{"id":"https://openalex.org/W4400871024","doi":"https://doi.org/10.1016/j.molliq.2024.125605","title":"Inhibitory mechanism of xanthine oxidase by 6-, 8- and 10-gingerol: Enzyme kinetics, multi-spectroscopy and molecular simulations","display_name":"Inhibitory mechanism of xanthine oxidase by 6-, 8- and 10-gingerol: Enzyme kinetics, multi-spectroscopy and molecular simulations","publication_year":2024,"publication_date":"2024-07-22","ids":{"openalex":"https://openalex.org/W4400871024","doi":"https://doi.org/10.1016/j.molliq.2024.125605"},"language":"en","primary_location":{"id":"doi:10.1016/j.molliq.2024.125605","doi":"https://doi.org/10.1016/j.molliq.2024.125605","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.molliq.2024.125605","pdf_url":null,"source":{"id":"https://openalex.org/S189140625","display_name":"Journal of Molecular Liquids","issn_l":"0167-7322","issn":["0167-7322","1873-3166"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Journal of Molecular Liquids","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.molliq.2024.125605","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Rui Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I14894300","display_name":"Foshan University","ror":"https://ror.org/02xvvvp28","country_code":"CN","type":"education","lineage":["https://openalex.org/I14894300"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Wang","raw_affiliation_strings":["School of Food Science and Engineering, Guangdong Provincial Key Laboratory of Intelligent Food Manufacturing, Foshan University, Foshan 528225, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Food Science and Engineering, Guangdong Provincial Key Laboratory of Intelligent Food Manufacturing, Foshan University, Foshan 528225, China","institution_ids":["https://openalex.org/I14894300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111264268","display_name":"Pei-Feng Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I14894300","display_name":"Foshan University","ror":"https://ror.org/02xvvvp28","country_code":"CN","type":"education","lineage":["https://openalex.org/I14894300"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pei-Feng Guo","raw_affiliation_strings":["School of Food Science and Engineering, Guangdong Provincial Key Laboratory of Intelligent Food Manufacturing, Foshan University, Foshan 528225, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Food Science and Engineering, Guangdong Provincial Key Laboratory of Intelligent Food Manufacturing, Foshan University, Foshan 528225, China","institution_ids":["https://openalex.org/I14894300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102462685","display_name":"Jing Nie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I14894300","display_name":"Foshan University","ror":"https://ror.org/02xvvvp28","country_code":"CN","type":"education","lineage":["https://openalex.org/I14894300"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Nie","raw_affiliation_strings":["School of Food Science and Engineering, Guangdong Provincial Key Laboratory of Intelligent Food Manufacturing, Foshan University, Foshan 528225, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Food Science and Engineering, Guangdong Provincial Key Laboratory of Intelligent Food Manufacturing, Foshan University, Foshan 528225, China","institution_ids":["https://openalex.org/I14894300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102817296","display_name":"Xing Hu","orcid":"https://orcid.org/0000-0002-4590-3671","observed_orcids":["https://orcid.org/0000-0002-4590-3671"]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xing Hu","raw_affiliation_strings":["State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, China","institution_ids":["https://openalex.org/I141649914"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yu-Wei Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164009","display_name":"Guangdong Baiyun University","ror":"https://ror.org/04wmrj902","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210164009"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu-Wei Wu","raw_affiliation_strings":["Faculty of Foreign Lauguages, Guangdong Baiyun University, Guangzhou 510641, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Foreign Lauguages, Guangdong Baiyun University, Guangzhou 510641, China","institution_ids":["https://openalex.org/I4210164009"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074292937","display_name":"Shu Zhu","orcid":"https://orcid.org/0000-0002-4239-2781","observed_orcids":["https://orcid.org/0000-0002-4239-2781"]},"institutions":[{"id":"https://openalex.org/I4405278738","display_name":"Zhejiang College of Security Technology","ror":"https://ror.org/00fkk2t28","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405278738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shu Zhu","raw_affiliation_strings":["Zhejiang College of Security Technology, Wenzhou 325000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang College of Security Technology, Wenzhou 325000, China","institution_ids":["https://openalex.org/I4405278738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103009657","display_name":"Bo-Ru Chen","orcid":"https://orcid.org/0000-0003-3661-1391","observed_orcids":["https://orcid.org/0000-0003-3661-1391"]},"institutions":[{"id":"https://openalex.org/I14894300","display_name":"Foshan