{"id":"https://openalex.org/W4401036205","doi":"https://doi.org/10.1002/cam4.70041","title":"Molecular subtypes of colorectal cancer in the era of precision oncotherapy: Current inspirations and future challenges","display_name":"Molecular subtypes of colorectal cancer in the era of precision oncotherapy: Current inspirations and future challenges","publication_year":2024,"publication_date":"2024-07-01","ids":{"openalex":"https://openalex.org/W4401036205","doi":"https://doi.org/10.1002/cam4.70041","pmid":"https://pubmed.ncbi.nlm.nih.gov/39054866","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11272957"},"language":"en","primary_location":{"id":"doi:10.1002/cam4.70041","doi":"https://doi.org/10.1002/cam4.70041","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cam4.70041","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cam4.70041","source":{"id":"https://openalex.org/S2754843627","display_name":"Cancer Medicine","issn_l":"2045-7634","issn":["2045-7634"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Medicine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cam4.70041","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054644660","display_name":"Qin Dang","orcid":"https://orcid.org/0000-0002-2521-625X","observed_orcids":["https://orcid.org/0000-0002-2521-625X"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qin Dang","raw_affiliation_strings":["Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China","Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010662503","display_name":"Lulu Zuo","orcid":"https://orcid.org/0009-0000-6722-3258","observed_orcids":["https://orcid.org/0009-0000-6722-3258"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lulu Zuo","raw_affiliation_strings":["Center for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China"],"raw_orcid":"https://orcid.org/0009-0000-6722-3258","affiliations":[{"raw_affiliation_string":"Center for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101270598","display_name":"Xinru Hu","orcid":"https://orcid.org/0009-0000-4740-2646","observed_orcids":["https://orcid.org/0009-0000-4740-2646"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinru Hu","raw_affiliation_strings":["Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051283231","display_name":"Zhaokai Zhou","orcid":"https://orcid.org/0000-0001-6628-3750","observed_orcids":["https://orcid.org/0000-0001-6628-3750"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhaokai Zhou","raw_affiliation_strings":["Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shuang Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuang Chen","raw_affiliation_strings":["Center for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007365699","display_name":"Shutong Liu","orcid":"https://orcid.org/0000-0003-0976-4966","observed_orcids":["https://orcid.org/0000-0003-0976-4966"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shutong Liu","raw_affiliation_strings":["Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113037224","display_name":"Yuhao Ba","orcid":"https://orcid.org/0009-0000-9265-747X","observed_orcids":["https://orcid.org/0009-0000-9265-747X"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuhao Ba","raw_affiliation_strings":["Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111067245","display_name":"Anning Zuo","orcid":"https://orcid.org/0009-0006-6779-8282","observed_orcids":["https://orcid.org/0009-0006-6779-8282"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Anning Zuo","raw_affiliation_strings":["Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101699407","display_name":"Hui Xu","orcid":"https://orcid.org/0009-0007-9551-0634","observed_orcids":["https://orcid.org/0009-0007-9551-0634"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Xu","raw_affiliation_strings":["Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068382512","display_name":"Siyuan Weng","orcid":"https://orcid.org/0000-0001-6645-648X","observed_orcids":["https://orcid.org/0000-0001-6645-648X"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Siyuan Weng","raw_affiliation_strings":["Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100769052","display_name":"Yuyuan Zhang","orcid":"https://orcid.org/0000-0002-0972-4537","observed_orcids":["https://orcid.org/0000-0002-0972-4537"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuyuan Zhang","raw_affiliation_strings":["Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050960828","display_name":"Peng Luo","orcid":"https://orcid.org/0000-0002-8215-2045","observed_orcids":["https://orcid.org/0000-0002-8215-2045"]},"institutions":[{"id":"https://openalex.org/I4210120929","display_name":"Zhujiang Hospital","ror":"https://ror.org/02mhxa927","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120929"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Luo","raw_affiliation_strings":["Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China"],"raw_orcid":"https://orcid.org/0000-0002-8215-2045","affiliations":[{"raw_affiliation_string":"Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210120929","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013651801","display_name":"Quan Cheng","orcid":"https://orcid.org/0000-0003-2401-5349","observed_orcids":["https://orcid.org/0000-0003-2401-5349"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Quan