{"id":"https://openalex.org/W4400732129","doi":"https://doi.org/10.1007/s13246-024-01458-1","title":"Mechanistic in silico explorations of the immunogenic and synergistic effects of radiotherapy and immunotherapy: a critical review","display_name":"Mechanistic in silico explorations of the immunogenic and synergistic effects of radiotherapy and immunotherapy: a critical review","publication_year":2024,"publication_date":"2024-07-17","ids":{"openalex":"https://openalex.org/W4400732129","doi":"https://doi.org/10.1007/s13246-024-01458-1","pmid":"https://pubmed.ncbi.nlm.nih.gov/39017990","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11666662"},"language":"en","primary_location":{"id":"doi:10.1007/s13246-024-01458-1","doi":"https://doi.org/10.1007/s13246-024-01458-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13246-024-01458-1","pdf_url":"https://link.springer.com/content/pdf/10.1007/s13246-024-01458-1.pdf","source":{"id":"https://openalex.org/S4210170766","display_name":"Physical and Engineering Sciences in Medicine","issn_l":"2662-4729","issn":["2662-4729","2662-4737"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physical and Engineering Sciences in Medicine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s13246-024-01458-1.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111260081","display_name":"Allison M. Ng","orcid":"https://orcid.org/0009-0008-5716-0802","observed_orcids":["https://orcid.org/0009-0008-5716-0802"]},"institutions":[{"id":"https://openalex.org/I177877127","display_name":"The University of Western Australia","ror":"https://ror.org/047272k79","country_code":"AU","type":"education","lineage":["https://openalex.org/I177877127"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Allison M. Ng","raw_affiliation_strings":["School of Physics, Mathematics and Computing, The University of Western Australia, Crawley, WA, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Physics, Mathematics and Computing, The University of Western Australia, Crawley, WA, Australia","institution_ids":["https://openalex.org/I177877127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006281956","display_name":"Kelly M. MacKinnon","orcid":"https://orcid.org/0000-0003-1868-2428","observed_orcids":["https://orcid.org/0000-0003-1868-2428"]},"institutions":[{"id":"https://openalex.org/I177877127","display_name":"The University of Western Australia","ror":"https://ror.org/047272k79","country_code":"AU","type":"education","lineage":["https://openalex.org/I177877127"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Kelly M. MacKinnon","raw_affiliation_strings":["National Centre for Asbestos Related Diseases, The University of Western Australia, Crawley, WA, Australia","School of Physics, Mathematics and Computing, The University of Western Australia, Crawley, WA, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre for Asbestos Related Diseases, The University of Western Australia, Crawley, WA, Australia","institution_ids":["https://openalex.org/I177877127"]},{"raw_affiliation_string":"School of Physics, Mathematics and Computing, The University of Western Australia, Crawley, WA, Australia","institution_ids":["https://openalex.org/I177877127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061361406","display_name":"Alistair Cook","orcid":"https://orcid.org/0000-0001-5339-5374","observed_orcids":["https://orcid.org/0000-0001-5339-5374"]},"institutions":[{"id":"https://openalex.org/I177877127","display_name":"The University of Western Australia","ror":"https://ror.org/047272k79","country_code":"AU","type":"education","lineage":["https://openalex.org/I177877127"]},{"id":"https://openalex.org/I4210148584","display_name":"Institute for Respiratory Health","ror":"https://ror.org/04n4wd093","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210148584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Alistair A. Cook","raw_affiliation_strings":["Institute for Respiratory Health, Institute for Respiratory Health, Perth, WA, Australia","National Centre for Asbestos Related Diseases, The University of Western Australia, Crawley, WA, Australia","School of Biomedical Sciences, The University of Western Australia, Crawley, WA, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Respiratory Health, Institute for Respiratory Health, Perth, WA, Australia","institution_ids":["https://openalex.org/I4210148584"]},{"raw_affiliation_string":"National Centre for Asbestos Related Diseases, The University of Western Australia, Crawley, WA, Australia","institution_ids":["https://openalex.org/I177877127"]},{"raw_affiliation_string":"School