{"id":"https://openalex.org/W4400723729","doi":"https://doi.org/10.3390/biomedicines12071593","title":"Voluntary Exercise Ameliorates Chronic Ethanol Withdrawal-Induced Adaptations of Opioid Receptor Expression in the Nucleus Accumbens, Dopamine Release, and Ethanol Consumption","display_name":"Voluntary Exercise Ameliorates Chronic Ethanol Withdrawal-Induced Adaptations of Opioid Receptor Expression in the Nucleus Accumbens, Dopamine Release, and Ethanol Consumption","publication_year":2024,"publication_date":"2024-07-17","ids":{"openalex":"https://openalex.org/W4400723729","doi":"https://doi.org/10.3390/biomedicines12071593","pmid":"https://pubmed.ncbi.nlm.nih.gov/39062166","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11274624"},"language":"en","primary_location":{"id":"doi:10.3390/biomedicines12071593","doi":"https://doi.org/10.3390/biomedicines12071593","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines12071593","pdf_url":null,"source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/biomedicines12071593","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Christina A Nelson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405264753","display_name":"Noorda College of Osteopathic Medicine","ror":"https://ror.org/02wdwpg14","country_code":"US","type":"education","lineage":["https://openalex.org/I4405264753"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina A Nelson","raw_affiliation_strings":["Department of Biomedical Sciences, Noorda College of Osteopathic Medicine, Provo, UT 84606, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Noorda College of Osteopathic Medicine, Provo, UT 84606, USA","institution_ids":["https://openalex.org/I4405264753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088711481","display_name":"James Brundage","orcid":"https://orcid.org/0000-0003-1603-6406","observed_orcids":["https://orcid.org/0000-0003-1603-6406"]},"institutions":[{"id":"https://openalex.org/I100005738","display_name":"Brigham Young University","ror":"https://ror.org/047rhhm47","country_code":"US","type":"education","lineage":["https://openalex.org/I100005738"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James N Brundage","raw_affiliation_strings":["Department of Psychology/Neuroscience , Brigham Young University ; Provo , Utah 84602","Department of Psychology/Neuroscience, Brigham Young University, Provo, UT 84602, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology/Neuroscience , Brigham Young University ; Provo , Utah 84602","institution_ids":["https://openalex.org/I100005738"]},{"raw_affiliation_string":"Department of Psychology/Neuroscience, Brigham Young University, Provo, UT 84602, USA","institution_ids":["https://openalex.org/I100005738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065006364","display_name":"Benjamin M. Williams","orcid":"https://orcid.org/0000-0002-2939-8206","observed_orcids":["https://orcid.org/0000-0002-2939-8206"]},"institutions":[{"id":"https://openalex.org/I100005738","display_name":"Brigham Young University","ror":"https://ror.org/047rhhm47","country_code":"US","type":"education","lineage":["https://openalex.org/I100005738"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin M Williams","raw_affiliation_strings":["Department of Psychology/Neuroscience , Brigham Young University ; Provo , Utah 84602","Department of Psychology/Neuroscience, Brigham Young University, Provo, UT 84602, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology/Neuroscience , Brigham Young University ; Provo , Utah 84602","institution_ids":["https://openalex.org/I100005738"]},{"raw_affiliation_string":"Department of Psychology/Neuroscience, Brigham Young University, Provo, UT 84602, USA","institution_ids":["https://openalex.org/I100005738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111085737","display_name":"Jared Baldridge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100005738","display_name":"Brigham Young University","ror":"https://ror.org/047rhhm47","country_code":"US","type":"education","lineage":["https://openalex.org/I100005738"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jared K Baldridge","raw_affiliation_strings":["Department of Psychology/Neuroscience , Brigham Young University ; Provo , Utah 84602","Department of Psychology/Neuroscience, Brigham Young University, Provo, UT 84602, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology/Neuroscience , Brigham Young University ; Provo , Utah 84602","institution_ids":["https://openalex.org/I100005738"]},{"raw_affiliation_string":"Department of Psychology/Neuroscience, Brigham Young