{"id":"https://openalex.org/W4400967366","doi":"https://doi.org/10.1016/j.ctrv.2024.102805","title":"Toxicities associated with sequential or combined use of immune checkpoint inhibitors and small targeted therapies in non-small cell lung cancer: A critical review of the literature","display_name":"Toxicities associated with sequential or combined use of immune checkpoint inhibitors and small targeted therapies in non-small cell lung cancer: A critical review of the literature","publication_year":2024,"publication_date":"2024-07-24","ids":{"openalex":"https://openalex.org/W4400967366","doi":"https://doi.org/10.1016/j.ctrv.2024.102805","pmid":"https://pubmed.ncbi.nlm.nih.gov/39111188"},"language":"en","primary_location":{"id":"doi:10.1016/j.ctrv.2024.102805","doi":"https://doi.org/10.1016/j.ctrv.2024.102805","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ctrv.2024.102805","pdf_url":null,"source":{"id":"https://openalex.org/S49831067","display_name":"Cancer Treatment Reviews","issn_l":"0305-7372","issn":["0305-7372","1532-1967"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Treatment Reviews","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.ctrv.2024.102805","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000308605","display_name":"Anne-Laure D\u00e9sage","orcid":"https://orcid.org/0009-0008-7778-6642","observed_orcids":["https://orcid.org/0009-0008-7778-6642"]},"institutions":[{"id":"https://openalex.org/I4210157006","display_name":"Centre Hospitalier Universitaire de Saint-\u00c9tienne","ror":"https://ror.org/04pn6vp43","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210157006"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Anne-Laure D\u00e9sage","raw_affiliation_strings":["Department of Pulmonology and Thoracic Oncology, North Hospital, University Hospital of Saint-Etienne, Saint-Etienne, France. Electronic address: anne-laure.desage@chu-st-etienne.fr","Department of Pulmonology and Thoracic Oncology, North Hospital, University Hospital of Saint-Etienne, Saint-Etienne, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonology and Thoracic Oncology, North Hospital, University Hospital of Saint-Etienne, Saint-Etienne, France. Electronic address: anne-laure.desage@chu-st-etienne.fr","institution_ids":["https://openalex.org/I4210157006"]},{"raw_affiliation_string":"Department of Pulmonology and Thoracic Oncology, North Hospital, University Hospital of Saint-Etienne, Saint-Etienne, France","institution_ids":["https://openalex.org/I4210157006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043441875","display_name":"M. Duruisseaux","orcid":"https://orcid.org/0000-0003-1495-0966","observed_orcids":["https://orcid.org/0000-0003-1495-0966"]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I203339264","display_name":"Universit\u00e9 de Lyon","ror":"https://ror.org/01rk35k63","country_code":"FR","type":"education","lineage":["https://openalex.org/I203339264"]},{"id":"https://openalex.org/I4210100596","display_name":"Hospices Civils de Lyon","ror":"https://ror.org/01502ca60","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596"]},{"id":"https://openalex.org/I4210125048","display_name":"Centre de Recherche en Canc\u00e9rologie de Lyon","ror":"https://ror.org/02mgw3155","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4210096427","https://openalex.org/I4210105738","https://openalex.org/I4210125048"]},{"id":"https://openalex.org/I4210136143","display_name":"H\u00f4pital Louis Pradel","ror":"https://ror.org/0396v4y86","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210136143"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Michael Duruisseaux","raw_affiliation_strings":["Respiratory Department, Louis Pradel Hospital, Hospices Civils de Lyon Cancer Institute, Lyon, France; Oncopharmacology Laboratory, Cancer Research Center of Lyon, UMR INSERM 1052 CNRS 5286, Lyon, France; Universit\u00e9 Claude Bernard, Universit\u00e9 de Lyon, Lyon, France","Oncopharmacology Laboratory, Cancer Research Center of Lyon, UMR INSERM 1052 CNRS 5286, Lyon, France","Respiratory Department, Louis Pradel Hospital, Hospices Civils de Lyon Cancer Institute, Lyon, France","Universit\u00e9 Claude Bernard, Universit\u00e9 de Lyon, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Respiratory Department, Louis Pradel Hospital, Hospices Civils de Lyon Cancer Institute, Lyon, France; Oncopharmacology Laboratory, Cancer Research Center of Lyon, UMR INSERM 1052 CNRS 5286, Lyon, France; Universit\u00e9 Claude Bernard, Universit\u00e9 de Lyon, Lyon, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210100596","https://openalex.org/I4210125048","https://openalex.org/I4210136143"]},{"raw_affiliation_string":"Oncopharmacology