{"id":"https://openalex.org/W4400906705","doi":"https://doi.org/10.1186/s12934-024-02480-4","title":"High production of enantiopure (R,R)-2,3-butanediol from crude glycerol by Klebsiella pneumoniae with an engineered oxidative pathway and a two-stage agitation strategy","display_name":"High production of enantiopure (R,R)-2,3-butanediol from crude glycerol by Klebsiella pneumoniae with an engineered oxidative pathway and a two-stage agitation strategy","publication_year":2024,"publication_date":"2024-07-23","ids":{"openalex":"https://openalex.org/W4400906705","doi":"https://doi.org/10.1186/s12934-024-02480-4","pmid":"https://pubmed.ncbi.nlm.nih.gov/39044245","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11267846"},"language":"en","primary_location":{"id":"doi:10.1186/s12934-024-02480-4","doi":"https://doi.org/10.1186/s12934-024-02480-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12934-024-02480-4","pdf_url":null,"source":{"id":"https://openalex.org/S171368329","display_name":"Microbial Cell Factories","issn_l":"1475-2859","issn":["1475-2859"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbial Cell Factories","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12934-024-02480-4","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046531349","display_name":"Min-Ho Jo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]},{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Min-Ho Jo","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering and Institute for the BioCentury, KAIST, Daejeon, 34141, Republic of Korea","Microbial Biotechnology Research Center, Jeonbuk Branch Institute, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup, Jeonbuk, 56212, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering and Institute for the BioCentury, KAIST, Daejeon, 34141, Republic of Korea","institution_ids":["https://openalex.org/I157485424"]},{"raw_affiliation_string":"Microbial Biotechnology Research Center, Jeonbuk Branch Institute, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup, Jeonbuk, 56212, Republic of Korea","institution_ids":["https://openalex.org/I73616290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079604233","display_name":"Jung\u2010Hyun Ju","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jung-Hyun Ju","raw_affiliation_strings":["Microbial Biotechnology Research Center, Jeonbuk Branch Institute, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup, Jeonbuk, 56212, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbial Biotechnology Research Center, Jeonbuk Branch Institute, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup, Jeonbuk, 56212, Republic of Korea","institution_ids":["https://openalex.org/I73616290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113741545","display_name":"Sun-Yeon Heo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sun-Yeon Heo","raw_affiliation_strings":["Microbial Biotechnology Research Center, Jeonbuk Branch Institute, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup, Jeonbuk, 56212, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbial Biotechnology Research Center, Jeonbuk Branch Institute, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup, Jeonbuk, 56212, Republic of Korea","institution_ids":["https://openalex.org/I73616290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109230890","display_name":"Chang-Bum Son","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Chang-Bum Son","raw_affiliation_strings":["Microbial Biotechnology Research Center, Jeonbuk Branch Institute, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup, Jeonbuk, 56212, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbial Biotechnology Research Center, Jeonbuk Branch Institute, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup, Jeonbuk, 56212, Republic of Korea","institution_ids":["https://openalex.org/I73616290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002413895","display_name":"Ki Jun Jeong","orcid":"https://orcid.org/0000-0002-9432-7519","observed_orcids":["https://orcid.org/0000-0002-9432-7519"]},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ki Jun Jeong","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering and Institute for the BioCentury, KAIST, Daejeon, 34141, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering and Institute for the BioCentury, KAIST, Daejeon, 34141, Republic of Korea","institution_ids":["https://openalex.org/I157485424"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103141436","display_name":"Baek-Rock Oh","orcid":"https://orcid.org/0000-0003-2762-8116","observed_orcids":["https://orcid.org/0000-0003-2762-8116"]},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Baek-Rock Oh","raw_affiliation_strings":["Microbial Biotechnology Research Center, Jeonbuk Branch Institute, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup, Jeonbuk, 56212, Republic of Korea. baekrock.oh@kribb.re.kr","Microbial Biotechnology Research Center, Jeonbuk Branch Institute, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup, Jeonbuk, 56212, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbial Biotechnology Research Center, Jeonbuk Branch Institute, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup, Jeonbuk, 56212, Republic of Korea. baekrock.oh@kribb.re.kr","institution_ids":["https://openalex.org/I73616290"]},{"raw_affiliation_string":"Microbial