{"id":"https://openalex.org/W4400937331","doi":"https://doi.org/10.1055/s-0044-1788734","title":"Heparin-Like Anticoagulant: First Case Described in a Metastatic Biliopancreatic Cancer","display_name":"Heparin-Like Anticoagulant: First Case Described in a Metastatic Biliopancreatic Cancer","publication_year":2024,"publication_date":"2024-07-24","ids":{"openalex":"https://openalex.org/W4400937331","doi":"https://doi.org/10.1055/s-0044-1788734","pmid":"https://pubmed.ncbi.nlm.nih.gov/39047992"},"language":"en","primary_location":{"id":"doi:10.1055/s-0044-1788734","doi":"https://doi.org/10.1055/s-0044-1788734","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0044-1788734","pdf_url":null,"source":{"id":"https://openalex.org/S96726197","display_name":"Seminars in Thrombosis and Hemostasis","issn_l":"0094-6176","issn":["0094-6176","1098-9064"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Thrombosis and Hemostasis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041431700","display_name":"Rosana Raimondi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]},{"id":"https://openalex.org/I4210119967","display_name":"Hospital de Cl\u00ednicas \"Jos\u00e9 de San Mart\u00edn\"","ror":"https://ror.org/02hbrab76","country_code":"AR","type":"healthcare","lineage":["https://openalex.org/I4210119967"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Rosana Raimondi","raw_affiliation_strings":["Bioqu\u00edmica Cl\u00ednica II, Departamento de Bioqu\u00edmica Cl\u00ednica, Facultad de Farmacia y Bioqu\u00edmica, Universidad de Buenos Aires, Buenos Aires, Argentina","Laboratorio de Hemostasia, Departamento de Bioqu\u00edmica Cl\u00ednica, Hospital de Cl\u00ednicas \u201cJos\u00e9 de San Mart\u00edn,\u201d Universidad de Buenos Aires. Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioqu\u00edmica Cl\u00ednica II, Departamento de Bioqu\u00edmica Cl\u00ednica, Facultad de Farmacia y Bioqu\u00edmica, Universidad de Buenos Aires, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I24354313"]},{"raw_affiliation_string":"Laboratorio de Hemostasia, Departamento de Bioqu\u00edmica Cl\u00ednica, Hospital de Cl\u00ednicas \u201cJos\u00e9 de San Mart\u00edn,\u201d Universidad de Buenos Aires. Buenos Aires, Argentina","institution_ids":["https://openalex.org/I24354313","https://openalex.org/I4210119967"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108282075","display_name":"Sof\u00eda Aguirre","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]},{"id":"https://openalex.org/I4210119967","display_name":"Hospital de Cl\u00ednicas \"Jos\u00e9 de San Mart\u00edn\"","ror":"https://ror.org/02hbrab76","country_code":"AR","type":"healthcare","lineage":["https://openalex.org/I4210119967"]}],"countries":["AR"],"is_corresponding":true,"raw_author_name":"Sofia Aguirre","raw_affiliation_strings":["Bioqu\u00edmica Cl\u00ednica II, Departamento de Bioqu\u00edmica Cl\u00ednica, Facultad de Farmacia y Bioqu\u00edmica, Universidad de Buenos Aires, Buenos Aires, Argentina","Laboratorio de Hemostasia, Departamento de Bioqu\u00edmica Cl\u00ednica, Hospital de Cl\u00ednicas \u201cJos\u00e9 de San Mart\u00edn,\u201d Universidad de Buenos Aires. Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioqu\u00edmica Cl\u00ednica II, Departamento de Bioqu\u00edmica Cl\u00ednica, Facultad de Farmacia y Bioqu\u00edmica, Universidad de Buenos Aires, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I24354313"]},{"raw_affiliation_string":"Laboratorio de Hemostasia, Departamento de Bioqu\u00edmica Cl\u00ednica, Hospital de Cl\u00ednicas \u201cJos\u00e9 de San Mart\u00edn,\u201d Universidad de Buenos Aires. Buenos Aires, Argentina","institution_ids":["https://openalex.org/I24354313","https://openalex.org/I4210119967"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Valeria Monserrat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]},{"id":"https://openalex.org/I4210119967","display_name":"Hospital de Cl\u00ednicas \"Jos\u00e9 de San Mart\u00edn\"","ror":"https://ror.org/02hbrab76","country_code":"AR","type":"healthcare","lineage":["https://openalex.org/I4210119967"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Valeria Monserrat","raw_affiliation_strings":["Bioqu\u00edmica Cl\u00ednica II, Departamento de Bioqu\u00edmica Cl\u00ednica, Facultad de Farmacia y Bioqu\u00edmica, Universidad de Buenos Aires, Buenos Aires, Argentina","Laboratorio de Hemostasia, Departamento de Bioqu\u00edmica Cl\u00ednica, Hospital de Cl\u00ednicas \u201cJos\u00e9 de San Mart\u00edn,\u201d Universidad de Buenos Aires. Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioqu\u00edmica Cl\u00ednica II, Departamento de Bioqu\u00edmica Cl\u00ednica, Facultad de Farmacia y Bioqu\u00edmica, Universidad de Buenos Aires, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I24354313"]},{"raw_affiliation_string":"Laboratorio de Hemostasia, Departamento de Bioqu\u00edmica Cl\u00ednica, Hospital de Cl\u00ednicas \u201cJos\u00e9 de San Mart\u00edn,\u201d Universidad de Buenos Aires. Buenos Aires, Argentina","institution_ids":["https://openalex.org/I24354313","https://openalex.org/I4210119967"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108311782","display_name":"Silvina Pons","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]},{"id":"https://openalex.org/I4210119967","display_name":"Hospital de Cl\u00ednicas \"Jos\u00e9 de San Mart\u00edn\"","ror":"https://ror.org/02hbrab76","country_code":"AR","type":"healthcare","lineage":["https://openalex.org/I4210119967"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Silvina Pons","raw_affiliation_strings":["Bioqu\u00edmica Cl\u00ednica II, Departamento de Bioqu\u00edmica Cl\u00ednica, Facultad de Farmacia y Bioqu\u00edmica, Universidad de Buenos Aires, Buenos Aires, Argentina","Laboratorio de Hemostasia, Departamento de Bioqu\u00edmica Cl\u00ednica, Hospital de Cl\u00ednicas \u201cJos\u00e9 de San Mart\u00edn,\u201d Universidad de Buenos Aires. Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioqu\u00edmica Cl\u00ednica II, Departamento de Bioqu\u00edmica Cl\u00ednica, Facultad de Farmacia y Bioqu\u00edmica, Universidad de Buenos Aires, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I24354313"]},{"raw_affiliation_string":"Laboratorio de Hemostasia, Departamento de Bioqu\u00edmica Cl\u00ednica, Hospital de Cl\u00ednicas \u201cJos\u00e9 de San Mart\u00edn,\u201d Universidad de Buenos Aires. Buenos Aires, Argentina","institution_ids":["https://openalex.org/I24354313","https://openalex.org/I4210119967"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050042789","display_name":"Dami\u00e1n M Contardo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]},{"id":"https://openalex.org/I4210119967","display_name":"Hospital de Cl\u00ednicas \"Jos\u00e9 de San Mart\u00edn\"","ror":"https://ror.org/02hbrab76","country_code":"AR","type":"healthcare","lineage":["https://openalex.org/I4210119967"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Damian Contardo","raw_affiliation_strings":["Departamento de Medicina, Hospital de Cl\u00ednicas \u201cJos\u00e9 de San Mart\u00edn,\u201d Universidad de Buenos Aires, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Medicina, Hospital de Cl\u00ednicas \u201cJos\u00e9 de San Mart\u00edn,\u201d Universidad de Buenos