{"id":"https://openalex.org/W4400934647","doi":"https://doi.org/10.1161/atvb.44.suppl_1.140","title":"Abstract 140: Exploring Protein Kinase C Theta (PKC\u03b8) Signaling In The Generation Of Procoagulant Platelet: Insights From Phosphoproteomics And Systems Analysis","display_name":"Abstract 140: Exploring Protein Kinase C Theta (PKC\u03b8) Signaling In The Generation Of Procoagulant Platelet: Insights From Phosphoproteomics And Systems Analysis","publication_year":2024,"publication_date":"2024-05-01","ids":{"openalex":"https://openalex.org/W4400934647","doi":"https://doi.org/10.1161/atvb.44.suppl_1.140"},"language":"en","primary_location":{"id":"doi:10.1161/atvb.44.suppl_1.140","doi":"https://doi.org/10.1161/atvb.44.suppl_1.140","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/atvb.44.suppl_1.140","pdf_url":null,"source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102615521","display_name":"Yiheng Zheng","orcid":"https://orcid.org/0009-0003-9539-6940","observed_orcids":["https://orcid.org/0009-0003-9539-6940"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yiheng Zheng","raw_affiliation_strings":["Oregon Health &amp; Science Univ, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health &amp; Science Univ, Portland, OR","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056784642","display_name":"Stephanie Reitsma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie Reitsma","raw_affiliation_strings":["UNC at Chapel hill, Chapel Hill, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNC at Chapel hill, Chapel Hill, NC","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111266831","display_name":"Sandler Jordan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandler Jordan","raw_affiliation_strings":["Oregon State Univ, Corvallis, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon State Univ, Corvallis, OR","institution_ids":["https://openalex.org/I131249849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006448195","display_name":"\u00d6zg\u00fcn Babur","orcid":"https://orcid.org/0000-0002-0239-5259","observed_orcids":["https://orcid.org/0000-0002-0239-5259"]},"institutions":[{"id":"https://openalex.org/I33434090","display_name":"University of Massachusetts Boston","ror":"https://ror.org/04ydmy275","country_code":"US","type":"education","lineage":["https://openalex.org/I33434090"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ozgun Babur","raw_affiliation_strings":["Univ of Massachusetts Boston, Milton, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Massachusetts Boston, Milton, MA","institution_ids":["https://openalex.org/I33434090"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011458875","display_name":"Alexander R. Melrose","orcid":"https://orcid.org/0000-0002-4659-5113","observed_orcids":["https://orcid.org/0000-0002-4659-5113"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Melrose","raw_affiliation_strings":["Oregon Health Science Univ, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health Science Univ, Portland, OR","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019186471","display_name":"Jiaqing Pang","orcid":"https://orcid.org/0000-0003-4623-3291","observed_orcids":["https://orcid.org/0000-0003-4623-3291"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"jiaqing pang","raw_affiliation_strings":["oregonhealth science university, portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"oregonhealth science university, portland, OR","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082111578","display_name":"Stefanie J. Hodapp","orcid":"https://orcid.org/0000-0002-3219-1927","observed_orcids":["https://orcid.org/0000-0002-3219-1927"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefanie Hodapp","raw_affiliation_strings":["UC San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UC San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081055838","display_name":"Alexandra C. Newton","orcid":"https://orcid.org/0000-0002-2906-3705","observed_orcids":["https://orcid.org/0000-0002-2906-3705"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexandra Newton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028451365","display_name":"Phillip A. Wilmarth","orcid":"https://orcid.org/0000-0002-7559-8727","observed_orcids":["https://orcid.org/0000-0002-7559-8727"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Phillip Wilmarth","raw_affiliation_strings":["OHSU, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"OHSU, Portland, OR","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053516142","display_name":"Ashok P. Reddy","orcid":"https://orcid.org/0000-0003-1967-6927","observed_orcids":["https://orcid.org/0000-0003-1967-6927"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashok Reddy","raw_affiliation_strings":["OHSU, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"OHSU, Portland, OR","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050978437","display_name":"Owen J. T. McCarty","orcid":"https://orcid.org/0000-0001-9481-0124","observed_orcids":["https://orcid.org/0000-0001-9481-0124"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Owen J McCarty","raw_affiliation_strings":["OREGON HEALTH SCIENCE UNIVERSITY, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"OREGON HEALTH SCIENCE UNIVERSITY, Portland, OR","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027762259","display_name":"Joseph E. Aslan","orcid":"https://orcid.org/0000-0002-8873-0387","observed_orcids":["https://orcid.org/0000-0002-8873-0387"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph E Aslan","raw_affiliation_strings":["Oregon Health Science Univ, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health Science Univ, Portland, OR","institution_ids":["https://openalex.org/I165690674"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"44","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-kinase-c-theta","display_name":"protein kinase C theta","score":0.9769999980926514},{"id":"https://openalex.org/keywords/procoagulant-platelets","display_name":"procoagulant platelets","score":0.8920000195503235},{"id":"https://openalex.org/keywords/platelet-activation","display_name":"platelet