{"id":"https://openalex.org/W4400880967","doi":"https://doi.org/10.1186/s41100-024-00553-z","title":"Acetate-containing bicarbonate dialysate increases all-cause mortality more than acetate-free bicarbonate dialysate containing citrate in hemodialysis patients","display_name":"Acetate-containing bicarbonate dialysate increases all-cause mortality more than acetate-free bicarbonate dialysate containing citrate in hemodialysis patients","publication_year":2024,"publication_date":"2024-07-22","ids":{"openalex":"https://openalex.org/W4400880967","doi":"https://doi.org/10.1186/s41100-024-00553-z"},"language":"en","primary_location":{"id":"doi:10.1186/s41100-024-00553-z","doi":"https://doi.org/10.1186/s41100-024-00553-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s41100-024-00553-z","pdf_url":"https://rrtjournal.biomedcentral.com/counter/pdf/10.1186/s41100-024-00553-z","source":{"id":"https://openalex.org/S2764611265","display_name":"Renal Replacement Therapy","issn_l":"2059-1381","issn":["2059-1381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Renal Replacement Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://rrtjournal.biomedcentral.com/counter/pdf/10.1186/s41100-024-00553-z","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108848862","display_name":"Kazuyoshi Okada","orcid":"https://orcid.org/0009-0008-0725-2688","observed_orcids":["https://orcid.org/0009-0008-0725-2688"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kazuyoshi Okada","raw_affiliation_strings":["Department of Nephrology, Kawashima Hospital, 6-1 Kitasakoichiban-cho, Tokushima-shi, Tokushima, 770-0011, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Kawashima Hospital, 6-1 Kitasakoichiban-cho, Tokushima-shi, Tokushima, 770-0011, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101509613","display_name":"Manabu Tashiro","orcid":"https://orcid.org/0000-0002-8860-6917","observed_orcids":["https://orcid.org/0000-0002-8860-6917"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Manabu Tashiro","raw_affiliation_strings":["Department of Nephrology, Kawashima Hospital, 6-1 Kitasakoichiban-cho, Tokushima-shi, Tokushima, 770-0011, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Kawashima Hospital, 6-1 Kitasakoichiban-cho, Tokushima-shi, Tokushima, 770-0011, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057133063","display_name":"Hiroyuki Michiwaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroyuki Michiwaki","raw_affiliation_strings":["Department of Clinical Engineering, Kawashima Hospital, Tokushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Engineering, Kawashima Hospital, Tokushima, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051081858","display_name":"Yusaku Tanaka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yusaku Tanaka","raw_affiliation_strings":["Department of Clinical Engineering, Kawashima Hospital, Tokushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Engineering, Kawashima Hospital, Tokushima, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113299259","display_name":"Syo Yamashita","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Syo Yamashita","raw_affiliation_strings":["Department of Clinical Engineering, Kawashima Hospital, Tokushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Engineering, Kawashima Hospital, Tokushima, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104110903","display_name":"Tomoko Inoue","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tomoko Inoue","raw_affiliation_strings":["Department of Nephrology, Kawashima Hospital, 6-1 Kitasakoichiban-cho, Tokushima-shi, Tokushima, 770-0011, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Kawashima Hospital, 6-1 Kitasakoichiban-cho, Tokushima-shi, Tokushima, 770-0011, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038764955","display_name":"Hisato Shima","orcid":"https://orcid.org/0000-0003-3918-4735","observed_orcids":["https://orcid.org/0000-0003-3918-4735"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hisato