{"id":"https://openalex.org/W4401014257","doi":"https://doi.org/10.22541/au.172202256.66303640/v1","title":"Additional biomarker other than HBsAg is required to determine Hepatitis B virus (HBV) functional cure in HIV/HBV coinfection","display_name":"Additional biomarker other than HBsAg is required to determine Hepatitis B virus (HBV) functional cure in HIV/HBV coinfection","publication_year":2024,"publication_date":"2024-07-26","ids":{"openalex":"https://openalex.org/W4401014257","doi":"https://doi.org/10.22541/au.172202256.66303640/v1"},"language":"en","primary_location":{"id":"doi:10.22541/au.172202256.66303640/v1","doi":"https://doi.org/10.22541/au.172202256.66303640/v1","is_oa":false,"landing_page_url":"https://doi.org/10.22541/au.172202256.66303640/v1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"parent_works":[],"lineage":["https://openalex.org/W4401014257"],"child_works_count":0,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003297746","display_name":"Linghua Li","orcid":"https://orcid.org/0000-0001-5711-8681","observed_orcids":["https://orcid.org/0000-0001-5711-8681"]},"institutions":[{"id":"https://openalex.org/I4210156462","display_name":"Guangzhou Eighth People's Hospital","ror":"https://ror.org/0534awx66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156462"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Linghua Li","raw_affiliation_strings":["Guangzhou Eighth People's Hospital"],"raw_orcid":"https://orcid.org/0000-0001-5711-8681","affiliations":[{"raw_affiliation_string":"Guangzhou Eighth People's Hospital","institution_ids":["https://openalex.org/I4210156462"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090897096","display_name":"Fei Gu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156462","display_name":"Guangzhou Eighth People's Hospital","ror":"https://ror.org/0534awx66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156462"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Gu","raw_affiliation_strings":["Guangzhou Eighth People's Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangzhou Eighth People's Hospital","institution_ids":["https://openalex.org/I4210156462"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kun Zeng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156462","display_name":"Guangzhou Eighth People's Hospital","ror":"https://ror.org/0534awx66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156462"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kun Zeng","raw_affiliation_strings":["Guangzhou Eighth People's Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangzhou Eighth People's Hospital","institution_ids":["https://openalex.org/I4210156462"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045886944","display_name":"Xianglong Lan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156462","display_name":"Guangzhou Eighth People's Hospital","ror":"https://ror.org/0534awx66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156462"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xianglong Lan","raw_affiliation_strings":["Guangzhou Eighth People's Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangzhou Eighth People's Hospital","institution_ids":["https://openalex.org/I4210156462"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079282835","display_name":"Yaozu He","orcid":"https://orcid.org/0000-0001-8919-534X","observed_orcids":["https://orcid.org/0000-0001-8919-534X"]},"institutions":[{"id":"https://openalex.org/I4210156462","display_name":"Guangzhou Eighth People's Hospital","ror":"https://ror.org/0534awx66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156462"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yaozu He","raw_affiliation_strings":["Guangzhou Eighth People's Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangzhou Eighth People's Hospital","institution_ids":["https://openalex.org/I4210156462"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010508635","display_name":"Feng Li","orcid":"https://orcid.org/0000-0002-7690-8870","observed_orcids":["https://orcid.org/0000-0002-7690-8870"]},"institutions":[{"id":"https://openalex.org/I4210156462","display_name":"Guangzhou Eighth People's Hospital","ror":"https://ror.org/0534awx66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156462"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng Li","raw_affiliation_strings":["Guangzhou Eighth People's Hospital"],"raw_orcid":"https://orcid.org/0000-0002-7690-8870","affiliations":[{"raw_affiliation_string":"Guangzhou Eighth People's Hospital","institution_ids":["https://openalex.org/I4210156462"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101680135","display_name":"Xiaoping Tang","orcid":"https://orcid.org/0000-0002-5067-659X","observed_orcids":["https://orcid.org/0000-0002-5067-659X"]},"institutions":[{"id":"https://openalex.org/I4210156462","display_name":"Guangzhou Eighth People's Hospital","ror":"https://ror.org/0534awx66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156462"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoping Tang","raw_affiliation_strings":["Guangzhou