{"id":"https://openalex.org/W4401040852","doi":"https://doi.org/10.17615/5cx4-wf37","title":"COVID-19: Clean up on IL-6","display_name":"COVID-19: Clean up on IL-6","publication_year":2024,"publication_date":"2024-07-27","ids":{"openalex":"https://openalex.org/W4401040852","doi":"https://doi.org/10.17615/5cx4-wf37"},"language":"en","primary_location":{"id":"pmh:cdr.lib.unc.edu:6m312104j","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/5cx4-wf37","pdf_url":"https://doi.org/10.17615/5cx4-wf37","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Journal of Respiratory Cell and Molecular Biology, 63(4)","raw_type":"Article"},"volume":null,"type":"article","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.17615/5cx4-wf37","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004142324","display_name":"Brian Murray","orcid":"https://orcid.org/0000-0001-6660-9749","observed_orcids":["https://orcid.org/0000-0001-6660-9749"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Murray, Brian P.","raw_affiliation_strings":["University of North Carolina at Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045094197","display_name":"Robert S. Hagan","orcid":"https://orcid.org/0000-0002-1504-0086","observed_orcids":["https://orcid.org/0000-0002-1504-0086"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hagan, Robert S.","raw_affiliation_strings":["University of North Carolina at Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044490454","display_name":"Jason R. Mock","orcid":"https://orcid.org/0000-0002-7022-0629","observed_orcids":["https://orcid.org/0000-0002-7022-0629"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mock, Jason R.","raw_affiliation_strings":["University of North Carolina at Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055761039","display_name":"Tanner Hedrick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hedrick, Tanner L.","raw_affiliation_strings":["University of North Carolina at Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.1505618,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9929999709129333},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9319999814033508},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.890999972820282},{"id":"https://openalex.org/keywords/il-6-receptor-inhibitor","display_name":"IL-6 receptor inhibitor","score":0.996999979019165},{"id":"https://openalex.org/keywords/cytokine-storm","display_name":"cytokine storm","score":0.9380000233650208},{"id":"https://openalex.org/keywords/il-6-inhibition","display_name":"IL-6 inhibition","score":0.8399999737739563},{"id":"https://openalex.org/keywords/off-label-drug-use","display_name":"off-label drug use","score":0.8330000042915344},{"id":"https://openalex.org/keywords/cytokine-dysregulation","display_name":"cytokine imbalance","score":0.5600000023841858}],"concepts":[{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.8128379583358765},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.5760799646377563},{"id":"https://openalex.org/C3006700255","wikidata":"https://www.wikidata.org/wiki/Q81068910","display_name":"2019-20 coronavirus outbreak","level":3,"score":0.572942852973938},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5280612111091614},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34919631481170654},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.131175696849823},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12470504641532898},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.09055319428443909},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:cdr.lib.unc.edu:6m312104j","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/5cx4-wf37","pdf_url":"https://doi.org/10.17615/5cx4-wf37","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Journal of Respiratory Cell and Molecular Biology, 63(4)","raw_type":"Article"},{"id":"doi:10.17615/5cx4-wf37","doi":"https://doi.org/10.17615/5cx4-wf37","is_oa":true,"landing_page_url":"https://doi.org/10.17615/5cx4-wf37","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"pmh:cdr.lib.unc.edu:6m312104j","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/5cx4-wf37","pdf_url":"https://doi.org/10.17615/5cx4-wf37","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Journal of Respiratory Cell and Molecular Biology, 63(4)","raw_type":"Article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9907000064849854}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4401040852.pdf","grobid_xml":"https://content.openalex.org/works/W4401040852.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3032047981","https://openalex.org/W3036445027","https://openalex.org/W3154092881","https://openalex.org/W3109708588","https://openalex.org/W4280552898","https://openalex.org/W3016568675","https://openalex.org/W3035222094","https://openalex.org/W3127595557","https://openalex.org/W3040956296","https://openalex.org/W3136497524"],"abstract_inverted_index":{"The":[0],"emergence":[1],"of":[2,37,50,58],"severe":[3],"acute":[4],"respiratory":[5],"syndrome":[6],"coronavirus":[7,65],"2":[8],"(SARS-CoV-2)":[9],"represents":[10],"the":[11,19,35,48],"latest":[12],"threat":[13],"to":[14,21,34],"global":[15],"health":[16],"security,":[17],"and":[18],"pressure":[20],"identify":[22],"effective":[23],"therapeutics":[24],"during":[25],"this":[26],"pandemic":[27],"is":[28,47,69],"immense.":[29],"This":[30],"stress":[31],"has":[32],"led":[33],"use":[36,49,83],"unproven":[38],"therapies":[39],"with":[40,64,79],"greater":[41],"than":[42],"minimal":[43],"risk.":[44],"One":[45],"example":[46],"IL-6":[51],"receptor":[52],"antagonists.":[53],"After":[54],"an":[55],"early":[56],"report":[57],"a":[59,76],"\u201ccytokine":[60],"storm\u201d":[61],"in":[62,72],"patients":[63],"disease":[66],"(COVID-19),":[67],"there":[68],"increased":[70],"interest":[71],"anti\u2013IL-6":[73],"therapy":[74],"as":[75],"treatment":[77],"option,":[78],"ill-defined":[80],"criteria":[81],"for":[82],"(1).":[84]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2024-07-27T00:00:00"}