Shima","raw_affiliation_strings":["Department of Nephrology, Kawashima Hospital, 6-1 Kitasakoichiban-cho, Tokushima-shi, Tokushima, 770-0011, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Kawashima Hospital, 6-1 Kitasakoichiban-cho, Tokushima-shi, Tokushima, 770-0011, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102089667","display_name":"Jun Minakuchi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jun Minakuchi","raw_affiliation_strings":["Department of Nephrology, Kawashima Hospital, 6-1 Kitasakoichiban-cho, Tokushima-shi, Tokushima, 770-0011, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Kawashima Hospital, 6-1 Kitasakoichiban-cho, Tokushima-shi, Tokushima, 770-0011, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5108848862"],"corresponding_institution_ids":[],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":0.7895,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.73929961,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":"10","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12840","display_name":"Renal function and acid-base balance","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dialysate-bicarbonate","display_name":"bicarbonate dialysate","score":0.8849999904632568},{"id":"https://openalex.org/keywords/hemodialysis","display_name":"hemodialysis","score":0.8320000171661377},{"id":"https://openalex.org/keywords/online-hemodiafiltration","display_name":"online hemodiafiltration","score":0.9980000257492065},{"id":"https://openalex.org/keywords/all-cause-mortality","display_name":"all-cause mortality","score":0.9800000190734863},{"id":"https://openalex.org/keywords/end-stage-renal-disease","display_name":"end-stage renal disease","score":0.718999981880188},{"id":"https://openalex.org/keywords/dialysate-composition","display_name":"dialysate composition","score":0.5360000133514404}],"concepts":[{"id":"https://openalex.org/C2781112554","wikidata":"https://www.wikidata.org/wiki/Q409202","display_name":"Bicarbonate","level":2,"score":0.8823948502540588},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7786895632743835},{"id":"https://openalex.org/C2778063415","wikidata":"https://www.wikidata.org/wiki/Q391744","display_name":"Hemodialysis","level":2,"score":0.7013643980026245},{"id":"https://openalex.org/C54847362","wikidata":"https://www.wikidata.org/wiki/Q177635","display_name":"Nephrology","level":2,"score":0.5653830766677856},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4934881925582886},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.36252301931381226},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3356895446777344}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1186/s41100-024-00553-z","doi":"https://doi.org/10.1186/s41100-024-00553-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s41100-024-00553-z","pdf_url":"https://rrtjournal.biomedcentral.com/counter/pdf/10.1186/s41100-024-00553-z","source":{"id":"https://openalex.org/S2764611265","display_name":"Renal Replacement Therapy","issn_l":"2059-1381","issn":["2059-1381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Renal Replacement Therapy","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:0a555f944f0b452d876e33f570ec366c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/0a555f944f0b452d876e33f570ec366c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Renal Replacement Therapy, Vol 10, Iss 1, Pp 1-9 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s41100-024-00553-z","doi":"https://doi.org/10.1186/s41100-024-00553-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s41100-024-00553-z","pdf_url":"https://rrtjournal.biomedcentral.com/counter/pdf/10.1186/s41100-024-00553-z","source":{"id":"https://openalex.org/S2764611265","display_name":"Renal Replacement Therapy","issn_l":"2059-1381","issn":["2059-1381"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Renal Replacement Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4400880967.pdf","grobid_xml":"https://content.openalex.org/works/W4400880967.