Cheng","raw_affiliation_strings":["Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China"],"raw_orcid":"https://orcid.org/0000-0003-2401-5349","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108139332","display_name":"Zaoqu Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]},{"id":"https://openalex.org/I4391767653","display_name":"Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences","ror":"https://ror.org/055qbch41","country_code":"CN","type":"facility","lineage":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zaoqu Liu","raw_affiliation_strings":["Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China","Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","Interventional Institute of Zhengzhou University, Zhengzhou, Henan, China","Interventional Treatment and Clinical Research Center of Henan Province, Zhengzhou, Henan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]},{"raw_affiliation_string":"Interventional Institute of Zhengzhou University, Zhengzhou, Henan, China","institution_ids":["https://openalex.org/I38877650"]},{"raw_affiliation_string":"Interventional Treatment and Clinical Research Center of Henan Province, Zhengzhou, Henan, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074864641","display_name":"Xinwei Han","orcid":"https://orcid.org/0000-0003-4407-4864","observed_orcids":["https://orcid.org/0000-0003-4407-4864"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xinwei Han","raw_affiliation_strings":["Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China","Interventional Institute of Zhengzhou University, Zhengzhou, Henan, China","Interventional Treatment and Clinical Research Center of Henan Province, Zhengzhou, Henan, China"],"raw_orcid":"https://orcid.org/0000-0003-4407-4864","affiliations":[{"raw_affiliation_string":"Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"Interventional Institute of Zhengzhou University, Zhengzhou, Henan, China","institution_ids":["https://openalex.org/I38877650"]},{"raw_affiliation_string":"Interventional Treatment and Clinical Research Center of Henan Province, Zhengzhou, Henan, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5074864641","https://openalex.org/A5108139332"],"corresponding_institution_ids":["https://openalex.org/I200296433","https://openalex.org/I38877650","https://openalex.org/I4210156804","https://openalex.org/I4391767653"],"apc_list":{"value":4270,"currency":"USD","value_usd":4270},"apc_paid":{"value":4270,"currency":"USD","value_usd":4270},"fwci":1.3869,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.81835938,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"13","issue":"14","first_page":"e70041","last_page":"e70041"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":1.0},{"id":"https://openalex.org/keywords/molecular-subtypes","display_name":"molecular subtypes","score":0.9739999771118164},{"id":"https://openalex.org/keywords/consensus-molecular-subtypes","display_name":"consensus molecular subtypes","score":0.8970000147819519},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.8450000286102295},{"id":"https://openalex.org/keywords/precision-oncology","display_name":"precision oncology","score":0.8230000138282776},{"id":"https://openalex.org/keywords/patient-stratification","display_name":"patient stratification","score":0.921999990940094},{"id":"https://openalex.org/keywords/organoids","display_name":"organoids","score":0.7279999852180481},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.996999979019165},{"id":"https://openalex.org/keywords/cell-lines","display_name":"cell lines","score":0.6420000195503235},{"id":"https://openalex.org/keywords/animal-models","display_name":"animal models","score":0.8740000128746033},{"id":"https://openalex.org/keywords/crispr-cas9","display_name":"CRISPR/Cas9","score":0.8199999928474426},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9589999914169312},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.9909999966621399},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"nanotechnology","score":0.875},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.7129999995231628}],"concepts":[{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.727668821811676},{"id":"https://openalex.org/C148043351","wikidata":"https://www.wikidata.org/wiki/Q4456944","display_name":"Current (fluid)","level":2,"score":0.7031777501106262},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5899074077606201},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5104026198387146},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3315514028072357},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31875741481781006},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.12187597155570984},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1002/cam4.70041","doi":"https://doi.org/10.1002/cam4.70041","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cam4.70041","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cam4.70041","source":{"id":"https://openalex.org/S2754843627","display_name":"Cancer Medicine","issn_l":"2045-7634","issn":["2045-7634"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11272957","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11272957","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11272957/pdf/CAM4-13-e70041.