University, Provo, UT 84602, USA","institution_ids":["https://openalex.org/I100005738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5099081849","display_name":"Alyssa L. Stockard","orcid":"https://orcid.org/0009-0005-6900-2615","observed_orcids":["https://orcid.org/0009-0005-6900-2615"]},"institutions":[{"id":"https://openalex.org/I100005738","display_name":"Brigham Young University","ror":"https://ror.org/047rhhm47","country_code":"US","type":"education","lineage":["https://openalex.org/I100005738"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alyssa L Stockard","raw_affiliation_strings":["Department of Psychology/Neuroscience , Brigham Young University ; Provo , Utah 84602","Department of Psychology/Neuroscience, Brigham Young University, Provo, UT 84602, USA"],"raw_orcid":"https://orcid.org/0009-0005-6900-2615","affiliations":[{"raw_affiliation_string":"Department of Psychology/Neuroscience , Brigham Young University ; Provo , Utah 84602","institution_ids":["https://openalex.org/I100005738"]},{"raw_affiliation_string":"Department of Psychology/Neuroscience, Brigham Young University, Provo, UT 84602, USA","institution_ids":["https://openalex.org/I100005738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050969419","display_name":"Charlton H. Bassett","orcid":"https://orcid.org/0009-0001-5219-1123","observed_orcids":["https://orcid.org/0009-0001-5219-1123"]},"institutions":[{"id":"https://openalex.org/I100005738","display_name":"Brigham Young University","ror":"https://ror.org/047rhhm47","country_code":"US","type":"education","lineage":["https://openalex.org/I100005738"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charlton H Bassett","raw_affiliation_strings":["Department of Psychology/Neuroscience , Brigham Young University ; Provo , Utah 84602","Department of Psychology/Neuroscience, Brigham Young University, Provo, UT 84602, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology/Neuroscience , Brigham Young University ; Provo , Utah 84602","institution_ids":["https://openalex.org/I100005738"]},{"raw_affiliation_string":"Department of Psychology/Neuroscience, Brigham Young University, Provo, UT 84602, USA","institution_ids":["https://openalex.org/I100005738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109748143","display_name":"Brandon J. Burger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405264753","display_name":"Noorda College of Osteopathic Medicine","ror":"https://ror.org/02wdwpg14","country_code":"US","type":"education","lineage":["https://openalex.org/I4405264753"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brandon J Burger","raw_affiliation_strings":["Department of Biomedical Sciences, Noorda College of Osteopathic Medicine, Provo, UT 84606, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Noorda College of Osteopathic Medicine, Provo, UT 84606, USA","institution_ids":["https://openalex.org/I4405264753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109748144","display_name":"Bridger T. Gunter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405264753","display_name":"Noorda College of Osteopathic Medicine","ror":"https://ror.org/02wdwpg14","country_code":"US","type":"education","lineage":["https://openalex.org/I4405264753"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bridger T Gunter","raw_affiliation_strings":["Department of Biomedical Sciences, Noorda College of Osteopathic Medicine, Provo, UT 84606, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Noorda College of Osteopathic Medicine, Provo, UT 84606, USA","institution_ids":["https://openalex.org/I4405264753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019004136","display_name":"Andrew J. Payne","orcid":"https://orcid.org/0009-0003-4510-7047","observed_orcids":["https://orcid.org/0009-0003-4510-7047"]},"institutions":[{"id":"https://openalex.org/I4405264753","display_name":"Noorda College of Osteopathic Medicine","ror":"https://ror.org/02wdwpg14","country_code":"US","type":"education","lineage":["https://openalex.org/I4405264753"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew J Payne","raw_affiliation_strings":["Department of Biomedical Sciences, Noorda College of Osteopathic Medicine, Provo, UT 84606, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Noorda College of Osteopathic Medicine, Provo, UT 84606, USA","institution_ids":["https://openalex.org/I4405264753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063262887","display_name":"Jordan T. Yorgason","orcid":"https://orcid.org/0000-0002-5687-0676","observed_orcids":["https://orcid.org/0000-0002-5687-0676"]},"institutions":[{"id":"https://openalex.org/I100005738","display_name":"Brigham