{"id":"https://openalex.org/W4400745181","doi":"https://doi.org/10.3389/fphar.2024.1430451","title":"THSD7A-associated membranous nephropathy involves both complement-mediated and autonomous podocyte injury","display_name":"THSD7A-associated membranous nephropathy involves both complement-mediated and autonomous podocyte injury","publication_year":2024,"publication_date":"2024-07-17","ids":{"openalex":"https://openalex.org/W4400745181","doi":"https://doi.org/10.3389/fphar.2024.1430451","pmid":"https://pubmed.ncbi.nlm.nih.gov/39086386","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11288966"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2024.1430451","doi":"https://doi.org/10.3389/fphar.2024.1430451","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2024.1430451","pdf_url":null,"source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fphar.2024.1430451","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115595012","display_name":"Jing Liu","orcid":"https://orcid.org/0009-0006-6436-6185","observed_orcids":["https://orcid.org/0009-0006-6436-6185"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jing Liu","raw_affiliation_strings":["Division of Nephrology, Department of Medicine, Toledo, OH, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Department of Medicine, Toledo, OH, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035025086","display_name":"Deepak K Malhotra","orcid":"https://orcid.org/0000-0003-1413-6681","observed_orcids":["https://orcid.org/0000-0003-1413-6681"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Deepak Malhotra","raw_affiliation_strings":["Division of Nephrology, Department of Medicine, Toledo, OH, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Department of Medicine, Toledo, OH, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066860889","display_name":"Yan Ge","orcid":"https://orcid.org/0000-0003-2129-9438","observed_orcids":["https://orcid.org/0000-0003-2129-9438"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yan Ge","raw_affiliation_strings":["Division of Nephrology, Department of Medicine, Toledo, OH, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Department of Medicine, Toledo, OH, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080039147","display_name":"William T. Gunning","orcid":"https://orcid.org/0000-0002-4190-2479","observed_orcids":["https://orcid.org/0000-0002-4190-2479"]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Gunning","raw_affiliation_strings":["Department of Pathology, The University of Toledo College of Medicine, Toledo, OH, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The University of Toledo College of Medicine, Toledo, OH, United States","institution_ids":["https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072191588","display_name":"Lance D. Dworkin","orcid":"https://orcid.org/0000-0002-2471-5989","observed_orcids":["https://orcid.org/0000-0002-2471-5989"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lance Dworkin","raw_affiliation_strings":["Division of Nephrology, Department of Medicine, Toledo, OH, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Department of Medicine, Toledo, OH, United States","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041867945","display_name":"Rujun Gong","orcid":"https://orcid.org/0000-0002-6302-2800","observed_orcids":["https://orcid.org/0000-0002-6302-2800"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Rujun Gong","raw_affiliation_strings":["Division of Nephrology, Department of Medicine, Toledo, OH, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Department of Medicine, Toledo, OH, United States","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5041867945"],"corresponding_institution_ids":[],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":3.7149,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.94177093,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"15","issue":null,"first_page":"1430451","last_page":"1430451"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/membranous-nephropathy","display_name":"membranous nephropathy","score":0.9610000252723694},{"id":"https://openalex.org/keywords/podocytopathy","display_name":"podocytopathy","score":0.6819999814033508},{"id":"https://openalex.org/keywords/complement-mediated-injury","display_name":"complement-mediated