of Biomedical Sciences, The University of Western Australia, Crawley, WA, Australia","institution_ids":["https://openalex.org/I177877127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060803828","display_name":"Rebecca A. D\u2019Alonzo","orcid":"https://orcid.org/0000-0001-6570-2140","observed_orcids":["https://orcid.org/0000-0001-6570-2140"]},"institutions":[{"id":"https://openalex.org/I177877127","display_name":"The University of Western Australia","ror":"https://ror.org/047272k79","country_code":"AU","type":"education","lineage":["https://openalex.org/I177877127"]},{"id":"https://openalex.org/I4210148584","display_name":"Institute for Respiratory Health","ror":"https://ror.org/04n4wd093","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210148584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Rebecca A. D\u2019Alonzo","raw_affiliation_strings":["Institute for Respiratory Health, Institute for Respiratory Health, Perth, WA, Australia","National Centre for Asbestos Related Diseases, The University of Western Australia, Crawley, WA, Australia","School of Physics, Mathematics and Computing, The University of Western Australia, Crawley, WA, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Respiratory Health, Institute for Respiratory Health, Perth, WA, Australia","institution_ids":["https://openalex.org/I4210148584"]},{"raw_affiliation_string":"National Centre for Asbestos Related Diseases, The University of Western Australia, Crawley, WA, Australia","institution_ids":["https://openalex.org/I177877127"]},{"raw_affiliation_string":"School of Physics, Mathematics and Computing, The University of Western Australia, Crawley, WA, Australia","institution_ids":["https://openalex.org/I177877127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001358054","display_name":"Pejman Rowshanfarzad","orcid":"https://orcid.org/0000-0001-8306-7742","observed_orcids":["https://orcid.org/0000-0001-8306-7742"]},"institutions":[{"id":"https://openalex.org/I177877127","display_name":"The University of Western Australia","ror":"https://ror.org/047272k79","country_code":"AU","type":"education","lineage":["https://openalex.org/I177877127"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Pejman Rowshanfarzad","raw_affiliation_strings":["Centre for Advanced Technologies in Cancer Research (CATCR), Perth, WA, Australia","School of Physics, Mathematics and Computing, The University of Western Australia, Crawley, WA, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Advanced Technologies in Cancer Research (CATCR), Perth, WA, Australia","institution_ids":[]},{"raw_affiliation_string":"School of Physics, Mathematics and Computing, The University of Western Australia, Crawley, WA, Australia","institution_ids":["https://openalex.org/I177877127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015006267","display_name":"Anna K. Nowak","orcid":"https://orcid.org/0000-0002-9317-9526","observed_orcids":["https://orcid.org/0000-0002-9317-9526"]},"institutions":[{"id":"https://openalex.org/I177877127","display_name":"The University of Western Australia","ror":"https://ror.org/047272k79","country_code":"AU","type":"education","lineage":["https://openalex.org/I177877127"]},{"id":"https://openalex.org/I4210148584","display_name":"Institute for Respiratory Health","ror":"https://ror.org/04n4wd093","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210148584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Anna K. Nowak","raw_affiliation_strings":["Institute for Respiratory Health, Institute for Respiratory Health, Perth, WA, Australia","Medical School, The University of Western Australia, Crawley, WA, Australia","National Centre for Asbestos Related Diseases, The University of Western Australia, Crawley, WA, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Respiratory Health, Institute for Respiratory Health, Perth, WA, Australia","institution_ids":["https://openalex.org/I4210148584"]},{"raw_affiliation_string":"Medical School, The University of Western Australia, Crawley, WA, Australia","institution_ids":["https://openalex.org/I177877127"]},{"raw_affiliation_string":"National Centre for Asbestos Related Diseases, The University of Western Australia, Crawley, WA, Australia","institution_ids":["https://openalex.org/I177877127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019896047","display_name":"Suki Gill","orcid":"https://orcid.org/0000-0001-9755-7232","observed_orcids":["https://orcid.org/0000-0001-9755-7232"]},"institutions":[{"id":"https://openalex.org/I177877127","display_name":"The