Young University","ror":"https://ror.org/047rhhm47","country_code":"US","type":"education","lineage":["https://openalex.org/I100005738"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jordan T Yorgason","raw_affiliation_strings":["Department of Psychology/Neuroscience , Brigham Young University ; Provo , Utah 84602","Department of Psychology/Neuroscience, Brigham Young University, Provo, UT 84602, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology/Neuroscience , Brigham Young University ; Provo , Utah 84602","institution_ids":["https://openalex.org/I100005738"]},{"raw_affiliation_string":"Department of Psychology/Neuroscience, Brigham Young University, Provo, UT 84602, USA","institution_ids":["https://openalex.org/I100005738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032942991","display_name":"Scott C. Steffensen","orcid":"https://orcid.org/0000-0001-6463-8861","observed_orcids":["https://orcid.org/0000-0001-6463-8861"]},"institutions":[{"id":"https://openalex.org/I100005738","display_name":"Brigham Young University","ror":"https://ror.org/047rhhm47","country_code":"US","type":"education","lineage":["https://openalex.org/I100005738"]},{"id":"https://openalex.org/I4405264753","display_name":"Noorda College of Osteopathic Medicine","ror":"https://ror.org/02wdwpg14","country_code":"US","type":"education","lineage":["https://openalex.org/I4405264753"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott C. Steffensen","raw_affiliation_strings":["Department of Psychology/Neuroscience , Brigham Young University ; Provo , Utah 84602","Department of Biomedical Sciences, Noorda College of Osteopathic Medicine, Provo, UT 84606, USA","Department of Psychology/Neuroscience, Brigham Young University, Provo, UT 84602, USA"],"raw_orcid":"https://orcid.org/0000-0001-6463-8861","affiliations":[{"raw_affiliation_string":"Department of Psychology/Neuroscience , Brigham Young University ; Provo , Utah 84602","institution_ids":["https://openalex.org/I100005738"]},{"raw_affiliation_string":"Department of Biomedical Sciences, Noorda College of Osteopathic Medicine, Provo, UT 84606, USA","institution_ids":["https://openalex.org/I4405264753"]},{"raw_affiliation_string":"Department of Psychology/Neuroscience, Brigham Young University, Provo, UT 84602, USA","institution_ids":["https://openalex.org/I100005738"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037850222","display_name":"Kyle B. Bills","orcid":"https://orcid.org/0000-0001-9742-3728","observed_orcids":["https://orcid.org/0000-0001-9742-3728"]},"institutions":[{"id":"https://openalex.org/I4405264753","display_name":"Noorda College of Osteopathic Medicine","ror":"https://ror.org/02wdwpg14","country_code":"US","type":"education","lineage":["https://openalex.org/I4405264753"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kyle B Bills","raw_affiliation_strings":["Department of Biomedical Sciences, Noorda College of Osteopathic Medicine, Provo, UT 84606, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Noorda College of Osteopathic Medicine, Provo, UT 84606, USA","institution_ids":["https://openalex.org/I4405264753"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5037850222"],"corresponding_institution_ids":["https://openalex.org/I4405264753"],"apc_list":{"value":2600,"currency":"CHF","value_usd":2955},"apc_paid":{"value":2600,"currency":"CHF","value_usd":2955},"fwci":0.8567,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.68471401,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"12","issue":"7","first_page":"1593","last_page":"1593"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.8812999725341797,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.8812999725341797,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.051899999380111694,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.03869999945163727,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/voluntary-exercise","display_name":"voluntary exercise","score":0.9990000128746033},{"id":"https://openalex.org/keywords/alcoholism","display_name":"alcoholism","score":0.8880000114440918},{"id":"https://openalex.org/keywords/kappa-opioid-receptor","display_name":"kappa opioid receptor","score":0.9629999995231628},{"id":"https://openalex.org/keywords/delta-opioid-receptor","display_name":"delta opioid receptor","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nucleus-accumbens","display_name":"nucleus accumbens","score":0.9929999709129333},{"id":"https://openalex.org/keywords/ventral-tegmental-area","display_name":"ventral