{"id":"https://openalex.org/W4400933763","doi":"https://doi.org/10.1021/acsomega.3c09902","title":"Synergistic Treatment of Breast Cancer by Combining the Antimicrobial Peptide Piscidin with a Modified Glycolipid","display_name":"Synergistic Treatment of Breast Cancer by Combining the Antimicrobial Peptide Piscidin with a Modified Glycolipid","publication_year":2024,"publication_date":"2024-07-24","ids":{"openalex":"https://openalex.org/W4400933763","doi":"https://doi.org/10.1021/acsomega.3c09902","pmid":"https://pubmed.ncbi.nlm.nih.gov/39130564","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11308023"},"language":"en","primary_location":{"id":"doi:10.1021/acsomega.3c09902","doi":"https://doi.org/10.1021/acsomega.3c09902","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.3c09902","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acsomega.3c09902","source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://pubs.acs.org/doi/pdf/10.1021/acsomega.3c09902","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035626113","display_name":"Rebecca T. Miceli","orcid":"https://orcid.org/0000-0002-2297-9219","observed_orcids":["https://orcid.org/0000-0002-2297-9219"]},"institutions":[{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca T. Miceli","raw_affiliation_strings":["Center for Biotechnology and Interdisciplinary Sciences, Rensselaer Polytechnic Institute, Troy, New York 12180, United States","Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, New York 12180, United States"],"raw_orcid":"https://orcid.org/0000-0002-2297-9219","affiliations":[{"raw_affiliation_string":"Center for Biotechnology and Interdisciplinary Sciences, Rensselaer Polytechnic Institute, Troy, New York 12180, United States","institution_ids":["https://openalex.org/I165799507"]},{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, New York 12180, United States","institution_ids":["https://openalex.org/I165799507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104505515","display_name":"Noah  G. Allen","orcid":"https://orcid.org/0000-0003-0998-8337","observed_orcids":["https://orcid.org/0000-0003-0998-8337"]},"institutions":[{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Noah G. Allen","raw_affiliation_strings":["Center for Biotechnology and Interdisciplinary Sciences, Rensselaer Polytechnic Institute, Troy, New York 12180, United States","Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biotechnology and Interdisciplinary Sciences, Rensselaer Polytechnic Institute, Troy, New York 12180, United States","institution_ids":["https://openalex.org/I165799507"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180, United States","institution_ids":["https://openalex.org/I165799507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014942710","display_name":"Bhagyashree Subramaniam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bhagyashree Subramaniam","raw_affiliation_strings":["Center for Biotechnology and Interdisciplinary Sciences, Rensselaer Polytechnic Institute, Troy, New York 12180, United States","Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, New York 12180, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biotechnology and Interdisciplinary Sciences, Rensselaer Polytechnic Institute, Troy, New York 12180, United States","institution_ids":["https://openalex.org/I165799507"]},{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, New York 12180, United States","institution_ids":["https://openalex.org/I165799507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113302033","display_name":"Livia Carmody","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Livia Carmody","raw_affiliation_strings":["Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, New York 12180, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, New York 12180, United States","institution_ids":["https://openalex.org/I165799507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043598718","display_name":"Jonathan S. Dordick","orcid":"https://orcid.org/0000-0001-7802-3702","observed_orcids":["https://orcid.org/0000-0001-7802-3702"]},"institutions":[{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan S. Dordick","raw_affiliation_strings":["Center for Biotechnology and Interdisciplinary Sciences, Rensselaer Polytechnic Institute, Troy, New York 12180, United States","Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180, United States","Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180, United States"],"raw_orcid":"https://orcid.org/0000-0001-7802-3702","affiliations":[{"raw_affiliation_string":"Center for Biotechnology and Interdisciplinary Sciences, Rensselaer Polytechnic Institute, Troy, New