University of Western Australia","ror":"https://ror.org/047272k79","country_code":"AU","type":"education","lineage":["https://openalex.org/I177877127"]},{"id":"https://openalex.org/I2802220196","display_name":"Sir Charles Gairdner Hospital","ror":"https://ror.org/01hhqsm59","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2799506148","https://openalex.org/I2800882159","https://openalex.org/I2802220196","https://openalex.org/I4210133657","https://openalex.org/I4396570646"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Suki Gill","raw_affiliation_strings":["Department of Radiation Oncology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia","School of Physics, Mathematics and Computing, The University of Western Australia, Crawley, WA, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia","institution_ids":["https://openalex.org/I2802220196"]},{"raw_affiliation_string":"School of Physics, Mathematics and Computing, The University of Western Australia, Crawley, WA, Australia","institution_ids":["https://openalex.org/I177877127"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072140983","display_name":"Martin A. Ebert","orcid":"https://orcid.org/0000-0002-6875-0719","observed_orcids":["https://orcid.org/0000-0002-6875-0719"]},"institutions":[{"id":"https://openalex.org/I177877127","display_name":"The University of Western Australia","ror":"https://ror.org/047272k79","country_code":"AU","type":"education","lineage":["https://openalex.org/I177877127"]},{"id":"https://openalex.org/I2800882159","display_name":"Government of Western Australia Department of Health","ror":"https://ror.org/01epcny94","country_code":"AU","type":"government","lineage":["https://openalex.org/I2799506148","https://openalex.org/I2800882159"]},{"id":"https://openalex.org/I2802220196","display_name":"Sir Charles Gairdner Hospital","ror":"https://ror.org/01hhqsm59","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2799506148","https://openalex.org/I2800882159","https://openalex.org/I2802220196","https://openalex.org/I4210133657","https://openalex.org/I4396570646"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Martin A. Ebert","raw_affiliation_strings":["Centre for Advanced Technologies in Cancer Research (CATCR), Perth, WA, Australia. Martin.Ebert@health.wa.gov.au","Department of Radiation Oncology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia. Martin.Ebert@health.wa.gov.au","School of Physics, Mathematics and Computing, The University of Western Australia, Crawley, WA, Australia. Martin.Ebert@health.wa.gov.au","School of Physics, Mathematics and Computing, The University of Western Australia, Crawley, WA, Australia"],"raw_orcid":"https://orcid.org/0000-0002-6875-0719","affiliations":[{"raw_affiliation_string":"Centre for Advanced Technologies in Cancer Research (CATCR), Perth, WA, Australia. Martin.Ebert@health.wa.gov.au","institution_ids":["https://openalex.org/I2800882159"]},{"raw_affiliation_string":"Department of Radiation Oncology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia. Martin.Ebert@health.wa.gov.au","institution_ids":["https://openalex.org/I2802220196"]},{"raw_affiliation_string":"School of Physics, Mathematics and Computing, The University of Western Australia, Crawley, WA, Australia. Martin.Ebert@health.wa.gov.au","institution_ids":["https://openalex.org/I177877127"]},{"raw_affiliation_string":"School of Physics, Mathematics and Computing, The University of Western Australia, Crawley, WA, Australia","institution_ids":["https://openalex.org/I177877127"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5072140983"],"corresponding_institution_ids":["https://openalex.org/I177877127","https://openalex.org/I2800882159","https://openalex.org/I2802220196"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":{"value":3790,"currency":"USD","value_usd":3790},"fwci":0.3316,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.37439724,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"47","issue":"4","first_page":"1291","last_page":"1306"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.6772000193595886,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.6772000193595886,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.29829999804496765,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radioimmunotherapy","display_name":"radioimmunotherapy","score":0.8180000185966492},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.6899999976158142},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.8930000066757202},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.9359999895095825},{"id":"https://openalex.org/keywords/treatment-scheduling","display_name":"treatment