{"id":"https://openalex.org/W4401022688","doi":"https://doi.org/10.21873/anticanres.17184","title":"Tertiary Lymphoid Structures in Brain Metastases of Lung Cancer: Prognostic Significance and Correlation With Clinical Outcomes","display_name":"Tertiary Lymphoid Structures in Brain Metastases of Lung Cancer: Prognostic Significance and Correlation With Clinical Outcomes","publication_year":2024,"publication_date":"2024-07-26","ids":{"openalex":"https://openalex.org/W4401022688","doi":"https://doi.org/10.21873/anticanres.17184","pmid":"https://pubmed.ncbi.nlm.nih.gov/39060050"},"language":"en","primary_location":{"id":"doi:10.21873/anticanres.17184","doi":"https://doi.org/10.21873/anticanres.17184","is_oa":true,"landing_page_url":"https://doi.org/10.21873/anticanres.17184","pdf_url":null,"source":{"id":"https://openalex.org/S157347057","display_name":"Anticancer Research","issn_l":"0250-7005","issn":["0250-7005","1791-7530"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4320800545","host_organization_name":"International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts","host_organization_lineage":["https://openalex.org/P4320800545"],"host_organization_lineage_names":["International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.21873/anticanres.17184","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073375776","display_name":"Shota Nohira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133851","display_name":"Aichi Cancer Center","ror":"https://ror.org/03kfmm080","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210133851"]},{"id":"https://openalex.org/I4405286296","display_name":"Aichi Cancer Center Research Institute","ror":"https://ror.org/01rsenb03","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210133851","https://openalex.org/I4405286296"]},{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"SHOTA NOHIRA","raw_affiliation_strings":["Department of Neurosurgery, Nagoya University Faculty of Medicine, Nagoya, Japan","Division of Translational Oncoimmunology, Aichi Cancer Center Research Institute, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Nagoya University Faculty of Medicine, Nagoya, Japan","institution_ids":["https://openalex.org/I60134161"]},{"raw_affiliation_string":"Division of Translational Oncoimmunology, Aichi Cancer Center Research Institute, Nagoya, Japan","institution_ids":["https://openalex.org/I4210133851","https://openalex.org/I4405286296"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015183063","display_name":"Shunichiro Kuramitsu","orcid":"https://orcid.org/0000-0002-8808-3140","observed_orcids":["https://orcid.org/0000-0002-8808-3140"]},"institutions":[{"id":"https://openalex.org/I4210133851","display_name":"Aichi Cancer Center","ror":"https://ror.org/03kfmm080","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210133851"]},{"id":"https://openalex.org/I4210152596","display_name":"Nagoya Medical Center","ror":"https://ror.org/04ftw3n55","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137409","https://openalex.org/I4210152596"]},{"id":"https://openalex.org/I4405286296","display_name":"Aichi Cancer Center Research Institute","ror":"https://ror.org/01rsenb03","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210133851","https://openalex.org/I4405286296"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"SHUNICHIRO KURAMITSU","raw_affiliation_strings":["Department of Neurosurgery, Nagoya Medical Center, Nagoya, Japan","Division of Translational Oncoimmunology, Aichi Cancer Center Research Institute, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Nagoya Medical Center, Nagoya, Japan","institution_ids":["https://openalex.org/I4210152596"]},{"raw_affiliation_string":"Division of Translational Oncoimmunology, Aichi Cancer Center Research Institute, Nagoya, Japan","institution_ids":["https://openalex.org/I4210133851","https://openalex.org/I4405286296"]}]},{"author_position":"middle","author":{"id":null,"display_name":"MASASUKE OHNO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133851","display_name":"Aichi Cancer Center","ror":"https://ror.org/03kfmm080","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210133851"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"MASASUKE OHNO","raw_affiliation_strings":["Department of Neurosurgery, Aichi Cancer Center, Nagoya, Japan; tennjikunezumi@gmail.com","Department of Neurosurgery, Aichi Cancer Center, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Aichi Cancer Center, Nagoya, Japan; tennjikunezumi@gmail.com","institution_ids":["https://openalex.org/I4210133851"]},{"raw_affiliation_string":"Department of Neurosurgery, Aichi Cancer