York 12180, United States","institution_ids":["https://openalex.org/I165799507"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180, United States","institution_ids":["https://openalex.org/I165799507"]},{"raw_affiliation_string":"Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180, United States","institution_ids":["https://openalex.org/I165799507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081421697","display_name":"David T. Corr","orcid":"https://orcid.org/0000-0002-4059-8591","observed_orcids":["https://orcid.org/0000-0002-4059-8591"]},"institutions":[{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David T. Corr","raw_affiliation_strings":["Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180, United States"],"raw_orcid":"https://orcid.org/0000-0002-4059-8591","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180, United States","institution_ids":["https://openalex.org/I165799507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000667476","display_name":"Myriam L. Cotten","orcid":"https://orcid.org/0000-0002-6732-1736","observed_orcids":["https://orcid.org/0000-0002-6732-1736"]},"institutions":[{"id":"https://openalex.org/I16285277","display_name":"William & Mary","ror":"https://ror.org/03hsf0573","country_code":"US","type":"education","lineage":["https://openalex.org/I16285277"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Myriam Cotten","raw_affiliation_strings":["Department of Applied Science, William & Mary, Williamsburg, Virginia 23185, United States"],"raw_orcid":"https://orcid.org/0000-0002-6732-1736","affiliations":[{"raw_affiliation_string":"Department of Applied Science, William & Mary, Williamsburg, Virginia 23185, United States","institution_ids":["https://openalex.org/I16285277"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049257620","display_name":"Richard A. Gross","orcid":"https://orcid.org/0000-0002-5050-3162","observed_orcids":["https://orcid.org/0000-0002-5050-3162"]},"institutions":[{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Richard A. Gross","raw_affiliation_strings":["Center for Biotechnology and Interdisciplinary Sciences, Rensselaer Polytechnic Institute, Troy, New York 12180, United States","Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, New York 12180, United States"],"raw_orcid":"https://orcid.org/0000-0002-5050-3162","affiliations":[{"raw_affiliation_string":"Center for Biotechnology and Interdisciplinary Sciences, Rensselaer Polytechnic Institute, Troy, New York 12180, United States","institution_ids":["https://openalex.org/I165799507"]},{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, New York 12180, United States","institution_ids":["https://openalex.org/I165799507"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5000667476","https://openalex.org/A5049257620"],"corresponding_institution_ids":["https://openalex.org/I16285277","https://openalex.org/I165799507"],"apc_list":{"value":1935,"currency":"USD","value_usd":1935},"apc_paid":{"value":1935,"currency":"USD","value_usd":1935},"fwci":0.777,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.69342477,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"9","issue":"31","first_page":"33408","last_page":"33424"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9564999938011169,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9564999938011169,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.00930000003427267,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/piscidin","display_name":"piscidin","score":0.7319999933242798},{"id":"https://openalex.org/keywords/sophorolipids","display_name":"sophorolipids","score":0.8930000066757202},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.777999997138977},{"id":"https://openalex.org/keywords/synergistic-drug-combination","display_name":"synergistic drug combination","score":0.8399999737739563},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.7409999966621399},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8859999775886536},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8999999761581421},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.9980000257492065},{"id":"https://openalex.org/keywords/necrosis","display_name":"necrosis","score":0.6610000133514404},{"id":"https://openalex.org/keywords/selectivity-index","display_name":"selectivity index","score":0.8199999928474426},{"id":"https://openalex.org/keywords/bt474-cells","display_name":"BT474 cells","score":0.8619999885559082},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.9769999980926514},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.6759999990463257},{"id":"https://openalex.org/keywords/hormone-receptor-positive-breast-cancer","display_name":"hormone