{"id":"https://openalex.org/W4400923375","doi":"https://doi.org/10.2174/0115734072325272240712114444","title":"Investigation on the Potential of Some N-phenylalkanehydrazides as Superoxide Anion Radical Scavengers and Glutathione Peroxidase Binders with ADME Prediction: Comparison with Vitamin C","display_name":"Investigation on the Potential of Some N-phenylalkanehydrazides as Superoxide Anion Radical Scavengers and Glutathione Peroxidase Binders with ADME Prediction: Comparison with Vitamin C","publication_year":2024,"publication_date":"2024-07-23","ids":{"openalex":"https://openalex.org/W4400923375","doi":"https://doi.org/10.2174/0115734072325272240712114444"},"language":"en","primary_location":{"id":"doi:10.2174/0115734072325272240712114444","doi":"https://doi.org/10.2174/0115734072325272240712114444","is_oa":false,"landing_page_url":"https://doi.org/10.2174/0115734072325272240712114444","pdf_url":null,"source":{"id":"https://openalex.org/S197782650","display_name":"Current Bioactive Compounds","issn_l":"1573-4072","issn":["1573-4072","1875-6646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Bioactive Compounds","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091937390","display_name":"Hanane Mouada","orcid":"https://orcid.org/0000-0002-0402-307X","observed_orcids":["https://orcid.org/0000-0002-0402-307X"]},"institutions":[{"id":"https://openalex.org/I4405252898","display_name":"Centre Universitaire Morsli Abdellah de Tipaza","ror":"https://ror.org/003b7tf67","country_code":"DZ","type":"education","lineage":["https://openalex.org/I4405252898"]}],"countries":["DZ"],"is_corresponding":true,"raw_author_name":"Hanane Mouada","raw_affiliation_strings":["Department of Process Engineering, University Center of Tipaza, Tipaza, 42022, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Process Engineering, University Center of Tipaza, Tipaza, 42022, Algeria","institution_ids":["https://openalex.org/I4405252898"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087154127","display_name":"Touhami Lanez","orcid":"https://orcid.org/0000-0002-3978-7635","observed_orcids":["https://orcid.org/0000-0002-3978-7635"]},"institutions":[{"id":"https://openalex.org/I4210157185","display_name":"University of Eloued","ror":"https://ror.org/05416s909","country_code":"DZ","type":"education","lineage":["https://openalex.org/I4210157185"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Touhami Lanez","raw_affiliation_strings":["Department of Chemistry, University of El Oued, El Oued, 39000, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of El Oued, El Oued, 39000, Algeria","institution_ids":["https://openalex.org/I4210157185"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5091937390"],"corresponding_institution_ids":["https://openalex.org/I4405252898"],"apc_list":null,"apc_paid":null,"fwci":0.4123,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.40810061,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"21","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13013","display_name":"Free Radicals and Antioxidants","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13013","display_name":"Free Radicals and Antioxidants","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/superoxide-radical-scavenging","display_name":"superoxide radical scavenging","score":0.9789999723434448},{"id":"https://openalex.org/keywords/glutathione-peroxidase","display_name":"glutathione peroxidase","score":0.9319999814033508},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.9319999814033508},{"id":"https://openalex.org/keywords/adme-prediction","display_name":"ADME prediction","score":0.847000002861023},{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":0.777999997138977},{"id":"https://openalex.org/keywords/drug-likeness","display_name":"drug-likeness","score":0.8270000219345093},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.9589999914169312},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.6019999980926514},{"id":"https://openalex.org/keywords/hydrogen-bonding","display_name":"hydrogen bonding","score":0.5609999895095825},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8204178810119629},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.7532792091369629},{"id":"https://openalex.org/C69366308","wikidata":"https://www.wikidata.org/wiki/Q2272286","display_name":"ADME","level":3,"score":0.6657885909080505},{"id":"https://openalex.org/C162008176","wikidata":"https://www.wikidata.org/wiki/Q419305","display_name":"Peroxidase","level":3,"score":0.6113264560699463},{"id":"https://openalex.org/C3020006800","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide radical","level":4,"score":0.5707033276557922},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.5287213921546936},{"id":"https://openalex.org/C2780022331","wikidata":"https://www.wikidata.org/wiki/Q199678","display_name":"Vitamin