Center, Nagoya, Japan","institution_ids":["https://openalex.org/I4210133851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041704850","display_name":"Mitsugu Fujita","orcid":"https://orcid.org/0000-0002-0000-9879","observed_orcids":["https://orcid.org/0000-0002-0000-9879","https://orcid.org/0009-0003-8067-2578"]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]},{"id":"https://openalex.org/I916559398","display_name":"Kindai University","ror":"https://ror.org/05kt9ap64","country_code":"JP","type":"education","lineage":["https://openalex.org/I916559398"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"MITSUGU FUJITA","raw_affiliation_strings":["Center for Medical Education and Clinical Training, Kindai University Faculty of Medicine, Osaka-Sayama, Japan; mfujita47@gmail.com","Division of Gastrointestinal Surgery, Department of Surgery, Graduate School of Medicine, Kobe University, Kobe, Japan","Center for Medical Education and Clinical Training, Kindai University Faculty of Medicine, Osaka-Sayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Medical Education and Clinical Training, Kindai University Faculty of Medicine, Osaka-Sayama, Japan; mfujita47@gmail.com","institution_ids":["https://openalex.org/I916559398"]},{"raw_affiliation_string":"Division of Gastrointestinal Surgery, Department of Surgery, Graduate School of Medicine, Kobe University, Kobe, Japan","institution_ids":["https://openalex.org/I65837984"]},{"raw_affiliation_string":"Center for Medical Education and Clinical Training, Kindai University Faculty of Medicine, Osaka-Sayama, Japan","institution_ids":["https://openalex.org/I916559398"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019586725","display_name":"Kimihiro Yamashita","orcid":"https://orcid.org/0000-0002-4208-7138","observed_orcids":["https://orcid.org/0000-0002-4208-7138"]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KIMIHIRO YAMASHITA","raw_affiliation_strings":["Division of Gastrointestinal Surgery, Department of Surgery, Graduate School of Medicine, Kobe University, Kobe, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastrointestinal Surgery, Department of Surgery, Graduate School of Medicine, Kobe University, Kobe, Japan","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104148656","display_name":"TORU NAGASAKA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"TORU NAGASAKA","raw_affiliation_strings":["Association of Medical Artificial Intelligence Curation (AMAIC), Nagoya, Japan","Division of Gastrointestinal Surgery, Department of Surgery, Graduate School of Medicine, Kobe University, Kobe, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Association of Medical Artificial Intelligence Curation (AMAIC), Nagoya, Japan","institution_ids":[]},{"raw_affiliation_string":"Division of Gastrointestinal Surgery, Department of Surgery, Graduate School of Medicine, Kobe University, Kobe, Japan","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047753230","display_name":"Shoichi Haimoto","orcid":"https://orcid.org/0000-0002-0495-8537","observed_orcids":["https://orcid.org/0000-0002-0495-8537"]},"institutions":[{"id":"https://openalex.org/I4210133851","display_name":"Aichi Cancer Center","ror":"https://ror.org/03kfmm080","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210133851"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"SHOICHI HAIMOTO","raw_affiliation_strings":["Department of Neurosurgery, Aichi Cancer Center, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Aichi Cancer Center, Nagoya, Japan","institution_ids":["https://openalex.org/I4210133851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088959558","display_name":"Noriaki Sakakura","orcid":"https://orcid.org/0000-0002-9598-9629","observed_orcids":["https://orcid.org/0000-0002-9598-9629"]},"institutions":[{"id":"https://openalex.org/I4210133851","display_name":"Aichi Cancer Center","ror":"https://ror.org/03kfmm080","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210133851"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"NORIAKI SAKAKURA","raw_affiliation_strings":["Department of Thoracic Surgery, Aichi Cancer Center, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, Aichi Cancer Center, Nagoya, Japan","institution_ids":["https://openalex.org/I4210133851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089569598","display_name":"Hirokazu Matsushita","orcid":"https://orcid.org/0000-0001-9069-7160","observed_orcids":["https://orcid.org/0000-0001-9069-7160"]},"institutions":[{"id":"https://openalex.org/I4210133851","display_name":"Aichi Cancer Center","ror":"https://ror.org/03kfmm080","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210133851"]},{"id":"https://openalex.org/I4405286296","display_name":"Aichi Cancer Center Research