{"id":"https://openalex.org/W4400848233","doi":"https://doi.org/10.1007/s00430-024-00799-8","title":"Repurposing promethazine hydrochloride to inhibit biofilm formation against Burkholderia thailandensis","display_name":"Repurposing promethazine hydrochloride to inhibit biofilm formation against Burkholderia thailandensis","publication_year":2024,"publication_date":"2024-07-20","ids":{"openalex":"https://openalex.org/W4400848233","doi":"https://doi.org/10.1007/s00430-024-00799-8","pmid":"https://pubmed.ncbi.nlm.nih.gov/39033094"},"language":"en","primary_location":{"id":"doi:10.1007/s00430-024-00799-8","doi":"https://doi.org/10.1007/s00430-024-00799-8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00430-024-00799-8","pdf_url":null,"source":{"id":"https://openalex.org/S182878189","display_name":"Medical Microbiology and Immunology","issn_l":"0044-3077","issn":["0044-3077","0300-8584","1432-1831"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Microbiology and Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088234223","display_name":"Kai-Zhong Xu","orcid":"https://orcid.org/0000-0003-4376-1937","observed_orcids":["https://orcid.org/0000-0003-4376-1937"]},"institutions":[{"id":"https://openalex.org/I20942203","display_name":"Hainan University","ror":"https://ror.org/03q648j11","country_code":"CN","type":"education","lineage":["https://openalex.org/I20942203"]},{"id":"https://openalex.org/I4210128478","display_name":"Hainan General Hospital","ror":"https://ror.org/030sr2v21","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128478"]},{"id":"https://openalex.org/I79731167","display_name":"Hainan Medical University","ror":"https://ror.org/004eeze55","country_code":"CN","type":"education","lineage":["https://openalex.org/I79731167"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kai-Zhong Xu","raw_affiliation_strings":["Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, 570311, China","Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Life and Health Sciences, Hainan University, Haikou, 570228, China","Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou, 570228, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, 570311, China","institution_ids":["https://openalex.org/I4210128478","https://openalex.org/I79731167"]},{"raw_affiliation_string":"Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Life and Health Sciences, Hainan University, Haikou, 570228, China","institution_ids":["https://openalex.org/I20942203"]},{"raw_affiliation_string":"Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou, 570228, China","institution_ids":["https://openalex.org/I20942203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102064057","display_name":"Chang You","orcid":"https://orcid.org/0009-0009-4676-7905","observed_orcids":["https://orcid.org/0009-0009-4676-7905"]},"institutions":[{"id":"https://openalex.org/I20942203","display_name":"Hainan University","ror":"https://ror.org/03q648j11","country_code":"CN","type":"education","lineage":["https://openalex.org/I20942203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chang You","raw_affiliation_strings":["Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Life and Health Sciences, Hainan University, Haikou, 570228, China","Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou, 570228, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Life and Health Sciences, Hainan University, Haikou, 570228, China","institution_ids":["https://openalex.org/I20942203"]},{"raw_affiliation_string":"Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou, 570228, China","institution_ids":["https://openalex.org/I20942203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100350001","display_name":"Yingjie Wang","orcid":"https://orcid.org/0000-0002-1352-6752","observed_orcids":["https://orcid.org/0000-0002-1352-6752"]},"institutions":[{"id":"https://openalex.org/I20942203","display_name":"Hainan University","ror":"https://ror.org/03q648j11","country_code":"CN","type":"education","lineage":["https://openalex.org/I20942203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying-Jie Wang","raw_affiliation_strings":["Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou, 570228, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou, 570228, China","institution_ids":["https://openalex.org/I20942203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042173097","display_name":"Owias Iqbal Dar","orcid":"https://orcid.org/0000-0002-8446-0156","observed_orcids":["https://orcid.org/0000-0002-8446-0156"]},"institutions":[{"id":"https://openalex.org/I20942203","display_name":"Hainan University","ror":"https://ror.org/03q648j11","country_code":"CN","type":"education","lineage":["https://openalex.org/I20942203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Owias Iqbal Dar","raw_affiliation_strings":["Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Chemistry