Laboratory, Cancer Research Center of Lyon, UMR INSERM 1052 CNRS 5286, Lyon, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210125048"]},{"raw_affiliation_string":"Respiratory Department, Louis Pradel Hospital, Hospices Civils de Lyon Cancer Institute, Lyon, France","institution_ids":["https://openalex.org/I4210100596","https://openalex.org/I4210136143"]},{"raw_affiliation_string":"Universit\u00e9 Claude Bernard, Universit\u00e9 de Lyon, Lyon, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I203339264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018362045","display_name":"Claire Lafitte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100596","display_name":"Hospices Civils de Lyon","ror":"https://ror.org/01502ca60","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596"]},{"id":"https://openalex.org/I4210136143","display_name":"H\u00f4pital Louis Pradel","ror":"https://ror.org/0396v4y86","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210136143"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Claire Lafitte","raw_affiliation_strings":["Respiratory Department, Louis Pradel Hospital, Hospices Civils de Lyon Cancer Institute, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Respiratory Department, Louis Pradel Hospital, Hospices Civils de Lyon Cancer Institute, Lyon, France","institution_ids":["https://openalex.org/I4210100596","https://openalex.org/I4210136143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036479509","display_name":"Sophie Bayle-Bleuez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157006","display_name":"Centre Hospitalier Universitaire de Saint-\u00c9tienne","ror":"https://ror.org/04pn6vp43","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210157006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sophie Bayle-Bleuez","raw_affiliation_strings":["Department of Pulmonology and Thoracic Oncology, North Hospital, University Hospital of Saint-Etienne, Saint-Etienne, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonology and Thoracic Oncology, North Hospital, University Hospital of Saint-Etienne, Saint-Etienne, France","institution_ids":["https://openalex.org/I4210157006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016370905","display_name":"CHRISTOS CHOUAID","orcid":"https://orcid.org/0000-0002-4290-5524","observed_orcids":["https://orcid.org/0000-0002-4290-5524"]},"institutions":[{"id":"https://openalex.org/I4210159273","display_name":"H\u00f4pital Intercommunal de Cr\u00e9teil","ror":"https://ror.org/04n1nkp35","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210159273"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christos Chouaid","raw_affiliation_strings":["Pneumology Department, Centre Hospitalier Intercommunal de Cr\u00e9teil, Cr\u00e9teil, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pneumology Department, Centre Hospitalier Intercommunal de Cr\u00e9teil, Cr\u00e9teil, France","institution_ids":["https://openalex.org/I4210159273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039103158","display_name":"P. Fournel","orcid":"https://orcid.org/0000-0002-3884-6816","observed_orcids":["https://orcid.org/0000-0002-3884-6816"]},"institutions":[{"id":"https://openalex.org/I4210157006","display_name":"Centre Hospitalier Universitaire de Saint-\u00c9tienne","ror":"https://ror.org/04pn6vp43","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210157006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierre Fournel","raw_affiliation_strings":["Department of Pulmonology and Thoracic Oncology, North Hospital, University Hospital of Saint-Etienne, Saint-Etienne, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonology and Thoracic Oncology, North Hospital, University Hospital of Saint-Etienne, Saint-Etienne, France","institution_ids":["https://openalex.org/I4210157006"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048989194","display_name":"Thomas Pierret","orcid":"https://orcid.org/0000-0002-4297-7413","observed_orcids":["https://orcid.org/0000-0002-4297-7413"]},"institutions":[{"id":"https://openalex.org/I4210100596","display_name":"Hospices Civils de Lyon","ror":"https://ror.org/01502ca60","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596"]},{"id":"https://openalex.org/I4210136143","display_name":"H\u00f4pital Louis Pradel","ror":"https://ror.org/0396v4y86","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210136143"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Thomas Pierret","raw_affiliation_strings":["Respiratory Department, Louis Pradel Hospital, Hospices Civils de Lyon Cancer Institute, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Respiratory Department, Louis Pradel Hospital, Hospices Civils de Lyon Cancer