{"id":"https://openalex.org/W4400744669","doi":"https://doi.org/10.1002/sscp.202400048","title":"Stability\u2010Indicating HPLC Method Development and Validation for the Quantification of Tofacitinib Citrate and Its Related Substances Using Hydrophilic Liquid Interaction Chromatography","display_name":"Stability\u2010Indicating HPLC Method Development and Validation for the Quantification of Tofacitinib Citrate and Its Related Substances Using Hydrophilic Liquid Interaction Chromatography","publication_year":2024,"publication_date":"2024-07-16","ids":{"openalex":"https://openalex.org/W4400744669","doi":"https://doi.org/10.1002/sscp.202400048"},"language":"en","primary_location":{"id":"doi:10.1002/sscp.202400048","doi":"https://doi.org/10.1002/sscp.202400048","is_oa":true,"landing_page_url":"https://doi.org/10.1002/sscp.202400048","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/sscp.202400048","source":{"id":"https://openalex.org/S4210212791","display_name":"Separation Science Plus","issn_l":"2573-1815","issn":["2573-1815"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SEPARATION SCIENCE PLUS","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/sscp.202400048","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037370826","display_name":"G. Sivaprasadu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I885392262","display_name":"GITAM University","ror":"https://ror.org/0440p1d37","country_code":"IN","type":"education","lineage":["https://openalex.org/I885392262"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"G. Sivaprasadu","raw_affiliation_strings":["Department of Chemistry, GSS, GITAM (Deemed to be University), Visakhapatnam, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, GSS, GITAM (Deemed to be University), Visakhapatnam, India","institution_ids":["https://openalex.org/I885392262"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047184989","display_name":"Pamerla Muralidhar","orcid":"https://orcid.org/0000-0002-0750-8881","observed_orcids":["https://orcid.org/0000-0002-0750-8881"]},"institutions":[{"id":"https://openalex.org/I885392262","display_name":"GITAM University","ror":"https://ror.org/0440p1d37","country_code":"IN","type":"education","lineage":["https://openalex.org/I885392262"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Muralidhar Pamerla","raw_affiliation_strings":["Department of Chemistry, GSS, GITAM (Deemed to be University), Visakhapatnam, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, GSS, GITAM (Deemed to be University), Visakhapatnam, India","institution_ids":["https://openalex.org/I885392262"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058972128","display_name":"Podilapu Atchutha Rao","orcid":"https://orcid.org/0000-0001-8810-176X","observed_orcids":["https://orcid.org/0000-0001-8810-176X"]},"institutions":[{"id":"https://openalex.org/I885392262","display_name":"GITAM University","ror":"https://ror.org/0440p1d37","country_code":"IN","type":"education","lineage":["https://openalex.org/I885392262"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Podilapu Atchutha Rao","raw_affiliation_strings":["Department of Chemistry, GSS, GITAM (Deemed to be University), Visakhapatnam, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, GSS, GITAM (Deemed to be University), Visakhapatnam, India","institution_ids":["https://openalex.org/I885392262"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102757670","display_name":"Adapaka Venkateswara Rao","orcid":"https://orcid.org/0009-0008-8374-457X","observed_orcids":["https://orcid.org/0009-0008-8374-457X"]},"institutions":[{"id":"https://openalex.org/I885392262","display_name":"GITAM University","ror":"https://ror.org/0440p1d37","country_code":"IN","type":"education","lineage":["https://openalex.org/I885392262"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Adapaka Venkateswara Rao","raw_affiliation_strings":["Department of Chemistry, GSS, GITAM (Deemed to be University), Visakhapatnam, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, GSS, GITAM (Deemed to be University), Visakhapatnam, India","institution_ids":["https://openalex.org/I885392262"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078716092","display_name":"Suresh Salakolusu","orcid":"https://orcid.org/0000-0002-0292-8545","observed_orcids":["https://orcid.org/0000-0002-0292-8545"]},"institutions":[{"id":"https://openalex.org/I885392262","display_name":"GITAM University","ror":"https://ror.org/0440p1d37","country_code":"IN","type":"education","lineage":["https://openalex.org/I885392262"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Suresh Salakolusu","raw_affiliation_strings":["Department of Chemistry, GSS, GITAM (Deemed to be University), Visakhapatnam, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, GSS, GITAM (Deemed to be