Aires, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I24354313","https://openalex.org/I4210119967"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111635976","display_name":"Alejandra Scazziota","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]},{"id":"https://openalex.org/I4210119967","display_name":"Hospital de Cl\u00ednicas \"Jos\u00e9 de San Mart\u00edn\"","ror":"https://ror.org/02hbrab76","country_code":"AR","type":"healthcare","lineage":["https://openalex.org/I4210119967"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Alejandra Scazziota","raw_affiliation_strings":["Bioqu\u00edmica Cl\u00ednica II, Departamento de Bioqu\u00edmica Cl\u00ednica, Facultad de Farmacia y Bioqu\u00edmica, Universidad de Buenos Aires, Buenos Aires, Argentina","Laboratorio de Hemostasia, Departamento de Bioqu\u00edmica Cl\u00ednica, Hospital de Cl\u00ednicas \u201cJos\u00e9 de San Mart\u00edn,\u201d Universidad de Buenos Aires. Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioqu\u00edmica Cl\u00ednica II, Departamento de Bioqu\u00edmica Cl\u00ednica, Facultad de Farmacia y Bioqu\u00edmica, Universidad de Buenos Aires, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I24354313"]},{"raw_affiliation_string":"Laboratorio de Hemostasia, Departamento de Bioqu\u00edmica Cl\u00ednica, Hospital de Cl\u00ednicas \u201cJos\u00e9 de San Mart\u00edn,\u201d Universidad de Buenos Aires. Buenos Aires, Argentina","institution_ids":["https://openalex.org/I24354313","https://openalex.org/I4210119967"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5108282075"],"corresponding_institution_ids":["https://openalex.org/I24354313","https://openalex.org/I4210119967"],"apc_list":null,"apc_paid":null,"fwci":0.2978,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.56385738,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"51","issue":"05","first_page":"623","last_page":"625"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.4187000095844269,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.4187000095844269,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.2289000004529953,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12352","display_name":"Heparin-Induced Thrombocytopenia and Thrombosis","score":0.04729999974370003,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heparin-like-anticoagulant","display_name":"heparin-like anticoagulant","score":0.9380000233650208},{"id":"https://openalex.org/keywords/metastatic-pancreatic-cancer","display_name":"metastatic pancreatic cancer","score":0.8240000009536743},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.7229999899864197},{"id":"https://openalex.org/keywords/anemia","display_name":"anemia","score":0.6209999918937683},{"id":"https://openalex.org/keywords/prolonged-activated-partial-thromboplastin-time","display_name":"prolonged activated partial thromboplastin time","score":0.8159999847412109},{"id":"https://openalex.org/keywords/anti-xa-activity","display_name":"anti-Xa activity","score":0.8820000290870667},{"id":"https://openalex.org/keywords/therapeutic-plasma-exchange","display_name":"plasma exchange","score":0.31700000166893005},{"id":"https://openalex.org/keywords/anticoagulation-reversal","display_name":"anticoagulant