{"id":"https://openalex.org/W4400964474","doi":"https://doi.org/10.1186/s40035-024-00425-w","title":"Dorsal raphe nucleus\u2013hippocampus serotonergic circuit underlies the depressive and cognitive impairments in 5\u00d7FAD male mice","display_name":"Dorsal raphe nucleus\u2013hippocampus serotonergic circuit underlies the depressive and cognitive impairments in 5\u00d7FAD male mice","publication_year":2024,"publication_date":"2024-07-24","ids":{"openalex":"https://openalex.org/W4400964474","doi":"https://doi.org/10.1186/s40035-024-00425-w","pmid":"https://pubmed.ncbi.nlm.nih.gov/39044270","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11267773"},"language":"en","primary_location":{"id":"doi:10.1186/s40035-024-00425-w","doi":"https://doi.org/10.1186/s40035-024-00425-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40035-024-00425-w","pdf_url":null,"source":{"id":"https://openalex.org/S2764798395","display_name":"Translational Neurodegeneration","issn_l":"2047-9158","issn":["2047-9158","2096-6466"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Neurodegeneration","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s40035-024-00425-w","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023210873","display_name":"Meiqin Chen","orcid":"https://orcid.org/0000-0003-1966-2429","observed_orcids":["https://orcid.org/0000-0003-1966-2429"]},"institutions":[{"id":"https://openalex.org/I111381250","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19","country_code":"CN","type":"education","lineage":["https://openalex.org/I111381250"]},{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meiqin Chen","raw_affiliation_strings":["Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, 361102, China","The Key Laboratory of Neural and Vascular Biology, Ministry of Education, College of Basic Medicine, Hebei Medical University, Shijiazhuang, 050017, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, 361102, China","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"The Key Laboratory of Neural and Vascular Biology, Ministry of Education, College of Basic Medicine, Hebei Medical University, Shijiazhuang, 050017, China","institution_ids":["https://openalex.org/I111381250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010226279","display_name":"Chenlu Wang","orcid":"https://orcid.org/0000-0001-5971-8699","observed_orcids":["https://orcid.org/0000-0001-5971-8699"]},"institutions":[{"id":"https://openalex.org/I4210087327","display_name":"First Affiliated Hospital of Xiamen University","ror":"https://ror.org/0006swh35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087327"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenlu Wang","raw_affiliation_strings":["Department of Anesthesiology, First Affiliated Hospital of Xiamen University, Xiamen, 361000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, First Affiliated Hospital of Xiamen University, Xiamen, 361000, China","institution_ids":["https://openalex.org/I4210087327"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115593536","display_name":"Yinan Lin","orcid":"https://orcid.org/0009-0005-6618-8637","observed_orcids":["https://orcid.org/0009-0005-6618-8637"]},"institutions":[{"id":"https://openalex.org/I4210087327","display_name":"First Affiliated Hospital of Xiamen University","ror":"https://ror.org/0006swh35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087327"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yinan Lin","raw_affiliation_strings":["Department of Anesthesiology, First Affiliated Hospital of Xiamen University, Xiamen, 361000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, First Affiliated Hospital of Xiamen University, Xiamen, 361000, China","institution_ids":["https://openalex.org/I4210087327"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101942973","display_name":"Yanbing Chen","orcid":"https://orcid.org/0000-0002-3093-2904","observed_orcids":["https://orcid.org/0000-0002-3093-2904","https://orcid.org/0000-0002-6489-0458"]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanbing Chen","raw_affiliation_strings":["Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, 361102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, 361102, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113269157","display_name":"Wenting Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenting Xie","raw_affiliation_strings":["Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, 361102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, 361102, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101536162","display_name":"Xiaoting Huang","orcid":"https://orcid.org/0009-0008-6141-3243","observed_orcids":["https://orcid.org/0009-0008-6141-3243","https://orcid.org/0000-0003-1276-238X"]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoting