{"id":"https://openalex.org/W4400976808","doi":"https://doi.org/10.3390/app14156493","title":"Silver Nanoparticles Conjugated with BK510Lys Endolysin for Gram-Negative Bacteria Inhibition","display_name":"Silver Nanoparticles Conjugated with BK510Lys Endolysin for Gram-Negative Bacteria Inhibition","publication_year":2024,"publication_date":"2024-07-25","ids":{"openalex":"https://openalex.org/W4400976808","doi":"https://doi.org/10.3390/app14156493"},"language":"en","primary_location":{"id":"doi:10.3390/app14156493","doi":"https://doi.org/10.3390/app14156493","is_oa":true,"landing_page_url":"https://doi.org/10.3390/app14156493","pdf_url":null,"source":{"id":"https://openalex.org/S4210205812","display_name":"Applied Sciences","issn_l":"2076-3417","issn":["2076-3417"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/app14156493","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079034059","display_name":"Diana Ram\u00edrez-S\u00e1enz","orcid":"https://orcid.org/0000-0002-6421-7407","observed_orcids":["https://orcid.org/0000-0002-6421-7407"]},"institutions":[{"id":"https://openalex.org/I129858807","display_name":"Universidad de Guanajuato","ror":"https://ror.org/058cjye32","country_code":"MX","type":"education","lineage":["https://openalex.org/I129858807"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Diana Ram\u00edrez Saenz","raw_affiliation_strings":["Doctorado en Biociencias, Divisi\u00f3n en Ciencias de la Vida Campus Irapuato-Salamanca, Universidad de Guanajuato, Irapuato 36500, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Doctorado en Biociencias, Divisi\u00f3n en Ciencias de la Vida Campus Irapuato-Salamanca, Universidad de Guanajuato, Irapuato 36500, Mexico","institution_ids":["https://openalex.org/I129858807"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049876201","display_name":"Juan Carlos Mart\u00ednez-Espinosa","orcid":"https://orcid.org/0000-0001-6208-7162","observed_orcids":["https://orcid.org/0000-0001-6208-7162"]},"institutions":[{"id":"https://openalex.org/I59361560","display_name":"Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/059sp8j34","country_code":"MX","type":"education","lineage":["https://openalex.org/I59361560"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"Juan Carlos Mart\u00ednez Espinosa","raw_affiliation_strings":["Instituto Polit\u00e9cnico Nacional-UPIIG, Silao de la Victoria 36275, Mexico"],"raw_orcid":"https://orcid.org/0000-0001-6208-7162","affiliations":[{"raw_affiliation_string":"Instituto Polit\u00e9cnico Nacional-UPIIG, Silao de la Victoria 36275, Mexico","institution_ids":["https://openalex.org/I59361560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105080909","display_name":"Andrea Guadalupe Valdivia Mancillas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrea Guadalupe Valdivia Mancillas","raw_affiliation_strings":["Servicios y Desarrollo de Biof\u00e1rmacos (SEDEBIO), S.C. de R.L. de C.V., Le\u00f3n 37548, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicios y Desarrollo de Biof\u00e1rmacos (SEDEBIO), S.C. de R.L. de C.V., Le\u00f3n 37548, Mexico","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018074309","display_name":"Alma Arianna Lechuga-Arana","orcid":"https://orcid.org/0000-0001-9467-0993","observed_orcids":["https://orcid.org/0000-0001-9467-0993"]},"institutions":[{"id":"https://openalex.org/I4405253371","display_name":"Universidad para el Bienestar Benito Ju\u00e1rez Garc\u00eda","ror":"https://ror.org/00kgetx37","country_code":"MX","type":"education","lineage":["https://openalex.org/I4405253371"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Alma Arianna Lechuga Arana","raw_affiliation_strings":["Organismo Coordinador de las Universidades Para el Bienestar Benito Ju\u00e1rez, Sede Cueramaro 84200, Mexico"],"raw_orcid":"https://orcid.org/0000-0001-9467-0993","affiliations":[{"raw_affiliation_string":"Organismo Coordinador de las Universidades Para el Bienestar Benito Ju\u00e1rez, Sede Cueramaro 84200, Mexico","institution_ids":["https://openalex.org/I4405253371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005909445","display_name":"Roc\u00edo Alejandra Silva Contreras","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59361560","display_name":"Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/059sp8j34","country_code":"MX","type":"education","lineage":["https://openalex.org/I59361560"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Roc\u00edo Alejandra Silva Contreras","raw_affiliation_strings":["Instituto Polit\u00e9cnico Nacional-UPIIG, Silao de la Victoria 36275, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Polit\u00e9cnico Nacional-UPIIG, Silao de la Victoria 36275, Mexico","institution_ids":["https://openalex.org/I59361560"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029404648","display_name":"Abner Josu\u00e9 