receptor-positive breast cancer","score":0.6420000195503235}],"concepts":[{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.8542728424072266},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.7807722091674805},{"id":"https://openalex.org/C540938839","wikidata":"https://www.wikidata.org/wiki/Q1201508","display_name":"Antimicrobial peptides","level":3,"score":0.49209803342819214},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4862610101699829},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3519311547279358},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.31968510150909424},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.258774995803833}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1021/acsomega.3c09902","doi":"https://doi.org/10.1021/acsomega.3c09902","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.3c09902","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acsomega.3c09902","source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11308023","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11308023","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11308023/pdf/ao3c09902.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"Text"},{"id":"pmid:39130564","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39130564","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS omega","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:edefa93177c14a9ea92aceab82344fb0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/edefa93177c14a9ea92aceab82344fb0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ACS Omega, Vol 9, Iss 31, Pp 33408-33424 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1021/acsomega.3c09902","doi":"https://doi.org/10.1021/acsomega.3c09902","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.3c09902","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acsomega.3c09902","source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3285410707","display_name":null,"funder_award_id":"A24-0043","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G49555899","display_name":"Biomolecular Science and Engineering Training Program","funder_award_id":"T32GM067545","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7375654453","display_name":null,"funder_award_id":"A24-0043","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7781113806","display_name":"Endosome-mitochondria interactions in breast cancer cells","funder_award_id":"R01CA233188","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4400933763.pdf","grobid_xml":"https://content.openalex.org/works/W4400933763.grobid-xml"},"referenced_works_count":105,"referenced_works":["https://openalex.org/W125106425","https://openalex.org/W1519535724","https://openalex.org/W1593256748","https://openalex.org/W1599912224","https://openalex.org/W1686529446","https://openalex.org/W1806289054","https://openalex.org/W1826201699","https://openalex.org/W1886767372","https://openalex.org/W1901887072","https://openalex.org/W1941910947","https://openalex.org/W1964393122","https://openalex.org/W1967888239","https://openalex.org/W1967894078","https://openalex.org/W1971873029","https://openalex.org/W1990138203","https://openalex.org/W1994682335","https://openalex.org/W2014669602","https://openalex.org/W2016562927","https://openalex.org/W2044475589","https://openalex.org/W2051951369","https://openalex.org/W2059181092","https://openalex.org/W2060550237","https://openalex.org/W2076163174","https://openalex.org/W2081424254","https://openalex.org/W2095458284","https://openalex.org/W2096439168","https://openalex.org/W2101615077","https://openalex.org/W2108300681","https://openalex.org/W2117783903","https://openalex.org/W2131640859","https://openalex.org/W2137149020","https://openalex.org/W2138803440","https://openalex.org/W2145457152","https://openalex.org/W2152793164","https://openalex.org/W2153850374","https://openalex.org/W2161756110","https://openalex.org/W2164110665","https://openalex.org/W2165781231","https://openalex.org/W2179142653","https://openalex.org/W2185324447","https://openalex.org/W2301078386","https://openalex.org/W2317877264","https://openalex.org/W2346255463","https://openalex.org/W2402947957","https://openalex.org/W2418367703","https://openalex.org/W2441193487","https://openalex.org/W2509642198","https://openalex.org/W2545174995","https://openalex.org/W2553842365","https://openalex.org/W2585583585","https://openalex.org/W2604229956","https://openalex.org/W2605790566","https://openalex.org/W2615246133","https://openalex.org/W2751356861","https://openalex.org/W2754673990","https://openalex.org/W2756562465","https://openalex.org/W2756784922","