tegmental area","score":0.9589999914169312},{"id":"https://openalex.org/keywords/dopamine-release","display_name":"dopamine release","score":1.0},{"id":"https://openalex.org/keywords/ethanol-intake","display_name":"ethanol consumption","score":0.9710000157356262},{"id":"https://openalex.org/keywords/exercise-therapy","display_name":"exercise therapy","score":0.5640000104904175}],"concepts":[{"id":"https://openalex.org/C2780948874","wikidata":"https://www.wikidata.org/wiki/Q640562","display_name":"Ventral tegmental area","level":4,"score":0.916869044303894},{"id":"https://openalex.org/C2776552330","wikidata":"https://www.wikidata.org/wiki/Q1476178","display_name":"Nucleus accumbens","level":3,"score":0.9028234481811523},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.5920528769493103},{"id":"https://openalex.org/C184389661","wikidata":"https://www.wikidata.org/wiki/Q14897645","display_name":"\u03ba-opioid receptor","level":4,"score":0.5495081543922424},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.48676037788391113},{"id":"https://openalex.org/C2779442783","wikidata":"https://www.wikidata.org/wiki/Q15326","display_name":"Alcohol use disorder","level":3,"score":0.4549197852611542},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.43057334423065186},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4107823669910431},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3359122574329376},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33284682035446167},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.32711851596832275},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3062897324562073},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.28486308455467224},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.12970083951950073},{"id":"https://openalex.org/C2781066024","wikidata":"https://www.wikidata.org/wiki/Q156","display_name":"Alcohol","level":2,"score":0.10282930731773376},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/biomedicines12071593","doi":"https://doi.org/10.3390/biomedicines12071593","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines12071593","pdf_url":null,"source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},{"id":"doi:10.20944/preprints202406.1605.v1","doi":"https://doi.org/10.20944/preprints202406.1605.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202406.1605.v1","pdf_url":"https://www.preprints.org/frontend/manuscript/71dfc742d4927de910b1c8eaeae7372d/download_pub","source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:11274624","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11274624","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11274624/pdf/biomedicines-12-01593.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"Text"},{"id":"pmid:39062166","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39062166","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:86ad168a4c3b461a87d04dfa0a19de4c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/86ad168a4c3b461a87d04dfa0a19de4c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomedicines, Vol 12, Iss 7, p 1593 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/biomedicines12071593","doi":"https://doi.org/10.3390/biomedicines12071593","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines12071593","pdf_url":null,"source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5519482337","display_name":"Nicotine and Alcohol Co-Dependence","funder_award_id":"R01DA035958","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G8116690844","display_name":"Neuroplasticity with alcohol dependence","funder_award_id":"R01AA020919","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G9000906917","display_name":"Neuroimmune mechanisms of alcohol reward","funder_award_id":"R01AA030577","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4400723729.pdf","grobid_xml":"https://content.openalex.org/works/W4400723729.grobid-xml"},"referenced_works_count":72,"referenced_works":["https://openalex.org/W1516478023","https://openalex.org/W1937702646","https://openalex.org/W1938381539","https://openalex.org/W1964384291","https://openalex.org/W1974621146","https://openalex.org/W1977192770","https://openalex.org/W1984267890","https://openalex.org/W1987507313","https://openalex.org/W1994609215","https://openalex.org/W1997095406","https://openalex.org/W2002721508","https://openalex.org/W2005020429","https://openalex.org/W2010455608","https://openalex.org/W2010555262","https://openalex.org/W2021066246","https://openalex.org/W2024063816","https://openalex.org/W2024138948","https://openalex.org/W2