{"id":"https://openalex.org/W4400975116","doi":"https://doi.org/10.3390/biomedicines12081664","title":"Combined Effects of Fibroblast Growth Factor-2 and Carbonate Apatite Granules on Periodontal Healing: An In Vivo and In Vitro Study","display_name":"Combined Effects of Fibroblast Growth Factor-2 and Carbonate Apatite Granules on Periodontal Healing: An In Vivo and In Vitro Study","publication_year":2024,"publication_date":"2024-07-25","ids":{"openalex":"https://openalex.org/W4400975116","doi":"https://doi.org/10.3390/biomedicines12081664","pmid":"https://pubmed.ncbi.nlm.nih.gov/39200129","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11352071"},"language":"en","primary_location":{"id":"doi:10.3390/biomedicines12081664","doi":"https://doi.org/10.3390/biomedicines12081664","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines12081664","pdf_url":null,"source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/biomedicines12081664","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105064557","display_name":"Naoki Miyata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149564915","display_name":"Tokyo Dental College","ror":"https://ror.org/0220f5b41","country_code":"JP","type":"education","lineage":["https://openalex.org/I149564915"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoki Miyata","raw_affiliation_strings":["Department of Periodontology, Tokyo Dental College, Chiyoda-ku, Tokyo 1010061, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontology, Tokyo Dental College, Chiyoda-ku, Tokyo 1010061, Japan","institution_ids":["https://openalex.org/I149564915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109752561","display_name":"Shinta Mori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149564915","display_name":"Tokyo Dental College","ror":"https://ror.org/0220f5b41","country_code":"JP","type":"education","lineage":["https://openalex.org/I149564915"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinta Mori","raw_affiliation_strings":["Department of Periodontology, Tokyo Dental College, Chiyoda-ku, Tokyo 1010061, Japan","Oral Health Science Center, Tokyo Dental College, Chiyoda-ku, Tokyo 1010061, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontology, Tokyo Dental College, Chiyoda-ku, Tokyo 1010061, Japan","institution_ids":["https://openalex.org/I149564915"]},{"raw_affiliation_string":"Oral Health Science Center, Tokyo Dental College, Chiyoda-ku, Tokyo 1010061, Japan","institution_ids":["https://openalex.org/I149564915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000863269","display_name":"Tasuku Murakami","orcid":"https://orcid.org/0009-0005-9189-2941","observed_orcids":["https://orcid.org/0009-0005-9189-2941"]},"institutions":[{"id":"https://openalex.org/I149564915","display_name":"Tokyo Dental College","ror":"https://ror.org/0220f5b41","country_code":"JP","type":"education","lineage":["https://openalex.org/I149564915"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tasuku Murakami","raw_affiliation_strings":["Department of Periodontology, Tokyo Dental College, Chiyoda-ku, Tokyo 1010061, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontology, Tokyo Dental College, Chiyoda-ku, Tokyo 1010061, Japan","institution_ids":["https://openalex.org/I149564915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004805313","display_name":"Takahiro Bizenjima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149564915","display_name":"Tokyo Dental College","ror":"https://ror.org/0220f5b41","country_code":"JP","type":"education","lineage":["https://openalex.org/I149564915"]},{"id":"https://openalex.org/I4405283335","display_name":"Tokyo Dental College Chiba Dental Center","ror":"https://ror.org/01ezrgx89","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405283335"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahiro Bizenjima","raw_affiliation_strings":["Chiba Dental Center, Tokyo Dental College, Mihama-ku, Chiba 2618502, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chiba Dental Center, Tokyo Dental College, Mihama-ku, Chiba 2618502, Japan","institution_ids":["https://openalex.org/I149564915","https://openalex.org/I4405283335"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000659027","display_name":"Fumi Seshima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149564915","display_name":"Tokyo Dental College","ror":"https://ror.org/0220f5b41","country_code":"JP","type":"education","lineage":["https://openalex.org/I149564915"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Fumi Seshima","raw_affiliation_strings":["Department of Periodontology, Tokyo Dental College, Chiyoda-ku, Tokyo 1010061, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontology, Tokyo Dental College, Chiyoda-ku, Tokyo 1010061, Japan","institution_ids":["https://openalex.org/I149564915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101832383","display_name":"Kentaro Imamura","orcid":"https://orcid.org/0000-0001-6428-3677","observed_orcids":["https://orcid.org/0000-0001-6428-3677"]},"institutions":[{"id":"https://openalex.org/I149564915","display_name":"Tokyo Dental College","ror":"https://ror.org/0220f5b41","country_code":"JP","type":"education","lineage":["https://openalex.org/I149564915"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kentaro Imamura","raw_affiliation_strings":["Department of Periodontology, Tokyo Dental College, Chiyoda-ku, Tokyo 1010061, Japan","Oral Health Science Center, Tokyo Dental College, Chiyoda-ku, Tokyo 1010061, Japan"],"raw_orcid":"https://orcid.org/0000-0001-6428-3677","affiliations":[{"raw_affiliation_string":"Department of Periodontology, Tokyo