{"id":"https://openalex.org/W4400722012","doi":"https://doi.org/10.1016/j.jprot.2024.105260","title":"Proteomic and Phosphoproteomic analysis of thyroid papillary carcinoma: Identification of potential biomarkers for metastasis","display_name":"Proteomic and Phosphoproteomic analysis of thyroid papillary carcinoma: Identification of potential biomarkers for metastasis","publication_year":2024,"publication_date":"2024-07-17","ids":{"openalex":"https://openalex.org/W4400722012","doi":"https://doi.org/10.1016/j.jprot.2024.105260","pmid":"https://pubmed.ncbi.nlm.nih.gov/39029786"},"language":"en","primary_location":{"id":"doi:10.1016/j.jprot.2024.105260","doi":"https://doi.org/10.1016/j.jprot.2024.105260","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jprot.2024.105260","pdf_url":null,"source":{"id":"https://openalex.org/S100014387","display_name":"Journal of Proteomics","issn_l":"1874-3919","issn":["1874-3919","1876-7737"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Proteomics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.jprot.2024.105260","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011819880","display_name":"Lingyao Peng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]},{"id":"https://openalex.org/I4210139110","display_name":"Hangzhou Hospital of Traditional Chinese Medicine","ror":"https://ror.org/03a8g0p38","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139110"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lingyao Peng","raw_affiliation_strings":["Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou 310007, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou 310007, China","institution_ids":["https://openalex.org/I114539943","https://openalex.org/I4210139110"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053411040","display_name":"Zhenxian Zhang","orcid":"https://orcid.org/0000-0002-9247-7185","observed_orcids":["https://orcid.org/0000-0002-9247-7185"]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]},{"id":"https://openalex.org/I4210139110","display_name":"Hangzhou Hospital of Traditional Chinese Medicine","ror":"https://ror.org/03a8g0p38","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139110"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenxian Zhang","raw_affiliation_strings":["Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou 310007, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou 310007, China","institution_ids":["https://openalex.org/I114539943","https://openalex.org/I4210139110"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wei Du","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Du","raw_affiliation_strings":["Hangzhou Institute of Standardization, Hangzhou 310000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hangzhou Institute of Standardization, Hangzhou 310000, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019652712","display_name":"Zhu Jiang","orcid":"https://orcid.org/0000-0002-2722-7665","observed_orcids":["https://orcid.org/0000-0002-2722-7665"]},"institutions":[{"id":"https://openalex.org/I4210137217","display_name":"Women's Hospital, School of Medicine, Zhejiang University","ror":"https://ror.org/042t7yh44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137217"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jiang Zhu","raw_affiliation_strings":["Women's Hospital School of Medicine Zhejiang University, 310006 Hangzhou, China. Electronic address: 0618383@zju.edu.cn","Women's Hospital School of Medicine Zhejiang University, 310006 Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Women's Hospital School of Medicine Zhejiang University, 310006 Hangzhou, China. Electronic address: 0618383@zju.edu.cn","institution_ids":["https://openalex.org/I4210137217","https://openalex.org/I76130692"]},{"raw_affiliation_string":"Women's Hospital School of Medicine Zhejiang University, 310006 Hangzhou, China","institution_ids":["https://openalex.org/I4210137217","https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018687022","display_name":"Wenkai Duan","orcid":"https://orcid.org/0000-0001-6239-5851","observed_orcids":["https://orcid.org/0000-0001-6239-5851"]},"institutions":[{"id":"https://openalex.org/I4210125098","display_name":"Hangzhou Vocational and Technical College","ror":"https://ror.org/03jjm4b17","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210125098"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wenkai Duan","raw_affiliation_strings":["Hangzhou Vocational and Technical College, Hangzhou 310018, China. Electronic address: kevin_dwk@163.com","Hangzhou Vocational and Technical College, Hangzhou 310018, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hangzhou Vocational and Technical College, Hangzhou 310018, China. Electronic address: kevin_dwk@163.com","institution_ids":["https://openalex.org/I4210125098"]},{"raw_affiliation_string":"Hangzhou Vocational and Technical College, Hangzhou 310018, China","institution_ids":["https://openalex.org/I4210125098"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5018687022","https://openalex.org/A5019652712"],"corresponding_institution_ids":["https://openalex.org/I4210125098","https://openalex.org/I4210137217","https://openalex.org/I76130692"],"apc_list":{"value":3450,"currency":"USD","value_usd":3450},"apc_paid":{"value":3450,"currency":"USD","value_usd":3450},"fwci":2.3088,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.88859257,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"306","issue":null,"first_page":"105260","last_page":"105260"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/papillary-thyroid-carcinoma","display_name":"papillary