{"id":"https://openalex.org/W4400872184","doi":"https://doi.org/10.1038/s41598-024-67591-9","title":"Creation of a spatially complex mucus bilayer on an in vitro colon model","display_name":"Creation of a spatially complex mucus bilayer on an in vitro colon model","publication_year":2024,"publication_date":"2024-07-22","ids":{"openalex":"https://openalex.org/W4400872184","doi":"https://doi.org/10.1038/s41598-024-67591-9","pmid":"https://pubmed.ncbi.nlm.nih.gov/39039235","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11263341"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-024-67591-9","doi":"https://doi.org/10.1038/s41598-024-67591-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-024-67591-9","pdf_url":null,"source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1038/s41598-024-67591-9","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078083129","display_name":"Cecilia Villegas-Novoa","orcid":"https://orcid.org/0000-0003-0522-6829","observed_orcids":["https://orcid.org/0000-0003-0522-6829"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cecilia Villegas-Novoa","raw_affiliation_strings":["Department of Bioengineering, University of Washington, Seattle, WA, 98195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Washington, Seattle, WA, 98195, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100741506","display_name":"Yuli Wang","orcid":"https://orcid.org/0000-0002-5500-3351","observed_orcids":["https://orcid.org/0000-0002-5500-3351"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuli Wang","raw_affiliation_strings":["Department of Bioengineering, University of Washington, Seattle, WA, 98195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Washington, Seattle, WA, 98195, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084492610","display_name":"Christopher E. Sims","orcid":"https://orcid.org/0000-0001-9991-3317","observed_orcids":["https://orcid.org/0000-0001-9991-3317"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher E. Sims","raw_affiliation_strings":["Department of Bioengineering, University of Washington, Seattle, WA, 98195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Washington, Seattle, WA, 98195, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048509828","display_name":"Nancy L. Allbritton","orcid":"https://orcid.org/0000-0002-9242-768X","observed_orcids":["https://orcid.org/0000-0002-9242-768X"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nancy L. Allbritton","raw_affiliation_strings":["Department of Bioengineering, University of Washington, Seattle, WA, 98195, USA. nlallbr@uw.edu","Department of Bioengineering, University of Washington, Seattle, WA, 98195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Washington, Seattle, WA, 98195, USA. nlallbr@uw.edu","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Bioengineering, University of Washington, Seattle, WA, 98195, USA","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5048509828"],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":{"value":2590,"currency":"USD","value_usd":2590},"apc_paid":{"value":2590,"currency":"USD","value_usd":2590},"fwci":8.3712,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.98537412,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"14","issue":"1","first_page":"16849","last_page":"16849"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.336899995803833,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.336899995803833,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.20100000500679016,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13199","display_name":"Digestive system and related health","score":0.0828000009059906,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colonic-mucus","display_name":"colonic mucus","score":0.8610000014305115},{"id":"https://openalex.org/keywords/in-vitro-colon-model","display_name":"in vitro colon model","score":0.7549999952316284},{"id":"https://openalex.org/keywords/goblet-cells","display_name":"goblet cells","score":0.8960000276565552},{"id":"https://openalex.org/keywords/air-liquid-interface-culture","display_name":"air-liquid interface culture","score":0.796999990940094},{"id":"https://openalex.org/keywords/lectin-binding","display_name":"lectin binding","score":0.7250000238418579},{"id":"https://openalex.org/keywords/mucus-flow","display_name":"mucus flow","score":0.5720000267028809}],"concepts":[{"id":"https://openalex.org/C2777312293","wikidata":"https://www.wikidata.org/wiki/Q3649349","display_name":"Mucus","level":2,"score":0.707861065864563},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6208930611610413},{"id":"https://openalex.org/C192157962","wikidata":"https://www.wikidata.org/wiki/Q4087243","display_name":"Bilayer","level":3,"score":0.5889232754707336},{"id":"https://openalex.org/C3020179232","wikidata":"https://www.wikidata.org/wiki/Q11083","display_name":"Distal colon","level":2,"score":0.4921361804008484},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.41368231177330017},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.39172086119651794},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3285997211933136},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2673874497413635},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20820769667625427},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20304837822914124},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12372201681137085},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.10492515563964844},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.09287065267562866}],"mesh":[{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009093","descriptor_name":"Mucus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020397","descriptor_name":"Goblet Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41598-024-67591-9","doi":"https://doi.org/10.1038/s41598-024-67591-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-024-67591-9","pdf_url":null,"source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11263341","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11263341","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11263341/pdf/41598_2024_Article_67591.