reversal","score":0.43799999356269836}],"concepts":[{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.7141733169555664},{"id":"https://openalex.org/C2778205648","wikidata":"https://www.wikidata.org/wiki/Q215118","display_name":"Anticoagulant","level":2,"score":0.6740736961364746},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6456799507141113},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.451454758644104},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.43763408064842224},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36695563793182373},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.32573816180229187}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1055/s-0044-1788734","doi":"https://doi.org/10.1055/s-0044-1788734","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0044-1788734","pdf_url":null,"source":{"id":"https://openalex.org/S96726197","display_name":"Seminars in Thrombosis and Hemostasis","issn_l":"0094-6176","issn":["0094-6176","1098-9064"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Thrombosis and Hemostasis","raw_type":"journal-article"},{"id":"pmid:39047992","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39047992","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in thrombosis and hemostasis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W81116470","https://openalex.org/W2029186758","https://openalex.org/W2080368470","https://openalex.org/W2418046184","https://openalex.org/W2997066936","https://openalex.org/W3115596436","https://openalex.org/W4220921137","https://openalex.org/W4297826890"],"related_works":["https://openalex.org/W2883455999","https://openalex.org/W1557699647","https://openalex.org/W1967761149","https://openalex.org/W2418046184","https://openalex.org/W2463710937","https://openalex.org/W1827182319","https://openalex.org/W3115596436","https://openalex.org/W2080368470","https://openalex.org/W2139318160","https://openalex.org/W3104309818"],"abstract_inverted_index":{"The":[0,194,248,455,693,853,882,903,929,953,1000,1223],"development":[1],"of":[2,38,58,62,85,121,124,146,164,174,183,201,214,224,231,237,281,287,304,316,384,450,464,469,485,491,501,519,560,568,574,583,665,696,782,805,807,855,865,871,878,893,922,931,950,955,987,1003,1014,1073,1080,1096,1106,1133,1144,1185,1195,1213,1219,1225],"acquired":[3],"heparin-like":[4,40,282,319,428,784,880,894,1034,1200,1214],"anticoagulants":[5,726,1035,1215],"in":[6,42,188,403,461,516,597,767,862,898,911,919,969,981,1037,1083,1130,1149,1163,1216],"vivo":[7],"is":[8,962,1085,1120,1207],"an":[9,233,404,666],"extremely":[10,266],"rare":[11],"condition":[12],"that":[13,95,294,671,809,1077,1110,1125],"has":[14,818,1146],"been":[15,728,765,787,819,1147],"associated":[16,732,820],"with":[17,47,54,253,257,284,600,711,733,821,837,851,926,946,1165,1168,1198],"hematological":[18,734],"malignancies":[19],"and":[20,28,60,74,88,92,112,140,157,239,268,277,306,394,411,577,579,595,658,683,717,722,742,746,753,773,792,829,845,857,869,989,993,1006,1063,1137,1140],"other":[21,747],"neoplastic":[22],"processes":[23],"such":[24,736],"as":[25,171,737,789,1101,1103],"bladder,":[26],"breast,":[27],"hepatocellular":[29],"carcinoma.[":[30],"1":[31,246,324,755,776],"]":[32,523,603,756,759,777,780,978,1040,1043,1046,1049,1153,1172],"We":[33],"report":[34],"here":[35],"the":[36,147,175,189,279,295,314,427,479,489,651,803,863,876,891,899,923,939,947,956,1004,1012,1015,1074,1078,1093,1104,1115,1131,1182,1192,1211],"finding":[37],"a":[39,43,55,172,180,198,202,217,227,240,254,285,317,437,482,492,499,522,548,572,580,602,636,675,690,704,838,846,858,879,963,985,1107,1121,1127,1196,1199],"anticoagulant":[41,320,422,957,1201],"young":[44],"patient":[45,195,296,569,652,694,832,1197],"diagnosed":[46],"metastatic":[48],"biliopancreatic":[49,707],"adenocarcinoma.":[50],"A":[51,132,150,467],"45-year-old":[52],"male":[53],"previous":[56,445],"history":[57],"alcoholism":[59],"smoking":[61],"66":[63],"packs-years":[64],"was":[65,130,153,169,192,265,271,275,292,297,321,423,441,453,458,474,662,681,686,906,916,935,991,998,1020,1059,1068