University","ror":"https://ror.org/02xvvvp28","country_code":"CN","type":"education","lineage":["https://openalex.org/I14894300"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bo-Ru Chen","raw_affiliation_strings":["School of Food Science and Engineering, Guangdong Provincial Key Laboratory of Intelligent Food Manufacturing, Foshan University, Foshan 528225, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Food Science and Engineering, Guangdong Provincial Key Laboratory of Intelligent Food Manufacturing, Foshan University, Foshan 528225, China","institution_ids":["https://openalex.org/I14894300"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jian Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I14894300","display_name":"Foshan University","ror":"https://ror.org/02xvvvp28","country_code":"CN","type":"education","lineage":["https://openalex.org/I14894300"]},{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Li","raw_affiliation_strings":["School of Food Science and Engineering, Guangdong Provincial Key Laboratory of Intelligent Food Manufacturing, Foshan University, Foshan 528225, China","School of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Food Science and Engineering, Guangdong Provincial Key Laboratory of Intelligent Food Manufacturing, Foshan University, Foshan 528225, China","institution_ids":["https://openalex.org/I14894300"]},{"raw_affiliation_string":"School of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112153620","display_name":"Xin\u2010An Zeng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I14894300","display_name":"Foshan University","ror":"https://ror.org/02xvvvp28","country_code":"CN","type":"education","lineage":["https://openalex.org/I14894300"]},{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xin-An Zeng","raw_affiliation_strings":["School of Food Science and Engineering, Guangdong Provincial Key Laboratory of Intelligent Food Manufacturing, Foshan University, Foshan 528225, China","School of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Food Science and Engineering, Guangdong Provincial Key Laboratory of Intelligent Food Manufacturing, Foshan University, Foshan 528225, China","institution_ids":["https://openalex.org/I14894300"]},{"raw_affiliation_string":"School of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102508011","display_name":"Feiyue Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I14894300","display_name":"Foshan University","ror":"https://ror.org/02xvvvp28","country_code":"CN","type":"education","lineage":["https://openalex.org/I14894300"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fei-Yue Xu","raw_affiliation_strings":["School of Food Science and Engineering, Guangdong Provincial Key Laboratory of Intelligent Food Manufacturing, Foshan University, Foshan 528225, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Food Science and Engineering, Guangdong Provincial Key Laboratory of Intelligent Food Manufacturing, Foshan University, Foshan 528225, China","institution_ids":["https://openalex.org/I14894300"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5102508011","https://openalex.org/A5112153620"],"corresponding_institution_ids":["https://openalex.org/I14894300","https://openalex.org/I90610280"],"apc_list":{"value":3380,"currency":"USD","value_usd":3380},"apc_paid":null,"fwci":2.6521,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.89613576,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"410","issue":null,"first_page":"125605","last_page":"125605"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12347","display_name":"Ginger and Zingiberaceae research","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12347","display_name":"Ginger and Zingiberaceae research","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.020500000566244125,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/xanthine-oxidase","display_name":"xanthine oxidase","score":0.9570000171661377},{"id":"https://openalex.org/keywords/gingerol","display_name":"gingerol","score":0.9210000038146973},{"id":"https://openalex.org/keywords/10-gingerol","display_name":"10-gingerol","score":0.9129999876022339},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.6890000104904175},{"id":"https://openalex.org/keywords/mixed-inhibition","display_name":"mixed-type inhibition","score":0.9269999861717224},{"id":"https://openalex.org/keywords/flavin-adenine-dinucleotide","display_name":"flavin adenine dinucleotide","score":0.8560000061988831},{"id":"https://openalex.org/keywords/uric-acid","display_name":"uric acid","score":0.7490000128746033},{"id":"https://openalex.org/keywords/enzyme-conformational-change","display_name":"enzyme conformational change","score":0.6650000214576721},{"id":"https://openalex.org/keywords/enzyme-stability","display_name":"enzyme stability","score":0.4480000138282776},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.3269999921321869},{"id":"https://openalex.org/keywords/binding-affinity","display_name":"binding affinity","score":0.4259999990463257}],"concepts":[{"id":"https://openalex.org/C2778102346","wikidata":"https://www.wikidata.org/wiki/Q412509","display_name":"Xanthine