{"id":"https://openalex.org/W4401034325","doi":"https://doi.org/10.3389/fphar.2024.1430548","title":"Gestodene, a novel positive allosteric modulator of PAR1, enhances PAR1-mediated human platelet aggregation","display_name":"Gestodene, a novel positive allosteric modulator of PAR1, enhances PAR1-mediated human platelet aggregation","publication_year":2024,"publication_date":"2024-07-26","ids":{"openalex":"https://openalex.org/W4401034325","doi":"https://doi.org/10.3389/fphar.2024.1430548","pmid":"https://pubmed.ncbi.nlm.nih.gov/39130626","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11310598"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2024.1430548","doi":"https://doi.org/10.3389/fphar.2024.1430548","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2024.1430548","pdf_url":null,"source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fphar.2024.1430548","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085460693","display_name":"Sohyeon Park","orcid":"https://orcid.org/0000-0002-5171-0083","observed_orcids":["https://orcid.org/0000-0002-5171-0083","https://orcid.org/0000-0002-2380-1922"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"So-Hyeon Park","raw_affiliation_strings":["College of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, Republic of Korea","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078836565","display_name":"Yunkyung Heo","orcid":"https://orcid.org/0000-0003-3780-7695","observed_orcids":["https://orcid.org/0000-0003-3780-7695"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yunkyung Heo","raw_affiliation_strings":["College of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, Republic of Korea","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113951000","display_name":"Il Kwon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Il Kwon","raw_affiliation_strings":["Integrative Research Institute for Cerebrovascular and Cardiovascular Diseases, Yonsei University College of Medicine, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrative Research Institute for Cerebrovascular and Cardiovascular Diseases, Yonsei University College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011363633","display_name":"Sungwoo Jo","orcid":"https://orcid.org/0000-0002-3768-5766","observed_orcids":["https://orcid.org/0000-0002-3768-5766"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sungwoo Jo","raw_affiliation_strings":["College of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, Republic of Korea","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029649001","display_name":"Hyejin Jeon","orcid":"https://orcid.org/0000-0003-0711-0766","observed_orcids":["https://orcid.org/0000-0003-0711-0766","https://orcid.org/0009-0000-3088-7499"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyejin Jeon","raw_affiliation_strings":["College of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, Republic of Korea","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001702285","display_name":"Yechan Lee","orcid":"https://orcid.org/0000-0002-4744-267X","observed_orcids":["https://orcid.org/0000-0002-4744-267X"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yechan Lee","raw_affiliation_strings":["College of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, Republic of Korea","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100412999","display_name":"Jieun Kim","orcid":"https://orcid.org/0000-0002-6498-5801","observed_orcids":["https://orcid.org/0000-0002-6498-5801"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jieun Kim","raw_affiliation_strings":["Graduate Program of Industrial Pharmaceutical Science, Yonsei University, Incheon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Program of Industrial Pharmaceutical Science, Yonsei University, Incheon, Republic of Korea","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006539124","display_name":"Ji Hoe Heo","orcid":"https://orcid.org/0000-0001-9898-3321","observed_orcids":["https://orcid.org/0000-0001-9898-3321","https://orcid.org/0000-0002-4004-8434"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Ji Hoe Heo","raw_affiliation_strings":["Department of Neurology, Yonsei University College of Medicine, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Yonsei University College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034765579","display_name":"Wan Namkung","orcid":"https://orcid.org/0000-0002-1480-7433","observed_orcids":["https://orcid.org/0000-0002-1480-7433"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Wan Namkung","raw_affiliation_strings":["College of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, Republic of Korea","Graduate Program of Industrial Pharmaceutical Science, Yonsei University, Incheon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, Republic of Korea","institution_ids":["https://openalex.org/I193775966"]},{"raw_affiliation_string":"Graduate Program