thyroid carcinoma","score":0.9139999747276306},{"id":"https://openalex.org/keywords/metastasis-biomarkers","display_name":"metastasis biomarkers","score":0.8920000195503235},{"id":"https://openalex.org/keywords/phosphoproteomics","display_name":"phosphoproteomics","score":0.8259999752044678},{"id":"https://openalex.org/keywords/proteomics","display_name":"proteomics","score":0.9480000138282776},{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.7860000133514404},{"id":"https://openalex.org/keywords/ml-7","display_name":"ML-7","score":0.824999988079071},{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":0.843999981880188},{"id":"https://openalex.org/keywords/amino-acid-metabolism","display_name":"amino acid metabolism","score":0.7480000257492065},{"id":"https://openalex.org/keywords/succinic-semialdehyde-dehydrogenase","display_name":"succinic semialdehyde dehydrogenase","score":0.8360000252723694},{"id":"https://openalex.org/keywords/pyruvate-carboxylase","display_name":"pyruvate carboxylase","score":0.9039999842643738},{"id":"https://openalex.org/keywords/adenine-nucleotide-translocator","display_name":"adenine nucleotide translocase","score":0.8339999914169312}],"concepts":[{"id":"https://openalex.org/C2779761222","wikidata":"https://www.wikidata.org/wiki/Q826522","display_name":"Thyroid cancer","level":3,"score":0.5834131240844727},{"id":"https://openalex.org/C2993294228","wikidata":"https://www.wikidata.org/wiki/Q13632630","display_name":"Thyroid carcinoma","level":3,"score":0.5780132412910461},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4959968030452728},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47822898626327515},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4605812728404999},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.45057326555252075},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3611053228378296},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.337380051612854},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.33185499906539917},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33077892661094666},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32594260573387146},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3214336037635803},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2500770092010498}],"mesh":[{"descriptor_ui":"D000077273","descriptor_name":"Thyroid Cancer, Papillary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000077273","descriptor_name":"Thyroid Cancer, Papillary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000077273","descriptor_name":"Thyroid Cancer, Papillary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000077273","descriptor_name":"Thyroid Cancer, Papillary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000077273","descriptor_name":"Thyroid Cancer, Papillary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000077273","descriptor_name":"Thyroid Cancer, Papillary","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000077273","descriptor_name":"Thyroid Cancer, Papillary","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000077273","descriptor_name":"Thyroid Cancer, Papillary","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000077273","descriptor_name":"Thyroid Cancer, Papillary","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000077273","descriptor_name":"Thyroid Cancer, Papillary","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jprot.2024.105260","doi":"https://doi.org/10.1016/j.jprot.2024.105260","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jprot.2024.105260","pdf_url":null,"source":{"id":"https://openalex.org/S100014387","display_name":"Journal of Proteomics","issn_l":"1874-3919","issn":["1874-3919","1876-7737"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Proteomics","raw_type":"journal-article"},{"id":"pmid:39029786","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39029786","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of proteomics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.jprot.2024.105260","doi":"https://doi.org/10.1016/j.jprot.2024.105260","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jprot.2024.105260","pdf_url":null,"source":{"id":"https://openalex.org/S100014387","display_name":"Journal of Proteomics","issn_l":"1874-3919","issn":["1874-3919","1876-7737"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Proteomics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1963900982","https://openalex.org/W1971877828","https://openalex.org/W2058326064","https://openalex.org/W2094433843","https://openalex.org/W2099603281","https://openalex.org/W2545003542","https://openalex.org/W2571998636","https://openalex.org/W2766244926","https://openalex.org/W2795059364","https://openalex.org/W2811355391","https://openalex.org/W2910870137","https://openalex.org/W2922772115","https://openalex.org/W2952919722","https://openalex.org/W2965295034","https://openalex.org/W3000075214","https://openalex.org/W3024796810","https://openalex.org/W3040121443","https://openalex.org/W3088334344","https://openalex.org/W3111204567","https://openalex.org/W3112658701","https://openalex.org/W3119664087","https://openalex.org/W3121378959","https://openalex.org/W3142980289","https://openalex.org/W3202751953","