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1542152315","https://openalex.org/W1906680479","https://openalex.org/W1966496201","https://openalex.org/W1980898895","https://openalex.org/W2009276506","https://openalex.org/W2012225387","https://openalex.org/W2033577946","https://openalex.org/W2038016273","https://openalex.org/W2054907419","https://openalex.org/W2069001075","https://openalex.org/W2080695163","https://openalex.org/W2084227076","https://openalex.org/W2107402265","https://openalex.org/W2108443420","https://openalex.org/W2111635289","https://openalex.org/W2993953294","https://openalex.org/W3000678916","https://openalex.org/W3202846536","https://openalex.org/W4200109054","https://openalex.org/W4225003801","https://openalex.org/W4301397081","https://openalex.org/W4383341834","https://openalex.org/W4395002624"],"related_works":["https://openalex.org/W6930206798","https://openalex.org/W3040629498","https://openalex.org/W4378781831","https://openalex.org/W3048674580","https://openalex.org/W3033834797","https://openalex.org/W2949212137","https://openalex.org/W2252722446","https://openalex.org/W4415425295","https://openalex.org/W2780689962","https://openalex.org/W1906680479"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"No":[2],"studies":[3],"have":[4],"compared":[5,28,87,108],"mortality":[6,29,85,133,187,222],"between":[7,30,76,88],"acetate-containing":[8],"bicarbonate":[9,14],"dialysate":[10,15],"(ABD)":[11],"and":[12,32,60,70,79,90,113,230],"acetate-free":[13],"containing":[16],"citrate":[17],"(AFD)":[18],"in":[19,34,92,144,164,205,211,226],"hemodialysis":[20],"(HD)":[21],"or":[22,51,63,95,163],"online":[23],"hemodiafiltration":[24],"(OHDF).":[25],"We":[26],"therefore":[27],"ABD":[31,58,68,89,135,192,220],"AFD":[33,61,71,91,143,195,225],"each":[35],"modality.":[36],"Methods":[37],"This":[38],"retrospective":[39],"observational":[40],"study":[41],"included":[42],"738":[43],"patients":[44,227],"who":[45],"were":[46,107],"receiving":[47],"super":[48],"high-flux":[49],"(SHF)":[50],"SHF":[52,229,231],"albumin-leaking":[53,232],"HD":[54,94,146,207],"(n":[55,65,168],"=":[56,66,149,161,169,177,203],"310:":[57],"235":[59],"75)":[62],"OHDF":[64,96,166,213],"428:":[67],"321":[69],"107)":[72],"at":[73],"our":[74],"institution":[75],"1":[77,80],"April":[78],"July":[81],"2017.":[82],"Three-year":[83],"all-cause":[84],"was":[86,120,136,188],"the":[93,110,145,165,206,212],"groups":[97],"using":[98,109,184],"a":[99],"propensity":[100,130],"score":[101,131],"matching":[102],"model.":[103],"Kaplan\u2013Meier":[104],"survival":[105],"curves":[106],"log-rank":[111],"test,":[112],"then":[114],"Cox":[115],"regression":[116],"analysis":[117],"with":[118,182],"adjustments":[119,183],"performed":[121],"for":[122],"some":[123,185],"covariates":[124],"that":[125,141,219],"remained":[126],"significant.":[127],"Results":[128],"After":[129],"matching,":[132],"on":[134,142,191,194,228],"not":[137,210],"significantly":[138,189],"different":[139],"from":[140],"group":[147,167],"[n":[148],"75;":[150],"hazard":[151],"ratio":[152],"(HR)":[153],"2.271,":[154],"95%":[155,173,199],"confidence":[156],"interval":[157],"(CI)":[158],"0.863\u20135.981,":[159],"P":[160,176,202],"0.087]":[162],"107;":[170],"HR":[171,197],"1.944,":[172],"CI":[174,200],"0.585\u20136.458,":[175],"0.269)":[178],"without":[179],"adjustments.":[180],"However,":[181],"covariates,":[186],"higher":[190],"than":[193,224],"(adjusted":[196],"4.501,":[198],"1.434\u201314.125,":[201],"0.010)":[204],"group,":[208],"but":[209],"group.":[214],"Conclusions":[215],"These":[216],"findings":[217],"suggest":[218],"worsens":[221],"more":[223],"HD.":[233],"Trial":[234],"registration:":[235],"UMIN":[236],"Clinical":[237],"Trials":[238],"Registry,":[239],"UMIN000053090.":[240],"Prospectively":[241],"registered":[242],"13":[243],"December":[244],"2023,":[245],"https://center6.umin.ac.jp/cgi-bin/ctr/ctr_view_reg.cgi?recptno=R000060581":[246],".":[247]},"counts_by_year":[{"year":2025,"cited_by_count":3}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2024-07-23T00:00:00"}