scheduling","score":0.734000027179718},{"id":"https://openalex.org/keywords/dose-fractionation","display_name":"dose fractionation","score":0.906000018119812},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5529999732971191},{"id":"https://openalex.org/keywords/treatment-effectiveness-prediction","display_name":"treatment efficacy prediction","score":0.6000000238418579},{"id":"https://openalex.org/keywords/tumor-immunology","display_name":"tumor immunology","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.8130692839622498},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6246495842933655},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5268236994743347},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3731394112110138},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33492225408554077},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.26897740364074707},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09023645520210266},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1007/s13246-024-01458-1","doi":"https://doi.org/10.1007/s13246-024-01458-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13246-024-01458-1","pdf_url":"https://link.springer.com/content/pdf/10.1007/s13246-024-01458-1.pdf","source":{"id":"https://openalex.org/S4210170766","display_name":"Physical and Engineering Sciences in Medicine","issn_l":"2662-4729","issn":["2662-4729","2662-4737"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physical and Engineering Sciences in Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11666662","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11666662","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11666662/pdf/13246_2024_Article_1458.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phys Eng Sci Med","raw_type":"Text"},{"id":"pmid:39017990","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39017990","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physical and engineering sciences in medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire/da761ce6-7cbd-4a12-82aa-ccfe1383c1b9","doi":null,"is_oa":true,"landing_page_url":"https://research-repository.uwa.edu.au/en/publications/da761ce6-7cbd-4a12-82aa-ccfe1383c1b9","pdf_url":null,"source":{"id":"https://openalex.org/S4306402492","display_name":"UWA Profiles and Research Repository (UWA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177877127","host_organization_name":"The University of Western Australia","host_organization_lineage":["https://openalex.org/I177877127"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Ng, A M, MacKinnon, K M, Cook, A A, D\u2019Alonzo, R A, Rowshanfarzad, P, Nowak, A K, Gill, S & Ebert, M A 2024, 'Mechanistic in silico explorations of the immunogenic and synergistic effects of radiotherapy and immunotherapy: a critical review : a critical review', Physical and Engineering Sciences in Medicine, vol. 47, no. 4, pp. 1291-1306. https://doi.org/10.1007/s13246-024-01458-1","raw_type":"info:eu-repo/semantics/review"}],"best_oa_location":{"id":"doi:10.1007/s13246-024-01458-1","doi":"https://doi.org/10.1007/s13246-024-01458-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13246-024-01458-1","pdf_url":"https://link.springer.com/content/pdf/10.1007/s13246-024-01458-1.pdf","source":{"id":"https://openalex.org/S4210170766","display_name":"Physical and Engineering Sciences in Medicine","issn_l":"2662-4729","issn":["2662-4729","2662-4737"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physical and Engineering Sciences in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320501","display_name":"Cancer Australia","ror":"https://ror.org/00510tw04"},{"id":"https://openalex.org/F4320320991","display_name":"University of Western Australia","ror":"https://ror.org/047272k79"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4400732129.pdf","grobid_xml":"https://content.openalex.org/works/W4400732129.