and Chemical Engineering, Hainan University, Haikou, 570228, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Chemistry and Chemical Engineering, Hainan University, Haikou, 570228, China","institution_ids":["https://openalex.org/I20942203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101591350","display_name":"Lu-Jun Yin","orcid":"https://orcid.org/0000-0002-2888-8131","observed_orcids":["https://orcid.org/0000-0002-2888-8131"]},"institutions":[{"id":"https://openalex.org/I20942203","display_name":"Hainan University","ror":"https://ror.org/03q648j11","country_code":"CN","type":"education","lineage":["https://openalex.org/I20942203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lu-Jun Yin","raw_affiliation_strings":["Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Life and Health Sciences, Hainan University, Haikou, 570228, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Life and Health Sciences, Hainan University, Haikou, 570228, China","institution_ids":["https://openalex.org/I20942203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111157296","display_name":"Shi-Liang Xiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20942203","display_name":"Hainan University","ror":"https://ror.org/03q648j11","country_code":"CN","type":"education","lineage":["https://openalex.org/I20942203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shi-Liang Xiang","raw_affiliation_strings":["Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou, 570228, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou, 570228, China","institution_ids":["https://openalex.org/I20942203"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071341357","display_name":"Ai\u2010Qun Jia","orcid":"https://orcid.org/0000-0002-8089-6200","observed_orcids":["https://orcid.org/0000-0002-8089-6200"]},"institutions":[{"id":"https://openalex.org/I20942203","display_name":"Hainan University","ror":"https://ror.org/03q648j11","country_code":"CN","type":"education","lineage":["https://openalex.org/I20942203"]},{"id":"https://openalex.org/I4210128478","display_name":"Hainan General Hospital","ror":"https://ror.org/030sr2v21","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128478"]},{"id":"https://openalex.org/I79731167","display_name":"Hainan Medical University","ror":"https://ror.org/004eeze55","country_code":"CN","type":"education","lineage":["https://openalex.org/I79731167"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ai-Qun Jia","raw_affiliation_strings":["Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, 570311, China. aqjia@hainmc.edu.cn","Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou, 570228, China. aqjia@hainmc.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, 570311, China. aqjia@hainmc.edu.cn","institution_ids":["https://openalex.org/I4210128478","https://openalex.org/I79731167"]},{"raw_affiliation_string":"Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou, 570228, China. aqjia@hainmc.edu.cn","institution_ids":["https://openalex.org/I20942203"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5071341357"],"corresponding_institution_ids":["https://openalex.org/I20942203","https://openalex.org/I4210128478","https://openalex.org/I79731167"],"apc_list":{"value":4690,"currency":"USD","value_usd":4690},"apc_paid":null,"fwci":1.5933,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.80825066,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":"213","issue":"1","first_page":"16","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12951","display_name":"Burkholderia infections and melioidosis","score":0.8881999850273132,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12951","display_name":"Burkholderia infections and melioidosis","score":0.8881999850273132,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.11110000312328339,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/promethazine-hydrochloride","display_name":"promethazine hydrochloride","score":0.9940000176429749},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.9049999713897705},{"id":"https://openalex.org/keywords/biofilm-formation","display_name":"biofilm formation","score":0.7900000214576721},{"id":"https://openalex.org/keywords/burkholderia-thailandensis","display_name":"Burkholderia thailandensis","score":0.996999979019165},{"id":"https://openalex.org/keywords/melioidosis","display_name":"melioidosis","score":0.9639999866485596},{"id":"https://openalex.org/keywords/lipase-activity","display_name":"lipase activity","score":0.9350000023841858},{"id":"https://openalex.org/keywords/antimicrobial-activity","display_name":"antimicrobial