Guti\u00e9rrez-Ch\u00e1vez","orcid":"https://orcid.org/0000-0003-1702-508X","observed_orcids":["https://orcid.org/0000-0003-1702-508X"]},"institutions":[{"id":"https://openalex.org/I129858807","display_name":"Universidad de Guanajuato","ror":"https://ror.org/058cjye32","country_code":"MX","type":"education","lineage":["https://openalex.org/I129858807"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"Abner Josu\u00e9 Guti\u00e9rrez Ch\u00e1vez","raw_affiliation_strings":["Doctorado en Biociencias, Divisi\u00f3n en Ciencias de la Vida Campus Irapuato-Salamanca, Universidad de Guanajuato, Irapuato 36500, Mexico"],"raw_orcid":"https://orcid.org/0000-0003-1702-508X","affiliations":[{"raw_affiliation_string":"Doctorado en Biociencias, Divisi\u00f3n en Ciencias de la Vida Campus Irapuato-Salamanca, Universidad de Guanajuato, Irapuato 36500, Mexico","institution_ids":["https://openalex.org/I129858807"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5029404648","https://openalex.org/A5049876201"],"corresponding_institution_ids":["https://openalex.org/I129858807","https://openalex.org/I59361560"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2728},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2728},"fwci":0.4374,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.4469295,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"14","issue":"15","first_page":"6493","last_page":"6493"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.7817000150680542,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.7817000150680542,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.19779999554157257,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/silver-nanoparticles","display_name":"silver nanoparticles","score":0.9990000128746033},{"id":"https://openalex.org/keywords/endolysin","display_name":"endolysin","score":0.8199999928474426},{"id":"https://openalex.org/keywords/gram-negative-bacteria","display_name":"Gram-negative bacteria","score":0.9390000104904175},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"antibacterial activity","score":0.7480000257492065},{"id":"https://openalex.org/keywords/green-synthesis","display_name":"green synthesis","score":0.7739999890327454},{"id":"https://openalex.org/keywords/lytic-activity","display_name":"lytic activity","score":0.6779999732971191},{"id":"https://openalex.org/keywords/antibiotic-alternatives","display_name":"antibiotic alternatives","score":0.4729999899864197},{"id":"https://openalex.org/keywords/antimicrobial-resistance","display_name":"antimicrobial resistance","score":0.734000027179718}],"concepts":[{"id":"https://openalex.org/C22538091","wikidata":"https://www.wikidata.org/wiki/Q2646830","display_name":"Lysin","level":5,"score":0.8916467428207397},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.7674293518066406},{"id":"https://openalex.org/C2776051709","wikidata":"https://www.wikidata.org/wiki/Q632006","display_name":"Gram-negative bacteria","level":4,"score":0.73344886302948},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.5859588980674744},{"id":"https://openalex.org/C19655278","wikidata":"https://www.wikidata.org/wiki/Q3293735","display_name":"Bacterial cell structure","level":3,"score":0.5565692782402039},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.5557677149772644},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5521284341812134},{"id":"https://openalex.org/C31499863","wikidata":"https://www.wikidata.org/wiki/Q905762","display_name":"Silver nanoparticle","level":3,"score":0.5331812500953674},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4555933475494385},{"id":"https://openalex.org/C2779518903","wikidata":"https://www.wikidata.org/wiki/Q857288","display_name":"Gram-positive bacteria","level":3,"score":0.44093939661979675},{"id":"https://openalex.org/C182615771","wikidata":"https://www.wikidata.org/wiki/Q1369386","display_name":"Lytic cycle","level":3,"score":0.41149720549583435},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.34472668170928955},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.30265048146247864},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26170647144317627},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21344363689422607},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.1988677680492401},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.1966913342475891},{"id":"https://openalex.org/C2776441376","wikidata":"https://www.wikidata.org/wiki/Q165028","display_name":"Bacteriophage","level":4,"score":0.15161332488059998},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.10244938731193542},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.04918906092643738},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3390/app14156493","doi":"https://doi.org/10.3390/app14156493","is_oa":true,"landing_page_url":"https://doi.org/10.3390/app14156493","pdf_url":null,"source":{"id":"https://openalex.org/S4210205812","display_name":"Applied