{"id":"https://openalex.org/W4400720276","doi":"https://doi.org/10.1055/s-0044-1788557","title":"Management of Unresectable Cholangiocarcinoma Using Modern Radiation Therapy Techniques","display_name":"Management of Unresectable Cholangiocarcinoma Using Modern Radiation Therapy Techniques","publication_year":2024,"publication_date":"2024-07-17","ids":{"openalex":"https://openalex.org/W4400720276","doi":"https://doi.org/10.1055/s-0044-1788557"},"language":"en","primary_location":{"id":"doi:10.1055/s-0044-1788557","doi":"https://doi.org/10.1055/s-0044-1788557","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1055/s-0044-1788557","pdf_url":null,"source":{"id":"https://openalex.org/S4210202450","display_name":"Digestive Disease Interventions","issn_l":"2472-8721","issn":["2472-8721","2472-873X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310321135","host_organization_name":"Georg Thieme Verlag","host_organization_lineage":["https://openalex.org/P4310321135","https://openalex.org/P4310320000"],"host_organization_lineage_names":["Georg Thieme Verlag","Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Digestive Disease Interventions","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104631627","display_name":"Deniz C. Demircioglu","orcid":"https://orcid.org/0009-0005-6595-3405","observed_orcids":["https://orcid.org/0009-0005-6595-3405"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deniz Demircioglu","raw_affiliation_strings":["Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070102419","display_name":"Lou-Anne G Acevedo-Moreno","orcid":"https://orcid.org/0000-0001-8793-2254","observed_orcids":["https://orcid.org/0000-0001-8793-2254"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lou-Anne Acevedo Moreno","raw_affiliation_strings":["Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006174923","display_name":"William Adrian Hall","orcid":"https://orcid.org/0000-0001-7017-6755","observed_orcids":["https://orcid.org/0000-0001-7017-6755"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William A. Hall","raw_affiliation_strings":["Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin"],"raw_orcid":"https://orcid.org/0000-0001-7017-6755","affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin","institution_ids":["https://openalex.org/I204308271"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5006174923"],"corresponding_institution_ids":["https://openalex.org/I204308271"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.19255916,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"08","issue":"04","first_page":"272","last_page":"278"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12460","display_name":"Pediatric Hepatobiliary Diseases and Treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cholangiocarcinoma","display_name":"cholangiocarcinoma","score":0.9789999723434448},{"id":"https://openalex.org/keywords/unresectable-disease","display_name":"unresectable disease","score":0.8169999718666077},{"id":"https://openalex.org/keywords/stereotactic-body-radiation-therapy","display_name":"stereotactic body radiotherapy","score":0.968999981880188},{"id":"https://openalex.org/keywords/radiotherapy-technique","display_name":"radiotherapy technique","score":0.43700000643730164},{"id":"https://openalex.org/keywords/chemoradiotherapy","display_name":"chemoradiotherapy","score":0.5789999961853027},{"id":"https://openalex.org/keywords/orthotopic-liver-transplantation","display_name":"orthotopic liver transplantation","score":0.9079999923706055},{"id":"https://openalex.org/keywords/combination-immunotherapy","display_name":"combination immunotherapy","score":0.8190000057220459},{"id":"https://openalex.org/keywords/locally-advanced-disease","display_name":"locally advanced disease","score":0.3709999918937683}],"concepts":[{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.6062139272689819},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.517273485660553},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.4160730838775635},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.3747536242008209},{"id":"https://openalex.org/C61434518","wikidata":"https://www.wikidata.org/wiki/Q932510","display_name":"General surgery","level":1,"score":0.3383522927761078}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-0044-1788557","doi":"https://doi.org/10.1055/s-0044-1788557","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1055/s-0044-1788557","pdf_url":null,"source":{"id":"https://openalex.org/S4210202450","display_name":"Digestive Disease Interventions","issn_l":"2472-8721","issn":["2472-8721","2472-873X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310321135","host_organization_name":"Georg Thieme Verlag","host_organization_lineage":["https://openalex.org/P4310321135","https://openalex.org/P4310320000"],"host_organization_lineage_names":["Georg Thieme Verlag","Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Digestive Disease