{"id":"https://openalex.org/W4400949161","doi":"https://doi.org/10.1038/s41586-024-07816-z","title":"Neural circuit basis of placebo pain relief","display_name":"Neural circuit basis of placebo pain relief","publication_year":2024,"publication_date":"2024-07-24","ids":{"openalex":"https://openalex.org/W4400949161","doi":"https://doi.org/10.1038/s41586-024-07816-z","pmid":"https://pubmed.ncbi.nlm.nih.gov/39048016","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11358037"},"language":"en","primary_location":{"id":"doi:10.1038/s41586-024-07816-z","doi":"https://doi.org/10.1038/s41586-024-07816-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41586-024-07816-z","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1038/s41586-024-07816-z","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Chong Chen","orcid":"https://orcid.org/0000-0002-8420-1410","observed_orcids":["https://orcid.org/0000-0002-8420-1410"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chong Chen","raw_affiliation_strings":["Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","UNC Neuroscience Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":"https://orcid.org/0000-0002-8420-1410","affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"UNC Neuroscience Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086685365","display_name":"Jesse K. Niehaus","orcid":"https://orcid.org/0000-0002-6800-4134","observed_orcids":["https://orcid.org/0000-0002-6800-4134"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jesse K. Niehaus","raw_affiliation_strings":["Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","UNC Neuroscience Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"UNC Neuroscience Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005311282","display_name":"Fatih Din\u00e7","orcid":"https://orcid.org/0000-0003-0921-0162","observed_orcids":["https://orcid.org/0000-0003-0921-0162"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fatih Dinc","raw_affiliation_strings":["CNC Program, Stanford University, Stanford, CA, USA","Department of Applied Physics, Stanford University, Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNC Program, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Applied Physics, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089738221","display_name":"Karen L. Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen L. Huang","raw_affiliation_strings":["Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","UNC Neuroscience Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"UNC Neuroscience Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058979284","display_name":"Alexander L. Barnette","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander L. Barnette","raw_affiliation_strings":["Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","UNC Neuroscience Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"UNC Neuroscience Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017149105","display_name":"Adrien Tassou","orcid":"https://orcid.org/0000-0003-2148-553X","observed_orcids":["https://orcid.org/0000-0003-2148-553X"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adrien Tassou","raw_affiliation_strings":["Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","UNC Neuroscience Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":"https://orcid.org/0000-0003-2148-553X","affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"UNC Neuroscience Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051259632","display_name":"S. Andrew Shuster","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Andrew Shuster","raw_affiliation_strings":["Department of Neurobiology, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lihua Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I195573530","display_name":"Janelia Research Campus","ror":"https://ror.org/013sk6x84","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410","https://openalex.org/I195573530"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lihua Wang","raw_affiliation_strings":["Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I195573530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069615450","display_name":"Andrew L. Lemire","orcid":"https://orcid.org/0000-0002-0624-3789","observed_orcids":["https://orcid.org/0000-0002-0624-3789"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I195573530","display_name":"Janelia Research Campus","ror":"https://ror.org/013sk6x84","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410","https://openalex.org/I195573530"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Lemire","raw_affiliation_strings":["Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA"],"raw_orcid":"https://orcid.org/0000-0002-0624-3789","affiliations":[{"raw_affiliation_string":"Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I195573530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013606443","display_name":"Vilas Menon","orcid":"https://orcid.org/0000-0002-4096-8601","observed_orcids":["https://orcid.org/0000-0002-4096-8601"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vilas Menon","raw_affiliation_strings":["Department of Neurology, Columbia