{"id":"https://openalex.org/W4400654384","doi":"https://doi.org/10.1111/apha.14201","title":"Endothelial histone deacetylase 1 activity impairs kidney microvascular NO signaling in rats fed a high\u2010salt diet","display_name":"Endothelial histone deacetylase 1 activity impairs kidney microvascular NO signaling in rats fed a high\u2010salt diet","publication_year":2024,"publication_date":"2024-07-15","ids":{"openalex":"https://openalex.org/W4400654384","doi":"https://doi.org/10.1111/apha.14201","pmid":"https://pubmed.ncbi.nlm.nih.gov/36945391","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10028933"},"language":"en","primary_location":{"id":"doi:10.1111/apha.14201","doi":"https://doi.org/10.1111/apha.14201","is_oa":true,"landing_page_url":"https://doi.org/10.1111/apha.14201","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/apha.14201","source":{"id":"https://openalex.org/S204890612","display_name":"Acta Physiologica","issn_l":"1748-1708","issn":["1748-1708","1748-1716"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Physiologica","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/apha.14201","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090374298","display_name":"Luke S. Dunaway","orcid":"https://orcid.org/0000-0002-7458-9669","observed_orcids":["https://orcid.org/0000-0002-7458-9669"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luke S. Dunaway","raw_affiliation_strings":["Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010967484","display_name":"Anthony K. Cook","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony K. Cook","raw_affiliation_strings":["Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027841026","display_name":"Cailin E. Kellum","orcid":"https://orcid.org/0000-0003-0113-6711","observed_orcids":["https://orcid.org/0000-0003-0113-6711"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cailin E. Kellum","raw_affiliation_strings":["Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058711854","display_name":"Claudia Edell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claudia Edell","raw_affiliation_strings":["Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005969107","display_name":"Davide Botta","orcid":"https://orcid.org/0000-0003-3926-0662","observed_orcids":["https://orcid.org/0000-0003-3926-0662"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Davide Botta","raw_affiliation_strings":["Department of Microbiology, Heersink School of Medicine, Immunology Institute, The University of Alabama at Birmingham, Birmingham, Alabama, USA"],"raw_orcid":"https://orcid.org/0000-0003-3926-0662","affiliations":[{"raw_affiliation_string":"Department of Microbiology, Heersink School of Medicine, Immunology Institute, The University of Alabama at Birmingham, Birmingham, Alabama, USA","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047551105","display_name":"Patrick Axel Molina","orcid":"https://orcid.org/0000-0001-8855-0880","observed_orcids":["https://orcid.org/0000-0001-8855-0880"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick A. Molina","raw_affiliation_strings":["Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013169687","display_name":"Randee S. Sedaka","orcid":"https://orcid.org/0000-0001-7014-0832","observed_orcids":["https://orcid.org/0000-0001-7014-0832"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Randee S. Sedaka","raw_affiliation_strings":["Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031586964","display_name":"Livius V. d\u2019Uscio","orcid":"https://orcid.org/0000-0001-9577-9480","observed_orcids":["https://orcid.org/0000-0001-9577-9480"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Livius V. d'Uscio","raw_affiliation_strings":["Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, USA","Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082346434","display_name":"Zvonimir S. Katu\u0161i\u0107","orcid":"https://orcid.org/0000-0001-7016-7883","observed_orcids":["https://orcid.org/0000-0001-7016-7883"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zvonimir S. Katusic","raw_affiliation_strings":["Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, USA","Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066047278","display_name":"David M. Pollock","orcid":"https://orcid.org/0000-0002-0233-2362","observed_orcids":["https://orcid.org/0000-0002-0233-2362","https://orcid.org/0000-0002-7546-6003"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David M. Pollock","raw_affiliation_strings":["Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063490518","display_name":"Edward W. Inscho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward W. Inscho","raw_affiliation_strings":["Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003642259","display_name":"Jennifer S. Pollock","orcid":"https://orcid.org/0000-0003-1956-0449","observed_orcids":["https://orcid.org/0000-0003-1956-0449"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jennifer