{"id":"https://openalex.org/W4400965735","doi":"https://doi.org/10.1208/s12249-024-02884-w","title":"Enhanced Skin Penetration and Efficacy: First and Second Generation Lipoidal Nanocarriers in Skin Cancer Therapy","display_name":"Enhanced Skin Penetration and Efficacy: First and Second Generation Lipoidal Nanocarriers in Skin Cancer Therapy","publication_year":2024,"publication_date":"2024-07-23","ids":{"openalex":"https://openalex.org/W4400965735","doi":"https://doi.org/10.1208/s12249-024-02884-w","pmid":"https://pubmed.ncbi.nlm.nih.gov/39044049"},"language":"en","primary_location":{"id":"doi:10.1208/s12249-024-02884-w","doi":"https://doi.org/10.1208/s12249-024-02884-w","is_oa":false,"landing_page_url":"https://doi.org/10.1208/s12249-024-02884-w","pdf_url":null,"source":{"id":"https://openalex.org/S1234972","display_name":"AAPS PharmSciTech","issn_l":"1530-9932","issn":["1530-9932"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AAPS PharmSciTech","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021619497","display_name":"Palak Sharma","orcid":"https://orcid.org/0000-0001-5116-3959","observed_orcids":["https://orcid.org/0000-0001-5116-3959"]},"institutions":[{"id":"https://openalex.org/I191972202","display_name":"Amity University","ror":"https://ror.org/02n9z0v62","country_code":"IN","type":"education","lineage":["https://openalex.org/I191972202"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Palak Sharma","raw_affiliation_strings":["Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Uttar Pradesh, 201301, Noida, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Uttar Pradesh, 201301, Noida, India","institution_ids":["https://openalex.org/I191972202"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049441259","display_name":"Shreya Kaul","orcid":"https://orcid.org/0000-0002-8540-3612","observed_orcids":["https://orcid.org/0000-0002-8540-3612"]},"institutions":[{"id":"https://openalex.org/I191972202","display_name":"Amity University","ror":"https://ror.org/02n9z0v62","country_code":"IN","type":"education","lineage":["https://openalex.org/I191972202"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Shreya Kaul","raw_affiliation_strings":["Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Uttar Pradesh, 201301, Noida, India. skaul@amity.edu","Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Uttar Pradesh, 201301, Noida, India"],"raw_orcid":"https://orcid.org/0000-0002-8540-3612","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Uttar Pradesh, 201301, Noida, India. skaul@amity.edu","institution_ids":["https://openalex.org/I191972202"]},{"raw_affiliation_string":"Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Uttar Pradesh, 201301, Noida, India","institution_ids":["https://openalex.org/I191972202"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058751417","display_name":"Neha Jain","orcid":"https://orcid.org/0000-0003-3827-5598","observed_orcids":["https://orcid.org/0000-0003-3827-5598","https://orcid.org/0009-0009-3887-9077"]},"institutions":[{"id":"https://openalex.org/I191972202","display_name":"Amity University","ror":"https://ror.org/02n9z0v62","country_code":"IN","type":"education","lineage":["https://openalex.org/I191972202"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Neha Jain","raw_affiliation_strings":["Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Uttar Pradesh, 201301, Noida, India. njain1@amity.edu","Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Uttar Pradesh, 201301, Noida, India"],"raw_orcid":"https://orcid.org/0000-0003-3827-5598","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Uttar Pradesh, 201301, Noida, India. njain1@amity.edu","institution_ids":["https://openalex.org/I191972202"]},{"raw_affiliation_string":"Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Uttar Pradesh, 201301, Noida, India","institution_ids":["https://openalex.org/I191972202"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003874983","display_name":"Manisha Pandey","orcid":"https://orcid.org/0000-0002-8249-9743","observed_orcids":["https://orcid.org/0000-0002-8249-9743"]},"institutions":[{"id":"https://openalex.org/I4210133503","display_name":"Central University of Haryana","ror":"https://ror.org/03mtwkv54","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210133503"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Manisha Pandey","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Central University of Haryana, Mahendergarh, Haryana, India"],"raw_orcid":"https://orcid.org/0000-0002-8249-9743","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Central University of