injury","score":0.7360000014305115},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.652999997138977},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.8880000114440918},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7210000157356262},{"id":"https://openalex.org/keywords/podocyte-apoptosis","display_name":"podocyte apoptosis","score":0.8259999752044678},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"actin cytoskeleton","score":0.9319999814033508},{"id":"https://openalex.org/keywords/acth","display_name":"ACTH","score":0.8220000267028809},{"id":"https://openalex.org/keywords/nephrotic-syndrome","display_name":"nephrotic syndrome","score":0.7179999947547913},{"id":"https://openalex.org/keywords/glomerular-injury","display_name":"glomerular injury","score":0.7670000195503235}],"concepts":[{"id":"https://openalex.org/C2775946357","wikidata":"https://www.wikidata.org/wiki/Q1713037","display_name":"Membranous nephropathy","level":4,"score":0.9089148044586182},{"id":"https://openalex.org/C2777146197","wikidata":"https://www.wikidata.org/wiki/Q138912","display_name":"Podocyte","level":4,"score":0.8700715899467468},{"id":"https://openalex.org/C2778415529","wikidata":"https://www.wikidata.org/wiki/Q1435223","display_name":"Focal segmental glomerulosclerosis","level":4,"score":0.5642037391662598},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5040827989578247},{"id":"https://openalex.org/C2778930706","wikidata":"https://www.wikidata.org/wiki/Q504790","display_name":"Nephrotic syndrome","level":2,"score":0.4745151400566101},{"id":"https://openalex.org/C2779561371","wikidata":"https://www.wikidata.org/wiki/Q570197","display_name":"Proteinuria","level":3,"score":0.4402351677417755},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4091756045818329},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39811092615127563},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35955649614334106},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19370949268341064},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.15242311358451843}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fphar.2024.1430451","doi":"https://doi.org/10.3389/fphar.2024.1430451","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2024.1430451","pdf_url":null,"source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11288966","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11288966","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11288966/pdf/fphar-15-1430451.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Pharmacol","raw_type":"Text"},{"id":"pmid:39086386","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39086386","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:bf16bca56947405899d9dfb84570641a","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/bf16bca56947405899d9dfb84570641a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 15 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2024.1430451","doi":"https://doi.org/10.3389/fphar.2024.1430451","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2024.1430451","pdf_url":null,"source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9907000064849854}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1676577325","display_name":"The Melanocortinergic pathway inglomerular disease","funder_award_id":"R01DK114006","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4400745181.pdf","grobid_xml":"https://content.openalex.org/works/W4400745181.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W53296430","https://openalex.org/W161240138","https://openalex.org/W1570798354","https://openalex.org/W1736487742","https://openalex.org/W1983119175","https://openalex.org/W2016300506","https://openalex.org/W2037144516","https://openalex.org/W2064922682","https://openalex.org/W2074202650","https://openalex.org/W2083712509","https://openalex.org/W2083760961","https://openalex.org/W2104270462","https://openalex.org/W2112549609","https://openalex.org/W2120467386","https://openalex.org/W2127127482","https://openalex.org/W2137689185","https://openalex.org/W2154852379","https://openalex.org/W2164126679","https://openalex.org/W2166822765","https://openalex.org/W2169656611","https://openalex.org/W2182390629","https://openalex.org/W2302857585","https://openalex.org/W2395598045","https://openalex.org/W2487014529","https://openalex.org/W2617482626","https://openalex.org/W2729445959","https://openalex.org/W2737743324","https://openalex.org/W2745663953","https://openalex.org/W2755990226","https://openalex.org