University), Visakhapatnam, India","institution_ids":["https://openalex.org/I885392262"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048017195","display_name":"Harihara Padhy","orcid":"https://orcid.org/0000-0003-1653-1861","observed_orcids":["https://orcid.org/0000-0003-1653-1861"]},"institutions":[{"id":"https://openalex.org/I885392262","display_name":"GITAM University","ror":"https://ror.org/0440p1d37","country_code":"IN","type":"education","lineage":["https://openalex.org/I885392262"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Harihara Padhy","raw_affiliation_strings":["Department of Chemistry, GSS, GITAM (Deemed to be University), Visakhapatnam, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, GSS, GITAM (Deemed to be University), Visakhapatnam, India","institution_ids":["https://openalex.org/I885392262"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050724913","display_name":"Ravi Kumar Ganta","orcid":"https://orcid.org/0000-0002-6772-3890","observed_orcids":["https://orcid.org/0000-0002-6772-3890"]},"institutions":[{"id":"https://openalex.org/I885392262","display_name":"GITAM University","ror":"https://ror.org/0440p1d37","country_code":"IN","type":"education","lineage":["https://openalex.org/I885392262"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Ravi Kumar Ganta","raw_affiliation_strings":["Department of Chemistry, GSS, GITAM (Deemed to be University), Visakhapatnam, India"],"raw_orcid":"https://orcid.org/0000-0002-6772-3890","affiliations":[{"raw_affiliation_string":"Department of Chemistry, GSS, GITAM (Deemed to be University), Visakhapatnam, India","institution_ids":["https://openalex.org/I885392262"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5047184989","https://openalex.org/A5050724913"],"corresponding_institution_ids":["https://openalex.org/I885392262"],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":{"value":3300,"currency":"USD","value_usd":3300},"fwci":1.3873,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.75266407,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"7","issue":"9","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tofacitinib-citrate","display_name":"tofacitinib citrate","score":1.0},{"id":"https://openalex.org/keywords/stability-indicating-method","display_name":"stability-indicating assay","score":0.7990000247955322},{"id":"https://openalex.org/keywords/hydrophilic-interaction-liquid-chromatography","display_name":"hydrophilic interaction liquid chromatography","score":0.906000018119812},{"id":"https://openalex.org/keywords/related-substances","display_name":"related substances","score":0.6510000228881836},{"id":"https://openalex.org/keywords/impurity-determination","display_name":"impurity determination","score":0.9210000038146973},{"id":"https://openalex.org/keywords/method-validation","display_name":"method validation","score":0.6399999856948853},{"id":"https://openalex.org/keywords/pharmaceutical-quality-control","display_name":"pharmaceutical quality control","score":0.5950000286102295},{"id":"https://openalex.org/keywords/degradation-studies","display_name":"degradation studies","score":0.6380000114440918}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8360739946365356},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.8290349245071411},{"id":"https://openalex.org/C116817701","wikidata":"https://www.wikidata.org/wiki/Q5955221","display_name":"Hydrophilic interaction chromatography","level":3,"score":0.6664785146713257},{"id":"https://openalex.org/C10390740","wikidata":"https://www.wikidata.org/wiki/Q2282401","display_name":"Analyte","level":2,"score":0.6584226489067078},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.6060978174209595},{"id":"https://openalex.org/C71987851","wikidata":"https://www.wikidata.org/wiki/Q7216430","display_name":"Impurity","level":2,"score":0.5923874974250793},{"id":"https://openalex.org/C2777682752","wikidata":"https://www.wikidata.org/wiki/Q8564473","display_name":"Forced degradation","level":4,"score":0.5472511649131775},{"id":"https://openalex.org/C119128265","wikidata":"https://www.wikidata.org/wiki/Q900165","display_name":"Detection limit","level":2,"score":0.5409648418426514},{"id":"https://openalex.org/C94412978","wikidata":"https://www.wikidata.org/wiki/Q103135","display_name":"Hydrolysis","level":2,"score":0.5058791041374207},{"id":"https://openalex.org/C2778886723","wikidata":"https://www.wikidata.org/wiki/Q3530324","display_name":"Tofacitinib","level":3,"score":0.4712677001953125},{"id":"https://openalex.org/C45188465","wikidata":"https://www.wikidata.org/wiki/Q645497","display_name":"Reversed-phase