,1157,1228],"admitted":[66],"to":[67,70,76,443,476,565,689,795,826,875,890,942,958,966,971,1011,1033,1181,1203,1209],"hospital":[68],"due":[69,688],"dyspnea":[71],"on":[72,551,639,655],"effort":[73],"inability":[75],"move":[77],"his":[78],"left":[79,148,659],"arm.":[80,149],"Patient":[81,329,531],"referred":[82],"weight":[83],"loss":[84],"30":[86],"kg":[87],"occasional":[89],"nausea,":[90],"vomiting,":[91],"night":[93],"sweats":[94],"evolved":[96],"over":[97],"several":[98],"months.":[99],"Initial":[100,211],"laboratory":[101,212,835,1174],"tests":[102,400],"showed":[103,161,833],"thrombocytopenia":[104],"(platelet":[105],"count":[106],"19":[107,357],"\u00d7":[108],"10":[109],"9":[110],"/L)":[111],"severe":[113],"anemia":[114],"(hemoglobin":[115],"5.2":[116],"g/dL),":[117],"which":[118],"required":[119,475,934],"transfusion":[120],"2":[122,508,511,977],"units":[123],"red":[125],"blood":[126,439],"cells.":[127],"No":[128,167,678],"bleeding":[129,670,1031,1053],"reported.":[131],"chest":[133],"computed":[134],"tomography":[135],"reported":[136,170,766,1148],"cervical":[137,203],"lymphadenopathy,":[138],"mediastinal":[139],"axillar":[141],"masses":[142],"generating":[143],"functional":[144],"impairment":[145],"lymphoproliferative":[151],"syndrome":[152],"suspected.":[154,322],"Flow":[155],"cytometry":[156],"bone":[158,176,190,718],"marrow":[159,177,191],"smear":[160],"no":[162,663,994,1065],"evidence":[163,664],"oncohematological":[165],"disease.":[166],"bruising":[168],"result":[173,286,840,886],"examination.":[178],"However,":[179],"massive":[181],"infiltration":[182],"nonhematological":[184],"malignant":[185],"tumor":[186,1099],"cells":[187],"observed.":[193],"also":[196],"underwent":[197],"surgical":[199],"procedure":[200],"lymph":[204],"node":[205],"biopsy":[206],"without":[207,849,1060],"any":[208,302],"hemostatic":[209],"complications.":[210],"assessment":[213],"hemostasis":[215],"revealed":[216,703,1076],"prolonged":[218,267,456,847],"activated":[219,367,632],"partial":[220,368,633],"thromboplastin":[221,369,634],"time":[222,229,263,270,351,356,513,609],"(aPTT)":[223],"67":[225,333,339],"seconds,":[226],"prothrombin":[228,376],"(PT)":[230],"67%,":[232],"international":[234,372],"normalized":[235,373,459,917],"ratio":[236,343,620],"1.31,":[238],"normal":[241,258,414,843],"fibrinogen":[242],"level":[243,500],"([":[244,506,586],"Table":[245,323,507,510,587,590],"]).":[247,509,589],"aPTT":[249,338,578,614,848,988,1005],"did":[250,1054],"not":[251,298,417,424,1086],"correct":[252,478],"1:1":[255],"mix":[256],"pooled":[259],"plasma":[260,382,532,570,925],"(NPP).":[261],"Thrombin":[262,350,512,527,608],"(TT)":[264],"reptilase":[269],"normal.":[272],"Anti-Xa":[273,360,624],"activity":[274,283,361,396,429,449,505,585,625,861,997],"assessed":[276],"established":[278,687],"presence":[280,315],"0.30":[288,362],"IU/mL.":[289],"As":[290],"it":[291],"confirmed":[293],"receiving":[299],"heparin":[300,312,497,808,872,973],"by":[301,431,896,909,960,1098,1230],"route":[303],"administration":[305],"preanalytical":[307],"errors":[308],"were":[309,397,401,412],"excluded":[310],"(including":[311],"contamination),":[313],"circulating":[318,1108,1183],"Coagulation":[325],"studies":[326],"at":[327,498,1159],"admission":[328],"Reference":[330,606],"interval":[331,607],"PT":[332,839,885,901],"70\u2013110%":[334],"INR":[335],"1.31":[336],"0.94\u20131.27":[337],"30\u201343":[340,617],"s":[341,354,359,613,618],"aPTT,":[342,366,619,631],"1.84":[344],"0.82\u20131.18":[345,623],"Fibrinogen":[346],"3.21":[347],"2\u20134":[348],"g/L":[349],"156":[352],"24\u201328":[353,612],"Reptilase":[355],"17\u201321":[358],"<0.10":[