Institute","ror":"https://ror.org/01rsenb03","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210133851","https://openalex.org/I4405286296"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"HIROKAZU MATSUSHITA","raw_affiliation_strings":["Division of Translational Oncoimmunology, Aichi Cancer Center Research Institute, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Translational Oncoimmunology, Aichi Cancer Center Research Institute, Nagoya, Japan","institution_ids":["https://openalex.org/I4210133851","https://openalex.org/I4405286296"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5114198008","display_name":"RYUTA SAITO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"RYUTA SAITO","raw_affiliation_strings":["Department of Neurosurgery, Nagoya University Faculty of Medicine, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Nagoya University Faculty of Medicine, Nagoya, Japan","institution_ids":["https://openalex.org/I60134161"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.5672,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.91717538,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"44","issue":"8","first_page":"3615","last_page":"3621"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.8511000275611877,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.8511000275611877,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.11990000307559967,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tertiary-lymphoid-structures","display_name":"tertiary lymphoid structures","score":1.0},{"id":"https://openalex.org/keywords/brain-metastases","display_name":"brain metastases","score":0.9660000205039978},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.9900000095367432},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.777999997138977},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.9470000267028809},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.968999981880188},{"id":"https://openalex.org/keywords/postoperative-survival","display_name":"postoperative survival","score":0.8360000252723694},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.597000002861023}],"concepts":[{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6867515444755554},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6087755560874939},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5553820133209229},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.4829946756362915},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4820788502693176},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4794810712337494},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.45758262276649475},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.44479015469551086},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42529892921447754},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.412007212638855},{"id":"https://openalex.org/C181152851","wikidata":"https://www.wikidata.org/wiki/Q712604","display_name":"Lymphatic system","level":2,"score":0.4116140604019165},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.273274689912796}],"mesh":[{"descriptor_ui":"D000072717","descriptor_name":"Tertiary Lymphoid Structures","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000072717","descriptor_name":"Tertiary Lymphoid Structures","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016246","descriptor_name":"Lymphocytes, Tumor-Infiltrating","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.21873/anticanres.17184","doi":"https://doi.org/10.21873/anticanres.17184","is_oa":true,"landing_page_url":"https://doi.org/10.21873/anticanres.17184","pdf_url":null,"source":{"id":"https://openalex.org/S157347057","display_name":"Anticancer Research","issn_l":"0250-7005","issn":["0250-7005","1791-7530"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4320800545","host_organization_name":"International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts","host_organization_lineage":["https://openalex.org/P4320800545"],"host_organization_lineage_names":["International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer Research","raw_type":"journal-article"},{"id":"pmid:39060050","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39060050","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"pmh:oai:irdb.nii.ac.jp:01152:0006789856","doi":null,"is_oa":true,"landing_page_url":"https://nagoya.repo.nii.ac.jp/records/2012505","pdf_url":"https://nagoya.repo.nii.ac.jp/record/2012505/files/k15291_thesis.