Institute, Lyon, France","institution_ids":["https://openalex.org/I4210100596","https://openalex.org/I4210136143"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5000308605"],"corresponding_institution_ids":["https://openalex.org/I4210157006"],"apc_list":{"value":4720,"currency":"USD","value_usd":4720},"apc_paid":{"value":4720,"currency":"USD","value_usd":4720},"fwci":1.6761,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.86663616,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"129","issue":null,"first_page":"102805","last_page":"102805"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.6729000210762024,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.6729000210762024,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.322299987077713,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.9380000233650208},{"id":"https://openalex.org/keywords/small-molecule-targeted-therapy","display_name":"small-molecule targeted therapy","score":0.7149999737739563},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9900000095367432},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.6840000152587891},{"id":"https://openalex.org/keywords/interstitial-lung-disease","display_name":"interstitial lung disease","score":0.8019999861717224},{"id":"https://openalex.org/keywords/drug-induced-hepatitis","display_name":"drug-induced hepatitis","score":0.699999988079071},{"id":"https://openalex.org/keywords/skin-diseases","display_name":"skin diseases","score":0.6819999814033508},{"id":"https://openalex.org/keywords/sequential-administration","display_name":"sequential administration","score":0.5580000281333923},{"id":"https://openalex.org/keywords/co-administration","display_name":"co-administration","score":0.8560000061988831},{"id":"https://openalex.org/keywords/treatment-sequencing","display_name":"treatment sequencing","score":0.7080000042915344},{"id":"https://openalex.org/keywords/immune-related-adverse-events","display_name":"immune-related adverse events","score":0.7160000205039978}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9359498023986816},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5219466090202332},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.48929664492607117},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.44774043560028076},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.44770151376724243},{"id":"https://openalex.org/C2780030458","wikidata":"https://www.wikidata.org/wiki/Q7041828","display_name":"Nivolumab","level":4,"score":0.44730234146118164},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.42990797758102417},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3842083811759949},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33524036407470703},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27513086795806885},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2140653431415558}],"mesh":[{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.ctrv.2024.102805","doi":"https://doi.org/10.1016/j.ctrv.2024.102805","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ctrv.2024.102805","pdf_url":null,"source":{"id":"https://openalex.org/S49831067","display_name":"Cancer Treatment Reviews","issn_l":"0305-7372","issn":["0305-7372","1532-1967"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Treatment Reviews","raw_type":"journal-article"},{"id":"pmid:39111188","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39111188","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer treatment reviews","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-04728403v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-04728403","pdf_url":"https://hal.science/hal-04728403/document","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Treatment Reviews, 2024, 129, ⟨10.1016/j.ctrv.2024.102805⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.ctrv.2024.102805","doi":"https://doi.org/10.1016/j.ctrv.2024.102805","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ctrv.2024.102805","pdf_url":null,"source":{"id":"https://openalex.org/S49831067","display_name":"Cancer Treatment Reviews","issn_l":"0305-7372","issn":["0305-7372","1532-1967"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Treatment