Interventions","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1514245243","https://openalex.org/W1843348728","https://openalex.org/W1844131367","https://openalex.org/W1902115884","https://openalex.org/W1964163902","https://openalex.org/W2015107633","https://openalex.org/W2028700227","https://openalex.org/W2085759768","https://openalex.org/W2088363341","https://openalex.org/W2100878505","https://openalex.org/W2101637122","https://openalex.org/W2111731512","https://openalex.org/W2170598509","https://openalex.org/W2312076955","https://openalex.org/W2337387091","https://openalex.org/W2513294598","https://openalex.org/W2517846777","https://openalex.org/W2544072314","https://openalex.org/W2560714200","https://openalex.org/W2606106498","https://openalex.org/W2742841145","https://openalex.org/W2758820912","https://openalex.org/W2765538386","https://openalex.org/W2769258456","https://openalex.org/W2890105736","https://openalex.org/W2904769505","https://openalex.org/W2906049052","https://openalex.org/W2921127436","https://openalex.org/W2941990263","https://openalex.org/W2942918541","https://openalex.org/W2965142538","https://openalex.org/W2965862568","https://openalex.org/W2973596517","https://openalex.org/W3099184267","https://openalex.org/W3136137585","https://openalex.org/W4210900483","https://openalex.org/W4211248913","https://openalex.org/W4309408826","https://openalex.org/W4311123084","https://openalex.org/W4312120480","https://openalex.org/W4365998338","https://openalex.org/W4378640325","https://openalex.org/W4388870509","https://openalex.org/W4389514588"],"related_works":["https://openalex.org/W2123046299","https://openalex.org/W3202772767","https://openalex.org/W3009442597","https://openalex.org/W2760270049","https://openalex.org/W1844131367","https://openalex.org/W4223934303","https://openalex.org/W4391091276","https://openalex.org/W2591174382","https://openalex.org/W4396667119","https://openalex.org/W2544072314"],"abstract_inverted_index":{"Abstract":[0],"Cholangiocarcinoma":[1],"(CCA)":[2],"is":[3,67,76,88,119,163,166],"a":[4,26,41,49,79,109,141,161,202,211,219,254],"malignancy":[5],"of":[6,29,53,94,111,117,125,208,239,264],"epithelial":[7],"cells":[8],"in":[9,35,168,176,225],"the":[10,36,86,92,131,150],"bile":[11,153],"duct,":[12,154],"categorized":[13],"based":[14],"on":[15],"its":[16],"anatomical":[17],"location":[18],"as":[19,85,149,189],"intrahepatic,":[20,62],"perihilar,":[21,63],"or":[22,100,195],"extrahepatic.":[23],"It":[24],"has":[25,40,48,127],"low":[27],"prevalence":[28],"\u223c1.6":[30],"cases":[31,227],"per":[32],"100,000":[33],"people":[34],"United":[37],"States,":[38],"but":[39],"poor":[42],"prognosis.":[43],"All":[44],"stages":[45],"included,":[46],"CCA":[47,66,162],"5-year":[50],"survival":[51],"rate":[52],"less":[54],"than":[55],"10%.":[56],"The":[57,123],"preferred":[58],"curative":[59],"treatment":[60],"for":[61,82,241],"and":[64,155,157,213,221,260],"extrahepatic":[65],"surgical":[68,104],"resection":[69,75],"combined":[70],"with":[71,247,250,266],"systemic":[72],"chemotherapy.":[73],"However,":[74],"not":[77],"always":[78],"viable":[80],"option":[81],"many":[83],"patients,":[84],"disease":[87],"often":[89,167,205],"discovered":[90],"at":[91],"time":[93],"diagnosis":[95],"to":[96,144,171,210,230],"be":[97,114,138],"either":[98],"metastatic":[99],"locally":[101],"advanced":[102],"precluding":[103],"resection.":[105],"In":[106],"this":[107,177],"setting,":[108],"variety":[110],"options":[112],"can":[113,137],"used,":[115],"one":[116,229],"which":[118],"radiation":[120,192,199],"therapy":[121,193,200],"(RT).":[122],"administration":[124],"RT":[126,175,209],"evolved":[128],"tremendously":[129],"over":[130],"past":[132],"decades.":[133],"Total":[134],"doses":[135],"given":[136],"limited":[139],"by":[140,253],"tumor's":[142],"proximity":[143,170],"regional":[145],"normal":[146],"organs":[147],"such":[148],"liver,":[151],"stomach,":[152],"small":[156],"large":[158],"bowel.":[159],"When":[160],"unresectable,":[164],"it":[165],"close":[169],"radiosensitive":[172],"organs.":[173],"Delivering":[174],"setting":[178],"therefore":[179],"requires":[180],"precise":[181],"delivery":[182],"techniques.":[183],"An":[184],"emerging":[185],"technique":[186],"known":[187],"broadly":[188],"stereotactic":[190,196],"body":[191,198],"(SBRT)":[194],"ablative":[197],"gives":[201],"highly":[203],"focused,":[204],"ablative,":[206],"form":[207],"defined":[212],"specific":[214],"target.":[215],"Categorically,":[216],"SBRT":[217,240,244,246,249,265],"offers":[218],"quick":[220],"efficient":[222],"management":[223],"option,":[224],"some":[226],"only":[228],"three":[231],"total":[232],"treatments.":[233],"This":[234],"narrative":[235],"reviews":[236],"various":[237],"applications":[238],"cholangiocarcinoma":[242],"including":[243],"alone,":[245],"chemotherapy,":[248],"chemotherapy":[251],"followed":[252],"liver":[255,258],"transplantation":[256],"(orthotopic":[257],"transplantation),":[259],"finally":[261],"novel":[262],"combinations":[263],"immunotherapy.":[267]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2024-07-18T00:00:00"}
