landscape via upstream regulators","display_name":"Socioeconomic inequalities in early adulthood disrupt the immune transcriptomic landscape via upstream regulators","publication_year":2024,"publication_date":"2024-01-13","ids":{"openalex":"https://openalex.org/W4401040902","doi":"https://doi.org/10.17615/3zvt-2r32"},"language":"en","primary_location":{"id":"pmh:oai:www.zora.uzh.ch:253113","doi":null,"is_oa":true,"landing_page_url":"https://www.zora.uzh.ch/id/eprint/253113/1/ZORA_s41598_024_51517_6.pdf","pdf_url":"https://www.zora.uzh.ch/id/eprint/253113/1/ZORA_s41598_024_51517_6.pdf","source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Ravi, Sudharshan; Shanahan, Michael J; Levitt, Brandt; Harris, Kathleen Mullan; Cole, Steven W (2024). Socioeconomic inequalities in early adulthood disrupt the immune transcriptomic landscape via upstream regulators. Scientific Reports, 14(1):1255.","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.zora.uzh.ch/id/eprint/253113/1/ZORA_s41598_024_51517_6.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037541907","display_name":"Kathleen Mullan Harris","orcid":"https://orcid.org/0000-0001-9757-1026","observed_orcids":["https://orcid.org/0000-0001-9757-1026"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harris, Kathleen Mullan","raw_affiliation_strings":["University of North Carolina at Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058075551","display_name":"Sudharshan Ravi","orcid":"https://orcid.org/0000-0001-6059-5403","observed_orcids":["https://orcid.org/0000-0001-6059-5403"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ravi, Sudharshan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Cole, Steven W.","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cole, Steven W.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016323042","display_name":"Brandt E. Levitt","orcid":"https://orcid.org/0000-0002-6001-8291","observed_orcids":["https://orcid.org/0000-0002-6001-8291"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Levitt, Brandt","raw_affiliation_strings":["University of North Carolina at Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056796118","display_name":"Michael J. Shanahan","orcid":"https://orcid.org/0000-0003-2139-3459","observed_orcids":["https://orcid.org/0000-0003-2139-3459","https://orcid.org/0000-0003-2475-669X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shanahan, Michael J.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.12174928,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10235","display_name":"Health disparities and outcomes","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/3306","display_name":"Health"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10235","display_name":"Health disparities and outcomes","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/3306","display_name":"Health"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T13633","display_name":"Public Health and Social Inequalities","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/3306","display_name":"Health"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/socioeconomic-status","display_name":"socioeconomic status","score":0.800000011920929},{"id":"https://openalex.org/keywords/socioeconomic-inequality","display_name":"socioeconomic disparities","score":0.8159999847412109},{"id":"https://openalex.org/keywords/young-adulthood","display_name":"early adulthood","score":0.8479999899864197},{"id":"https://openalex.org/keywords/immune-system","display_name":"immune system","score":0.7360000014305115},{"id":"https://openalex.org/keywords/immune-transcriptome","display_name":"immune transcriptome","score":0.734000027179718},{"id":"https://openalex.org/keywords/upstream-regulators","display_name":"upstream regulators","score":0.5720000267028809},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.9789999723434448},{"id":"https://openalex.org/keywords/gene-regulatory-networks","display_name":"gene regulatory networks","score":0.6919999718666077},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.9879999756813049},{"id":"https://openalex.org/keywords/health-disparities","display_name":"health disparities","score":0.597000002861023},{"id":"https://openalex.org/keywords/chronic-disease-risk","display_name":"chronic disease risk","score":0.746999979019165}],"concepts":[{"id":"https://openalex.org/C45555294","wikidata":"https://www.wikidata.org/wiki/Q28113351","display_name":"Inequality","level":2,"score":0.6045206785202026},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5955433249473572},{"id":"https://openalex.org/C147077947","wikidata":"https://www.wikidata.org/wiki/Q1515895","display_name":"Socioeconomic status","level":3,"score":0.5833236575126648},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4898531138896942},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48962312936782837},{"id":"https://openalex.org/C191172861","wikidata":"https://www.wikidata.org/wiki/Q7899321","display_name":"Upstream (networking)","level":2,"score":0.4641839861869812},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.2612295150756836},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21821755170822144},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.20577725768089294},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.19430658221244812},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1440752148628235},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.12947618961334229},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10883629322052002},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.06057709455490112},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:www.zora.uzh.ch:253113","doi":null,"is_oa":true,"landing_page_url":"https://www.zora.uzh.ch/id/eprint/253113/1/ZORA_s41598_024_51517_6.pdf","pdf_url":"https://www.zora.uzh.ch/id/eprint/253113/1/ZORA_s41598_024_51517_6.pdf","source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Ravi, Sudharshan; Shanahan, Michael J; Levitt, Brandt; Harris, Kathleen Mullan; Cole, Steven W (2024). Socioeconomic inequalities in early adulthood disrupt the immune transcriptomic landscape via upstream regulators. Scientific Reports, 14(1):1255.