/W2792441704","https://openalex.org/W2803593737","https://openalex.org/W2804465482","https://openalex.org/W2902647266","https://openalex.org/W2927939151","https://openalex.org/W2939436376","https://openalex.org/W2977665112","https://openalex.org/W3034245697","https://openalex.org/W3084391638","https://openalex.org/W3108400251","https://openalex.org/W3112905706","https://openalex.org/W3143678149","https://openalex.org/W3151337960","https://openalex.org/W3216591159","https://openalex.org/W4206671482","https://openalex.org/W4213021225","https://openalex.org/W4225000320","https://openalex.org/W4284674092","https://openalex.org/W4310461872","https://openalex.org/W4317617320","https://openalex.org/W4318344487","https://openalex.org/W4390064641","https://openalex.org/W6686033271"],"related_works":["https://openalex.org/W2745663953","https://openalex.org/W7131636173","https://openalex.org/W2395598045","https://openalex.org/W2804465482","https://openalex.org/W4284674092","https://openalex.org/W7167244522","https://openalex.org/W2553324652","https://openalex.org/W4385954094","https://openalex.org/W4396995831","https://openalex.org/W4236148048"],"abstract_inverted_index":{"Membranous":[0],"nephropathy":[1],"(MN)":[2],"continues":[3],"to":[4,76,147,176,207],"be":[5,208,222,248],"a":[6,16,67,83,91,177,242],"leading":[7],"cause":[8],"of":[9,23,51,60,86,100,112,157,171,232,241],"nephrotic":[10],"syndrome":[11],"in":[12,19,45,54,131,141,143],"non-diabetic":[13],"adults.":[14],"As":[15],"unique":[17],"subtype":[18],"the":[20,49,77,96,148,189,230,239],"serology-based":[21],"classification":[22],"MN,":[24,195],"thrombospondin":[25],"type":[26],"1":[27],"domain":[28],"containing":[29],"7A":[30],"(THSD7A)-associated":[31],"MN":[32,62,88,114,253],"has":[33],"attracted":[34],"increasing":[35],"interest,":[36],"because,":[37],"unlike":[38],"other":[39],"autoantigens,":[40],"THSD7A":[41],"is":[42],"also":[43,138],"expressed":[44],"preclinical":[46],"species,":[47],"facilitating":[48],"study":[50],"its":[52],"role":[53],"MN.":[55,233],"A":[56],"heterologous":[57],"mouse":[58,84],"model":[59,85,103,220],"THSD7A-associated":[61,87],"was":[63,72,104],"previously":[64],"established":[65],"using":[66],"proprietary":[68],"in-house":[69],"antibody":[70,94,150],"that":[71,135,218],"unfortunately":[73],"not":[74],"available":[75,93,244],"research":[78],"community.":[79],"Here,":[80],"we":[81],"developed":[82],"by":[89,106],"administering":[90],"commercially":[92,243],"targeting":[95],"most":[97],"N-terminal":[98],"part":[99],"THSD7A.":[101],"Our":[102],"characterized":[105],"heavy":[107],"proteinuria":[108,127,213],"and":[109,128,165,210,214],"pathological":[110],"features":[111],"human":[113],"without":[115],"sex":[116],"differences.":[117],"Complement":[118],"depletion":[119],"with":[120,199],"cobra":[121],"venom":[122],"factor":[123],"only":[124],"partially":[125],"attenuated":[126,212],"glomerular":[129,215],"injury":[130],"this":[132,219],"model,":[133,236],"entailing":[134],"complement-independent":[136],"pathomechanisms":[137],"contribute.":[139],"Consistently,":[140],"vitro":[142],"primary":[144,194],"podocytes,":[145],"exposure":[146],"anti-THSD7A":[149,245],"caused":[151],"evident":[152],"podocytopathic":[153],"changes,":[154],"including":[155],"disruption":[156],"actin":[158],"cytoskeleton":[159],"integrity,":[160],"podocyte":[161,185],"hypermobility,":[162],"oxidative":[163],"stress,":[164],"apoptotic":[166],"cell":[167],"death.":[168],"These":[169],"signs":[170],"podocytopathy":[172],"were":[173],"preserved,":[174],"albeit":[175],"lesser":[178],"extent,":[179],"after":[180],"complement":[181],"inactivation,":[182],"indicating":[183],"autonomous":[184],"injury.":[186],"Furthermore,":[187],"as":[188],"first":[190],"FDA-approved":[191],"treatment":[192],"for":[193,224,252],"adrenocorticotropic":[196],"hormone":[197],"therapy":[198],"repository":[200],"corticotropin":[201],"injection":[202],"(Purified":[203],"Cortrophin":[204],"Gel\u00ae)":[205],"appeared":[206],"beneficial":[209],"significantly":[211],"injury,":[216],"suggesting":[217],"may":[221],"useful":[223],"developing":[225],"novel":[226],"treatments":[227],"or":[228],"understanding":[229],"pathogenesis":[231],"Collectively,":[234],"our":[235],"based":[237],"on":[238],"use":[240],"antibody,":[246],"will":[247],"an":[249],"important":[250],"tool":[251],"research.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2024-07-18T00:00:00"}