363,627,628],"IU/mL":[364,452,503,629],"Abbreviations:":[365],"time;":[370],"INR,":[371],"ratio;":[374],"PT,":[375],"time.":[377,635],"To":[378],"exclude":[379],"additional":[380,1023],"coagulopathies,":[381],"levels":[383,1162],"factors":[385],"II,":[386],"V,":[387],"VII,":[388],"X,":[389],"VIII,":[390],"IX,":[391],"XI,":[392],"XII,":[393],"antithrombin":[395],"determined.":[398],"All":[399,1246],"performed":[402,425,550,638],"automated":[405],"coagulometer":[406],"STA-Compact":[407],"Max":[408],"(Stago,":[409],"France)":[410],"within":[413,842],"limits":[415],"(data":[416],"shown).":[418],"Testing":[419,549,637],"for":[420,1022],"lupus":[421],"given":[426],"identified":[430,788],"anti-Xa":[432,448,504,584,860,996],"assay.":[433],"Three":[434],"days":[435,556,644,648,700],"later,":[436],"new":[438],"sample":[440,553,641],"drawn":[442],"confirm":[444],"findings.":[446],"An":[447,1070],"0.44":[451,626],"found.":[454,999],"TT":[457,490,576,856,915,990,1007],"after":[460,515,557,596,645,649,918,980],"vitro":[462,517,598,912,920,982],"addition":[463,518],"protamine":[465,483,520,927,932,961],"sulfate.":[466,800,928],"concentration":[468,484,525],"4.5":[470],"antiheparin":[471],"units/mL":[472],"(AHU/mL)":[473,526],"completely":[477],"TT,":[480],"while":[481],"0.45":[486,502,536],"AHU/mL":[487],"corrected":[488],"NPP":[493,530,944],"containing":[494],"commercial":[495,900],"unfractionated":[496,951,972],"results":[514,593],"sulfate[":[521],"Protamine":[524],"time(s)":[528],"Heparinized":[529],"0.00":[533],">300":[534,535,610],"25.5":[537],"153.1":[538],"0.60":[539],"26.1":[540],"119.8":[541],"2.50":[542],"23.1":[543],"32.1":[544],"4.50":[545],"23.5":[546],"26.4":[547],"second":[552,640],"collected":[554,642],"3":[555,588,591,643,699,758,779,1039],"admission.":[558,646],"Addition":[559],"heparanase":[561,983],"(Dade":[562],"Hepzyme,":[563],"Siemens)":[564],"0.5":[566],"mL":[567],"caused":[571],"shortening":[573,986],"both":[575,656],"complete":[581],"neutralization":[582,892,921,959],"Tests":[592],"before":[594],"digestion":[599],"heparanase[":[601],"Before":[604],"After":[605],"33":[611],"115":[615],"54":[616],"3.15":[621],"1.48":[622],"Abbreviation:":[630],"Twelve":[647],"admission,":[650],"developed":[653],"hematomas":[654],"arms":[657],"flank.":[660],"There":[661],"intra":[667],"or":[668,798,974],"retroperitoneal":[669],"could":[672,1176],"have":[673,727,764,786,1028],"explained":[674],"Grey-Turner's":[676],"sign.":[677],"specific":[679,1066],"therapy":[680],"implemented,":[682],"palliative":[684],"care":[685],"terminal":[691],"prognosis.":[692],"died":[695],"cardiopulmonary":[697],"arrest":[698],"later.":[701],"Autopsy":[702],"poorly":[705],"differentiated":[706],"ductal":[708],"adenocarcinoma":[709],"(PDAC)":[710],"multiple":[712,738],"angiolymphatic":[713],"embolism,":[714],"ganglionar":[715],"involvement,":[716],"marrow,":[719],"pleural,":[720],"gastric":[721],"pulmonary":[723],"metastases.":[724],"Heparin-like":[725],"previously":[729],"described,":[730],"typically":[731],"malignancies,":[735],"myeloma,":[739],"systemic":[740,751,827],"mastocytosis,":[741],"chronic":[743],"lymphoid":[744],"leukemia,":[745],"situations":[748],"like":[749],"asthma,":[750],"candidiasis,":[752],"pregnancy.[":[754],"[":[757,778,1041,1044,1047],"Among":[760],"solid":[761],"tumors,":[762],"they":[763],"breast":[768],"carcinoma,":[769,772],"transitional":[770],"cell":[771,1135],"bladder":[774],"cancer.