Dental College, Chiyoda-ku, Tokyo 1010061, Japan","institution_ids":["https://openalex.org/I149564915"]},{"raw_affiliation_string":"Oral Health Science Center, Tokyo Dental College, Chiyoda-ku, Tokyo 1010061, Japan","institution_ids":["https://openalex.org/I149564915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051207544","display_name":"Atsushi Sait\u00f4","orcid":"https://orcid.org/0000-0002-0065-2207","observed_orcids":["https://orcid.org/0000-0002-0065-2207"]},"institutions":[{"id":"https://openalex.org/I149564915","display_name":"Tokyo Dental College","ror":"https://ror.org/0220f5b41","country_code":"JP","type":"education","lineage":["https://openalex.org/I149564915"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Atsushi Saito","raw_affiliation_strings":["Department of Periodontology, Tokyo Dental College, Chiyoda-ku, Tokyo 1010061, Japan","Oral Health Science Center, Tokyo Dental College, Chiyoda-ku, Tokyo 1010061, Japan"],"raw_orcid":"https://orcid.org/0000-0002-0065-2207","affiliations":[{"raw_affiliation_string":"Department of Periodontology, Tokyo Dental College, Chiyoda-ku, Tokyo 1010061, Japan","institution_ids":["https://openalex.org/I149564915"]},{"raw_affiliation_string":"Oral Health Science Center, Tokyo Dental College, Chiyoda-ku, Tokyo 1010061, Japan","institution_ids":["https://openalex.org/I149564915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5051207544"],"corresponding_institution_ids":["https://openalex.org/I149564915"],"apc_list":{"value":2600,"currency":"CHF","value_usd":2955},"apc_paid":{"value":2600,"currency":"CHF","value_usd":2955},"fwci":1.3233,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.76360053,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"12","issue":"8","first_page":"1664","last_page":"1664"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.73580002784729,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.73580002784729,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.2565999925136566,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10359","display_name":"Dental Implant Techniques and Outcomes","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fibroblast-growth-factor-2","display_name":"fibroblast growth factor 2","score":0.9900000095367432},{"id":"https://openalex.org/keywords/periodontal-healing","display_name":"periodontal healing","score":0.9350000023841858},{"id":"https://openalex.org/keywords/periodontal-defects","display_name":"periodontal defects","score":0.9390000104904175},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.7450000047683716},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.9229999780654907},{"id":"https://openalex.org/keywords/mc3t3-e1-cells","display_name":"MC3T3-E1 cells","score":0.972000002861023},{"id":"https://openalex.org/keywords/runx2","display_name":"Runx2","score":0.8920000195503235},{"id":"https://openalex.org/keywords/osterix","display_name":"Osterix","score":0.902999997138977},{"id":"https://openalex.org/keywords/osteocalcin","display_name":"osteocalcin","score":0.9210000038146973},{"id":"https://openalex.org/keywords/cell-adhesion-and-proliferation","display_name":"cell adhesion and proliferation","score":0.6600000262260437},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.414000004529953}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7459264993667603},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6385773420333862},{"id":"https://openalex.org/C2777746296","wikidata":"https://www.wikidata.org/wiki/Q178397","display_name":"Apatite","level":2,"score":0.6291740536689758},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.543404221534729},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.49959254264831543},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4413049817085266},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.4391060173511505},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.4132493734359741},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.412739098072052},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20687934756278992},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1683432161808014},{"id":"https://openalex.org/C199289684","wikidata":"https://www.wikidata.org/wiki/Q83353","display_name":"Mineralogy","level":1,"score":0.1588793396949768},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1484811007976532},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.140598863363266},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07384723424911499},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.05158787965774536}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.3390/biomedicines12081664","doi":"https://doi.org/10.3390/biomedicines12081664","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines12081664","pdf_url":null,"source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11352071","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11352071","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11352071/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"Text"},{"id":"pmid:39200129","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39200129","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:56cfbf95232e4390a4439995a0330df5","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/56cfbf95232e4390a4439995a0330df5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomedicines, Vol 12, Iss 8, p 1664 (2024)","raw_type":"article"},{"id":"pmh:oai:ir.tdc.ac.jp:10130/6916","doi":null,"is_oa":true,"landing_page_url":"http://www.ncbi.nlm.nih.gov/pubmed/39200129","pdf_url":null,"source":{"id":"https://openalex.org/S4306401320","display_name":"Institutional