Haryana, Mahendergarh, Haryana, India","institution_ids":["https://openalex.org/I4210133503"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011562041","display_name":"Upendra Nagaich","orcid":"https://orcid.org/0000-0003-0076-6885","observed_orcids":["https://orcid.org/0000-0003-0076-6885"]},"institutions":[{"id":"https://openalex.org/I85461943","display_name":"Saveetha University","ror":"https://ror.org/0034me914","country_code":"IN","type":"education","lineage":["https://openalex.org/I85461943"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Upendra Nagaich","raw_affiliation_strings":["Center for Global Health Research, Saveetha Medical College, Saveetha Institute of Medical and Technical Science, Chennai, India"],"raw_orcid":"https://orcid.org/0000-0003-0076-6885","affiliations":[{"raw_affiliation_string":"Center for Global Health Research, Saveetha Medical College, Saveetha Institute of Medical and Technical Science, Chennai, India","institution_ids":["https://openalex.org/I85461943"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5049441259","https://openalex.org/A5058751417"],"corresponding_institution_ids":["https://openalex.org/I191972202"],"apc_list":{"value":3890,"currency":"USD","value_usd":3890},"apc_paid":null,"fwci":0.3629,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.30160858,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"25","issue":"6","first_page":"170","last_page":"170"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/skin-cancer","display_name":"skin cancer","score":0.7850000262260437},{"id":"https://openalex.org/keywords/lipid-nanocarriers","display_name":"lipid-based nanocarriers","score":0.878000020980835},{"id":"https://openalex.org/keywords/solid-lipid-nanoparticles","display_name":"solid lipid nanoparticles","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nanostructured-lipid-carriers","display_name":"nanostructured lipid carriers","score":1.0},{"id":"https://openalex.org/keywords/skin-penetration","display_name":"skin penetration","score":0.7559999823570251},{"id":"https://openalex.org/keywords/topical-drug-delivery","display_name":"topical drug delivery","score":0.7609999775886536},{"id":"https://openalex.org/keywords/basal-cell-carcinoma","display_name":"basal cell carcinoma","score":0.8289999961853027},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/squamous-cell-carcinoma","display_name":"squamous cell carcinoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nanocarrier-toxicity","display_name":"nanocarrier toxicity","score":0.7049999833106995},{"id":"https://openalex.org/keywords/local-drug-delivery","display_name":"local drug delivery","score":0.5740000009536743},{"id":"https://openalex.org/keywords/chemotherapeutics","display_name":"chemotherapeutics","score":0.48100000619888306},{"id":"https://openalex.org/keywords/nucleic-acid-delivery","display_name":"nucleic acid delivery","score":0.6620000004768372},{"id":"https://openalex.org/keywords/peptide-delivery","display_name":"peptide delivery","score":0.8259999752044678}],"concepts":[{"id":"https://openalex.org/C18150654","wikidata":"https://www.wikidata.org/wiki/Q17153796","display_name":"Nanocarriers","level":3,"score":0.926356852054596},{"id":"https://openalex.org/C2777789703","wikidata":"https://www.wikidata.org/wiki/Q192102","display_name":"Skin cancer","level":3,"score":0.6598622798919678},{"id":"https://openalex.org/C199529486","wikidata":"https://www.wikidata.org/wiki/Q7557912","display_name":"Solid lipid nanoparticle","level":3,"score":0.5664984583854675},{"id":"https://openalex.org/C2778804307","wikidata":"https://www.wikidata.org/wiki/Q809758","display_name":"Basal cell carcinoma","level":3,"score":0.5552437901496887},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.5460805892944336},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45359063148498535},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44354817271232605},{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.4333919286727905},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.42228639125823975},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3948891758918762},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34185558557510376},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3349965810775757},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.3171364665031433},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19107404351234436},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.1647064983844757},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11216136813163757}],"mesh":[{"descriptor_ui":"D000279","descriptor_name":"Administration, Cutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012869","descriptor_name":"Skin Absorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1208/s12249-024-02884-w","doi":"https://doi.org/10.1208/s12249-024-02884-w","is_oa":false,"landing_page_url":"https://doi.org/10.1208/s12249-024-02884-w","pdf_url":null,"source":{"id":"https://openalex.org/S1234972","display_name":"AAPS PharmSciTech","issn_l":"1530-9932","issn":["1530-9932"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AAPS PharmSciTech","raw_type":"journal-article"},{"id":"pmid:39044049","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39044049","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AAPS PharmSciTech","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":97,"referenced_works":["https://openalex.org/W36957974","https://openalex.org/W116002160","https://openalex.org/W1669527760","https://openalex.org/W1899126153","https://openalex.org/W1961436140","https://openalex.org/W1970311282","https://openalex.org/W1970842651","https://openalex.org/W1979617673","https://openalex.org/W1985416071","https://openalex.org/W1990107938","https://openalex.org/W2013630484","https://openalex.org/W2024833805","https://openalex.org/W2026196886","https://openalex.org/W2029021413","https://openalex.org/W2029390954","https://openalex.org/W2052057632","https://openalex.org/W2054435240","https://openalex.org/W2055642350","https://openalex.org/W2056493684","https://openalex.org/W2063693238","https://openalex.org/W2065893956","https://openalex.org/W2090392987","https://openalex.org/W2093748269","https://openalex.org/W2112512122","https://openalex.org/W2141162588","https://openalex.org/W2147511063","https://openalex.org/W2168711434","https://openalex.org/W2181309556","https://openalex.org/W2265120954","https://openalex.org/W2323418370","https://openalex.org/W2341236969","https://openalex.org/W2388009875","https://openalex.org/W2585359117","https://openalex.org/W2606741379","https://openalex.org/W2711278234","https://openalex.org/W2783535999","https://openalex.org/W2792854179","https://openalex.org/W2793629808","https://openalex.org/W2810248278","https://openalex.org/W2907947399","https://openalex.org/W2924237595","https://openalex.org/W2936858823","https://openalex.org/W2943168741","https://openalex.org/W2952884998","https://openalex.org/W2955795461","https://openalex.org/W2982111523","https://openalex.org/W3002485558","https://openalex.org/W3011793063","https://openalex.org/W3018286430","https://openalex.org/W3023818232","https://openalex.org/W3024753345","https://openalex.org/W3033415079","https://openalex.org/W3038010884","https://openalex.org/W3040057801","https://openalex.org/W3040066830","https://openalex.org/W3045553188","https://openalex.org/W3048581459","https://openalex.org/W3083353681","https://openalex.org/W3086762656","https://openalex.org/W3105274477","https://openalex.org/W3109746568","https://openalex.org/W3110326604","https://openalex.org/W3115706060","https://openalex.org/W3118550572","https://openalex.org/W3133606670","https://openalex.org/W3152963860","https://openalex.org/W3156272201","https://openalex.org/W3156955099","https://openalex.org/W3175862485","https://openalex.org/W3179230430","https://openalex.org/W3193015189","https://openalex.org/W3200129314","https://openalex.org/W3203396486","https://openalex.org/W3209856269","https://openalex.org/W3209917793","https://openalex.org/W3213835326","https://openalex.org/W4206697787","https://openalex.org/W4212902902","https://openalex.org/W4223557378","https://openalex.org/W4281661786","https://openalex.org/W4282981689","https://openalex.org/W4285591421","https://openalex.org/W4288438312","https://openalex.org/W4295084373","https://openalex.org/W4300690180","https://openalex.org/W4304182689","https://openalex.org/W4315700889","https://openalex.org/W4319457762","https://openalex.org/W4322624415","https://openalex.org/W4327739333","https://openalex.org/W4366772503","https://openalex.org/W4378380780","https://openalex.org/W4381470791","https://openalex.org/W4382934801","https://openalex.org/W4385215048","https://openalex.org/W4385607506","https://openalex.org/W4387407657"],"related_works":["https://openalex.org/W4406213942","https://openalex.org/W7170885169","https://openalex.org/W4406991344","https://openalex.org/W4412414685","https://openalex.org/W4400788800","https://openalex.org/W4415054948","https://openalex.org/W3080088468","https://openalex.org/W7163081629","https://openalex.org/W2765525576","https://openalex.org/W4394964527"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-07-25T00:00:00"}