Huang","raw_affiliation_strings":["Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, 361102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, 361102, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115594139","display_name":"Fan Zhang","orcid":"https://orcid.org/0009-0001-0721-340X","observed_orcids":["https://orcid.org/0009-0001-0721-340X"]},"institutions":[{"id":"https://openalex.org/I111381250","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19","country_code":"CN","type":"education","lineage":["https://openalex.org/I111381250"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fan Zhang","raw_affiliation_strings":["The Key Laboratory of Neural and Vascular Biology, Ministry of Education, College of Basic Medicine, Hebei Medical University, Shijiazhuang, 050017, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Key Laboratory of Neural and Vascular Biology, Ministry of Education, College of Basic Medicine, Hebei Medical University, Shijiazhuang, 050017, China","institution_ids":["https://openalex.org/I111381250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045775498","display_name":"Congrui Fu","orcid":"https://orcid.org/0000-0002-2125-9893","observed_orcids":["https://orcid.org/0000-0002-2125-9893"]},"institutions":[{"id":"https://openalex.org/I111381250","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19","country_code":"CN","type":"education","lineage":["https://openalex.org/I111381250"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Congrui Fu","raw_affiliation_strings":["The Key Laboratory of Neural and Vascular Biology, Ministry of Education, College of Basic Medicine, Hebei Medical University, Shijiazhuang, 050017, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Key Laboratory of Neural and Vascular Biology, Ministry of Education, College of Basic Medicine, Hebei Medical University, Shijiazhuang, 050017, China","institution_ids":["https://openalex.org/I111381250"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kai Zhuang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kai Zhuang","raw_affiliation_strings":["Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, 361102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, 361102, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008607594","display_name":"Tingting Zou","orcid":"https://orcid.org/0000-0002-7240-1378","observed_orcids":["https://orcid.org/0000-0002-7240-1378"]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tingting Zou","raw_affiliation_strings":["Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, 361102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, 361102, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033922302","display_name":"Dan Can","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dan Can","raw_affiliation_strings":["Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, 361102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, 361102, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100395266","display_name":"Huifang Li","orcid":"https://orcid.org/0000-0003-3744-3254","observed_orcids":["https://orcid.org/0000-0003-3744-3254"]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huifang Li","raw_affiliation_strings":["Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, 361102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, 361102, China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100770373","display_name":"Shengxi Wu","orcid":"https://orcid.org/0000-0002-3210-9567","observed_orcids":["https://orcid.org/0000-0002-3210-9567"]},"institutions":[{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shengxi Wu","raw_affiliation_strings":["Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an, 710032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an, 710032, China","institution_ids":["https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020886964","display_name":"Ceng Luo","orcid":"https://orcid.org/0000-0003-3742-7713","observed_orcids":["https://orcid.org/0000-0003-3742-7713"]},"institutions":[{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ceng Luo","raw_affiliation_strings":["Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an, 710032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an, 710032, China","institution_ids":["https://openalex.org/I9916479"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5115590908","display_name":"Jie