University, New York, NY, USA"],"raw_orcid":"https://orcid.org/0000-0002-4096-8601","affiliations":[{"raw_affiliation_string":"Department of Neurology, Columbia University, New York, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009172988","display_name":"Kimberly Ritola","orcid":"https://orcid.org/0000-0002-5666-2973","observed_orcids":["https://orcid.org/0000-0002-5666-2973"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimberly Ritola","raw_affiliation_strings":["Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","UNC Neuroscience Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"UNC Neuroscience Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045731954","display_name":"Adam W. Hantman","orcid":"https://orcid.org/0000-0002-6563-1423","observed_orcids":["https://orcid.org/0000-0002-6563-1423"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam W. Hantman","raw_affiliation_strings":["Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","UNC Neuroscience Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"UNC Neuroscience Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010189175","display_name":"Hongkui Zeng","orcid":"https://orcid.org/0000-0002-0326-5878","observed_orcids":["https://orcid.org/0000-0002-0326-5878"]},"institutions":[{"id":"https://openalex.org/I1314596251","display_name":"Allen Institute for Brain Science","ror":"https://ror.org/00dcv1019","country_code":"US","type":"facility","lineage":["https://openalex.org/I1314596251","https://openalex.org/I4210140341"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongkui Zeng","raw_affiliation_strings":["Allen Institute for Brain Science, Seattle, WA, USA"],"raw_orcid":"https://orcid.org/0000-0002-0326-5878","affiliations":[{"raw_affiliation_string":"Allen Institute for Brain Science, Seattle, WA, USA","institution_ids":["https://openalex.org/I1314596251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009631067","display_name":"Mark J. Schnitzer","orcid":"https://orcid.org/0000-0002-1431-8533","observed_orcids":["https://orcid.org/0000-0002-1431-8533"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark J. Schnitzer","raw_affiliation_strings":["CNC Program, Stanford University, Stanford, CA, USA","Department of Applied Physics, Stanford University, Stanford, CA, USA","Department of Biology, Stanford University, Stanford, CA, USA","Department of Neurosurgery, Stanford University, Stanford, CA, USA","Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA","James H. Clark Center for Biomedical Engineering & Sciences, Stanford University, Stanford, CA, USA"],"raw_orcid":"https://orcid.org/0000-0002-1431-8533","affiliations":[{"raw_affiliation_string":"CNC Program, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Applied Physics, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Biology, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Neurosurgery, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I97018004"]},{"raw_affiliation_string":"James H. Clark Center for Biomedical Engineering & Sciences, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052695181","display_name":"Gr\u00e9gory Scherrer","orcid":"https://orcid.org/0000-0002-1983-5126","observed_orcids":["https://orcid.org/0000-0002-1983-5126"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gr\u00e9gory Scherrer","raw_affiliation_strings":["Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. gregory_scherrer@med.unc.edu","Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. gregory_scherrer@med.unc.edu","UNC Neuroscience Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. gregory_scherrer@med.unc.edu","Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":"https://orcid.org/0000-0002-1983-5126","affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. gregory_scherrer@med.unc.edu","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. gregory_scherrer@med.unc.edu","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"UNC Neuroscience Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. gregory_scherrer@med.unc.edu","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5052695181"],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":{"value":12290,"currency":"USD","value_usd":12290},"apc_paid":{"value":12290,"currency":"USD","value_usd":12290},"fwci":18.7583,"has_fulltext":false,"cited_by_count":86,"citation_normalized_percentile":{"value":0.99814931,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"632","issue":"8027","first_page":"1092","last_page":"1100"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12035","display_name":"Pain Management and Placebo Effect","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12035","display_name":"Pain Management and Placebo Effect","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.00930000003427267,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/placebo-analgesia","display_name":"placebo analgesia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/rostral-anterior-cingulate-cortex","display_name":"rostral anterior cingulate cortex","score":0.9350000023841858},{"id":"https://openalex.org/keywords/pontine-nuclei","display_name":"pontine