{"id":"https://openalex.org/W4400829195","doi":"https://doi.org/10.17021/1992-6499-2024-2-27-36","title":"Impact of hypoxia on the immune system","display_name":"Impact of hypoxia on the immune system","publication_year":2024,"publication_date":"2024-07-17","ids":{"openalex":"https://openalex.org/W4400829195","doi":"https://doi.org/10.17021/1992-6499-2024-2-27-36"},"language":"en","primary_location":{"id":"doi:10.17021/1992-6499-2024-2-27-36","doi":"https://doi.org/10.17021/1992-6499-2024-2-27-36","is_oa":true,"landing_page_url":"http://dx.doi.org/10.17021/1992-6499-2024-2-27-36","pdf_url":null,"source":{"id":"https://openalex.org/S4387288814","display_name":"ASTRAKHAN MEDICAL JOURNAL","issn_l":"1992-6499","issn":["1992-6499"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Astrakhan medical journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://dx.doi.org/10.17021/1992-6499-2024-2-27-36","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029908230","display_name":"\u0413. \u0410. \u0418\u0433\u043d\u0430\u0442\u0435\u043d\u043a\u043e","orcid":"https://orcid.org/0000-0003-3611-1186","observed_orcids":["https://orcid.org/0000-0003-3611-1186"]},"institutions":[{"id":"https://openalex.org/I89207983","display_name":"Donetsk National Medical University","ror":"https://ror.org/00hdaxs89","country_code":"UA","type":"education","lineage":["https://openalex.org/I89207983"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"G. A. Ignatenko","raw_affiliation_strings":["Donetsk State Medical University named after M. Gorky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Donetsk State Medical University named after M. Gorky","institution_ids":["https://openalex.org/I89207983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022222435","display_name":"Alexander S. Prilutsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89207983","display_name":"Donetsk National Medical University","ror":"https://ror.org/00hdaxs89","country_code":"UA","type":"education","lineage":["https://openalex.org/I89207983"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"A. S. Prilutskiy","raw_affiliation_strings":["Donetsk State Medical University named after M. Gorky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Donetsk State Medical University named after M. Gorky","institution_ids":["https://openalex.org/I89207983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042319822","display_name":"N. N. Bondarenko","orcid":"https://orcid.org/0000-0001-7452-7006","observed_orcids":["https://orcid.org/0000-0001-7452-7006"]},"institutions":[{"id":"https://openalex.org/I89207983","display_name":"Donetsk National Medical University","ror":"https://ror.org/00hdaxs89","country_code":"UA","type":"education","lineage":["https://openalex.org/I89207983"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"N. N. Bondarenko","raw_affiliation_strings":["Donetsk State Medical University named after M. Gorky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Donetsk State Medical University named after M. Gorky","institution_ids":["https://openalex.org/I89207983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000098429","display_name":"O. A. Prilutskaia","orcid":"https://orcid.org/0000-0002-2175-7841","observed_orcids":["https://orcid.org/0000-0002-2175-7841"]},"institutions":[{"id":"https://openalex.org/I89207983","display_name":"Donetsk National Medical University","ror":"https://ror.org/00hdaxs89","country_code":"UA","type":"education","lineage":["https://openalex.org/I89207983"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"O. A. Prilutskaya","raw_affiliation_strings":["Donetsk State Medical University named after M. Gorky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Donetsk State Medical University named after M. Gorky","institution_ids":["https://openalex.org/I89207983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108810402","display_name":"A. V. Dubovaya","orcid":"https://orcid.org/0000-0002-7999-8656","observed_orcids":["https://orcid.org/0000-0002-7999-8656"]},"institutions":[{"id":"https://openalex.org/I89207983","display_name":"Donetsk National Medical University","ror":"https://ror.org/00hdaxs89","country_code":"UA","type":"education","lineage":["https://openalex.org/I89207983"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"A. V. Dubovaya","raw_affiliation_strings":["Donetsk State Medical University named after M. Gorky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Donetsk State Medical University named after M. Gorky","institution_ids":["https://openalex.org/I89207983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082334485","display_name":"V. A. Tolstoy","orcid":"https://orcid.org/0009-0002-4586-3718","observed_orcids":["https://orcid.org/0009-0002-4586-3718"]},"institutions":[{"id":"https://openalex.org/I89207983","display_name":"Donetsk National Medical University","ror":"https://ror.org/00hdaxs89","country_code":"UA","type":"education","lineage":["https://openalex.org/I89207983"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"V. A. Tolstoy","raw_affiliation_strings":["Donetsk State Medical University named after M. Gorky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Donetsk State Medical University named after M. Gorky","institution_ids":["https://openalex.org/I89207983"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086557031","display_name":"A. A. Kaluga","orcid":"https://orcid.org/0000-0002-1489-9382","observed_orcids":["https://orcid.org/0000-0002-1489-9382"]},"institutions":[{"id":"https://openalex.org/I89207983","display_name":"Donetsk National Medical University","ror":"https://ror.org/00hdaxs89","country_code":"UA","type":"education","lineage":["https://openalex.org/I89207983"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"A. A. Kaluga","raw_affiliation_strings":["Donetsk State Medical University named after M. Gorky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Donetsk State Medical University named after