Sciences","issn_l":"2076-3417","issn":["2076-3417"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Sciences","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:a457fe6249fb4e799bb2f099f4475bfa","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a457fe6249fb4e799bb2f099f4475bfa","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Applied Sciences, Vol 14, Iss 15, p 6493 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/app14156493","doi":"https://doi.org/10.3390/app14156493","is_oa":true,"landing_page_url":"https://doi.org/10.3390/app14156493","pdf_url":null,"source":{"id":"https://openalex.org/S4210205812","display_name":"Applied Sciences","issn_l":"2076-3417","issn":["2076-3417"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1970642338","https://openalex.org/W2007129047","https://openalex.org/W2008472945","https://openalex.org/W2076403255","https://openalex.org/W2078550130","https://openalex.org/W2148260760","https://openalex.org/W2320828750","https://openalex.org/W2790364695","https://openalex.org/W2808316037","https://openalex.org/W2883107975","https://openalex.org/W2903842646","https://openalex.org/W2960026351","https://openalex.org/W2992911892","https://openalex.org/W3017115593","https://openalex.org/W3025634756","https://openalex.org/W3034015152","https://openalex.org/W3087336041","https://openalex.org/W3093585346","https://openalex.org/W3108044245","https://openalex.org/W3115418511","https://openalex.org/W3120585210","https://openalex.org/W4292416214","https://openalex.org/W4377030680","https://openalex.org/W4377289822","https://openalex.org/W4385365033","https://openalex.org/W4386520935","https://openalex.org/W4388198165","https://openalex.org/W4391430252","https://openalex.org/W4392349824","https://openalex.org/W4394975952","https://openalex.org/W7155066828"],"related_works":["https://openalex.org/W4410440074","https://openalex.org/W2909293299","https://openalex.org/W2139098375","https://openalex.org/W2883907821","https://openalex.org/W4295007917","https://openalex.org/W4391366375","https://openalex.org/W2057401975","https://openalex.org/W2481857140","https://openalex.org/W4286487496","https://openalex.org/W863912145"],"abstract_inverted_index":{"In":[0],"the":[1,4,8,14,23,33,44,48,54,58,63,79,83,140,160,176,189,192,201,213,223],"last":[2],"decade,":[3],"problems":[5],"caused":[6,22],"by":[7,92],"excessive":[9],"use":[10,34],"of":[11,16,25,35,67,86,105,132,145,153,167,175,225],"antibiotics":[12],"and":[13,32,52,103,115,125,129,156,188],"emergence":[15],"multi-resistant":[17],"patterns":[18],"in":[19,62,171],"Gram-negative":[20,87,177,232],"bacteria":[21,131,178],"generation":[24],"several":[26],"alternatives":[27],"and/or":[28],"replacements,":[29],"including":[30],"endolysins":[31,55,70,113],"silver":[36],"nanomaterials":[37],"(AgNPs).":[38],"It":[39],"has":[40],"been":[41],"shown":[42],"that":[43,81,122,138,166,184,195,210],"AgNPs":[45,89,116,168],"help":[46],"overcome":[47],"bacterial":[49],"lipopolysaccharide":[50],"barrier":[51],"allow":[53],"to":[56,119],"reach":[57],"cell":[59],"wall;":[60],"therefore,":[61],"present":[64],"investigation,":[65],"conjugates":[66,121,141],"BK510":[68],"commercial":[69],"(BK510Lys)":[71],"with":[72],"metallic":[73],"nanoparticles":[74],"were":[75,90,110,117,123],"made,":[76],"which":[77],"eliminated":[78],"obstacle":[80],"represents":[82],"outer":[84],"membrane":[85],"bacteria.":[88,233],"produced":[91],"green":[93],"synthesis":[94],"using":[95,139],"Lepidium":[96],"virginicum":[97],"extract":[98],"as":[99],"a":[100,143,148,151,197],"reducing":[101],"agent,":[102],"diameters":[104],"16.06":[106],"\u00b1":[107],"4.23":[108],"nm":[109],"obtained.":[111],"The":[112,135],"BK510Lys":[114,187],"used":[118],"generate":[120],"characterized":[124],"evaluated":[126],"against":[127],"gram-negative":[128],"gram-positive":[130],"veterinary":[133],"interest.":[134],"results":[136,215],"indicated":[137],"at":[142,157],"concentration":[144],"0.01":[146],"mg/mL,":[147],"2:1":[149],"ratio,":[150],"temperature":[152],"40":[154],"\u00b0C,":[155],"pH":[158],"5,":[159],"inhibitory":[161],"effect":[162,199],"was":[163,182,204],"greater":[164],"than":[165,173],"(0.5":[169],"\u00b5g/mL)":[170],"more":[172],"65%":[174],"analyzed.":[179],"Furthermore,":[180],"it":[181],"determined":[183],"for":[185,222,230],"both":[186],"AgNP-BK510Lys":[190],"conjugate,":[191],"only":[193],"factor":[194],"had":[196],"significant":[198],"on":[200,212],"lytic":[202],"activity":[203],"their":[205],"concentration.":[206],"Finally,":[207],"we":[208],"concluded":[209],"based":[211],"promising":[214],"obtained,":[216],"future":[217],"follow-up":[218],"can":[219],"be":[220],"conducted":[221],"formulation":[224],"highly":[226],"specific":[227],"alternative":[228],"drugs":[229],"super-resistant":[231]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-07-26T00:00:00"}