https://openalex.org/W2766031263","https://openalex.org/W2768449248","https://openalex.org/W2790320662","https://openalex.org/W2801598991","https://openalex.org/W2810304164","https://openalex.org/W2889224376","https://openalex.org/W2891380366","https://openalex.org/W2904897241","https://openalex.org/W2908197926","https://openalex.org/W2914412606","https://openalex.org/W2916911849","https://openalex.org/W2920020242","https://openalex.org/W2926346373","https://openalex.org/W2945779280","https://openalex.org/W2947088163","https://openalex.org/W2949780892","https://openalex.org/W2981163294","https://openalex.org/W2981754764","https://openalex.org/W2982506976","https://openalex.org/W2987126840","https://openalex.org/W2989083977","https://openalex.org/W3005689864","https://openalex.org/W3010773449","https://openalex.org/W3011404964","https://openalex.org/W3015067383","https://openalex.org/W3022795804","https://openalex.org/W3028485101","https://openalex.org/W3032331589","https://openalex.org/W3044337970","https://openalex.org/W3099500949","https://openalex.org/W3135896406","https://openalex.org/W3138173231","https://openalex.org/W3159019997","https://openalex.org/W3162780336","https://openalex.org/W3169975630","https://openalex.org/W3175611718","https://openalex.org/W3193714727","https://openalex.org/W3215341881","https://openalex.org/W4200374079","https://openalex.org/W4205899910","https://openalex.org/W4210875240","https://openalex.org/W4220798004","https://openalex.org/W4225415865","https://openalex.org/W4226302116","https://openalex.org/W4281389884","https://openalex.org/W4362507031","https://openalex.org/W4367174544","https://openalex.org/W4387816229"],"related_works":["https://openalex.org/W4387816229","https://openalex.org/W2884846185","https://openalex.org/W2163574436","https://openalex.org/W3186408715","https://openalex.org/W4362507031","https://openalex.org/W4399500141","https://openalex.org/W7165611955","https://openalex.org/W2032836533","https://openalex.org/W2183740737","https://openalex.org/W4220874488"],"abstract_inverted_index":{"High":[0],"Resolution":[1],"Image":[2],"Download":[3],"MS":[4],"PowerPoint":[5],"Slide":[6],"Piscidin":[7],"3":[8],"(P3),":[9],"a":[10,16,43,86,142,156,172,201],"peptide":[11,53],"produced":[12],"by":[13,33,58],"fish,":[14],"and":[15,27,91,138,141,182],"hexyl":[17],"ester-modified":[18],"sophorolipid":[19],"(SL-HE),":[20],"have":[21],"individually":[22],"shown":[23],"promise":[24],"as":[25],"antimicrobial":[26,61],"anticancer":[28,111],"drugs.":[29],"A":[30],"recent":[31],"report":[32],"our":[34],"team":[35],"revealed":[36],"that":[37,101,147,204],"combining":[38],"P3":[39],"with":[40],"SL-HE":[41,56,180],"in":[42,48,52,134,151],"1:8":[44,103],"molar":[45,104],"ratio":[46,105],"resulted":[47],"an":[49,93,125,132],"8-fold":[50],"enhancement":[51],"activity,":[54],"while":[55],"improved":[57,186],"25-fold":[59],"its":[60],"activity":[62],"against":[63,113],"the":[64,73,102,110,122,152,167,177,190,195,209],"Gram-positive":[65],"microorganism":[66],"Bacillus":[67],"cereus":[68],".":[69],"Extending":[70],"these":[71],"findings,":[72],"same":[74],"P3/SL-HE":[75,107,199],"combination":[76,170,197],"was":[77,162],"assessed":[78],"on":[79],"two":[80],"breast":[81,116,212],"cancer":[82],"cell":[83,89,96,117,128,158],"lines:":[84],"BT-474,":[85],"hormonally":[87],"positive":[88],"line,":[90,159],"MDA-MB-231,":[92],"aggressive":[94],"triple-negative":[95],"line.":[97],"The":[98],"results":[99,192],"demonstrated":[100],"of":[106,124,179,198,211],"synergistically":[108],"enhances":[109],"effects":[112],"both":[114],"tumorigenic":[115],"lines.":[118],"Mechanistic":[119],"studies":[120],"indicate":[121],"activation":[123],"intrinsic":[126],"apoptotic":[127],"death":[129],"mechanism":[130],"through":[131],"increase":[133],"reactive":[135],"oxygen":[136],"species":[137],"mitochondrial":[139],"dysfunction":[140],"secondary":[143],"programmed":[144],"necrotic":[145],"pathway":[146],"involves":[148],"pore":[149],"formation":[150],"plasma":[153],"membrane.":[154],"When":[155],"fibroblast":[157],"CCD1065SK":[160],"HDF,":[161],"utilized":[163],"to":[164,176],"determine":[165],"selectivity,":[166],"synergistic":[168,196],"SL-HE/P3":[169],"exhibited":[171],"protective":[173],"property":[174],"compared":[175],"use":[178],"alone":[181],"therefore":[183],"afforded":[184],"vastly":[185],"selectivity":[187],"indices.":[188],"Given":[189],"promising":[191],"reported":[193],"herein,":[194],"constitutes":[200],"novel":[202],"strategy":[203],"merits":[205],"further":[206],"study":[207],"for":[208],"treatment":[210],"cancer.":[213]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2024-07-25T00:00:00"}