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"}],"best_oa_location":{"id":"doi:10.21873/anticanres.17184","doi":"https://doi.org/10.21873/anticanres.17184","is_oa":true,"landing_page_url":"https://doi.org/10.21873/anticanres.17184","pdf_url":null,"source":{"id":"https://openalex.org/S157347057","display_name":"Anticancer Research","issn_l":"0250-7005","issn":["0250-7005","1791-7530"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4320800545","host_organization_name":"International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts","host_organization_lineage":["https://openalex.org/P4320800545"],"host_organization_lineage_names":["International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G233944379","display_name":"Development of CAR-T Cell Therapy Targeting Metastatic Brain Tumors Using Tumor Microenvironmental B Cells","funder_award_id":"22K09223","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7899634931","display_name":"The mechanisms of NK-like exhaustion of CAR-T cells in glioblastoma","funder_award_id":"23K15677","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4401022688.pdf","grobid_xml":"https://content.openalex.org/works/W4401022688.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1760562407","https://openalex.org/W1974820090","https://openalex.org/W2116574496","https://openalex.org/W2302719382","https://openalex.org/W2782930756","https://openalex.org/W2902771649","https://openalex.org/W2945057866","https://openalex.org/W2952481429","https://openalex.org/W2965297936","https://openalex.org/W3159719186","https://openalex.org/W3181404157","https://openalex.org/W3198041401","https://openalex.org/W3202268960","https://openalex.org/W4200418659","https://openalex.org/W4205511851","https://openalex.org/W4211260961","https://openalex.org/W4220915836","https://openalex.org/W4280636966","https://openalex.org/W4288452447","https://openalex.org/W4365141200","https://openalex.org/W4384695641"],"related_works":["https://openalex.org/W4401305845","https://openalex.org/W4401051166","https://openalex.org/W7128930199","https://openalex.org/W4410057706","https://openalex.org/W4408113163","https://openalex.org/W7160210087","https://openalex.org/W7148963461","https://openalex.org/W4415519829","https://openalex.org/W7205010186","https://openalex.org/W4413258581"],"abstract_inverted_index":{"BACKGROUND/AIM:":[0],"The":[1,20,177],"prognosis":[2],"of":[3,22,32,55,70,126,161,173,179,196],"patients":[4,50],"with":[5,51,81,140],"brain":[6],"metastases":[7],"(BMs)":[8],"originating":[9],"from":[10,48,98],"lung":[11,56,104,164],"cancer":[12,105],"remains":[13],"poor,":[14],"despite":[15],"advancements":[16],"in":[17,87,102,163],"treatment":[18],"strategies.":[19],"role":[21],"tertiary":[23],"lymphoid":[24],"structures":[25,207],"(TLSs)":[26],"within":[27,76,93,181],"the":[28,66,124,141,159,174,182,193],"tumor":[29,187],"immune":[30,194],"microenvironment":[31,188],"BMs":[33,54,166,197],"has":[34],"not":[35,114,138],"been":[36],"extensively":[37],"explored.":[38],"PATIENTS":[39],"AND":[40],"METHODS:":[41],"This":[42],"study":[43],"utilized":[44],"patient-derived":[45],"clinical":[46,82],"samples":[47],"17":[49],"histologically":[52],"confirmed":[53],"cancer,":[57],"undergoing":[58],"surgical":[59],"resection.":[60],"Immunohistochemistry":[61],"was":[62,121],"employed":[63],"to":[64,208],"analyze":[65],"presence":[67,160],"and":[68,72,117,167,198],"characteristics":[69],"TLS":[71,111,127,135,180],"tumor-infiltrating":[73],"lymphocytes":[74],"(TILs)":[75],"BM":[77,94],"tissues,":[78,95],"correlating":[79],"these":[80,206],"outcomes.":[83,211],"RESULTS:":[84],"TLSs,":[85],"albeit":[86],"their":[88,99,169],"immature":[89],"form,":[90],"were":[91],"identified":[92],"distinguishing":[96],"them":[97],"mature":[100],"counterparts":[101],"primary":[103],"tissues.":[106],"A":[107],"significant":[108],"correlation":[109],"between":[110],"density":[112,128,136],"(but":[113],"TIL":[115],"density)":[116],"improved":[118],"postoperative":[119],"survival":[120],"observed,":[122],"underscoring":[123],"potential":[125,200],"as":[129],"an":[130],"independent":[131,172],"prognostic":[132,150,170],"marker.":[133],"Furthermore,":[134],"did":[137],"correlate":[139],"Graded":[142],"Prognostic":[143],"Assessment":[144],"(GPA)":[145],"index,":[146],"suggesting":[147],"its":[148],"unique":[149,183],"value":[151],"beyond":[152],"conventional":[153],"predictors.":[154],"CONCLUSION:":[155],"Our":[156],"findings":[157],"reveal":[158],"TLSs":[162],"cancer-derived":[165],"highlight":[168],"significance,":[171],"GPA":[175],"index.":[176],"identification":[178],"central":[184],"nervous":[185],"system":[186],"offers":[189],"new":[190],"insights":[191],"into":[192],"landscape":[195],"suggests":[199],"avenues":[201],"for":[202],"immunotherapeutic":[203],"interventions":[204],"targeting":[205],"improve":[209],"patient":[210]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-07-27T00:00:00"}