M. Gorky","institution_ids":["https://openalex.org/I89207983"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I89207983"],"apc_list":null,"apc_paid":null,"fwci":0.1359,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.35577158,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"19","issue":"2","first_page":"27","last_page":"36"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.82669997215271,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.82669997215271,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0284000001847744,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.0210999995470047,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/immune-system","display_name":"immune system","score":0.8100000023841858},{"id":"https://openalex.org/keywords/hif-1alpha","display_name":"HIF-1\u03b1","score":0.8429999947547913},{"id":"https://openalex.org/keywords/hypoxia-inducible-factor","display_name":"hypoxia-inducible factor","score":0.9660000205039978},{"id":"https://openalex.org/keywords/immune-regulation","display_name":"immune regulation","score":0.9070000052452087},{"id":"https://openalex.org/keywords/natural-immunity","display_name":"natural immunity","score":0.9079999923706055},{"id":"https://openalex.org/keywords/adaptive-immunity","display_name":"adaptive immunity","score":0.9509999752044678},{"id":"https://openalex.org/keywords/oxygen-deficiency","display_name":"oxygen deficiency","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.7490418553352356},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6032792329788208},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3472273051738739},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3151348829269409},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23485416173934937},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.23082545399665833},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.12900209426879883},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.17021/1992-6499-2024-2-27-36","doi":"https://doi.org/10.17021/1992-6499-2024-2-27-36","is_oa":true,"landing_page_url":"http://dx.doi.org/10.17021/1992-6499-2024-2-27-36","pdf_url":null,"source":{"id":"https://openalex.org/S4387288814","display_name":"ASTRAKHAN MEDICAL JOURNAL","issn_l":"1992-6499","issn":["1992-6499"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Astrakhan medical journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.17021/1992-6499-2024-2-27-36","doi":"https://doi.org/10.17021/1992-6499-2024-2-27-36","is_oa":true,"landing_page_url":"http://dx.doi.org/10.17021/1992-6499-2024-2-27-36","pdf_url":null,"source":{"id":"https://openalex.org/S4387288814","display_name":"ASTRAKHAN MEDICAL JOURNAL","issn_l":"1992-6499","issn":["1992-6499"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Astrakhan medical journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1028634185","https://openalex.org/W1234711455","https://openalex.org/W1936396560","https://openalex.org/W1973546677","https://openalex.org/W2001750319","https://openalex.org/W2003783360","https://openalex.org/W2009461061","https://openalex.org/W2045296432","https://openalex.org/W2050714142","https://openalex.org/W2085609942","https://openalex.org/W2086264253","https://openalex.org/W2086513198","https://openalex.org/W2113052538","https://openalex.org/W2117936947","https://openalex.org/W2130035222","https://openalex.org/W2139439558","https://openalex.org/W2139595663","https://openalex.org/W2143519655","https://openalex.org/W2164467190","https://openalex.org/W2482434238","https://openalex.org/W2600492060","https://openalex.org/W2767490296","https://openalex.org/W2932199720","https://openalex.org/W2936370774","https://openalex.org/W3035713497","https://openalex.org/W3082874919","https://openalex.org/W3092326438","https://openalex.org/W3137466158","https://openalex.org/W3145278406","https://openalex.org/W3178794784","https://openalex.org/W3203225375","https://openalex.org/W3213859756","https://openalex.org/W4213155622","https://openalex.org/W4313731033","https://openalex.org/W4317618540","https://openalex.org/W4319316521","https://openalex.org/W4321442372"],"related_works":["https://openalex.org/W3133490592","https://openalex.org/W2312872405","https://openalex.org/W2105491891","https://openalex.org/W2084019555","https://openalex.org/W3158959738","https://openalex.org/W2080274549","https://openalex.org/W2763829062","https://openalex.org/W1917494022","https://openalex.org/W3001653173","https://openalex.org/W2034917327"],"abstract_inverted_index":{"Hypoxia":[0],"is":[1,8,34,98,113,119],"a":[2,9,19,46,86,101],"condition":[3],"that":[4,38,80],"occurs":[5],"when":[6],"there":[7],"decrease":[10,20],"in":[11,21,42,50,134],"the":[12,22,65,69,74,81,90,93,110,135,138],"normal":[13],"level":[14],"of":[15,26,71,83,92,103,117,127,137,140,143],"oxygen":[16,48,84],"due":[17],"to":[18,29,36],"availability":[23],"or":[24],"delivery":[25],"this":[27],"gas":[28],"cells":[30,142],"and":[31,52,56,145],"tissues.":[32],"It":[33],"important":[35],"note":[37],"hypoxic":[39],"conditions":[40],"occur":[41],"many":[43],"diseases.":[44],"With":[45],"low":[47],"content":[49],"tissues":[51],"cells,":[53],"numerous":[54],"physiological":[55],"pathological":[57],"changes":[58],"occur.":[59],"The":[60,77,115,125],"article":[61],"summarizes":[62],"information":[63],"from":[64],"scientific":[66],"literature":[67],"on":[68,73,89],"effect":[70,88],"hypoxia":[72,131],"immune":[75,94],"system.":[76],"analysis":[78,136],"shows":[79],"lack":[82],"has":[85],"significant":[87],"regulation":[91],"response.":[95],"This":[96],"influence":[97,126],"mediated":[99],"by":[100,106,122,130],"family":[102],"factors":[104,118,128],"induced":[105,129],"hypoxia.":[107],"Among":[108],"them,":[109],"most":[111],"studied":[112],"HIF-1\u03b1.":[114],"action":[116],"carried":[120],"out":[121],"various":[123],"mechanisms.":[124],"was":[132],"registered":[133],"function":[139],"all":[141],"natural":[144],"acquired":[146],"immunity.":[147]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2024-07-20T00:00:00"}