{"id":"https://openalex.org/W4400930867","doi":"https://doi.org/10.1002/bmc.5965","title":"Assessment of remdesivir and its nucleoside metabolite in beagle dogs and healthy humans by liquid chromatography coupled with triple quadrupole mass spectrometry","display_name":"Assessment of remdesivir and its nucleoside metabolite in beagle dogs and healthy humans by liquid chromatography coupled with triple quadrupole mass spectrometry","publication_year":2024,"publication_date":"2024-07-22","ids":{"openalex":"https://openalex.org/W4400930867","doi":"https://doi.org/10.1002/bmc.5965","pmid":"https://pubmed.ncbi.nlm.nih.gov/39039650"},"language":"en","primary_location":{"id":"doi:10.1002/bmc.5965","doi":"https://doi.org/10.1002/bmc.5965","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bmc.5965","pdf_url":null,"source":{"id":"https://openalex.org/S123979729","display_name":"Biomedical Chromatography","issn_l":"0269-3879","issn":["0269-3879","1099-0801"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical Chromatography","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027760492","display_name":"Naveen Kumar Dubey","orcid":"https://orcid.org/0000-0003-2295-6989","observed_orcids":["https://orcid.org/0000-0003-2295-6989"]},"institutions":[{"id":"https://openalex.org/I4210162011","display_name":"Jubilant Life Sciences (India)","ror":"https://ror.org/05sxgbh67","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210162011"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Naveen Kumar Dubey","raw_affiliation_strings":["Jubilant Generics Limited, Noida, India"],"raw_orcid":"https://orcid.org/0000-0003-2295-6989","affiliations":[{"raw_affiliation_string":"Jubilant Generics Limited, Noida, India","institution_ids":["https://openalex.org/I4210162011"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Peeyush Jain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162011","display_name":"Jubilant Life Sciences (India)","ror":"https://ror.org/05sxgbh67","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210162011"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Peeyush Jain","raw_affiliation_strings":["Jubilant Generics Limited, Noida, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jubilant Generics Limited, Noida, India","institution_ids":["https://openalex.org/I4210162011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106237104","display_name":"Ankit Raj","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162011","display_name":"Jubilant Life Sciences (India)","ror":"https://ror.org/05sxgbh67","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210162011"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ankit Raj","raw_affiliation_strings":["Jubilant Generics Limited, Noida, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jubilant Generics Limited, Noida, India","institution_ids":["https://openalex.org/I4210162011"]}]},{"author_position":"last","author":{"id":null,"display_name":"Sandeep Tiwari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162011","display_name":"Jubilant Life Sciences (India)","ror":"https://ror.org/05sxgbh67","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210162011"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sandeep Tiwari","raw_affiliation_strings":["Jubilant Generics Limited, Noida, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jubilant Generics Limited, Noida, India","institution_ids":["https://openalex.org/I4210162011"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5027760492"],"corresponding_institution_ids":["https://openalex.org/I4210162011"],"apc_list":{"value":3680,"currency":"USD","value_usd":3680},"apc_paid":null,"fwci":0.2522,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.33478518,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":95},"biblio":{"volume":"38","issue":"10","first_page":"e5965","last_page":"e5965"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.013799999840557575,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/remdesivir","display_name":"remdesivir","score":1.0},{"id":"https://openalex.org/keywords/gs-441524","display_name":"GS-441524","score":0.996999979019165},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9909999966621399},{"id":"https://openalex.org/keywords/beagle","display_name":"beagle dogs","score":0.8019999861717224},{"id":"https://openalex.org/keywords/human-volunteers","display_name":"human volunteers","score":0.6669999957084656},{"id":"https://openalex.org/keywords/plasma-quantification","display_name":"plasma quantification","score":0.8069999814033508},{"id":"https://openalex.org/keywords/intravenous-formulation","display_name":"intravenous formulation","score":0.671999990940094},{"id":"https://openalex.org/keywords/oral-tablets","display_name":"oral tablets","score":0.6970000267028809},{"id":"https://openalex.org/keywords/drug-formulation-comparison","display_name":"drug formulation comparison","score":0.4790000021457672},{"id":"https://openalex.org/keywords/analytical-method-validation","display_name":"analytical method validation","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C2776820430","wikidata":"https://www.wikidata.org/wiki/Q21102","display_name":"Beagle","level":2,"score":0.9086782932281494},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8059813976287842},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.7278540134429932},{"id":"https://openalex.org/C23531484","wikidata":"https://www.wikidata.org/wiki/Q3196863","display_name":"Calibration curve","level":3,"score":0.6900956630706787},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.6680549383163452},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.6123983860015869},{"id":"https://openalex.org/C74774607","wikidata":"https://www.wikidata.org/wiki/Q7251495","display_name":"Protein precipitation","level":3,"score":0.5970532298088074},{"id":"https://openalex.org/C172493649","wikidata":"https://www.wikidata.org/wiki/Q7843529","display_name":"Triple quadrupole mass