activation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/pkcdelta","display_name":"PKC\u03b4","score":0.8069999814033508},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.8690000176429749},{"id":"https://openalex.org/keywords/mitochondrial-calcium-signaling","display_name":"mitochondrial calcium signaling","score":0.8190000057220459},{"id":"https://openalex.org/keywords/phosphatidylserine-exposure","display_name":"phosphatidylserine exposure","score":0.968999981880188},{"id":"https://openalex.org/keywords/platelet-microparticles","display_name":"platelet microparticles","score":0.8299999833106995},{"id":"https://openalex.org/keywords/fibrin-formation","display_name":"fibrin formation","score":0.9459999799728394},{"id":"https://openalex.org/keywords/collagen-related-peptide","display_name":"collagen-related peptide","score":0.5389999747276306},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.6159999966621399}],"concepts":[{"id":"https://openalex.org/C6675166","wikidata":"https://www.wikidata.org/wiki/Q7187538","display_name":"Phosphoproteomics","level":5,"score":0.8846535682678223},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.8339660167694092},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.6672070026397705},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5319621562957764},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.44530197978019714},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.41879767179489136},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40593552589416504},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3937050402164459},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.370583713054657},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32909244298934937},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28310251235961914},{"id":"https://openalex.org/C87325107","wikidata":"https://www.wikidata.org/wiki/Q7251493","display_name":"Protein phosphorylation","level":4,"score":0.16825151443481445}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/atvb.44.suppl_1.140","doi":"https://doi.org/10.1161/atvb.44.suppl_1.140","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/atvb.44.suppl_1.140","pdf_url":null,"source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4387270291","https://openalex.org/W2097453620","https://openalex.org/W4240543953","https://openalex.org/W6962813734","https://openalex.org/W2007424618","https://openalex.org/W2026640819","https://openalex.org/W2037687934","https://openalex.org/W2338981919","https://openalex.org/W7172362243","https://openalex.org/W823813889"],"abstract_inverted_index":{"Background:":[0],"Platelet":[1,67],"activation":[2],"plays":[3],"a":[4,140,269],"pivotal":[5],"role":[6],"in":[7,33,87,175,197],"physiological":[8],"hemostasis":[9],"and":[10,69,96,125,142,170,226,273,287],"thrombosis.":[11],"Protein":[12],"Kinase":[13],"C":[14],"theta":[15],"(PKC\u03b8)":[16],"isoforms":[17,120],"exert":[18],"significant":[19],"regulatory":[20],"influence":[21],"on":[22,107,148,167],"platelet":[23,34,53,157,168,182,198,290],"activation.":[24],"While":[25],"specific":[26,118],"PKC":[27,119,134],"family":[28],"members":[29],"have":[30],"well-defined":[31],"roles":[32,37],"function,":[35],"the":[36,93,108,133,176,205,221,231,234,241,247,262,277],"of":[38,47,114,146,154,178,223,236,243,249,261,279],"PKC\u03b8":[39,48,84,94,110,129,163,173,202,217,280],"remain":[40],"less":[41],"explored.":[42],"Objectives:":[43],"To":[44,82],"determine":[45,128],"mechanisms":[46,86],"signaling":[49,68,286],"that":[50,122,153,161,216,260],"orchestrate":[51],"procoagulant":[52,199,224,244,289],"generation.":[54,291],"Methods:":[55],"Platelets":[56],"were":[57,71,98],"prepared":[58],"from":[59],"healthy":[60],"human":[61],"donors":[62],"for":[63,208],"ex":[64],"vivo":[65],"experiments.":[66],"function":[70,158],"studied":[72],"following":[73],"stimulation":[74],"with":[75,116,150,256],"GPVI":[76],"agonist":[77],"crosslinked":[78],"collagen-related":[79],"peptide":[80],"(CRP-XL).":[81],"investigate":[83],"inhibition":[85,174,203,218],"platelets,":[88,245],"small":[89],"molecule":[90],"inhibitors":[91,117],"targeting":[92],"(CC-90005":[95],"C20)":[97],"employed.":[99],"Results:":[100],"From":[101,132],"phosphoproteomics,":[102],"we":[103,138],"noted":[104,139],"prominent":[105],"phosphorylation":[106,278],"C-terminus":[109],"at":[111,281],"Ser685.":[112],"Pretreatment":[113],"platelets":[115,225],"revealed":[121,160],"PKC\u03b1/\u03b2,":[123],"PKC\u03b8,":[124,149],"PKC\u0394":[126,272],"activities":[127,275],"Ser685":[130],"phosphorylation.":[131],"Inhibitors":[135],"Activity":[136],"Curves,":[137],"robust":[141],"selective":[143],"inhibitory":[144],"impact":[145,166],"CC-90005":[147,250],"specificity":[151],"surpassing":[152,259],"C20.":[155],"Parallel":[156],"analyses":[159],"inhibiting":[162],"had":[164],"minimal":[165],"spreading":[169],"aggregation.":[171],"However,":[172],"presence":[177],"Ca":[179],"2+":[180],"upregulated":[181],"phosphatidylserine":[183],"(PS)":[184],"exposure,":[185],"as":[186],"measured":[187],"by":[188,194],"flow":[189],"cytometry.":[190],"This":[191],"was":[192],"accompanied":[193],"an":[195],"increase":[196],"activity,":[200],"where":[201],"reduced":[204,240],"lag":[206],"time":[207],"fibrin":[209],"formation.":[210],"Furthermore,":[211],"fluorescence":[212],"microscopy":[213],"also":[214],"found":[215],"significantly":[219],"augmented":[220],"proportion":[222],"microparticles.":[227],"Additionally,":[228],"compared":[229],"to":[230],"control":[232,263],"group,":[233],"use":[235],"cyclosporin":[237],"A":[238],"(CsA)":[239],"production":[242],"but":[246],"addition":[248],"or":[251],"C20":[252],"rescued":[253],"this":[254],"phenomenon,":[255],"signal":[257],"intensity":[258],"group.":[264],"Conclusions:":[265],"Our":[266],"study":[267],"proposes":[268],"model":[270],"wherein":[271],"PKC\u03b1/\u03b2":[274],"induce":[276],"S685,":[282],"influencing":[283],"mitochondrial":[284],"calcium":[285],"supporting":[288]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2024-07-25T00:00:00"}