C","level":2,"score":0.4838489592075348},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.44556841254234314},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.4054625332355499},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3771089017391205},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2515503764152527},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.17126357555389404},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2174/0115734072325272240712114444","doi":"https://doi.org/10.2174/0115734072325272240712114444","is_oa":false,"landing_page_url":"https://doi.org/10.2174/0115734072325272240712114444","pdf_url":null,"source":{"id":"https://openalex.org/S197782650","display_name":"Current Bioactive Compounds","issn_l":"1573-4072","issn":["1573-4072","1875-6646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Bioactive Compounds","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1964546362","https://openalex.org/W1991429069","https://openalex.org/W1998180194","https://openalex.org/W2008718419","https://openalex.org/W2020906191","https://openalex.org/W2027511837","https://openalex.org/W2029718364","https://openalex.org/W2050175611","https://openalex.org/W2078706245","https://openalex.org/W2096134196","https://openalex.org/W2128294421","https://openalex.org/W2141151960","https://openalex.org/W2144483204","https://openalex.org/W2179628549","https://openalex.org/W2593436234","https://openalex.org/W2747819399","https://openalex.org/W2762484850","https://openalex.org/W2888801897","https://openalex.org/W2927107056","https://openalex.org/W2990199891","https://openalex.org/W3013352992","https://openalex.org/W3073123617","https://openalex.org/W3169239182","https://openalex.org/W3173513928","https://openalex.org/W3185516537","https://openalex.org/W3200447692","https://openalex.org/W3200756181","https://openalex.org/W4232135728","https://openalex.org/W4280649942","https://openalex.org/W4296480567","https://openalex.org/W4303579043","https://openalex.org/W4317534781","https://openalex.org/W4361027198","https://openalex.org/W4376137838","https://openalex.org/W4376154696","https://openalex.org/W4383422932","https://openalex.org/W4385439180","https://openalex.org/W4386565845","https://openalex.org/W4388047510","https://openalex.org/W4390937805"],"related_works":["https://openalex.org/W4210323726","https://openalex.org/W6998619478","https://openalex.org/W7221772076","https://openalex.org/W4402591080","https://openalex.org/W7155520626","https://openalex.org/W7171519430","https://openalex.org/W2097987586","https://openalex.org/W4399988250","https://openalex.org/W1810630288","https://openalex.org/W2549581436"],"abstract_inverted_index":{"Objective:":[0],"An":[1],"investigation":[2],"on":[3],"the":[4,28,32,52,64,72,101,111,114,122,125,137,152,157,163,180],"antioxidant":[5,53,147,195],"activity":[6],"and":[7,23,83,106,145,159,184,206],"ADME":[8,59],"properties":[9,60],"of":[10,27,104,113,140,204],"some":[11],"N-phenylalkanehydrazides":[12],"(NPhs)":[13],"in":[14,124,162],"comparison":[15],"with":[16,87,89,142,146,172],"ascorbic":[17,94],"acid":[18],"was":[19,36,44,118,149],"carried":[20],"out.":[21],"Materials":[22],"Methods:":[24],"The":[25,68,198],"power":[26],"compounds":[29,74,115],"to":[30,46,51,93],"scavenge":[31],"superoxide":[33],"anion":[34],"radical":[35,133,144],"examined":[37],"using":[38,63],"cyclic":[39],"voltammetry.":[40],"Furthermore,":[41],"molecular":[42],"docking":[43],"used":[45],"examine":[47],"how":[48],"NPhs":[49],"bind":[50],"enzyme":[54,148],"glutathione":[55],"peroxidase":[56],"(GPx).":[57],"Finally,":[58,175],"were":[61],"predicted":[62],"SwissADME":[65],"webserver.":[66],"Results:":[67],"results":[69],"showed":[70],"that":[71,209],"studied":[73],"had":[75],"significantly":[76],"higher":[77],"EC50":[78,112],"values":[79,98],"than":[80],"Vitamin":[81],"C":[82],"displayed":[84],"spontaneous":[85],"binding":[86,90,141,153],"GPx":[88],"energy":[91],"similar":[92],"acid.":[95],"Also,":[96],"substantial":[97],"emerged":[99],"from":[100],"predictive":[102],"analysis":[103],"drug-likeness":[105,183],"bioavailability":[107,185],"characteristics.":[108],"Discussion:":[109],"First,":[110],"under":[116],"study":[117,200],"determined":[119],"by":[120,151],"assessing":[121],"decrease":[123],"anodic":[126],"current":[127,199],"peak":[128],"intensity;":[129],"this":[130],"demonstrated":[131],"significant":[132],"scavenging":[134],"activity.":[135],"Next,":[136],"electrostatic":[138],"way":[139],"ROS":[143],"disclosed":[150],"free":[154],"energies;":[155],"however,":[156],"oxygen":[158],"nitrogen":[160],"atoms":[161],"compounds'":[164],"structures":[165],"might":[166],"make":[167],"many":[168],"conventional":[169],"hydrogen":[170],"bonds":[171],"amino":[173],"acids.":[174],"NPh":[176],"(a)":[177],"followed":[178],"all":[179],"rules":[181],"for":[182,192],"estimates,":[186],"making":[187],"it":[188],"a":[189,202],"promising":[190],"moiety":[191],"synthesising":[193],"new":[194],"chemicals.":[196],"Conclusion:":[197],"is":[201],"hybrid":[203],"experimental":[205],"computational":[207],"methods":[208],"complement":[210],"each":[211],"other":[212],"perfectly.":[213]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-07-24T00:00:00"}