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:39039235","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39039235","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:c1d4b7b3c9d04bd0a838556f4afc0620","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/c1d4b7b3c9d04bd0a838556f4afc0620","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-024-67591-9","doi":"https://doi.org/10.1038/s41598-024-67591-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-024-67591-9","pdf_url":null,"source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4000000059604645,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3233684897","display_name":"Development of a microphysiologic system to assay the interaction of the human colonic epithelium on Clostridium difficile","funder_award_id":"R01DK120606","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6161852781","display_name":null,"funder_award_id":"DK120606","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8108422591","display_name":null,"funder_award_id":"DK121580","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8443314202","display_name":"Developing an optimized cell based platform for assays of the gastrointestinal enteroendocrine system","funder_award_id":"R44DK121580","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8539622277","display_name":"Developing a platform and optimized cell system for enteroendocrine cell-based assays and compound screening","funder_award_id":"R43DK121580","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000135049","display_name":null,"funder_award_id":"DK121580","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320310094","display_name":"University of Washington","ror":"https://ror.org/00cvxb145"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1491526770","https://openalex.org/W1569885333","https://openalex.org/W1965847743","https://openalex.org/W1967729566","https://openalex.org/W1978195655","https://openalex.org/W1993723900","https://openalex.org/W1996933969","https://openalex.org/W2018163270","https://openalex.org/W2053352622","https://openalex.org/W2059855607","https://openalex.org/W2071244928","https://openalex.org/W2072965356","https://openalex.org/W2089234414","https://openalex.org/W2091369121","https://openalex.org/W2098201429","https://openalex.org/W2100672979","https://openalex.org/W2108636884","https://openalex.org/W2126131092","https://openalex.org/W2154144191","https://openalex.org/W2167279371","https://openalex.org/W2195777839","https://openalex.org/W2214747519","https://openalex.org/W2330566617","https://openalex.org/W2462023038","https://openalex.org/W2472575791","https://openalex.org/W2593017724","https://openalex.org/W2766670989","https://openalex.org/W2771385705","https://openalex.org/W2801858122","https://openalex.org/W2806830617","https://openalex.org/W2886230392","https://openalex.org/W2890605864","https://openalex.org/W2897044614","https://openalex.org/W2916244827","https://openalex.org/W2923393751","https://openalex.org/W2965377824","https://openalex.org/W2965587317","https://openalex.org/W2985983100","https://openalex.org/W2990307813","https://openalex.org/W3003235085","https://openalex.org/W3005484627","https://openalex.org/W3037480564","https://openalex.org/W3112193720","https://openalex.org/W3124251397","https://openalex.org/W3129258187","https://openalex.org/W3153812969","https://openalex.org/W3159974931","https://openalex.org/W3210001296","https://openalex.org/W4200105651","https://openalex.org/W4206765902","https://openalex.org/W4225660631","https://openalex.org/W4283328502","https://openalex.org/W4311309888"],"related_works":["https://openalex.org/W2965587317","https://openalex.org/W2059855607","https://openalex.org/W6943860194","https://openalex.org/W3210001296","https://openalex.org/W2127227914","https://openalex.org/W7152620942","https://openalex.org/W214948707","https://openalex.org/W2018491726","https://openalex.org/W4288053089","https://openalex.org/W2075322231"],"abstract_inverted_index":{"The":[0,137],"colonic":[1],"epithelium":[2],"is":[3],"comprised":[4],"of":[5,17,27,33,157,192],"three-dimensional":[6],"crypts":[7,36,63,109],"(3D)":[8],"lined":[9],"with":[10,37,64,88,183],"mucus":[11,39,66,95,116,130,153,171,178,193],"secreted":[12],"by":[13,132],"a":[14,28,38,52,65],"heterogeneous":[15],"population":[16],"goblet":[18],"cells.":[19],"In":[20,148],"this":[21],"study,":[22],"we":[23],"report":[24],"the":[25,43,94,97,108,144,150,158,162,184],"formation":[26],"long-lived,":[29,140],"and":[30,80,106,166,177,189,195],"self-renewing":[31],"replica":[32],"human":[34,159],"3D":[35],"layer":[40],"patterned":[41],"in":[42,96,111,123,134,151,198],"X-Y-Z":[44],"dimensions.":[45],"Primary":[46],"colon":[47],"cells":[48],"were":[49],"cultured":[50],"on":[51],"shaped":[53],"scaffold":[54],"under":[55],"an":[56,74],"air-liquid":[57],"interface":[58],"to":[59,181,186],"yield":[60],"architecturally":[61],"accurate":[62],"bilayer":[67,163],"(605":[68],"\u00b1":[69,77,83],"180":[70],"\u03bcm":[71],"thick)":[72],"possessing":[73],"inner":[75],"(149":[76],"50":[78,142],"\u03bcm)":[79,85],"outer":[81],"(435":[82],"111":[84],"region.":[86],"Lectins":[87],"distinct":[89,102],"carbohydrate-binding":[90],"preferences":[91],"demonstrated":[92],"that":[93,104],"intercrypt":[98],"regions":[99],"was":[100,139],"chemically":[101],"from":[103,120],"above":[105],"within":[107],"replicating":[110],"vivo":[112],"chemical":[113,175],"patterning.":[114],"Constitutive":[115],"secretion":[117,128,179],"ejected":[118],"beads":[119],"crypt":[121],"lumens":[122],"8-10":[124],"days,":[125,143],"while":[126],"agonist-stimulated":[127],"increased":[129],"thickness":[131],"17-fold":[133],"8":[135],"h.":[136],"tissue":[138],">":[141],"longest":[145],"time":[146],"assessed.":[147],"conclusion,":[149],"vitro":[152],"replicated":[154],"key":[155],"physiology":[156],"mucus,":[160],"including":[161],"(Z)":[164],"structure":[165],"intercrypt-crypt":[167],"(X-Y)":[168],"zones,":[169],"constitutive":[170],"flow,":[172],"spatially":[173],"complex":[174],"attributes,":[176],"response":[180],"stimulation,":[182],"potential":[185],"reveal":[187],"local":[188],"global":[190],"determinants":[191],"function":[194],"its":[196],"breakdown":[197],"disease.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-07-23T00:00:00"}
