{"id":"https://openalex.org/W4400726477","doi":"https://doi.org/10.1371/journal.pone.0300565","title":"Differentially expressed heterogeneous overdispersion genes testing for count data","display_name":"Differentially expressed heterogeneous overdispersion genes testing for count data","publication_year":2024,"publication_date":"2024-07-17","ids":{"openalex":"https://openalex.org/W4400726477","doi":"https://doi.org/10.1371/journal.pone.0300565","pmid":"https://pubmed.ncbi.nlm.nih.gov/36865247","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9980115"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0300565","doi":"https://doi.org/10.1371/journal.pone.0300565","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0300565","pdf_url":null,"source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pone.0300565","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101564744","display_name":"Yubai Yuan","orcid":"https://orcid.org/0000-0002-3847-2228","observed_orcids":["https://orcid.org/0000-0002-3847-2228"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yubai Yuan","raw_affiliation_strings":["Department of Statistics, The Pennsylvania State University, State College, PA, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, The Pennsylvania State University, State College, PA, United States of America","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100786563","display_name":"Qi Xu","orcid":"https://orcid.org/0000-0003-1127-6523","observed_orcids":["https://orcid.org/0000-0003-1127-6523"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qi Xu","raw_affiliation_strings":["Department of Statistics, University of California Irvine, Irvine, CA, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-1127-6523","affiliations":[{"raw_affiliation_string":"Department of Statistics, University of California Irvine, Irvine, CA, United States of America","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012174646","display_name":"Agaz Hussain Wani","orcid":"https://orcid.org/0000-0002-0540-2952","observed_orcids":["https://orcid.org/0000-0002-0540-2952"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Agaz Wani","raw_affiliation_strings":["Genomics Program, College of Public Health, University of South Florida, Tampa, FL, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Program, College of Public Health, University of South Florida, Tampa, FL, United States of America","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006269392","display_name":"Jan Dahrendorff","orcid":"https://orcid.org/0000-0003-4114-6842","observed_orcids":["https://orcid.org/0000-0003-4114-6842"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jan Dahrendorff","raw_affiliation_strings":["Genomics Program, College of Public Health, University of South Florida, Tampa, FL, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Program, College of Public Health, University of South Florida, Tampa, FL, United States of America","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086613634","display_name":"Chengqi C. Q. Wang","orcid":"https://orcid.org/0000-0002-7582-3824","observed_orcids":["https://orcid.org/0000-0002-7582-3824"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chengqi Wang","raw_affiliation_strings":["Genomics Program, College of Public Health, University of South Florida, Tampa, FL, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Program, College of Public Health, University of South Florida, Tampa, FL, United States of America","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027115223","display_name":"Arlina Shen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arlina Shen","raw_affiliation_strings":["University of California Berkeley, Berkeley, CA, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California Berkeley, Berkeley, CA, United States of America","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052435125","display_name":"Janelle Donglasan","orcid":"https://orcid.org/0000-0002-3147-0449","observed_orcids":["https://orcid.org/0000-0002-3147-0449"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janelle Donglasan","raw_affiliation_strings":["Genomics Program, College of Public Health, University of South Florida, Tampa, FL, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Program, College of Public Health, University of South Florida, Tampa, FL, United States of America","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080371765","display_name":"Sarah C. Burgan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Burgan","raw_affiliation_strings":["Genomics Program, College of Public Health, University of South Florida, Tampa, FL, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Program, College of Public Health, University of South Florida, Tampa, FL, United States of America","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zachary Graham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zachary Graham","raw_affiliation_strings":["Genomics Program, College of Public Health, University of South Florida, Tampa, FL, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Program, College of Public Health, University of South Florida, Tampa, FL, United States of America","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026464787","display_name":"Monica Uddin","orcid":"https://orcid.org/0000-0001-7404-2068","observed_orcids":["https://orcid.org/0000-0001-7404-2068"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monica Uddin","raw_affiliation_strings":["Genomics Program, College of Public Health, University of South Florida, Tampa, FL, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Program, College of Public Health, University of South Florida, Tampa, FL, United States of America","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064052128","display_name":"Derek E. Wildman","orcid":"https://orcid.org/0000-0002-6374-5136","observed_orcids":["https://orcid.org/0000-0002-6374-5136"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Derek