Biotechnology Research Center, Jeonbuk Branch Institute, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup, Jeonbuk, 56212, Republic of Korea","institution_ids":["https://openalex.org/I73616290"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5103141436"],"corresponding_institution_ids":["https://openalex.org/I73616290"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":{"value":3390,"currency":"USD","value_usd":3390},"fwci":1.8988,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.86521897,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"23","issue":"1","first_page":"205","last_page":"205"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10171","display_name":"Biofuel production and bioconversion","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10661","display_name":"biodegradable polymer synthesis and properties","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crude-glycerol","display_name":"crude glycerol","score":0.8610000014305115},{"id":"https://openalex.org/keywords/klebsiella-pneumoniae","display_name":"Klebsiella pneumoniae","score":0.9909999966621399},{"id":"https://openalex.org/keywords/meso-2-3-butanediol","display_name":"meso-2,3-butanediol","score":0.8980000019073486},{"id":"https://openalex.org/keywords/two-stage-fermentation","display_name":"two-stage fermentation","score":0.718999981880188},{"id":"https://openalex.org/keywords/1-3-propanediol","display_name":"1,3-propanediol","score":0.8989999890327454}],"concepts":[{"id":"https://openalex.org/C2780881558","wikidata":"https://www.wikidata.org/wiki/Q132501","display_name":"Glycerol","level":2,"score":0.9053775072097778},{"id":"https://openalex.org/C2775991252","wikidata":"https://www.wikidata.org/wiki/Q209157","display_name":"2,3-Butanediol","level":3,"score":0.8885493278503418},{"id":"https://openalex.org/C2777058267","wikidata":"https://www.wikidata.org/wiki/Q132592","display_name":"Klebsiella pneumoniae","level":4,"score":0.8681872487068176},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.5828076004981995},{"id":"https://openalex.org/C2779394659","wikidata":"https://www.wikidata.org/wiki/Q161514","display_name":"1,3-Propanediol","level":3,"score":0.5543279051780701},{"id":"https://openalex.org/C2982740256","wikidata":"https://www.wikidata.org/wiki/Q56064425","display_name":"Carbon source","level":2,"score":0.5112390518188477},{"id":"https://openalex.org/C134121241","wikidata":"https://www.wikidata.org/wiki/Q899301","display_name":"Yield (engineering)","level":2,"score":0.4985947608947754},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48726215958595276},{"id":"https://openalex.org/C32611913","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Titer","level":3,"score":0.4514341950416565},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.4506880044937134},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26542243361473083},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25634610652923584},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22885441780090332},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2056770622730255},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.14251390099525452},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002072","descriptor_name":"Butylene Glycols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005285","descriptor_name":"Fermentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005990","descriptor_name":"Glycerol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007711","descriptor_name":"Klebsiella pneumoniae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007711","descriptor_name":"Klebsiella pneumoniae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011409","descriptor_name":"Propylene Glycols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060847","descriptor_name":"Metabolic Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12934-024-02480-4","doi":"https://doi.org/10.1186/s12934-024-02480-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12934-024-02480-4","pdf_url":null,"source":{"id":"https://openalex.org/S171368329","display_name":"Microbial Cell Factories","issn_l":"1475-2859","issn":["1475-2859"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbial Cell Factories","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11267846","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11267846","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11267846/pdf/12934_2024_Article_2480.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microb Cell Fact","raw_type":"Text"},{"id":"pmid:39044245","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39044245","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbial cell factories","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:999c75d630254861a086e63269b2bbf7","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/999c75d630254861a086e63269b2bbf7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Microbial Cell Factories, Vol 23, Iss 1, Pp 1-13 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12934-024-02480-4","doi":"https://doi.org/10.1186/s12934-024-02480-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12934-024-02480-4","pdf_url":null,"source":{"id":"https://openalex.org/S171368329","display_name":"Microbial Cell