Zhang","orcid":"https://orcid.org/0009-0004-5173-9996","observed_orcids":["https://orcid.org/0009-0004-5173-9996","https://orcid.org/0000-0002-0417-8725","https://orcid.org/0009-0006-4342-8025","https://orcid.org/0000-0001-5381-0515"]},"institutions":[{"id":"https://openalex.org/I111381250","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19","country_code":"CN","type":"education","lineage":["https://openalex.org/I111381250"]},{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]},{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]},{"id":"https://openalex.org/I4210118397","display_name":"Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital","ror":"https://ror.org/01qh26a66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210118397"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jie Zhang","raw_affiliation_strings":["Department of Neurology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610054, China. jiezhang@xmu.edu.cn","Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, 361102, China. jiezhang@xmu.edu.cn","Institute of Neuroscience, Fujian Medical University, Fuzhou, 350004, China. jiezhang@xmu.edu.cn","The Key Laboratory of Neural and Vascular Biology, Ministry of Education, College of Basic Medicine, Hebei Medical University, Shijiazhuang, 050017, China. jiezhang@xmu.edu.cn","Department of Neurology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610054, China","Institute of Neuroscience, Fujian Medical University, Fuzhou, 350004, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610054, China. jiezhang@xmu.edu.cn","institution_ids":["https://openalex.org/I150229711"]},{"raw_affiliation_string":"Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, 361102, China. jiezhang@xmu.edu.cn","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"Institute of Neuroscience, Fujian Medical University, Fuzhou, 350004, China. jiezhang@xmu.edu.cn","institution_ids":["https://openalex.org/I129708740"]},{"raw_affiliation_string":"The Key Laboratory of Neural and Vascular Biology, Ministry of Education, College of Basic Medicine, Hebei Medical University, Shijiazhuang, 050017, China. jiezhang@xmu.edu.cn","institution_ids":["https://openalex.org/I111381250"]},{"raw_affiliation_string":"Department of Neurology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610054, China","institution_ids":["https://openalex.org/I150229711","https://openalex.org/I4210118397"]},{"raw_affiliation_string":"Institute of Neuroscience, Fujian Medical University, Fuzhou, 350004, China","institution_ids":["https://openalex.org/I129708740"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5115590908"],"corresponding_institution_ids":["https://openalex.org/I111381250","https://openalex.org/I129708740","https://openalex.org/I150229711","https://openalex.org/I191208505","https://openalex.org/I4210118397"],"apc_list":{"value":2890,"currency":"USD","value_usd":2890},"apc_paid":{"value":2890,"currency":"USD","value_usd":2890},"fwci":4.3822,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.95812317,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"13","issue":"1","first_page":"34","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.6586999893188477,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.6586999893188477,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.13459999859333038,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.07670000195503235,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dorsal-raphe-nucleus","display_name":"dorsal raphe nucleus","score":0.9070000052452087},{"id":"https://openalex.org/keywords/hippocampal-ca1","display_name":"hippocampal CA1","score":0.8379999995231628},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8209999799728394},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.8130000233650208},{"id":"https://openalex.org/keywords/5xfad-mice","display_name":"5xFAD mice","score":0.9160000085830688},{"id":"https://openalex.org/keywords/5-ht1b-receptor","display_name":"5-HT1B receptor","score":0.8320000171661377},{"id":"https://openalex.org/keywords/5-ht4-receptor","display_name":"5-HT4 receptor","score":1.0},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.9399999976158142},{"id":"https://openalex.org/keywords/chemogenetic-activation","display_name":"chemogenetic activation","score":0.6140000224113464},{"id":"https://openalex.org/keywords/optogenetic-stimulation","display_name":"optogenetic stimulation","score":0.902999997138977},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C32610206","wikidata":"https://www.wikidata.org/wiki/Q5298804","display_name":"Dorsal raphe nucleus","level":5,"score":0.8949705958366394},{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.8624224662780762},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.8009783029556274},{"id":"https://openalex.org/C50738837","wikidata":"https://www.wikidata.org/wiki/Q781492","display_name":"Optogenetics","level":2,"score":0.7547351121902466},{"id":"https://openalex.org/C2777865548","wikidata":"https://www.wikidata.org/wiki/Q2061493","display_name":"Raphe