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Med","raw_type":"Text"},{"id":"pmid:39054866","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39054866","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer medicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:6f026d69004340e2bcbde92bb28d5019","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6f026d69004340e2bcbde92bb28d5019","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Medicine, Vol 13, Iss 14, Pp n/a-n/a (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/cam4.70041","doi":"https://doi.org/10.1002/cam4.70041","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cam4.70041","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cam4.70041","source":{"id":"https://openalex.org/S2754843627","display_name":"Cancer Medicine","issn_l":"2045-7634","issn":["2045-7634"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4307919333","display_name":null,"funder_award_id":"221100310100","funder_id":"https://openalex.org/F4320336593","funder_display_name":"Henan Provincial Science and Technology Research Project"}],"funders":[{"id":"https://openalex.org/F4320336593","display_name":"Henan Provincial Science and Technology Research Project","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4401036205.pdf","grobid_xml":"https://content.openalex.org/works/W4401036205.grobid-xml"},"referenced_works_count":171,"referenced_works":["https://openalex.org/W1669428397","https://openalex.org/W1741548448","https://openalex.org/W1934094702","https://openalex.org/W1940241680","https://openalex.org/W1968907488","https://openalex.org/W1988075836","https://openalex.org/W2016650805","https://openalex.org/W2029864630","https://openalex.org/W2033751993","https://openalex.org/W2038143310","https://openalex.org/W2039347760","https://openalex.org/W2043398720","https://openalex.org/W2044461134","https://openalex.org/W2054913636","https://openalex.org/W2066560754","https://openalex.org/W2073636239","https://openalex.org/W2074175804","https://openalex.org/W2079530127","https://openalex.org/W2095692554","https://openalex.org/W2100173894","https://openalex.org/W2101327682","https://openalex.org/W2102354469","https://openalex.org/W2108516575","https://openalex.org/W2119746400","https://openalex.org/W2120490763","https://openalex.org/W2120921373","https://openalex.org/W2142300779","https://openalex.org/W2143537730","https://openalex.org/W2144987077","https://openalex.org/W2147297736","https://openalex.org/W2152454229","https://openalex.org/W2154075765","https://openalex.org/W2154697747","https://openalex.org/W2154941270","https://openalex.org/W2161548174","https://openalex.org/W2166982925","https://openalex.org/W2262414037","https://openalex.org/W2274106006","https://openalex.org/W2331667420","https://openalex.org/W2336815607","https://openalex.org/W2398894736","https://openalex.org/W2403475582","https://openalex.org/W2407632247","https://openalex.org/W2421455087","https://openalex.org/W2548051234","https://openalex.org/W2563720483","https://openalex.org/W2569086487","https://openalex.org/W2570447124","https://openalex.org/W2596261790","https://openalex.org/W2606930464","https://openalex.org/W2610846186","https://openalex.org/W2616284760","https://openalex.org/W2617865703","https://openalex.org/W2729239885","https://openalex.org/W2737082469","https://openalex.org/W2746814386","https://openalex.org/W2757008523","https://openalex.org/W2760216793","https://openalex.org/W2762502577","https://openalex.org/W2781642641","https://openalex.org/W2783275286","https://openalex.org/W2783521052","https://openalex.org/W2784868445","https://openalex.org/W2785396603","https://openalex.org/W2792874817","https://openalex.org/W2797024694","https://openalex.org/W2797931455","https://openalex.org/W2798041799","https://openalex.org/W2802206159","https://openalex.org/W2803164733","https://openalex.org/W2858268852","https://openalex.org/W2917791553","https://openalex.org/W2922154162","https://openalex.org/W2923548794","https://openalex.org/W2943196840","https://openalex.org/W2943661498","https://openalex.org/W2948870515","https://openalex.org/W2951546814","https://openalex.org/W2952200067","https://openalex.org/W2960393442","https://openalex.org/W2970045605","https://openalex.org/W2976007626","https://openalex.org/W2978373708","https://openalex.org/W2979848380","https://openalex.org/W2981002467","https://openalex.org/W2983692009","https://openalex.org/W2993280565","https://openalex.org/W2994559322","https://openalex.org/W2996325559","https://openalex.org/W2999281781","https://openalex.org/W3000368668","https://openalex.org/W3007470603","https://openalex.org/W3013418488","https://openalex.org/W3020093160","https://openalex.org/W3024627825","https://openalex.org/W3026831615","https://openalex.org/W3036371598","https://openalex.org/W3044545082","https://openalex.org/W3045385411","https://openalex.org/W3047693299","https://openalex.org/W3082670483","https://openalex.org/W3085427829","https://openalex.org/W3093085024","https://openalex.org/W3095726304","https://openalex.org/W3114069140","https://openalex.org/W3118206804","https://openalex.org/W3118937338