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W1846159518","https://openalex.org/W1912124796","https://openalex.org/W1919159045","https://openalex.org/W2000770117","https://openalex.org/W2030612376","https://openalex.org/W2068727486","https://openalex.org/W2090830065","https://openalex.org/W2107241007","https://openalex.org/W2117157957","https://openalex.org/W2117878645","https://openalex.org/W2159094759","https://openalex.org/W2167429049","https://openalex.org/W2183674768","https://openalex.org/W2263759961","https://openalex.org/W2345978567","https://openalex.org/W2411685931","https://openalex.org/W2429444364","https://openalex.org/W2794762714","https://openalex.org/W2804500674","https://openalex.org/W2892224885","https://openalex.org/W2900887235","https://openalex.org/W2903196192","https://openalex.org/W2918589641","https://openalex.org/W2919428266","https://openalex.org/W2954542121","https://openalex.org/W2962522375","https://openalex.org/W2967213355","https://openalex.org/W2981529300","https://openalex.org/W2990211116","https://openalex.org/W3005802010","https://openalex.org/W3005824507","https://openalex.org/W3005897484","https://openalex.org/W3015178699","https://openalex.org/W3023417503","https://openalex.org/W3042819313","https://openalex.org/W3048653574","https://openalex.org/W3080921966","https://openalex.org/W3081663584","https://openalex.org/W3093786718","https://openalex.org/W3106819346","https://openalex.org/W3111084373","https://openalex.org/W3112830100","https://openalex.org/W3128903240","https://openalex.org/W3131120802","https://openalex.org/W3138225123","https://openalex.org/W3184308115","https://openalex.org/W3204182287","https://openalex.org/W3204908221","https://openalex.org/W3214365348","https://openalex.org/W4200092823","https://openalex.org/W4210738594","https://openalex.org/W4220937030","https://openalex.org/W4220959955","https://openalex.org/W4224213971","https://openalex.org/W4236476849","https://openalex.org/W4280515635","https://openalex.org/W4286449403","https://openalex.org/W4368367446","https://openalex.org/W4378172829","https://openalex.org/W4384500243","https://openalex.org/W4386592162","https://openalex.org/W4387827507"],"related_works":["https://openalex.org/W2478486416","https://openalex.org/W2429444364","https://openalex.org/W2954542121","https://openalex.org/W4224236830","https://openalex.org/W7001980965","https://openalex.org/W4213359935","https://openalex.org/W7045802331","https://openalex.org/W4225694258","https://openalex.org/W4405316583","https://openalex.org/W4366149851"],"abstract_inverted_index":{"Immunotherapy":[0],"is":[1],"a":[2,29,211],"rapidly":[3],"evolving":[4],"field,":[5],"with":[6,21,94,149,198],"many":[7],"models":[8,56,75,123,164],"attempting":[9],"to":[10,25,106,116,139,168,195,202],"describe":[11],"its":[12],"impact":[13],"on":[14,85,127],"the":[15,43,58,64,81,86,90,122,128,153,163,169,175,181,184,204],"immune":[16,66,87,95],"system,":[17,88],"especially":[18],"when":[19,108],"paired":[20],"radiotherapy.":[22],"Tumor":[23],"response":[24],"this":[26,51],"combination":[27,150],"involves":[28],"complex":[30],"spatiotemporal":[31],"dynamic":[32],"which":[33,143],"makes":[34],"either":[35],"clinical":[36,141,158],"or":[37,89,118],"pre-clinical":[38],"in":[39,54,77,171],"vivo":[40],"investigation":[41],"across":[42],"resulting":[44],"extensive":[45],"solution":[46],"space":[47],"extremely":[48],"difficult.":[49],"In":[50],"review,":[52],"several":[53],"silico":[55],"of":[57,83,92,133,183],"interaction":[59],"between":[60,157,162],"radiotherapy,":[61],"immunotherapy,":[62],"and":[63,111,131,135,174,189,207,215],"patient's":[65],"system":[67],"are":[68],"examined.":[69],"The":[70,98],"study":[71],"included":[72],"only":[73],"mathematical":[74],"published":[76],"English":[78],"that":[79,101],"investigated":[80],"effects":[82],"radiotherapy":[84,110,117,134],"effect":[91],"immuno-radiotherapy":[93],"checkpoint":[96],"inhibitors.":[97],"findings":[99],"indicate":[100],"treatment":[102,147,187,208],"efficacy":[103,148],"was":[104],"predicted":[105],"improve":[107],"both":[109],"immunotherapy":[112,119],"were":[113],"administered,":[114],"compared":[115],"alone.":[120],"However,":[121],"do":[124],"not":[125],"agree":[126],"optimal":[129,154],"schedule":[130,188,209],"fractionation":[132],"immunotherapy.":[136],"This":[137,160],"corresponds":[138],"relevant":[140],"trials,":[142],"report":[144],"an":[145],"improved":[146],"therapy,":[151],"however,":[152],"scheduling":[155],"varies":[156],"trials.":[159],"discrepancy":[161],"can":[165],"be":[166,196],"attributed":[167],"variation":[170],"model":[172,190,206],"approach":[173],"specific":[176,212],"cancer":[177,213],"types":[178],"modeled,":[179],"making":[180],"determination":[182],"optimum":[185],"general":[186],"challenging.":[191],"Further":[192],"research":[193],"needs":[194],"conducted":[197],"similar":[199],"data":[200],"sets":[201],"evaluate":[203],"best":[205],"for":[210],"type":[214],"stage.":[216]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-07-18T00:00:00"}