nuclei","score":0.9959999918937683},{"id":"https://openalex.org/keywords/purkinje-cells","display_name":"Purkinje cells","score":0.7269999980926514},{"id":"https://openalex.org/keywords/cerebellum","display_name":"cerebellum","score":0.7289999723434448},{"id":"https://openalex.org/keywords/opioid-receptors","display_name":"opioid receptors","score":0.7480000257492065},{"id":"https://openalex.org/keywords/pain-expectation","display_name":"pain anticipation","score":0.574999988079071},{"id":"https://openalex.org/keywords/pain-threshold","display_name":"pain threshold","score":0.3269999921321869}],"concepts":[{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7412590384483337},{"id":"https://openalex.org/C2993247534","wikidata":"https://www.wikidata.org/wiki/Q621261","display_name":"Pain relief","level":2,"score":0.5655689239501953},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4463457763195038},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3853105306625366},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3795030117034912},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.23267194628715515},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.11135265231132507},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08043354749679565}],"mesh":[{"descriptor_ui":"D000698","descriptor_name":"Analgesia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006179","descriptor_name":"Gyrus Cinguli","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006179","descriptor_name":"Gyrus Cinguli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009434","descriptor_name":"Neural Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D011149","descriptor_name":"Pons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D011149","descriptor_name":"Pons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011689","descriptor_name":"Purkinje Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011957","descriptor_name":"Receptors, Opioid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015990","descriptor_name":"Placebo Effect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017288","descriptor_name":"Pain Threshold","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017288","descriptor_name":"Pain Threshold","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058748","descriptor_name":"Pain Perception","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D059031","descriptor_name":"Anticipation, Psychological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D059408","descriptor_name":"Pain Management","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059408","descriptor_name":"Pain Management","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D059408","descriptor_name":"Pain Management","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41586-024-07816-z","doi":"https://doi.org/10.1038/s41586-024-07816-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41586-024-07816-z","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11358037","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11358037","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"Text"},{"id":"pmid:39048016","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39048016","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:nat:nature:v:632:y:2024:i:8027:d:10.1038_s41586-024-07816-z","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41586-024-07816-z","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41586-024-07816-z","doi":"https://doi.org/10.1038/s41586-024-07816-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41586-024-07816-z","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1507193343","display_name":"Targeting GPCRs in amygdalar and cortical neural ensembles to treat pain aversion","funder_award_id":"R01NS118504","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7132948261","display_name":"Amygdala mechanisms of pain aversion","funder_award_id":"R01NS106301","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000902911","display_name":"A comprehensive dissection of cell types, circuits and molecular adaptations during opioid use","funder_award_id":"R01DA054583","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G9000917579","display_name":"Characterizing the connectivity and molecular composition of opioid-sensitive neurons in the periaqueductal gray","funder_award_id":"F32DA057779","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":73,"referenced_works":["https://openalex.org/W1518596071","https://openalex.org/W1526791253","https://openalex.org/W1858802571","https://openalex.org/W1899857231","https://openalex.org/W1969282585","https://openalex.org/W1976435105","https://openalex.org/W1976846134","https://openalex.org/W1986801115","https://openalex.org/W1987971958","https://openalex.org/W1989177035","https://openalex.org/W1995360097","https://openalex.org/W2003950330","https://openalex.org/W2004133746","https://openalex.org/W2012571406","https://openalex.org/W2013135848","https://openalex.org/W2020677557","https://openalex.org/W2025663766","https://openalex.org/W2045812316","https://openalex.org/W2055646391","https://openalex.org/W2070893697","https://openalex.org/W2