nuclei","level":5,"score":0.5373557806015015},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.4720519483089447},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.4554736614227295},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.4519089460372925},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.43629151582717896},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.374347448348999},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15818947553634644},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.15070584416389465}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009434","descriptor_name":"Neural Pathways","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009434","descriptor_name":"Neural Pathways","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059326","descriptor_name":"Serotonergic Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D059326","descriptor_name":"Serotonergic Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D062308","descriptor_name":"Optogenetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065847","descriptor_name":"Dorsal Raphe Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s40035-024-00425-w","doi":"https://doi.org/10.1186/s40035-024-00425-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40035-024-00425-w","pdf_url":null,"source":{"id":"https://openalex.org/S2764798395","display_name":"Translational Neurodegeneration","issn_l":"2047-9158","issn":["2047-9158","2096-6466"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Neurodegeneration","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11267773","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11267773","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11267773/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transl Neurodegener","raw_type":"Text"},{"id":"pmid:39044270","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39044270","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational neurodegeneration","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:68fae01d1fde4914afd8fb2a24557f2a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/68fae01d1fde4914afd8fb2a24557f2a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-21 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s40035-024-00425-w","doi":"https://doi.org/10.1186/s40035-024-00425-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40035-024-00425-w","pdf_url":null,"source":{"id":"https://openalex.org/S2764798395","display_name":"Translational Neurodegeneration","issn_l":"2047-9158","issn":["2047-9158","2096-6466"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Neurodegeneration","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3280987154","display_name":null,"funder_award_id":"81925010","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4100415592","display_name":null,"funder_award_id":"92149303","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4432051912","display_name":null,"funder_award_id":"NV20230014","funder_id":"https://openalex.org/F4320335666","funder_display_name":"Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research, Ministry of Education"},{"id":"https://openalex.org/G452835714","display_name":null,"funder_award_id":"U1905207","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7742202721","display_name":null,"funder_award_id":"91849205","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8157109598","display_name":null,"funder_award_id":"NV20230010","funder_id":"https://openalex.org/F4320335666","funder_display_name":"Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research, Ministry of Education"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321106","display_name":"Ministry of Education of the People's Republic of China","ror":"https://ror.org/01mv9t934"},{"id":"https://openalex.org/F4320335666","display_name":"Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research, Ministry of Education","ror":null},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4400964474.pdf","grobid_xml":"https://content.openalex.org/works/W4400964474.grobid-xml"},"referenced_works_count":85,"referenced_works":["https://openalex.org/W1557005889","https://openalex.org/W1557660450","https://openalex.org/W1561144079","https://openalex.org/W1797736032","https://openalex.org/W1828538530","https://openalex.org/W1974224579","https://openalex.org/W1978303655","https://openalex.org/W1982388019","https://openalex.org/W1986959846","https://openalex.org/W2001835393","https://openalex.org/W2002074089","https://openalex.org/W2002841699","https://openalex.org/W2008663231","https://openalex.org/W2010391271","https://openalex.org/W2023055592","https://openalex.org/W2028405984","https://openalex.org/W2028541643","https://openalex.org/W2029821777","https://openalex.org/W2033269723","https://openalex.org/W2035466313","https://openalex.org/W2039821827","https://openalex.org/W2043407651","https://openalex.org/W2046345642","https://openalex.org/W2047387084","https://openalex.org/W2048790339","https://openalex.org/W2051508159","https://openalex.org/W2053124111","https://openalex.org/W2054750416","https://openalex.org/W2059445871","https://openalex.org/W2064063251","https://openalex.org/W2068344738","https://openalex.org/W2073094854","https://openalex.org/W2077338272","https://openalex.org/W2086230387","https://openalex.org/W2086925294","https://openalex.org/W2090737759","https://openalex.org/W2103186609","https://openalex.org/W2106188323","https://openalex.org/W2106531784","https://openalex.org/W2128969673","https://openalex.org/W2135190897","https://openalex.org/W2135987299","https://openalex.org/W2155667685","https://openalex.org/W2166105988","https://openalex.org/W2416322224","https://openalex.org/W2444168455","https://openalex.org/W2461807154","https://openalex.org/W2561980828","https://openalex.org/W2566853258","https://openalex.org/W2789328564","https://openalex.org/W2801981707","https://openalex.org/W2885924264","https://openalex.org/W2888526386","https://openalex.org/W2890430536","https://openalex.org/W2907012699","https://openalex.org/W2958619441","https://openalex.org/W2964862628","https://openalex.org/W2965425168","https://openalex.org/W3005036587","https://openalex.org/W3008959547","https://openalex.org/W3025636421","https://openalex.org/W3110888695","https://openalex.org/W3127728724","https://openalex.org/W3131646863","https://openalex.org/W3139461084","https://openalex.org/W3142533463","https://openalex.org/W3143313154","https://openalex.org/W3180631374","https://openalex.org/W3198667187","https://openalex.org/W3202576321","https://openalex.org/W4211072901","https://openalex.org/W4220825176","https://openalex.org/W4281820016","https://openalex.org/W4307232559","https://openalex.org/W4311115662","https://openalex.org/W4311242262","https://openalex.org/W4311279323","https://openalex.org/W4311664787","https://openalex.org/W4318474745","https://openalex.org/W4318752902","https://openalex.org/W4321523471","https://openalex.org/W4323043930","https://openalex.org/W4323052117","https://openalex.org/W4323653267","https://openalex.org/W4380052141"],"related_works":["https://openalex.org/W6920957902","https://openalex.org/W4394958565","https://openalex.org/W3023327927","https://openalex.org/W4407041882","https://openalex.org/W4387271841","https://openalex.org/W4390195475","https://openalex.org/W3097684887","https://openalex.org/W2790770934","https://openalex.org/W4378760142","https://openalex.org/W4319338178"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Depressive":[2],"symptoms":[3,121,145],"often":[4],"occur":[5],"in":[6,35,46,70,73,103,125,149],"patients":[7],"with":[8],"Alzheimer's":[9],"disease":[10],"(AD)":[11],"and":[12,38,60,90,122,133,146,172,174],"exacerbate":[13],"the":[14,19,24,81,94,114,119,143,154],"pathogenesis":[15],"of":[16,45,83,105,113,138],"AD.":[17,181],"However,":[18],"neural":[20,116,156],"circuit":[21,69,117,157],"mechanisms":[22],"underlying":[23],"AD-associated":[25,71],"depression":[26,72,171],"remain":[27],"unclear.":[28],"The":[29],"serotonergic":[30,68],"system":[31],"plays":[32],"crucial":[33],"roles":[34],"both":[36,101],"AD":[37,74,173],"depression.":[39],"Methods":[40],"We":[41,78],"used":[42],"a":[43,166],"combination":[44],"vivo":[47],"trans-synaptic":[48],"circuit-dissecting":[49],"anatomical":[50],"approaches,":[51],"chemogenetic":[52],"manipulations,":[53,55],"optogenetic":[54,111],"pharmacological":[56],"methods,":[57],"behavioral":[58],"testing,":[59],"electrophysiological":[61],"recording":[62],"to":[63,93,158],"investigate":[64],"dorsal":[65,84,95],"raphe":[66,85],"nucleus":[67,86],"mouse":[75],"model.":[76],"Results":[77],"found":[79],"that":[80],"activity":[82],"serotonin":[87,129],"neurons":[88],"(DRN5-HT)":[89],"their":[91],"projections":[92],"hippocampal":[96],"CA1":[97],"(dCA1)":[98],"terminals":[99],"(DRN5-HT-dCA1CaMKII)":[100],"decreased":[102],"brains":[104],"early":[106],"5\u00d7FAD":[107,126,150],"mice.":[108],"Chemogenetic":[109],"or":[110,140],"activation":[112,137],"DRN5-HT-dCA1CaMKII":[115,155],"attenuated":[118,142],"depressive":[120,144],"cognitive":[123,147],"impairments":[124,148],"mice":[127,151],"through":[128],"receptor":[130],"1B":[131],"(5-HT1BR)":[132],"4":[134],"(5-HT4R).":[135],"Pharmacological":[136],"5-HT1BR":[139],"5-HT4R":[141],"by":[152],"regulating":[153],"improve":[159],"synaptic":[160],"plasticity.":[161],"Conclusions":[162],"These":[163],"findings":[164],"provide":[165,175],"new":[167],"mechanistic":[168],"connection":[169],"between":[170],"potential":[176],"pharmaceutical":[177],"prevention":[178],"targets":[179],"for":[180]},"counts_by_year":[{"year":2026,"cited_by_count":16},{"year":2025,"cited_by_count":16}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2024-07-25T00:00:00"}