Wildman","raw_affiliation_strings":["Genomics Program, College of Public Health, University of South Florida, Tampa, FL, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Program, College of Public Health, University of South Florida, Tampa, FL, United States of America","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029794342","display_name":"Annie Qu","orcid":"https://orcid.org/0000-0002-8396-7828","observed_orcids":["https://orcid.org/0000-0002-8396-7828"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Annie Qu","raw_affiliation_strings":["Department of Statistics, University of California Irvine, Irvine, CA, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-8396-7828","affiliations":[{"raw_affiliation_string":"Department of Statistics, University of California Irvine, Irvine, CA, United States of America","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5029794342"],"corresponding_institution_ids":["https://openalex.org/I204250578"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":0.2588,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.44404997,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"19","issue":"7","first_page":"e0300565","last_page":"e0300565"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9204000234603882,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9204000234603882,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.053700000047683716,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.016899999231100082,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/differential-gene-expression","display_name":"differential gene expression","score":0.8579999804496765},{"id":"https://openalex.org/keywords/rna-seq-read-counts","display_name":"RNA-seq read counts","score":0.7720000147819519},{"id":"https://openalex.org/keywords/overdispersion","display_name":"overdispersion","score":0.9589999914169312},{"id":"https://openalex.org/keywords/count-data","display_name":"count data","score":0.6869999766349792},{"id":"https://openalex.org/keywords/small-sample-size","display_name":"small sample size","score":0.7139999866485596},{"id":"https://openalex.org/keywords/microglial-cells","display_name":"microglial cells","score":0.9330000281333923},{"id":"https://openalex.org/keywords/stress-hormones","display_name":"stress hormones","score":0.7319999933242798}],"concepts":[{"id":"https://openalex.org/C117236510","wikidata":"https://www.wikidata.org/wiki/Q7113620","display_name":"Overdispersion","level":4,"score":0.976157546043396},{"id":"https://openalex.org/C33643355","wikidata":"https://www.wikidata.org/wiki/Q5176731","display_name":"Count data","level":3,"score":0.7850804924964905},{"id":"https://openalex.org/C129848803","wikidata":"https://www.wikidata.org/wiki/Q2564360","display_name":"Sample size determination","level":2,"score":0.5539990067481995},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5212371945381165},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.518152117729187},{"id":"https://openalex.org/C193244246","wikidata":"https://www.wikidata.org/wiki/Q5432696","display_name":"False discovery rate","level":3,"score":0.5108308792114258},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4949018359184265},{"id":"https://openalex.org/C87007009","wikidata":"https://www.wikidata.org/wiki/Q210832","display_name":"Statistical hypothesis testing","level":2,"score":0.4752093255519867},{"id":"https://openalex.org/C183905921","wikidata":"https://www.wikidata.org/wiki/Q1038757","display_name":"Multiple comparisons problem","level":2,"score":0.45800185203552246},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.45294660329818726},{"id":"https://openalex.org/C91025261","wikidata":"https://www.wikidata.org/wiki/Q7269460","display_name":"Quasi-likelihood","level":4,"score":0.4302446246147156},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.34806710481643677},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3449341654777527},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.32529741525650024},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.24499168992042542},{"id":"https://openalex.org/C100906024","wikidata":"https://www.wikidata.org/wiki/Q205692","display_name":"Poisson distribution","level":2,"score":0.2075607180595398},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.17063471674919128}],"mesh":[],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pone.0300565","doi":"https://doi.org/10.1371/journal.pone.0300565","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0300565","pdf_url":null,"source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"doi:10.1101/2023.02.21.529455","doi":"https://doi.org/10.1101/2023.02.21.529455","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2023.02.21.529455","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/02/22/2023.02.21.529455.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:11253971","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11253971","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11253971/pdf/pone.0300565.