activity","score":0.5370000004768372},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.460999995470047}],"concepts":[{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.663975179195404},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6485289335250854},{"id":"https://openalex.org/C519536355","wikidata":"https://www.wikidata.org/wiki/Q21021151","display_name":"Repurposing","level":2,"score":0.5629878044128418},{"id":"https://openalex.org/C2778794651","wikidata":"https://www.wikidata.org/wiki/Q422970","display_name":"Promethazine","level":2,"score":0.46151256561279297},{"id":"https://openalex.org/C2780855054","wikidata":"https://www.wikidata.org/wiki/Q135239","display_name":"Burkholderia","level":3,"score":0.4234161376953125},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4116177558898926},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34030359983444214},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2677537798881531},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.171006441116333},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008049","descriptor_name":"Lipase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008049","descriptor_name":"Lipase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011398","descriptor_name":"Promethazine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018441","descriptor_name":"Biofilms","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018441","descriptor_name":"Biofilms","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D019117","descriptor_name":"Burkholderia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019117","descriptor_name":"Burkholderia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019117","descriptor_name":"Burkholderia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D053038","descriptor_name":"Quorum Sensing","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s00430-024-00799-8","doi":"https://doi.org/10.1007/s00430-024-00799-8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00430-024-00799-8","pdf_url":null,"source":{"id":"https://openalex.org/S182878189","display_name":"Medical Microbiology and Immunology","issn_l":"0044-3077","issn":["0044-3077","0300-8584","1432-1831"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Microbiology and Immunology","raw_type":"journal-article"},{"id":"pmid:39033094","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39033094","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical microbiology and immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1915102885","display_name":null,"funder_award_id":"82160664","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7441991693","display_name":null,"funder_award_id":"221CXTD434","funder_id":"https://openalex.org/F4320322866","funder_display_name":"Natural Science Foundation of Hainan Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322866","display_name":"Natural Science Foundation of Hainan Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1977085294","https://openalex.org/W1985643401","https://openalex.org/W1986442317","https://openalex.org/W2031873338","https://openalex.org/W2069576102","https://openalex.org/W2099114009","https://openalex.org/W2107277218","https://openalex.org/W2114360920","https://openalex.org/W2149213807","https://openalex.org/W2149615908","https://openalex.org/W2160310346","https://openalex.org/W2335854789","https://openalex.org/W2407415576","https://openalex.org/W2603188767","https://openalex.org/W2605925759","https://openalex.org/W2791114218","https://openalex.org/W2895426708","https://openalex.org/W2906958253","https://openalex.org/W2952504636","https://openalex.org/W2959317181","https://openalex.org/W2999992613","https://openalex.org/W3007805911","https://openalex.org/W3016455540","https://openalex.org/W3016570956","https://openalex.org/W3080663755","https://openalex.org/W3107797051","https://openalex.org/W3113822468","https://openalex.org/W3197903513","https://openalex.org/W3207385378","https://openalex.org/W3211795435","https://openalex.org/W4210511772","https://openalex.org/W4214921255","https://openalex.org/W4256269580","https://openalex.org/W4280625199","https://openalex.org/W4283743595","https://openalex.org/W4289593681","https://openalex.org/W4292722363","https://openalex.org/W4293063542","https://openalex.org/W4294991783","https://openalex.org/W4298443621","https://openalex.org/W4303856833","https://openalex.org/W4304689865","https://openalex.org/W4307093009","https://openalex.org/W4320481059","https://openalex.org/W4375947520","https://openalex.org/W4378902411","https://openalex.org/W4388736174"],"related_works":["https://openalex.org/W2565433901","https://openalex.org/W7056272088","https://openalex.org/W4388736174","https://openalex.org/W7202073916","https://openalex.org/W7140750869","https://openalex.org/W7220231565","https://openalex.org/W4390965521","https://openalex.org/W7215781199","https://openalex.org/W2113349997","https://openalex.org/W7120548369"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-07-21T00:00:00"}