https://openalex.org/W3208691473","https://openalex.org/W4206722756","https://openalex.org/W4211214747","https://openalex.org/W4214929667","https://openalex.org/W4309683029","https://openalex.org/W4320896752","https://openalex.org/W4353100326","https://openalex.org/W4376131851","https://openalex.org/W4386154016","https://openalex.org/W4386346546","https://openalex.org/W4387798365","https://openalex.org/W4391229489","https://openalex.org/W4391825326"],"related_works":["https://openalex.org/W4391340888","https://openalex.org/W2947855202","https://openalex.org/W4387798365","https://openalex.org/W1992311095","https://openalex.org/W4404009870","https://openalex.org/W1993543634","https://openalex.org/W2131243337","https://openalex.org/W4391341413","https://openalex.org/W2237777990","https://openalex.org/W2381173361"],"abstract_inverted_index":{"Thyroid":[0],"cancer":[1,233],"has":[2],"emerged":[3],"as":[4,77,82,126,361],"the":[5,28,36,96,115,154,217,265,273,289,300,317,346],"most":[6],"rapidly":[7],"proliferating":[8],"solid":[9],"neoplasm.":[10],"In":[11],"this":[12,174,262],"study,":[13],"we":[14],"included":[15],"a":[16,56,85,237],"cohort":[17],"of":[18,38,51,58,90,131,163,261,267,275,284,291,302,308,322,363],"patients":[19],"who":[20],"underwent":[21],"sonographic":[22],"assessment":[23,109],"and":[24,62,84,99,117,134,146,169,204,228,245,269,280,320,336],"surgical":[25],"intervention":[26],"at":[27,40],"Sir":[29],"Run":[30,31],"Shaw":[32],"Hospital,":[33],"associated":[34,349],"with":[35,288,350],"School":[37],"Medicine":[39],"Zhejiang":[41],"University,":[42],"spanning":[43],"from":[44],"January":[45],"2019":[46],"to":[47,95,181,315],"June":[48],"2020.":[49],"Stratification":[50],"cases":[52],"was":[53],"based":[54],"on":[55,104,256,345],"combination":[57],"preoperative":[59],"ultrasonographic":[60],"evaluations":[61],"postoperative":[63],"histopathological":[64],"diagnoses,":[65],"resulting":[66],"in":[67,114,123,153,171,231,239,272,299,312,328],"three":[68],"distinct":[69],"groups:":[70],"high-risk":[71],"papillary":[72,324],"thyroid":[73,92,232,303,323],"carcinoma":[74,325],"(PTC)":[75],"labeled":[76],"C1,":[78],"low-risk":[79],"PTC":[80,105,182,279,351],"designated":[81],"C2,":[83],"control":[86],"group":[87],"(N)":[88],"composed":[89],"benign":[91],"tissue":[93],"adjacent":[94],"carcinoma.":[97,304],"Proteomic":[98],"phosphoproteomic":[100,270,337],"analyses":[101],"were":[102,120,150],"conducted":[103],"specimens.":[106],"The":[107,259,306],"comparative":[108,158],"revealed":[110],"that":[111,249,282,358],"proteins":[112,139],"up-regulated":[113],"C1/N":[116],"C2/N":[118],"groups":[119],"predominantly":[121],"involved":[122],"functions":[124],"such":[125],"amino":[127,240],"acid":[128,241],"binding,":[129],"binding":[130],"phosphorylated":[132,186,189],"compounds,":[133],"serine":[135],"protease":[136],"activity.":[137],"Notably,":[138],"like":[140],"NADH":[141],"dehydrogenase,":[142,197,200],"ATP":[143],"synthase,":[144],"oxidoreductases,":[145],"iron":[147],"ion":[148],"channels":[149],"significantly":[151],"elevated":[152],"C1":[155],"versus":[156],"C2":[157],"group.":[159],"Through":[160],"meticulous":[161],"analysis":[162],"differential":[164],"expression":[165],"multiples,":[166],"statistical":[167],"significance,":[168],"involvement":[170],"metabolic":[172],"pathways,":[173],"study":[175,340],"identified":[176],"eight":[177,355],"potential":[178,314],"biomarkers":[179,357],"pertinent":[180],"metastasis":[183],"diagnostics,":[184],"encompassing":[185],"myosin":[187],"10,":[188],"proline-directed":[190],"protein":[191,212],"kinase,":[192],"leucine":[193],"tRNA":[194],"synthetase,":[195],"2-oxo-isovalerate":[196],"succinic":[198],"semialdehyde":[199],"ADP/ATPtranslocase,":[201],"pyruvate":[202],"carboxylase,":[203],"fibrinogen.":[205],"Therapeutic":[206],"assays":[207],"employing":[208],"metformin,":[209],"an":[210,253],"AMP-activated":[211],"kinase":[213],"(AMPK)":[214],"activator,":[215],"alongside":[216],"phosphorylation-specific":[218],"inhibitor":[219],"ML-7":[220],"targeting":[221],"Myosin10,":[222],"demonstrated":[223],"attenuated":[224],"cellular":[225],"proliferation,":[226],"migration,":[227],"invasion":[229],"capabilities":[230],"cells,":[234],"accompanied":[235],"by":[236],"reduction":[238],"pools.":[242],"Cellular":[243],"colocalization":[244],"interaction":[246],"studies":[247],"elucidated":[248],"AMPK":[250,285],"activation":[251],"imposes":[252],"inhibitory":[254],"influence":[255],"Myosin10":[257,292],"levels.":[258],"findings":[260],"research":[263,310],"corroborate":[264],"utility":[266],"proteomic":[268,335],"platforms":[271],"identification":[274],"metastatic":[276,330,364],"markers":[277],"for":[278],"suggest":[281],"modulation":[283],"activity,":[286],"coupled":[287],"inhibition":[290],"phosphorylation,":[293],"may":[294],"forge":[295],"novel":[296,356],"therapeutic":[297],"avenues":[298],"management":[301,321],"SIGNIFICANCE:":[305],"significance":[307],"our":[309,339],"lies":[311],"its":[313,329],"transform":[316],"current":[318],"understanding":[319],"(PTC),":[326],"particularly":[327],"form.":[331],"By":[332],"integrating":[333],"both":[334],"analyses,":[338],"not":[341],"only":[342],"sheds":[343],"light":[344],"molecular":[347],"alterations":[348],"but":[352],"also":[353],"identifies":[354],"could":[359],"serve":[360],"indicators":[362],"potential.":[365]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2024-07-18T00:00:00"}