Resources for Unique Collection and Academic Archives (Tokyo Dental College)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149564915","host_organization_name":"Tokyo Dental College","host_organization_lineage":["https://openalex.org/I149564915"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:irdb.nii.ac.jp:00899:0007221794","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10130/6916","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomedicines","raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.3390/biomedicines12081664","doi":"https://doi.org/10.3390/biomedicines12081664","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines12081664","pdf_url":null,"source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8340238352","display_name":"Laying the groundwork for FGF-2 combination therapy for poorly-contained defects","funder_award_id":"22K21001","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4400975116.pdf","grobid_xml":"https://content.openalex.org/works/W4400975116.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W64786230","https://openalex.org/W1568141334","https://openalex.org/W1942877698","https://openalex.org/W1973060516","https://openalex.org/W1977824763","https://openalex.org/W1979737063","https://openalex.org/W1988264011","https://openalex.org/W1993251464","https://openalex.org/W2002266713","https://openalex.org/W2004663024","https://openalex.org/W2011477365","https://openalex.org/W2017415389","https://openalex.org/W2026003049","https://openalex.org/W2049458076","https://openalex.org/W2073464308","https://openalex.org/W2079403920","https://openalex.org/W2081257201","https://openalex.org/W2098389224","https://openalex.org/W2102252079","https://openalex.org/W2106618287","https://openalex.org/W2111026515","https://openalex.org/W2119102689","https://openalex.org/W2119874687","https://openalex.org/W2123420091","https://openalex.org/W2131718036","https://openalex.org/W2156288673","https://openalex.org/W2158045333","https://openalex.org/W2158850803","https://openalex.org/W2598699043","https://openalex.org/W2793141294","https://openalex.org/W2886417554","https://openalex.org/W2887798202","https://openalex.org/W2897328472","https://openalex.org/W2903175462","https://openalex.org/W2904546992","https://openalex.org/W2913232887","https://openalex.org/W2956261236","https://openalex.org/W2981231513","https://openalex.org/W2990853812","https://openalex.org/W3091802666","https://openalex.org/W3092059397","https://openalex.org/W3092996928","https://openalex.org/W3095501722","https://openalex.org/W3136465925","https://openalex.org/W3165808871","https://openalex.org/W4214827995","https://openalex.org/W4220771269","https://openalex.org/W4293366059","https://openalex.org/W4308970691","https://openalex.org/W4366764697","https://openalex.org/W4388982303","https://openalex.org/W6675397841"],"related_works":["https://openalex.org/W3165808871","https://openalex.org/W4366764697","https://openalex.org/W4412200800","https://openalex.org/W4403171265","https://openalex.org/W4220771269","https://openalex.org/W2042027035","https://openalex.org/W7161165719","https://openalex.org/W2020947956","https://openalex.org/W2002367182","https://openalex.org/W2913232887"],"abstract_inverted_index":{"The":[0,112,128,200],"aim":[1],"of":[2,15,18,73,136,165,194,206],"this":[3],"study":[4],"was":[5,52,93,104,146],"to":[6,66,220,231],"investigate":[7],"in":[8,11,33,38,77,87,98,212],"vivo":[9],"and":[10,58,70,168,196,221,225],"vitro":[12,62],"the":[13,16,34,71,83,88,99,109,123,141,151,156,174,179,182,192,204,213],"effectiveness":[14],"use":[17,205],"fibroblast":[19],"growth":[20],"factor":[21],"(FGF)-2":[22],"with":[23,42,122,140,173,178,208],"carbonate":[24],"apatite":[25],"(CO3Ap)":[26],"on":[27,223],"periodontal":[28,214],"healing.":[29],"Periodontal":[30],"defects":[31],"created":[32],"maxillary":[35],"first":[36],"molars":[37],"rats":[39],"were":[40,64,198],"treated":[41],"FGF-2,":[43],"CO3Ap,":[44],"FGF-2":[45,89,110,113,124,129,152,157,183,207,216],"+":[46,90,114,130,158,184],"CO3Ap":[47,91,100,115,126,131,142,159,175,180,185,209,224],"or":[48,125],"left":[49],"unfilled.":[50],"Healing":[51],"evaluated":[53],"using":[54],"microcomputed":[55],"tomography,":[56],"histological,":[57],"immunohistochemical":[59],"analyses.":[60],"In":[61,154],"experiments":[63],"performed":[65],"assess":[67],"cellular":[68],"behaviors":[69],"expression":[72],"osteoblastic":[74,227],"differentiation":[75],"markers":[76],"MC3T3-E1":[78],"cells.":[79],"At":[80],"4":[81],"weeks,":[82],"bone":[84,120,233],"volume":[85],"fraction":[86],"group":[92,116,132,160,186],"significantly":[94,188],"greater":[95,118,134,163],"than":[96],"that":[97,203],"group,":[101,143,181],"but":[102,144,191],"there":[103,145],"no":[105,147],"significant":[106,148],"difference":[107,149],"from":[108,150],"group.":[111,127,153,176],"demonstrated":[117],"new":[119],"compared":[121,139,172],"showed":[133,187],"levels":[135],"osteocalcin-positive":[137],"cells":[138,171],"vitro,":[155],"exhibited":[161],"a":[162],"extent":[164],"cell":[166,218],"attachment":[167,219],"more":[169],"elongated":[170],"Compared":[177],"higher":[189],"viability/proliferation,":[190],"expressions":[193],"Runx2":[195],"Sp7":[197],"reduced.":[199],"results":[201],"indicated":[202],"enhanced":[210],"healing":[211],"defects.":[215],"promoted":[217],"proliferation":[222],"regulated":[226],"differentiation,":[228],"thereby":[229],"contributing":[230],"novel":[232],"formation.":[234]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2024-07-26T00:00:00"}