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:cdr.lib.unc.edu:x059ck712","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/3zvt-2r32","pdf_url":"https://doi.org/10.17615/3zvt-2r32","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, 14(1)","raw_type":"Article"},{"id":"doi:10.17615/3zvt-2r32","doi":"https://doi.org/10.17615/3zvt-2r32","is_oa":true,"landing_page_url":"https://doi.org/10.17615/3zvt-2r32","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.5167/uzh-253113","doi":"https://doi.org/10.5167/uzh-253113","is_oa":true,"landing_page_url":"https://doi.org/10.5167/uzh-253113","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"pmh:oai:www.zora.uzh.ch:253113","doi":null,"is_oa":true,"landing_page_url":"https://www.zora.uzh.ch/id/eprint/253113/1/ZORA_s41598_024_51517_6.pdf","pdf_url":"https://www.zora.uzh.ch/id/eprint/253113/1/ZORA_s41598_024_51517_6.pdf","source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Ravi, Sudharshan; Shanahan, Michael J; Levitt, Brandt; Harris, Kathleen Mullan; Cole, Steven W (2024). Socioeconomic inequalities in early adulthood disrupt the immune transcriptomic landscape via upstream regulators. Scientific Reports, 14(1):1255.","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"},{"score":0.7578999996185303,"id":"https://metadata.un.org/sdg/10","display_name":"Reduced inequalities"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4153928499","display_name":"Social Context, the Life Course, and Genetic Transcription in Add Health","funder_award_id":"R01HD087061","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G422804853","display_name":"The National Longitudinal Study of Adolescent  to Adult Health","funder_award_id":"P01HD031921","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G5173858953","display_name":null,"funder_award_id":"P01-HD31921","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G597551293","display_name":null,"funder_award_id":"P01\u2010HD31921","funder_id":"https://openalex.org/F4320332600","funder_display_name":"University of North Carolina at Chapel Hill"},{"id":"https://openalex.org/G6711538161","display_name":"Social regulation of pro-inflammatory monocytes","funder_award_id":"R01AG043404","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8138265818","display_name":"Social Regulation of Gene Expression","funder_award_id":"R01AG033590","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G842791841","display_name":"Social status and the regulation of the genome: longitudinal and cross-species studies","funder_award_id":"197964","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G9000354797","display_name":null,"funder_award_id":"AG017265","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000877824","display_name":"USC/UCLA Center on Biodemography and Population Health","funder_award_id":"P30AG017265","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332524","display_name":"Gillings School of Public Health","ror":"https://ror.org/0130frc33"},{"id":"https://openalex.org/F4320332600","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337364","display_name":"National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4306642255","https://openalex.org/W3004940273","https://openalex.org/W4383858971","https://openalex.org/W3127153307","https://openalex.org/W4399596229","https://openalex.org/W2773789320","https://openalex.org/W2893998109","https://openalex.org/W2560272376","https://openalex.org/W4401992988","https://openalex.org/W4412453836"],"abstract_inverted_index":{"Disparities":[0],"in":[1,32,67,106,123,126,141],"socio-economic":[2],"status":[3],"(SES)":[4],"predict":[5],"many":[6,109],"immune":[7,19,92],"system-related":[8],"diseases,":[9],"and":[10,17,80],"previous":[11],"research":[12],"documents":[13],"relationships":[14],"between":[15],"SES":[16],"the":[18,39,49,68,91,114,117,127],"cell":[20],"transcriptome.":[21],"Drawing":[22],"on":[23],"a":[24,33,60,73,103],"bioinformatically-informed":[25],"network":[26],"approach,":[27],"we":[28],"situate":[29],"these":[30,111],"findings":[31],"broader":[34],"molecular":[35,128],"framework":[36],"by":[37],"examining":[38],"upstream":[40,121],"regulators":[41,122],"of":[42,53,64,83,90,110,120,130,137],"SES-associated":[43],"transcriptional":[44],"alterations.":[45],"Data":[46],"come":[47],"from":[48],"National":[50],"Longitudinal":[51],"Study":[52],"Adolescent":[54],"to":[55,134],"Adult":[56],"Health":[57],"(Add":[58],"Health),":[59],"nationally":[61],"representative":[62],"sample":[63],"4543":[65],"adults":[66],"United":[69],"States.":[70],"Results":[71],"reveal":[72,116],"network-of":[74],"differentially":[75],"expressed":[76],"genes,":[77],"transcription":[78,84],"factors,":[79],"protein":[81],"neighbors":[82],"factors-that":[85],"shows":[86],"widespread":[87],"SES-related":[88],"dysregulation":[89],"system.":[93],"Mediational":[94],"models":[95],"suggest":[96],"that":[97],"body":[98],"mass":[99],"index":[100],"(BMI)":[101],"plays":[102],"key":[104],"role":[105,119],"accounting":[107],"for":[108],"associations.":[112],"Overall,":[113],"results":[115],"central":[118],"socioeconomic":[124],"differences":[125],"basis":[129],"immunity,":[131],"which":[132],"propagate":[133],"increase":[135],"risk":[136],"chronic":[138],"health":[139],"conditions":[140],"later-life.":[142]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2024-07-27T00:00:00"}