075715972","https://openalex.org/W2077374589","https://openalex.org/W2084072056","https://openalex.org/W2088980803","https://openalex.org/W2094347820","https://openalex.org/W2096416725","https://openalex.org/W2103393785","https://openalex.org/W2106207830","https://openalex.org/W2111663549","https://openalex.org/W2131938193","https://openalex.org/W2135382170","https://openalex.org/W2157903425","https://openalex.org/W2168067765","https://openalex.org/W2169456326","https://openalex.org/W2172201406","https://openalex.org/W2336480635","https://openalex.org/W2443156510","https://openalex.org/W2510746232","https://openalex.org/W2561980828","https://openalex.org/W2574480161","https://openalex.org/W2595087345","https://openalex.org/W2763027666","https://openalex.org/W2767493153","https://openalex.org/W2781822280","https://openalex.org/W2786017571","https://openalex.org/W2791401629","https://openalex.org/W2804230025","https://openalex.org/W2886720387","https://openalex.org/W2887114371","https://openalex.org/W2887387063","https://openalex.org/W2887789520","https://openalex.org/W2890125899","https://openalex.org/W2897395006","https://openalex.org/W2903618123","https://openalex.org/W2904345154","https://openalex.org/W2908670724","https://openalex.org/W2920761311","https://openalex.org/W2929898295","https://openalex.org/W2950849463","https://openalex.org/W3012587076","https://openalex.org/W3049305214","https://openalex.org/W3092754847","https://openalex.org/W3096332317","https://openalex.org/W3117290853","https://openalex.org/W3134682531","https://openalex.org/W3157082924","https://openalex.org/W3162218953","https://openalex.org/W3164692211","https://openalex.org/W3198310432","https://openalex.org/W3214642075","https://openalex.org/W4212917819","https://openalex.org/W4312190896","https://openalex.org/W4388216802"],"related_works":["https://openalex.org/W4407830935","https://openalex.org/W53299543","https://openalex.org/W7151932656","https://openalex.org/W7058551353","https://openalex.org/W4411791944","https://openalex.org/W2020677557","https://openalex.org/W2312363293","https://openalex.org/W7154629232","https://openalex.org/W7096071543","https://openalex.org/W2094347820"],"abstract_inverted_index":{"Placebo":[0],"effects":[1,39,62],"are":[2],"notable":[3],"demonstrations":[4],"of":[5,14,19,26,37,50,60,74,118,130,136,147,153,164,182,193,205,217,234],"mind\u2013body":[6],"interactions1,2.":[7],"During":[8],"pain":[9,20,75,110,131,161,173,210,235],"perception,":[10],"in":[11,99,112,124,142,160,179,208],"the":[12,24,35,48,56,72,89,134,165,180,206,215,232,248],"absence":[13,181],"any":[15],"treatment,":[16],"an":[17,151],"expectation":[18,73,233],"relief":[21,76,111,132,236],"can":[22],"reduce":[23],"experience":[25,46],"pain\u2014a":[27],"phenomenon":[28],"known":[29],"as":[30],"placebo":[31,38,61,169,183],"analgesia3\u20136.":[32],"However,":[33],"despite":[34],"strength":[36],"and":[40,47,121,139,171],"their":[41],"impact":[42],"on":[43],"everyday":[44],"human":[45],"failure":[49],"clinical":[51],"trials":[52],"for":[53,202],"new":[54],"therapeutics7,":[55],"neural":[57,119],"circuit":[58],"basis":[59],"has":[63],"remained":[64],"unclear.":[65],"Here":[66],"we":[67],"show":[68],"that":[69,86,106,128,245],"analgesia":[70,170,178],"from":[71,231],"is":[77,237],"mediated":[78,238],"by":[79,239],"rostral":[80,240],"anterior":[81,241],"cingulate":[82,242],"cortex":[83,243],"(rACC)":[84],"neurons":[85,138,149,195,244],"project":[87,246],"to":[88,227,247],"pontine":[90,249],"nucleus":[91,94],"(rACC\u2192Pn)\u2014a":[92],"precerebellar":[93],"with":[95,223],"no":[96],"established":[97],"function":[98],"pain.":[100,229],"We":[101],"created":[102],"a":[103,158,203],"behavioural":[104],"assay":[105],"generates":[107],"placebo-like":[108],"anticipatory":[109],"mice.":[113],"In":[114],"vivo":[115],"calcium":[116],"imaging":[117],"activity":[120,135,189],"electrophysiological":[122],"recordings":[123],"brain":[125],"slices":[126],"showed":[127],"expectations":[129],"boost":[133],"rACC\u2192Pn":[137,166,194],"potentiate":[140],"neurotransmission":[141],"this":[143,219],"pathway.":[144],"Transcriptomic":[145],"studies":[146],"Pn":[148],"revealed":[150],"abundance":[152],"opioid":[154],"receptors,":[155],"further":[156],"suggesting":[157],"role":[159,204],"modulation.":[162,211],"Inhibition":[163],"pathway":[167,222],"disrupted":[168],"decreased":[172],"thresholds,":[174],"whereas":[175],"activation":[176],"elicited":[177],"conditioning.":[184],"Finally,":[185],"Purkinje":[186],"cells":[187],"exhibited":[188],"patterns":[190],"resembling":[191],"those":[192],"during":[196],"pain-relief":[197],"expectation,":[198],"providing":[199],"cellular-level":[200],"evidence":[201],"cerebellum":[207],"cognitive":[209],"These":[212],"findings":[213],"open":[214],"possibility":[216],"targeting":[218],"prefrontal":[220],"cortico-ponto-cerebellar":[221],"drugs":[224],"or":[225],"neurostimulation":[226],"treat":[228],"Analgesia":[230],"nucleus.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":35},{"year":2025,"cited_by_count":41},{"year":2024,"cited_by_count":10}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-07-25T00:00:00"}