Eighth People's Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangzhou Eighth People's Hospital","institution_ids":["https://openalex.org/I4210156462"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056903875","display_name":"Fengyu Hu","orcid":"https://orcid.org/0000-0002-8649-7913","observed_orcids":["https://orcid.org/0000-0002-8649-7913"]},"institutions":[{"id":"https://openalex.org/I4210156462","display_name":"Guangzhou Eighth People's Hospital","ror":"https://ror.org/0534awx66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156462"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fengyu Hu","raw_affiliation_strings":["Guangzhou Eighth People's Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangzhou Eighth People's Hospital","institution_ids":["https://openalex.org/I4210156462"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5003297746"],"corresponding_institution_ids":["https://openalex.org/I4210156462"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-hbv-coinfection","display_name":"HIV/HBV coinfection","score":0.9850000143051147},{"id":"https://openalex.org/keywords/hbsag-loss","display_name":"HBsAg loss","score":0.8320000171661377},{"id":"https://openalex.org/keywords/hbv-replication","display_name":"HBV replication","score":0.7089999914169312},{"id":"https://openalex.org/keywords/viral-biomarkers","display_name":"viral biomarkers","score":0.7160000205039978},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.968999981880188},{"id":"https://openalex.org/keywords/hbsag-levels","display_name":"HBsAg levels","score":0.4880000054836273}],"concepts":[{"id":"https://openalex.org/C2777410769","wikidata":"https://www.wikidata.org/wiki/Q2282887","display_name":"HBsAg","level":4,"score":0.9067502021789551},{"id":"https://openalex.org/C2777813720","wikidata":"https://www.wikidata.org/wiki/Q1243018","display_name":"Coinfection","level":3,"score":0.850020170211792},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.8120802640914917},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6920746564865112},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6540318727493286},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5133363604545593},{"id":"https://openalex.org/C2777382497","wikidata":"https://www.wikidata.org/wiki/Q6853","display_name":"Hepatitis B","level":2,"score":0.5095889568328857},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.4300290644168854},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4193834364414215},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.396780788898468},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20933058857917786},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.22541/au.172202256.66303640/v1","doi":"https://doi.org/10.22541/au.172202256.66303640/v1","is_oa":false,"landing_page_url":"https://doi.org/10.22541/au.172202256.66303640/v1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W2083989879","https://openalex.org/W2087944742","https://openalex.org/W2142153682","https://openalex.org/W2408333651","https://openalex.org/W2512371825","https://openalex.org/W2583222485","https://openalex.org/W2794868160","https://openalex.org/W2898189026","https://openalex.org/W2900781853","https://openalex.org/W2969729875","https://openalex.org/W2980684990","https://openalex.org/W3010144421","https://openalex.org/W4213161034","https://openalex.org/W4250985192","https://openalex.org/W4280582189","https://openalex.org/W4318670141"],"related_works":["https://openalex.org/W4399970874","https://openalex.org/W3181656942","https://openalex.org/W3010144421","https://openalex.org/W4417508380","https://openalex.org/W4213161034","https://openalex.org/W4410876541","https://openalex.org/W4416150964","https://openalex.org/W4318670141","https://openalex.org/W4416023742","https://openalex.org/W4200269985"],"abstract_inverted_index":{"Among":[0],"1550":[1],"human":[2],"immunodeficiency":[3],"virus":[4,7],"(HIV)/Hepatitis":[5],"B":[6],"(HBV)":[8],"coinfected":[9],"individuals":[10,21],"receiving":[11],"antiretroviral":[12],"therapy":[13],"(ART)":[14],"over":[15],"three":[16],"years":[17],"in":[18,66,76,95],"Guangzhou,":[19],"China,":[20],"(8.2%)":[22],"achieved":[23],"HBsAg":[24,26,41,78,85],"loss.":[25],"loss":[27,79,86],"was":[28,63],"positively":[29],"associated":[30],"with":[31],"a":[32,39,54],"longer":[33],"treatment":[34],"(median":[35,43],"6.57":[36],"years)":[37],"and":[38],"lower":[40],"level":[42],"645.2":[44],"COI)":[45],"at":[46],"the":[47,77],"baseline.":[48],"However,":[49],"HBV":[50,60,74,92],"pre-genomic":[51],"RNA":[52],"(pgRNA),":[53],"promising":[55],"viral":[56],"biomarker":[57],"for":[58],"asserting":[59],"functional":[61,93],"cure,":[62],"still":[64],"detected":[65],"43.9%":[67],"(44/98)":[68],"of":[69],"them,":[70],"implying":[71],"an":[72],"active":[73],"replication":[75],"individuals.":[80],"Our":[81],"observation":[82],"suggested":[83],"that":[84],"alone":[87],"could":[88],"not":[89],"reliably":[90],"predict":[91],"cure":[94],"HIV/HBV":[96],"coinfection.":[97]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2024-07-27T00:00:00"}