chromatography","level":3,"score":0.39632439613342285},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.058811843395233154},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/sscp.202400048","doi":"https://doi.org/10.1002/sscp.202400048","is_oa":true,"landing_page_url":"https://doi.org/10.1002/sscp.202400048","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/sscp.202400048","source":{"id":"https://openalex.org/S4210212791","display_name":"Separation Science Plus","issn_l":"2573-1815","issn":["2573-1815"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SEPARATION SCIENCE PLUS","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1002/sscp.202400048","doi":"https://doi.org/10.1002/sscp.202400048","is_oa":true,"landing_page_url":"https://doi.org/10.1002/sscp.202400048","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/sscp.202400048","source":{"id":"https://openalex.org/S4210212791","display_name":"Separation Science Plus","issn_l":"2573-1815","issn":["2573-1815"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SEPARATION SCIENCE PLUS","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4400744669.pdf","grobid_xml":"https://content.openalex.org/works/W4400744669.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W581328780","https://openalex.org/W1903123446","https://openalex.org/W1904274713","https://openalex.org/W1943118026","https://openalex.org/W1988559810","https://openalex.org/W2000257447","https://openalex.org/W2014330392","https://openalex.org/W2046350672","https://openalex.org/W2089842002","https://openalex.org/W2142643922","https://openalex.org/W2145600171","https://openalex.org/W2323714765","https://openalex.org/W2564596038","https://openalex.org/W2580130954","https://openalex.org/W2581390112","https://openalex.org/W2612141088","https://openalex.org/W2725156521","https://openalex.org/W2891176903","https://openalex.org/W2905168985","https://openalex.org/W3017020421","https://openalex.org/W3021093547","https://openalex.org/W3021673208","https://openalex.org/W3036856247","https://openalex.org/W3099939244","https://openalex.org/W3115823007","https://openalex.org/W3127738491","https://openalex.org/W3152185393","https://openalex.org/W3196447504","https://openalex.org/W3217639822","https://openalex.org/W4248199980"],"related_works":["https://openalex.org/W2581390112","https://openalex.org/W7127169906","https://openalex.org/W4413477097","https://openalex.org/W4407994617","https://openalex.org/W7218696044","https://openalex.org/W2750640820","https://openalex.org/W7203994058","https://openalex.org/W1903123446","https://openalex.org/W3196447504","https://openalex.org/W4235177943"],"abstract_inverted_index":{"ABSTRACT":[0],"A":[1],"new":[2],"stability\u2010indicating":[3],"RPHPLC":[4],"method":[5,25,136],"with":[6,73,108],"short":[7],"run":[8],"time":[9],"has":[10],"been":[11],"developed":[12],"and":[13,18,37,48,72,88,90,97,112,122,146,160,164,167,169,193],"validated":[14],"for":[15,80,86,106,120,129,144,150,178],"tofacitinib":[16,91,123,151],"citrate":[17],"its":[19],"related":[20],"substances.":[21],"The":[22,135,153],"novel":[23],"HPLC":[24],"integrates":[26],"hydrophilic":[27],"interaction":[28],"liquid":[29],"chromatography":[30],"(HILIC)":[31],"technology":[32],"as":[33,174],"the":[34,74,175,184],"stationary":[35,176],"phase":[36,41,177],"employs":[38],"a":[39,53,66,81],"mobile":[40],"composed":[42],"of":[43,56,186],"phosphate":[44],"buffer":[45],"(pH":[46],"7.0)":[47],"acetonitrile":[49],"(45:55,":[50],"%v/v)":[51],"at":[52,69,78,94,110,114,132],"flow":[54],"rate":[55],"0.5":[57],"mL/min":[58],"under":[59,158],"isocratic":[60],"elution.":[61],"Analytes":[62],"were":[63],"monitored":[64],"via":[65],"UV":[67],"detector":[68],"210":[70],"nm":[71],"column":[75],"oven":[76],"temperature":[77],"30\u00b0C":[79],"20\u2010min":[82],"analysis.":[83],"Precision":[84],"(%RSD)":[85],"Impurity\u2010A":[87],"Impurity\u2010B":[89],"met":[92],"specifications":[93],"2.4%,":[95],"0.8%,":[96],"0.0%,":[98],"respectively.":[99],"Accuracy":[100],"ranged":[101],"from":[102,140],"86%":[103],"to":[104,142,148],"100%":[105],"impurities,":[107],"LOD":[109],"0.03%":[111],"LOQ":[113,141,147],"0.05%\u20130.06%.":[115],"Correlation":[116],"coefficients":[117],"exceeded":[118],"0.999":[119],"impurities":[121,145],"citrate.":[124,152],"Solution":[125],"stability":[126,155],"was":[127,138,156],"confirmed":[128],"24":[130],"h":[131],"room":[133],"temperature.":[134],"range":[137],"extended":[139],"\u223c1.5%":[143],"\u223c150%":[149],"method's":[154],"evaluated":[157],"acid":[159],"base":[161],"hydrolysis,":[162,166],"oxidative":[163],"water":[165],"thermal":[168],"photolytic":[170],"degradation.":[171],"Introducing":[172],"HILIC":[173],"this":[179],"work":[180],"proved":[181],"effective,":[182],"eliminating":[183],"need":[185],"ion":[187],"pair":[188],"reagents,":[189],"reducing":[190],"analysis":[191],"time,":[192],"ensuring":[194],"consistent":[195],"results.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2024-07-18T00:00:00"}