of Industrial Pharmaceutical Science, Yonsei University, Incheon, Republic of Korea","institution_ids":["https://openalex.org/I193775966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5006539124","https://openalex.org/A5034765579"],"corresponding_institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210160791"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":1.1531,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.78847146,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"15","issue":null,"first_page":"1430548","last_page":"1430548"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.8481000065803528,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.8481000065803528,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.14659999310970306,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12352","display_name":"Heparin-Induced Thrombocytopenia and Thrombosis","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gestodene","display_name":"gestodene","score":0.9959999918937683},{"id":"https://openalex.org/keywords/positive-allosteric-modulators","display_name":"positive allosteric modulators","score":0.8989999890327454},{"id":"https://openalex.org/keywords/protease-activated-receptor-1","display_name":"protease-activated receptor 1","score":0.9210000038146973},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.8579999804496765},{"id":"https://openalex.org/keywords/thrombin","display_name":"thrombin","score":0.6380000114440918},{"id":"https://openalex.org/keywords/calcium-mobilization","display_name":"calcium mobilization","score":0.8939999938011169},{"id":"https://openalex.org/keywords/vorapaxar","display_name":"vorapaxar","score":0.8320000171661377},{"id":"https://openalex.org/keywords/venous-thromboembolism","display_name":"venous thromboembolism","score":0.8740000128746033},{"id":"https://openalex.org/keywords/oral-contraceptives","display_name":"oral contraceptives","score":0.9229999780654907},{"id":"https://openalex.org/keywords/erk1-2-phosphorylation","display_name":"ERK1/2 phosphorylation","score":0.8930000066757202}],"concepts":[{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.7397844195365906},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.737760066986084},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.7328049540519714},{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.6433960199356079},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5931555032730103},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5525802373886108},{"id":"https://openalex.org/C2776038425","wikidata":"https://www.wikidata.org/wiki/Q2649417","display_name":"Allosteric modulator","level":4,"score":0.5507515072822571},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.520088791847229},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3977191150188446},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.39577963948249817},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2961709499359131},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26754048466682434},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2301647663116455},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17590880393981934}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fphar.2024.1430548","doi":"https://doi.org/10.3389/fphar.2024.1430548","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2024.1430548","pdf_url":null,"source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11310598","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11310598","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11310598/pdf/fphar-15-1430548.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Pharmacol","raw_type":"Text"},{"id":"pmid:39130626","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39130626","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:67672e0af5c44d6fa1c35245e93b5e99","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/67672e0af5c44d6fa1c35245e93b5e99","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 15 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2024.1430548","doi":"https://doi.org/10.3389/fphar.2024.1430548","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2024.1430548","pdf_url":null,"source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1271398877","display_name":null,"funder_award_id":"2018R1A6A1A03023718","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G1626366641","display_name":null,"funder_award_id":"NRF-2018R1A6A1A03023718","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G4545941462","display_name":null,"funder_award_id":"NRF-2018R1A6A1A03023718","funder_id":"https://openalex.org/F4320320671","funder_display_name":"National Research Foundation"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4401034325.pdf","grobid_xml":"https://content.openalex.org/works/W4401034325.