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:36865247","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36865247","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Preprint"},{"id":"pmid:39018275","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39018275","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9980115","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9980115","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9980115/pdf/nihpp-2023.02.21.529455v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmh:oai:RePEc:plo:pone00:0300565","doi":null,"is_oa":false,"landing_page_url":"https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0300565","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:303ec5b65e2c400794352b4914874ad8","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/303ec5b65e2c400794352b4914874ad8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 19, Iss 7 (2024)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:d1fea5b4ed5440ae8c9332c18a16b978","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d1fea5b4ed5440ae8c9332c18a16b978","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 19, Iss 7, p e0300565 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0300565","doi":"https://doi.org/10.1371/journal.pone.0300565","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0300565","pdf_url":null,"source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5662037965","display_name":null,"funder_award_id":"R01MD011728","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"},{"id":"https://openalex.org/G9000895257","display_name":"Epigenomic Predictors of PTSD and Traumatic Stress in an African American Cohort","funder_award_id":"R01MD011728","funder_id":"https://openalex.org/F4320337534","funder_display_name":"National Institute on Minority Health and Health Disparities"}],"funders":[{"id":"https://openalex.org/F4320306080","display_name":"Foundation for the National Institutes of Health","ror":"https://ror.org/00k86s890"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337534","display_name":"National Institute on Minority Health and Health Disparities","ror":"https://ror.org/0493hgw16"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4400726477.pdf","grobid_xml":"https://content.openalex.org/works/W4400726477.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1964608340","https://openalex.org/W1977244886","https://openalex.org/W1977391294","https://openalex.org/W1996614939","https://openalex.org/W2006802054","https://openalex.org/W2024425375","https://openalex.org/W2031205682","https://openalex.org/W2036194871","https://openalex.org/W2050237761","https://openalex.org/W2057424087","https://openalex.org/W2060476820","https://openalex.org/W2061084580","https://openalex.org/W2074414424","https://openalex.org/W2074589301","https://openalex.org/W2078420687","https://openalex.org/W2083201121","https://openalex.org/W2088677979","https://openalex.org/W2090043394","https://openalex.org/W2100596675","https://openalex.org/W2107018762","https://openalex.org/W2110017531","https://openalex.org/W2110065044","https://openalex.org/W2114104545","https://openalex.org/W2121024352","https://openalex.org/W2121265716","https://openalex.org/W2137586531","https://openalex.org/W2145416275","https://openalex.org/W2146201774","https://openalex.org/W2152239989","https://openalex.org/W2154431984","https://openalex.org/W2166820820","https://openalex.org/W2192253841","https://openalex.org/W2212574367","https://openalex.org/W2224154098","https://openalex.org/W2560318884","https://openalex.org/W2616754551","https://openalex.org/W2740846930","https://openalex.org/W2809514549","https://openalex.org/W2914650668","https://openalex.org/W2914861780","https://openalex.org/W2953050629","https://openalex.org/W2999146435","https://openalex.org/W4232513052","https://openalex.org/W4241715325","https://openalex.org/W4245341977","https://openalex.org/W4255830679","https://openalex.org/W4296028038","https://openalex.org/W4309322228"],"related_works":["https://openalex.org/W1490261451","https://openalex.org/W2519586062","https://openalex.org/W2902163767","https://openalex.org/W997850813","https://openalex.org/W1589771869","https://openalex.org/W2119034410","https://openalex.org/W2105572161","https://openalex.org/W2950615701","https://openalex.org/W2258109946","https://openalex.org/W2114405789"],"abstract_inverted_index":{"The":[0],"mRNA-seq":[1],"data":[2,164,189],"analysis":[3,64,102],"is":[4,44,59,156],"a":[5,98,115,128,142,184],"powerful":[6],"technology":[7],"for":[8,39,135],"inferring":[9],"information":[10,122],"from":[11,90,123,190],"biological":[12],"systems":[13],"of":[14,32,151],"interest.":[15],"Specifically,":[16],"the":[17,30,51,78,136,148,159,180],"sequenced":[18],"RNA":[19],"fragments":[20,34],"are":[21],"aligned":[22],"with":[23],"genomic":[24],"reference":[25],"sequences,":[26],"and":[27,92,114,126,131,165,172],"we":[28],"count":[29,55,163],"number":[31],"sequence":[33],"corresponding":[35],"to":[36,69,85,146,183,195,203],"each":[37,40],"gene":[38,43],"condition.":[41],"A":[42],"identified":[45],"as":[46],"differentially":[47,152],"expressed":[48,153,199],"(DE)":[49],"if":[50],"difference":[52],"in":[53,174],"its":[54],"numbers":[56],"between":[57],"conditions":[58,125],"statistically":[60],"significant.":[61],"Several":[62],"statistical":[63],"methods":[65,80],"have":[66],"been":[67],"developed":[68],"detect":[70,196],"DE":[71,87,176],"genes":[72,88,106,200],"based":[73,109],"on":[74,110,158],"RNA-seq":[75,137,161],"data.":[76],"However,":[77],"existing":[79,169],"could":[81],"suffer":[82],"decreasing":[83],"power":[84,150],"identify":[86],"arising":[89],"overdispersion":[91,105,112,133],"limited":[93],"sample":[94,121],"size.":[95],"We":[96,178],"propose":[97],"new":[99],"differential":[100],"expression":[101],"procedure:":[103],"heterogeneous":[104,111],"testing":[107],"(DEHOGT)":[108],"modeling":[113,134],"post-hoc":[116],"inference":[117],"procedure.":[118],"DEHOGT":[119,140,155,193],"integrates":[120],"all":[124],"provides":[127],"more":[129,197],"flexible":[130],"adaptive":[132],"read":[138,162],"count.":[139],"adopts":[141],"gene-wise":[143],"estimation":[144],"scheme":[145],"enhance":[147],"detection":[149],"genes.":[154,177],"tested":[157],"synthetic":[160],"outperforms":[166],"two":[167],"popular":[168],"methods,":[170],"DESeq":[171],"EdgeR,":[173],"detecting":[175],"apply":[179],"proposed":[181],"method":[182],"test":[185],"dataset":[186],"using":[187],"RNAseq":[188],"microglial":[191,204],"cells.":[192],"tends":[194],"differently":[198],"potentially":[201],"related":[202],"cells":[205],"under":[206],"different":[207],"stress":[208],"hormones":[209],"treatments.":[210]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-07-18T00:00:00"}