Factories","issn_l":"1475-2859","issn":["1475-2859"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbial Cell Factories","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Responsible consumption and production","id":"https://metadata.un.org/sdg/12","score":0.5925999879837036}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4269722226","display_name":null,"funder_award_id":"KGM5482423","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G6069729942","display_name":null,"funder_award_id":"KGM5482423","funder_id":"https://openalex.org/F4320322110","funder_display_name":"Korea Research Institute of Bioscience and Biotechnology"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322110","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W610472860","https://openalex.org/W1501645518","https://openalex.org/W1780323655","https://openalex.org/W1964184380","https://openalex.org/W1970764403","https://openalex.org/W1972261835","https://openalex.org/W1974329558","https://openalex.org/W1978053930","https://openalex.org/W1980368537","https://openalex.org/W1989061866","https://openalex.org/W2014361215","https://openalex.org/W2014544211","https://openalex.org/W2028054553","https://openalex.org/W2050386368","https://openalex.org/W2087331674","https://openalex.org/W2091741880","https://openalex.org/W2107277218","https://openalex.org/W2108706107","https://openalex.org/W2116137883","https://openalex.org/W2123504916","https://openalex.org/W2123767496","https://openalex.org/W2147106412","https://openalex.org/W2149262008","https://openalex.org/W2151938593","https://openalex.org/W2164579471","https://openalex.org/W2164618978","https://openalex.org/W2398988382","https://openalex.org/W2407003327","https://openalex.org/W2412311153","https://openalex.org/W2760348791","https://openalex.org/W2795002851","https://openalex.org/W2808122003","https://openalex.org/W2920822548","https://openalex.org/W3110259824","https://openalex.org/W3144345065","https://openalex.org/W3152934011","https://openalex.org/W3169612077","https://openalex.org/W3171980001","https://openalex.org/W3211856957","https://openalex.org/W4221008018","https://openalex.org/W4230436756","https://openalex.org/W4319312702","https://openalex.org/W4360956646","https://openalex.org/W4385577835","https://openalex.org/W4399496732","https://openalex.org/W6941013355"],"related_works":["https://openalex.org/W4404941712","https://openalex.org/W6902197928","https://openalex.org/W4399496732","https://openalex.org/W610472860","https://openalex.org/W2151938593","https://openalex.org/W7133671318","https://openalex.org/W2594096710","https://openalex.org/W7095924839","https://openalex.org/W2412311153","https://openalex.org/W2050706210"],"abstract_inverted_index":{"BACKGROUND:":[0],"(R,R)-2,3-butanediol":[1],"(BDO)":[2],"is":[3,11,40,199,233],"employed":[4],"in":[5,31,55,139,201,212,220],"a":[6,25,117,190,217],"variety":[7],"of":[8,22,51,62,76,86,95,111,134,147,165,168,172,175,180,192,229],"applications":[9],"and":[10,93,132,178,208],"gaining":[12],"prominence":[13],"due":[14],"to":[15,68,82,126,226,237],"its":[16],"unique":[17],"physicochemical":[18],"features.":[19],"The":[20,72,84],"use":[21],"glycerol":[23,43,157,185,241],"as":[24,103,242],"carbon":[26,245],"source":[27],"for":[28],"2,3-BDO":[29],"production":[30,60,207],"Klebsiella":[32,221],"pneumoniae":[33,57,78],"has":[34],"been":[35],"limited,":[36],"since":[37],"1,3-propanediol":[38],"(PDO)":[39],"generated":[41],"during":[42],"fermentation.":[44],"RESULTS:":[45],"In":[46,224],"this":[47,115,232],"study,":[48],"the":[49,52,59,104,109,135,145,163,205,227,234,243],"inactivation":[50],"budC":[53],"gene":[54,137],"K.":[56,77],"increased":[58],"rate":[61],"(R,R)-2,3-BDO":[63,87,96,112,140,148,169,215,239],"from":[64,124],"21.92":[65],"\u00b1":[66,70],"2.10":[67],"92.05":[69],"1.20%.":[71],"major":[73],"isomer":[74],"form":[75],"(meso-2,3-BDO)":[79],"was":[80,88,97,158,186],"shifted":[81],"(R,R)-2,3-BDO.":[83],"purity":[85,110,146,191,219],"examined":[89],"by":[90],"agitation":[91,119],"speed,":[92],"98.54%":[94],"obtained":[98],"at":[99],"500":[100,125],"rpm.":[101],"However,":[102],"cultivation":[105],"period":[106],"got":[107],"longer,":[108],"declined.":[113],"For":[114],"problem,":[116],"two-step":[118],"speed":[120],"control":[121],"strategy":[122],"(adjusted":[123],"400":[127],"rpm":[128],"after":[129],"24":[130],"h)":[131],"over-expression":[133],"dhaD":[136],"involved":[138],"biosynthesis":[141],"were":[142],"used.":[143],"Nevertheless,":[144],"still":[149],"gradually":[150],"decreased":[151],"over":[152],"time.":[153],"Finally,":[154],"when":[155],"pure":[156],"replaced":[159],"with":[160,216],"crude":[161,184],"glycerol,":[162],"titer":[164],"89.47":[166],"g/L":[167,171],"(1.69":[170],"meso-2,3-BDO),":[173],"productivity":[174,209],"1.24":[176],"g/L/h,":[177],"yield":[179],"0.35":[181],"g/g":[182],"consumed":[183],"achieved":[187],"while":[188],"maintaining":[189],"98%":[193],"or":[194],"higher.":[195],"CONCLUSIONS:":[196],"This":[197],"study":[198,236],"meaningful":[200],"that":[202,213],"it":[203],"demonstrated":[204],"highest":[206],"among":[210],"studies":[211],"produced":[214],"high":[218],"sp.":[222],"strains.":[223],"addition,":[225],"best":[228],"our":[230],"knowledge,":[231],"first":[235],"produce":[238],"using":[240],"sole":[244],"source.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-07-24T00:00:00"}