Reviews","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.75,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W2010121426","https://openalex.org/W2128339707","https://openalex.org/W2156353875","https://openalex.org/W2198093519","https://openalex.org/W2300615341","https://openalex.org/W2520362701","https://openalex.org/W2527905628","https://openalex.org/W2563339506","https://openalex.org/W2567564314","https://openalex.org/W2743419024","https://openalex.org/W2753065806","https://openalex.org/W2770828094","https://openalex.org/W2782863308","https://openalex.org/W2783137027","https://openalex.org/W2791886669","https://openalex.org/W2796582438","https://openalex.org/W2803642760","https://openalex.org/W2890230728","https://openalex.org/W2891460256","https://openalex.org/W2892640821","https://openalex.org/W2893824814","https://openalex.org/W2903379674","https://openalex.org/W2904320752","https://openalex.org/W2921321818","https://openalex.org/W2922107046","https://openalex.org/W2925446385","https://openalex.org/W2945590213","https://openalex.org/W2980670340","https://openalex.org/W2982321167","https://openalex.org/W3001408868","https://openalex.org/W3005583371","https://openalex.org/W3007051114","https://openalex.org/W3007861548","https://openalex.org/W3047747528","https://openalex.org/W3085485176","https://openalex.org/W3085689295","https://openalex.org/W3086933470","https://openalex.org/W3165887339","https://openalex.org/W3189100847","https://openalex.org/W3192186338","https://openalex.org/W3214261332","https://openalex.org/W4205562805","https://openalex.org/W4212841488","https://openalex.org/W4213154320","https://openalex.org/W4223502512","https://openalex.org/W4225140159","https://openalex.org/W4281491769","https://openalex.org/W4283452162","https://openalex.org/W4317761498","https://openalex.org/W4323033684","https://openalex.org/W4365516770","https://openalex.org/W4377141166","https://openalex.org/W4382517844","https://openalex.org/W4393999470","https://openalex.org/W6774438956","https://openalex.org/W6800139247","https://openalex.org/W6839362850"],"related_works":["https://openalex.org/W4388586239","https://openalex.org/W3021851930","https://openalex.org/W2898986397","https://openalex.org/W2981652925","https://openalex.org/W2800160190","https://openalex.org/W2890849069","https://openalex.org/W3004135494","https://openalex.org/W4221108986","https://openalex.org/W4223433636","https://openalex.org/W3215438668"],"abstract_inverted_index":{"BACKGROUND:":[0],"Immune":[1],"checkpoint":[2],"inhibitors":[3],"(ICIs)":[4],"have":[5,201],"become":[6],"standard-of-care":[7],"at":[8],"different":[9],"stage":[10],"disease":[11],"in":[12,29,46,92,129,208,219,233],"non-small":[13],"cell":[14],"lung":[15,125],"cancer":[16],"(NSCLC).":[17],"Based":[18],"on":[19,74,169],"the":[20,75,99,105,130,170,228],"increasing":[21],"characterization":[22],"of":[23,60,77,85,121,132,138,155,161,172,205,210],"molecular":[24],"aberrations":[25],"and":[26,36,87,98,135,140,153,176,238,242],"oncogenic":[27],"drivers":[28],"NSCLC,":[30],"it":[31],"is":[32,54,188],"expected":[33],"that":[34],"more":[35,37,159],"patients":[38],"will":[39],"benefit":[40],"from":[41,108],"orally":[42],"small":[43,88,141,163,185,243],"targeted":[44,89,142,164,186,216,244],"therapies":[45,90,217],"NSCLC.":[47,220],"However,":[48],"their":[49],"concomitant":[50,136,212],"or":[51,82,213],"sequential":[52,81,134,214],"use":[53,84],"associated":[55,79],"with":[56,80],"an":[57],"increased":[58],"risk":[59],"a":[61,118,148,151,162],"various":[62,119],"toxicity":[63],"pattern.":[64],"METHODS:":[65],"Relevant":[66],"publications":[67],"were":[68,102],"included":[69],"if":[70],"they":[71],"reported":[72],"data":[73],"question":[76],"toxicities":[78,122,145,157,207,232],"combined":[83],"ICIs":[86,139,197,241],"used":[91],"NSCLC":[93],"treatment.":[94],"MEDLINE,":[95],"Google":[96],"Scholar,":[97],"Cochrane":[100],"Library":[101],"searched":[103],"for":[104,178],"following":[106],"request,":[107],"database":[109],"inception":[110],"until":[111],"June":[112],"2023.":[113],"RESULTS:":[114],"This":[115,166],"review":[116,167],"highlighted":[117],"pattern":[120],"(i.e.,":[123],"interstitial":[124],"disease,":[126],"hepatitis,":[127],"dermatoses)":[128],"context":[131],"both":[133,211],"administration":[137,175,218],"therapies.":[143],"Such":[144],"seem":[146],"rather":[147],"\"drug-effect\"":[149],"than":[150],"\"class-effect\"":[152],"some":[154],"these":[156,231],"are":[158,223],"specific":[160],"therapy.":[165],"highlights":[168],"impact":[171],"treatment":[173],"sequence":[174],"emphasis":[177],"physicians":[179],"to":[180,192,202,225,235,239],"be":[181,203],"particularly":[182],"careful":[183],"whether":[184],"therapy":[187,245],"administered":[189],"within":[190],"one":[191],"three":[193],"months":[194],"after":[195],"last":[196],"injection.":[198],"CONCLUSION:":[199],"Physicians":[200],"aware":[204],"severe":[206],"case":[209],"ICIs/small":[215],"Further":[221],"studies":[222],"needed":[224],"better":[226],"understand":[227],"mechanisms":[229],"underlying":[230],"order":[234],"prevent":[236],"them":[237],"refine":[240],"sequencing":[246],"strategy.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}