oxidase","level":3,"score":0.8263947367668152},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.7278218865394592},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6355697512626648},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.6186270117759705},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5354189276695251},{"id":"https://openalex.org/C32891209","wikidata":"https://www.wikidata.org/wiki/Q483666","display_name":"Spectroscopy","level":2,"score":0.4792497158050537},{"id":"https://openalex.org/C56856141","wikidata":"https://www.wikidata.org/wiki/Q883112","display_name":"Enzyme kinetics","level":4,"score":0.4516028165817261},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.387279748916626},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33220040798187256},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.32943934202194214},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.11028271913528442},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08109140396118164},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07639986276626587},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.molliq.2024.125605","doi":"https://doi.org/10.1016/j.molliq.2024.125605","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.molliq.2024.125605","pdf_url":null,"source":{"id":"https://openalex.org/S189140625","display_name":"Journal of Molecular Liquids","issn_l":"0167-7322","issn":["0167-7322","1873-3166"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Journal of Molecular Liquids","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.molliq.2024.125605","doi":"https://doi.org/10.1016/j.molliq.2024.125605","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.molliq.2024.125605","pdf_url":null,"source":{"id":"https://openalex.org/S189140625","display_name":"Journal of Molecular Liquids","issn_l":"0167-7322","issn":["0167-7322","1873-3166"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Journal of Molecular Liquids","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4000000059604645,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1643213837","display_name":null,"funder_award_id":"U23A20267","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3883234738","display_name":null,"funder_award_id":"2022A1515110186","funder_id":"https://openalex.org/F4320337111","funder_display_name":"Basic and Applied Basic Research Foundation of Guangdong Province"},{"id":"https://openalex.org/G5444181434","display_name":null,"funder_award_id":"32172348","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6498359640","display_name":null,"funder_award_id":"31972205","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7143856747","display_name":null,"funder_award_id":"2022M721196","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"},{"id":"https://openalex.org/G7964423799","display_name":null,"funder_award_id":"2023YFD2101000","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"},{"id":"https://openalex.org/F4320327069","display_name":"Foshan University","ror":"https://ror.org/02xvvvp28"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null},{"id":"https://openalex.org/F4320337111","display_name":"Basic and Applied Basic Research Foundation of Guangdong Province","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W787482168","https://openalex.org/W1024036315","https://openalex.org/W1074809087","https://openalex.org/W1588979652","https://openalex.org/W2002469023","https://openalex.org/W2009356149","https://openalex.org/W2034917714","https://openalex.org/W2039806864","https://openalex.org/W2041694963","https://openalex.org/W2049505234","https://openalex.org/W2056564326","https://openalex.org/W2075705506","https://openalex.org/W2092995205","https://openalex.org/W2099246483","https://openalex.org/W2130541969","https://openalex.org/W2171268876","https://openalex.org/W2312295870","https://openalex.org/W2486962198","https://openalex.org/W2491458126","https://openalex.org/W2759453173","https://openalex.org/W2771006933","https://openalex.org/W2790580737","https://openalex.org/W2900220652","https://openalex.org/W2921292382","https://openalex.org/W2936607721","https://openalex.org/W2942110698","https://openalex.org/W2978483879","https://openalex.org/W2997761418","https://openalex.org/W3001022681","https://openalex.org/W3015014887","https://openalex.org/W3016618745","https://openalex.org/W3026693047","https://openalex.org/W3035190080","https://openalex.org/W3044108113","https://openalex.org/W3082620643","https://openalex.org/W3091850792","https://openalex.org/W3092592343","https://openalex.org/W3137871973","https://openalex.org/W3141481706","https://openalex.org/W3155147493","https://openalex.org/W3195357476","https://openalex.org/W3196572461","https://openalex.org/W3202971910","https://openalex.org/W4200610664","https://openalex.org/W4283265546","https://openalex.org/W4376604851","https://openalex.org/W4388011755","https://openalex.org/W4392715188"],"related_works":["https://openalex.org/W4400026513","https://openalex.org/W4315485830","https://openalex.org/W3111205390","https://openalex.org/W2007020504","https://openalex.org/W40952352","https://openalex.org/W4365441459","https://openalex.org/W2486962198","https://openalex.org/W3196572461","https://openalex.org/W3155147493","https://openalex.org/W4403097875"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-07-23T00:00:00"}