025909283","https://openalex.org/W2030288942","https://openalex.org/W2037457092","https://openalex.org/W2038525893","https://openalex.org/W2044711161","https://openalex.org/W2047318846","https://openalex.org/W2050166523","https://openalex.org/W2051482469","https://openalex.org/W2054849655","https://openalex.org/W2057657658","https://openalex.org/W2063121143","https://openalex.org/W2064637992","https://openalex.org/W2066788081","https://openalex.org/W2066848874","https://openalex.org/W2067287774","https://openalex.org/W2069615045","https://openalex.org/W2083585149","https://openalex.org/W2084200679","https://openalex.org/W2087281007","https://openalex.org/W2088522292","https://openalex.org/W2088866868","https://openalex.org/W2096908749","https://openalex.org/W2103337254","https://openalex.org/W2106719141","https://openalex.org/W2125710074","https://openalex.org/W2128443527","https://openalex.org/W2133672910","https://openalex.org/W2134366865","https://openalex.org/W2136118156","https://openalex.org/W2157387402","https://openalex.org/W2165149801","https://openalex.org/W2169863475","https://openalex.org/W2327477195","https://openalex.org/W2429738326","https://openalex.org/W2472518156","https://openalex.org/W2503223074","https://openalex.org/W2755924589","https://openalex.org/W2756527586","https://openalex.org/W2785380492","https://openalex.org/W2793350608","https://openalex.org/W2892028585","https://openalex.org/W2892131175","https://openalex.org/W2893186854","https://openalex.org/W2903920169","https://openalex.org/W2913667649","https://openalex.org/W2954254306","https://openalex.org/W2971649686","https://openalex.org/W2993922671","https://openalex.org/W3085900608","https://openalex.org/W3087285577","https://openalex.org/W4231884481","https://openalex.org/W4294990921","https://openalex.org/W4306925987","https://openalex.org/W4386814867","https://openalex.org/W4406056430"],"related_works":["https://openalex.org/W3085900608","https://openalex.org/W7167858462","https://openalex.org/W2541579214","https://openalex.org/W2256358091","https://openalex.org/W4399692049","https://openalex.org/W1968098627","https://openalex.org/W2258001964","https://openalex.org/W3084991006","https://openalex.org/W4389025974","https://openalex.org/W3175946165"],"abstract_inverted_index":{"Exercise":[0],"has":[1,40],"increasingly":[2],"been":[3,41],"recognized":[4],"as":[5,190],"an":[6],"adjunctive":[7],"therapy":[8],"for":[9,33,188,194],"alcohol-use":[10],"disorder":[11],"(AUD),":[12],"yet":[13],"our":[14],"understanding":[15],"of":[16,29,83,181],"its":[17],"underlying":[18],"neurological":[19],"mechanisms":[20],"remains":[21],"limited.":[22],"This":[23],"knowledge":[24],"gap":[25],"impedes":[26],"the":[27,52,64,81,100,114,132,161,178,186],"development":[28],"evidence-based":[30],"exercise":[31,85,121,167,189],"guidelines":[32],"AUD":[34],"treatment.":[35],"Chronic":[36],"ethanol":[37],"(EtOH)":[38],"exposure":[39],"shown":[42],"to":[43,73,157,172],"upregulate":[44],"and":[45,93,102,104,127,134,147,163],"sensitize":[46],"kappa":[47],"opioid":[48,95],"receptors":[49],"(KORs)":[50],"in":[51,63,86,99,110,113,131,138,150,160],"nucleus":[53],"accumbens":[54],"(NAc),":[55],"which":[56,70],"is":[57],"innervated":[58],"by":[59],"dopamine":[60],"(DA)":[61],"neurons":[62],"midbrain":[65],"ventral":[66],"tegmental":[67],"area":[68],"(VTA),":[69],"may":[71],"contribute":[72],"AUD-related":[74,182],"behaviors.":[75],"In":[76],"this":[77],"study,":[78],"we":[79],"investigated":[80],"impact":[82],"voluntary":[84,120,166],"EtOH-dependent":[87],"mice":[88],"on":[89,107],"EtOH":[90,123],"consumption,":[91,124],"KOR":[92,126,151],"delta":[94],"receptor":[96],"(DOR)":[97],"expression":[98,130,159],"NAc":[101,162],"VTA,":[103],"functional":[105],"effects":[106],"EtOH-induced":[108,136,148],"alterations":[109,149],"DA":[111,139,173],"release":[112],"NAc.":[115],"Our":[116],"findings":[117,176],"reveal":[118],"that":[119],"reduces":[122,125],"enhances":[128],"DOR":[129,158],"NAc,":[133],"modifies":[135],"adaptations":[137],"release,":[140],"suggesting":[141],"a":[142,191],"competitive":[143],"interaction":[144],"between":[145],"exercise-induced":[146],"expression.":[152],"We":[153],"also":[154],"found":[155],"changes":[156,171],"VTA":[164],"with":[165],"but":[168],"no":[169],"significant":[170],"release.":[174],"These":[175],"elucidate":[177],"complex":[179],"interplay":[180],"neurobiological":[183],"processes,":[184],"highlighting":[185],"potential":[187],"therapeutic":[192],"intervention":[193],"AUD.":[195]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2024-07-18T00:00:00"}