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W187268731","https://openalex.org/W252726373","https://openalex.org/W383361769","https://openalex.org/W1574035578","https://openalex.org/W1907663636","https://openalex.org/W1970306387","https://openalex.org/W1972147469","https://openalex.org/W1975249589","https://openalex.org/W1979306178","https://openalex.org/W1982641617","https://openalex.org/W1988212011","https://openalex.org/W1991755293","https://openalex.org/W1999011481","https://openalex.org/W2007667328","https://openalex.org/W2019874022","https://openalex.org/W2022660048","https://openalex.org/W2032505028","https://openalex.org/W2035369931","https://openalex.org/W2054266243","https://openalex.org/W2058252463","https://openalex.org/W2065258513","https://openalex.org/W2069023792","https://openalex.org/W2072101129","https://openalex.org/W2079884282","https://openalex.org/W2091112630","https://openalex.org/W2095765250","https://openalex.org/W2097396972","https://openalex.org/W2098610477","https://openalex.org/W2128698842","https://openalex.org/W2132629607","https://openalex.org/W2142021807","https://openalex.org/W2145113562","https://openalex.org/W2146033039","https://openalex.org/W2152386656","https://openalex.org/W2155922333","https://openalex.org/W2158910198","https://openalex.org/W2176327465","https://openalex.org/W2468385423","https://openalex.org/W2567958607","https://openalex.org/W2569682967","https://openalex.org/W2793047080","https://openalex.org/W3003244975","https://openalex.org/W3042255612","https://openalex.org/W3132039641","https://openalex.org/W3145223454","https://openalex.org/W4206611768","https://openalex.org/W4240484557","https://openalex.org/W4295981426","https://openalex.org/W4388928506"],"related_works":["https://openalex.org/W4378648869","https://openalex.org/W2552711016","https://openalex.org/W120386687","https://openalex.org/W3175724779","https://openalex.org/W383361769","https://openalex.org/W2145113562","https://openalex.org/W2588719578","https://openalex.org/W2095765250","https://openalex.org/W2097396972","https://openalex.org/W2979999078"],"abstract_inverted_index":{"Background:":[0],"Protease-activated":[1],"receptor":[2],"1":[3],"(PAR1)":[4],"is":[5,33,226],"expressed":[6],"in":[7,29,101,134,157,195,199],"human":[8,30,135,143,200],"platelets":[9],"and":[10,75,104,126,142,150,164,174,178,211,232],"can":[11],"be":[12],"activated":[13],"by":[14,83,185,222],"low":[15],"concentrations":[16],"of":[17,23,39,44,50,57,73,79,85,94,118,122,124,172,176,207,218,230,241],"thrombin.":[18],"Vorapaxar,":[19],"a":[20,45,54,70,96,115,158,204,227],"selective":[21,228],"antagonist":[22],"PAR1,":[24,95],"inhibits":[25],"thrombin-induced":[26],"calcium":[27,155],"mobilization":[28],"platelet,":[31],"which":[32],"associated":[34,244],"with":[35,245],"an":[36,107],"increased":[37,169,190,239],"risk":[38,56,240],"bleeding.":[40],"Conversely,":[41],"the":[42,77,179,215,238],"administration":[43],"positive":[46],"allosteric":[47],"modulator":[48],"(PAM)":[49],"PAR1":[51,74,81,86,173,231],"may":[52],"pose":[53],"substantial":[55],"thrombosis":[58],"due":[59],"to":[60],"inducing":[61],"excessive":[62],"platelet":[63,88,130,209,219],"activation.":[64,89],"In":[65],"this":[66],"study,":[67],"we":[68],"discovered":[69],"novel":[71,116],"PAM":[72,84,117,229],"investigated":[76,133],"effect":[78],"enhanced":[80,147],"activation":[82,131],"on":[87,129],"Methods:":[90],"To":[91],"find":[92],"PAMs":[93],"cell-based":[97],"screen":[98],"was":[99,112],"performed":[100],"HT29":[102],"cells,":[103],"finally,":[105],"gestodene,":[106],"oral":[108],"contraceptive":[109],"drug":[110],"(OC),":[111],"identified":[113],"as":[114],"PAR1.":[119,223],"The":[120],"mechanism":[121,236],"action":[123],"gestodene":[125,188,202],"its":[127],"effects":[128,181],"were":[132,182],"megakaryocytic":[136],"leukemia":[137],"cell":[138],"line":[139],"MEG-01":[140,196],"cells":[141],"platelet.":[144],"Results:":[145],"Gestodene":[146,167,225],"both":[148],"thrombin-":[149],"PAR1-activating":[151],"peptide":[152],"(AP)-induced":[153],"intracellular":[154],"levels":[156],"dose-dependent":[159],"manner":[160],"without":[161],"altering":[162],"PAR2":[163],"PAR4":[165],"activity.":[166],"significantly":[168,183],"PAR1-AP-induced":[170,208],"internalization":[171],"phosphorylation":[175],"ERK1/2,":[177],"enhancing":[180],"blocked":[184],"vorapaxar.":[186],"Furthermore,":[187],"potently":[189],"PAR1-AP":[191],"induced":[192],"morphological":[193],"changes":[194],"cells.":[197],"Remarkably,":[198],"blood,":[201],"exerted":[203],"robust":[205],"augmentation":[206],"aggregation,":[210],"vorapaxar":[212],"effectively":[213],"attenuated":[214],"gestodene-induced":[216],"enhancement":[217],"aggregation":[220],"mediated":[221],"Conclusion:":[224],"suggest":[233],"one":[234],"possible":[235],"for":[237],"venous":[242],"thromboembolism":[243],"OCs":[246],"containing":[247],"gestodene.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-07-27T00:00:00"}