","https://openalex.org/W3119715349","https://openalex.org/W3122332729","https://openalex.org/W3128646645","https://openalex.org/W3129740653","https://openalex.org/W3129916146","https://openalex.org/W3130224122","https://openalex.org/W3130748467","https://openalex.org/W3131326663","https://openalex.org/W3137058175","https://openalex.org/W3137405376","https://openalex.org/W3142728032","https://openalex.org/W3155346956","https://openalex.org/W3166800855","https://openalex.org/W3179159625","https://openalex.org/W3195543277","https://openalex.org/W3199902190","https://openalex.org/W3212753789","https://openalex.org/W3213578305","https://openalex.org/W3217081290","https://openalex.org/W3217207321","https://openalex.org/W4205537349","https://openalex.org/W4210302427","https://openalex.org/W4210534116","https://openalex.org/W4211101327","https://openalex.org/W4220665248","https://openalex.org/W4223510971","https://openalex.org/W4280562132","https://openalex.org/W4281748749","https://openalex.org/W4282933763","https://openalex.org/W4282941681","https://openalex.org/W4285265880","https://openalex.org/W4285492196","https://openalex.org/W4286009811","https://openalex.org/W4288808015","https://openalex.org/W4292448908","https://openalex.org/W4295678035","https://openalex.org/W4296286093","https://openalex.org/W4302424584","https://openalex.org/W4306366824","https://openalex.org/W4308637878","https://openalex.org/W4308773246","https://openalex.org/W4309313244","https://openalex.org/W4309436637","https://openalex.org/W4313608248","https://openalex.org/W4317754473","https://openalex.org/W4319662879","https://openalex.org/W4319737564","https://openalex.org/W4319868781","https://openalex.org/W4323316367","https://openalex.org/W4323352145","https://openalex.org/W4323355707","https://openalex.org/W4324046169","https://openalex.org/W4324046265","https://openalex.org/W4327952359","https://openalex.org/W4367292848","https://openalex.org/W4376136828","https://openalex.org/W4381252673","https://openalex.org/W4381598368","https://openalex.org/W4381714968","https://openalex.org/W4386032380","https://openalex.org/W4388133682","https://openalex.org/W4388909098","https://openalex.org/W4391025148","https://openalex.org/W4391403718"],"related_works":["https://openalex.org/W2985795188","https://openalex.org/W2803164733","https://openalex.org/W6980753542","https://openalex.org/W3024527391","https://openalex.org/W2885902223","https://openalex.org/W7119471614","https://openalex.org/W1934094702","https://openalex.org/W4367180662","https://openalex.org/W4365805780","https://openalex.org/W4380589460"],"abstract_inverted_index":{"BACKGROUND:":[0],"Colorectal":[1],"cancer":[2],"(CRC)":[3],"is":[4],"among":[5],"the":[6,17,48,178,182],"most":[7,49],"hackneyed":[8],"malignancies.":[9],"Even":[10],"patients":[11,95],"with":[12,96,177],"identical":[13],"clinical":[14,25,71,120,143],"symptoms":[15],"and":[16,64,91,115,123,142,150,171,185],"same":[18],"TNM":[19],"stage":[20],"still":[21],"exhibit":[22],"radically":[23],"different":[24],"outcomes":[26],"after":[27],"receiving":[28],"equivalent":[29],"treatment":[30],"regimens,":[31],"indicating":[32],"extensive":[33],"heterogeneity":[34,83,90],"of":[35,40,84,113,131],"CRC.":[36,85,155],"Myriad":[37],"molecular":[38,52,111],"subtypes":[39,112,132],"CRC":[41,94,114,188],"have":[42],"been":[43,58],"exploited":[44],"for":[45,61,102,187],"decades,":[46],"including":[47,158],"compelling":[50],"consensus":[51],"subtype":[53],"(CMS)":[54],"classification":[55,75],"that":[56],"has":[57],"broadly":[59],"applied":[60],"patient":[62],"stratification":[63],"biomarker-drug":[65],"combination":[66],"formulation.":[67],"Encountering":[68],"barriers":[69],"to":[70,77,146,180],"translation,":[72],"however,":[73],"CMS":[74],"fails":[76],"fully":[78],"reflect":[79],"inter-":[80],"or":[81],"intra-tumor":[82],"As":[86],"a":[87],"consequence,":[88],"addressing":[89],"precisely":[92],"managing":[93],"unique":[97],"characteristics":[98],"remain":[99],"arduous":[100],"tasks":[101],"clinicians.":[103],"REVIEW:":[104],"In":[105,127],"this":[106],"review,":[107],"we":[108],"systematically":[109],"summarize":[110],"further":[116],"elaborate":[117],"on":[118],"their":[119],"applications,":[121],"limitations,":[122],"future":[124],"orientations.":[125],"CONCLUSION:":[126],"recent":[128],"years,":[129],"exploration":[130],"through":[133],"cell":[134],"lines,":[135],"animal":[136],"models,":[137],"patient-derived":[138],"xenografts":[139],"(PDXs),":[140],"organoids,":[141],"trials":[144],"contributes":[145],"refining":[147],"biological":[148],"insights":[149],"unraveling":[151],"subtype-specific":[152],"therapies":[153],"in":[154],"Therapeutic":[156],"interventions":[157],"nanotechnology,":[159],"clustered":[160],"regulatory":[161],"interspaced":[162],"short":[163],"palindromic":[164],"repeat/CRISPR-associated":[165],"nuclease":[166],"9":[167],"(CRISPR/Cas9),":[168],"gut":[169],"microbiome,":[170],"liquid":[172],"biopsy":[173],"are":[174],"powerful":[175],"tools":[176],"possibility":[179],"shift":[181],"immunologic":[183],"landscape":[184],"outlook":[186],"precise":[189],"medicine.":[190]},"counts_by_year":[{"year":2026,"cited_by_count":20},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-07-27T00:00:00"}