[":[775],"Most":[781],"these":[783],"compounds":[785],"glycosaminoglycans,":[790],"biochemically":[791],"structurally":[793],"similar":[794],"heparin,":[796,868],"keratin,":[797],"chondroitin":[799],"These":[801],"resemble":[802],"mechanism":[804],"action":[806],"inactivates":[810],"coagulation":[811],"proteases":[812],"through":[813],"antithrombin.":[814],"Clinically,":[815],"excessive":[816],"production":[817,1095],"bleeding,":[822],"ranging":[823],"from":[824,1114],"epistaxis":[825],"hemorrhage":[828],"death.":[830],"Our":[831,1173],"initial":[834,883],"testing":[836],"nearly":[841],"range":[844],"correction":[850],"NPP.":[852],"prolongation":[854],"measurable":[859],"absence":[864],"exogenously":[866],"administered":[867],"exclusion":[870],"contamination,":[873],"lead":[874],"suspicion":[877],"event.":[881],"near-normal":[884],"might":[887,1008],"be":[888,1009,1178],"attributed":[889,1010,1032,1180],"substances":[895],"polybrene":[897],"reagent.":[902],"inhibitory":[904],"effect":[905],"further":[907],"characterized":[908],"two":[910],"tests.":[913],"First,":[914],"patient's":[924],"amount":[930,940,949],"sulfate":[933,968,1123],"10-fold":[936],"higher":[937,1161],"than":[938],"needed":[941],"neutralize":[943],"spiked":[945],"same":[948],"heparin.":[952],"resistance":[954],"feature":[964],"ascribed":[965],"heparan":[967,1112,1122],"contrast":[970],"low-molecular-weight":[975],"heparin.[":[976],"Second,":[979],"digestion,":[984],"observed":[992],"residual":[995],"incomplete":[1001],"normalization":[1002],"heterogeneity":[1013],"polysaccharide.":[1016],"Unfortunately,":[1017],"insufficient":[1018],"material":[1019],"available":[1021],"biochemical":[1024],"characterization.":[1025],"Some":[1026,1089],"authors":[1027],"described":[1029],"significant":[1030],"released":[1036],"vivo.[":[1038],"4":[1042],"5":[1045],"6":[1048],"In":[1050,1188],"our":[1051,1231],"case":[1052,1194,1227],"eventually":[1055],"arise,":[1056],"but":[1057],"this":[1058,1186,1217,1226],"hemodynamic":[1061],"compromise":[1062],"therefore":[1064,1177],"treatment":[1067],"implemented.":[1069],"extensive":[1071],"review":[1072],"literature":[1075],"source":[1079,1212],"endogenous":[1081],"heparinoids":[1082],"patients":[1084,1164],"well":[1087,1102],"understood.":[1088],"proposed":[1090],"theories":[1091],"are":[1092],"direct":[1094],"glycosaminoglycans":[1097],"cells,":[1100],"release":[1105],"enzyme":[1109],"cleaves":[1111],"chains":[1113],"endothelial":[1116],"glycocalyx.":[1117],"Syndecan-1":[1118],"(CD138)":[1119],"proteoglycan":[1124],"plays":[1126],"key":[1128],"role":[1129],"modulation":[1132],"cancer":[1134],"proliferation":[1136],"invasion,":[1138],"inflammation,":[1139],"matrix":[1141],"remodeling.":[1142],"Overexpression":[1143],"CD138":[1145,1156],"PDAC":[1150,1166],"tissue.[":[1151],"7":[1152],"Moreover,":[1154],"serum":[1155],"found":[1158],"significantly":[1160],"compared":[1167],"healthy":[1169],"controls.[":[1170],"8":[1171],"findings":[1175],"likely":[1179],"form":[1184],"proteoglycan.":[1187],"conclusion,":[1189],"we":[1190],"describe":[1191],"first":[1193],"related":[1202],"PDAC.":[1204],"Further":[1205],"research":[1206],"necessary":[1208],"investigate":[1210],"type":[1218],"pathology.":[1220],"Ethical":[1221],"Approval":[1222],"publication":[1224],"approved":[1229],"local":[1232],"ethics":[1233],"committee.":[1234],"Publication":[1235],"History":[1236],"Article":[1237],"published":[1238],"online:":[1239],"24":[1240],"July":[1241],"2024":[1242],"\u00a9":[1243],"2024.":[1244],"Thieme.":[1245],"rights":[1247],"reserved.":[1248],"Thieme":[1249],"Medical":[1250],"Publishers,":[1251],"Inc.":[1252],"333":[1253],"Seventh":[1254],"Avenue,":[1255],"18th":[1256],"Floor,":[1257],"New":[1258],"York,":[1259],"NY":[1260],"10001,":[1261],"USA":[1262]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2024-07-25T00:00:00"}