spectrometer","level":5,"score":0.5350798964500427},{"id":"https://openalex.org/C149151106","wikidata":"https://www.wikidata.org/wiki/Q4677569","display_name":"Active metabolite","level":3,"score":0.5036556124687195},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.502213716506958},{"id":"https://openalex.org/C40684141","wikidata":"https://www.wikidata.org/wiki/Q902061","display_name":"Electrospray ionization","level":3,"score":0.4571395516395569},{"id":"https://openalex.org/C71043704","wikidata":"https://www.wikidata.org/wiki/Q17144692","display_name":"Selected reaction monitoring","level":4,"score":0.35426855087280273},{"id":"https://openalex.org/C119128265","wikidata":"https://www.wikidata.org/wiki/Q900165","display_name":"Detection limit","level":2,"score":0.2879002094268799},{"id":"https://openalex.org/C31827203","wikidata":"https://www.wikidata.org/wiki/Q874296","display_name":"Tandem mass spectrometry","level":3,"score":0.2235814332962036},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.0838315486907959},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.05408748984336853},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.047547340393066406},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000249","descriptor_name":"Adenosine Monophosphate","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D000249","descriptor_name":"Adenosine Monophosphate","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000249","descriptor_name":"Adenosine Monophosphate","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057230","descriptor_name":"Limit of Detection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/bmc.5965","doi":"https://doi.org/10.1002/bmc.5965","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bmc.5965","pdf_url":null,"source":{"id":"https://openalex.org/S123979729","display_name":"Biomedical Chromatography","issn_l":"0269-3879","issn":["0269-3879","1099-0801"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical Chromatography","raw_type":"journal-article"},{"id":"pmid:39039650","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39039650","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical chromatography : BMC","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9074000120162964,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W2292021561","https://openalex.org/W2899412393","https://openalex.org/W2899919129","https://openalex.org/W2900081729","https://openalex.org/W2900186284","https://openalex.org/W2935101654","https://openalex.org/W2947193913","https://openalex.org/W2953224333","https://openalex.org/W2962765467","https://openalex.org/W3005527412","https://openalex.org/W3006645647","https://openalex.org/W3007969569","https://openalex.org/W3010096359","https://openalex.org/W3013460037","https://openalex.org/W3015490759","https://openalex.org/W3021344470","https://openalex.org/W3036830028","https://openalex.org/W3122893202","https://openalex.org/W4200410467","https://openalex.org/W4238788977","https://openalex.org/W4243029384","https://openalex.org/W4243049009"],"related_works":["https://openalex.org/W3036830028","https://openalex.org/W3183167780","https://openalex.org/W4283215791","https://openalex.org/W4223521501","https://openalex.org/W3122893202","https://openalex.org/W3021344470","https://openalex.org/W4411976513","https://openalex.org/W3133596801","https://openalex.org/W3108910283","https://openalex.org/W4377029052"],"abstract_inverted_index":{"The":[0,76,153,181,214],"aim":[1],"of":[2,10,234],"this":[3],"study":[4],"was":[5,113,216],"to":[6,70,229],"assess":[7],"the":[8,11,20,86,119,231,235],"pharmacokinetics":[9],"existing":[12],"remdesivir":[13,29,48,122,179,195,208],"intravenous":[14,236],"formulation":[15,24],"(100":[16],"mg":[17,26],"dose)":[18,27],"against":[19],"newly":[21],"developed":[22,63],"oral":[23],"(20":[25],"for":[28,47,79,163,170,178,194,199,207,212],"and":[30,49,58,64,82,96,125,140,172,196,201,209,221,238,246],"its":[31,50],"active":[32,51],"nucleoside":[33,52],"metabolite":[34,53],"(GS-441524)":[35,54],"in":[36,55,85,105,149,187,218,243],"beagle":[37,56,80,188,219,244],"dogs":[38,81,245],"followed":[39],"by":[40],"healthy":[41,247],"human":[42,59,83,202,222],"volunteers.":[43],"A":[44,108],"quantification":[45],"method":[46],"dog":[57,189,220],"plasma":[60,90,190,203],"has":[61],"been":[62],"validated":[65],"using":[66,116,142],"liquid":[67],"chromatography":[68],"coupled":[69],"triple":[71],"quadrupole":[72],"mass":[73,144],"spectrometry":[74],"detection.":[75],"analytical":[77],"methods":[78,225],"differ":[84],"calibration":[87,182],"curve":[88,183],"range,":[89],"matrix,":[91],"processing":[92],"volume,":[93],"reconstitution":[94],"volume":[95],"injection":[97,237],"volume;":[98],"however":[99],"all":[100],"other":[101],"parameters":[102,233],"were":[103,127,157,185,226],"same":[104],"both":[106],"methods.":[107],"simple":[109],"protein":[110],"precipitation":[111],"extraction":[112],"carried":[114],"out":[115],"acetonitrile":[117],"containing":[118],"internal":[120],"standard":[121],"D5.":[123,180],"Remdesivir":[124],"GS-441524":[126,171],"separated":[128],"on":[129],"an":[130],"Endurus":[131],"C-18P,":[132],"100":[133],"\u00d7":[134],"4.6":[135],"mm,":[136],"3":[137],"\u03bcm":[138],"column":[139],"detected":[141],"a":[143],"spectrometer":[145],"with":[146],"electrospray":[147],"ionization":[148],"positive":[150],"ion":[151,154],"mode.":[152],"transitions":[155],"used":[156,228],"m/z":[158,161,165,168,173,176],"603.1":[159],"\u2192":[160,167,175],"200.0":[162],"remdesivir,":[164],"292.0":[166],"202.2":[169],"608.2":[174],"205.1":[177],"results":[184],"linear":[186],"(2.0-2,000.8":[191],"ng/ml":[192,198,205,211],"range":[193,206],"2.0-1,500.4":[197],"GS-441524)":[200],"(30.0-4,503.9":[204],"2.0-200.4":[210],"GS-441524).":[213],"recovery":[215],">90%":[217],"plasma.":[223],"These":[224],"successfully":[227],"determine":[230],"pharmacokinetic":[232],"subcutaneous":[239],"tablets":[240],"dosage":[241],"forms":[242],"humans.":[248]},"counts_by_year":[{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-07-24T00:00:00"}