S. Pollock","raw_affiliation_strings":["Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5003642259"],"corresponding_institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"],"apc_list":{"value":4900,"currency":"USD","value_usd":4900},"apc_paid":{"value":4900,"currency":"USD","value_usd":4900},"fwci":1.1295,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.76405719,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"240","issue":"9","first_page":"e14201","last_page":"e14201"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9320999979972839,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9320999979972839,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12075","display_name":"Sodium Intake and Health","score":0.017100000753998756,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.011099999770522118,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hdac1","display_name":"HDAC1","score":0.9419999718666077},{"id":"https://openalex.org/keywords/high-salt-diet","display_name":"high-salt diet","score":0.8059999942779541},{"id":"https://openalex.org/keywords/nitric-oxide-signaling","display_name":"nitric oxide signaling","score":0.9549999833106995},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.9160000085830688},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.49300000071525574},{"id":"https://openalex.org/keywords/tetrahydrobiopterin","display_name":"tetrahydrobiopterin","score":0.8889999985694885},{"id":"https://openalex.org/keywords/antioxidant-therapy","display_name":"antioxidant therapy","score":0.4169999957084656},{"id":"https://openalex.org/keywords/renal-hypertension","display_name":"renal hypertension","score":0.3019999861717224}],"concepts":[{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.7031437158584595},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6906408071517944},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6679840683937073},{"id":"https://openalex.org/C2780636983","wikidata":"https://www.wikidata.org/wiki/Q2713567","display_name":"Afferent arterioles","level":4,"score":0.5614191293716431},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.47390711307525635},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45122992992401123},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4423450231552124},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3465207815170288},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3203921318054199},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24914991855621338},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.18949660658836365},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.12489601969718933}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.1111/apha.14201","doi":"https://doi.org/10.1111/apha.14201","is_oa":true,"landing_page_url":"https://doi.org/10.1111/apha.14201","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/apha.14201","source":{"id":"https://openalex.org/S204890612","display_name":"Acta Physiologica","issn_l":"1748-1708","issn":["1748-1708","1748-1716"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Physiologica","raw_type":"journal-article"},{"id":"doi:10.1101/2023.03.08.531731","doi":"https://doi.org/10.1101/2023.03.08.531731","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2023.03.08.531731","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/03/10/2023.03.08.531731.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:11329346","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11329346/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11329346/pdf/nihms-2007636.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Physiol (Oxf)","raw_type":"Text"},{"id":"pmid:36945391","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36945391","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Preprint"},{"id":"pmid:39007513","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39007513","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta physiologica (Oxford, England)","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:11206427","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11329346","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:10028933","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10028933","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10028933/pdf/nihpp-2023.03.08.531731v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1111/apha.14201","doi":"https://doi.org/10.1111/apha.14201","is_oa":true,"landing_page_url":"https://doi.org/10.1111/apha.14201","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/apha.14201","source":{"id":"https://openalex.org/S204890612","display_name":"Acta Physiologica","issn_l":"1748-1708","issn":["1748-1708","1748-1716"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Physiologica","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.5899999737739563,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G110108432","display_name":"Integrating novel mechanisms controlling sodium excretion and blood pressure","funder_award_id":"P01HL136267","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2282699913","display_name":"PRedoctoral Interdisciplinary training in renal physiology and MEdicine (PRIME)","funder_award_id":"T32DK116672","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4185632288","display_name":"TLR4 in the Regulation of Renal Microvascular Function","funder_award_id":"R01DK044628","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G477637483","display_name":"HDAC1 Regulation of Endothelial NO","funder_award_id":"F31HL149235","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5067959802","display_name":"PURINERGIC REGULATION OF THE RENAL MICROVASCULATURE","funder_award_id":"R29DK044628","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5084382227","display_name":"Time Restricted Feeding in Diet Induced Obesity Improves Aortic Damage and Endothelial Function Through Reducing Th17 Cells","funder_award_id":"F31HL167626","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5705031753","display_name":null,"funder_award_id":"P01 HL136267","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G6148640933","display_name":"Novel mechanisms of salt-sensitivity and diurnal blood pressure rhythm","funder_award_id":"15SFRN24450002","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G6738802141","display_name":"UAB Predoctoral Training Grant in Translational and Molecular Sciences","funder_award_id":"T32GM109780","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7901811566","display_name":"Novel Endothelial and Immunologic Mechanisms of Pathophysiology in Sickle Cell Disease","funder_award_id":"F31HL151264","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000301154","display_name":null,"funder_award_id":"DK044628","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000896049","display_name":"Timing of Diet and Kidney Pathophysiology in Diet-Induced Obesity","funder_award_id":"R01DK134562","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000897483","display_name":"UAB Nutrition Obesity Research Center (NORC)","funder_award_id":"P30DK056336","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000910948","display_name":"PRedOctoral PhD and MD research training in TEams (PROmoTE)","funder_award_id":"R25DK112731","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4400654384.pdf","grobid_xml":"https://content.openalex.org/works/W4400654384.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1889649839","https://openalex.org/W1919643921","https://openalex.org/W1970858662","https://openalex.org/W1981691650","https://openalex.org/W1993510744","https://openalex.org/W1997023449","https://openalex.org/W2008222617","https://openalex.org/W2009826707","https://openalex.org/W2019879620","https://openalex.org/W2027231152","https://openalex.org/W2042959178","https://openalex.org/W2049287094","https://openalex.org/W2050924109","https://openalex.org/W2055269121","https://openalex.org/W2063819389","https://openalex.org/W2073236176","https://openalex.org/W2081948913","https://openalex.org/W2090166347","https://openalex.org/W2097084183","https://openalex.org/W2103196707","https://openalex.org/W2107741169","https://openalex.org/W2113056756","https://openalex.org/W2125436925","https://openalex.org/W2126525811","https://openalex.org/W2139276570","https://openalex.org/W2140203545","https://openalex.org/W2152995664","https://openalex.org/W2155257259","https://openalex.org/W2157511493","https://openalex.org/W2157931247","https://openalex.org/W2169783450","https://openalex.org/W2170925020","https://openalex.org/W2271364972","https://openalex.org/W2320230258","https://openalex.org/W2337180881","https://openalex.org/W2544808727","https://openalex.org/W2568655318","https://openalex.org/W2745845107","https://openalex.org/W2766155083","https://openalex.org/W2767680419","https://openalex.org/W2767934785","https://openalex.org/W2783583681","https://openalex.org/W2887670047","https://openalex.org/W2906586808","https://openalex.org/W2985383328","https://openalex.org/W2987167066","https://openalex.org/W3034669795","https://openalex.org/W3042628793","https://openalex.org/W3116297993","https://openalex.org/W3133367969","https://openalex.org/W3180257396"],"related_works":["https://openalex.org/W3175643624","https://openalex.org/W3166177694","https://openalex.org/W3083966472","https://openalex.org/W3116297993","https://openalex.org/W3177037253","https://openalex.org/W2971661921","https://openalex.org/W4415262501","https://openalex.org/W1993974202","https://openalex.org/W7101120583","https://openalex.org/W2091620131"],"abstract_inverted_index":{"AIM:":[0],"We":[1,108,139,211],"aimed":[2],"to":[3,86,146,170,173,221],"test":[4],"the":[5,57,61,89,115,142,150,153,158,161,165,180,195,203,231],"hypothesis":[6],"that":[7,87,213],"a":[8,21,77,81,183,236],"high-salt":[9],"diet":[10,36,85,151,159],"(HS)":[11],"impairs":[12],"NO":[13,47,112,145,176,208,223,242],"signaling":[14,48,113],"in":[15,114,135],"kidney":[16,90,136,162],"microvascular":[17,240],"endothelial":[18,93,137,189,216,241],"cells":[19,94],"through":[20,218],"histone":[22],"deacetylase":[23],"1":[24],"(HDAC1)-dependent":[25],"mechanism.":[26],"METHODS:":[27],"Male":[28],"Sprague":[29],"Dawley":[30],"rats":[31,169],"were":[32,72,95],"fed":[33],"normal":[34],"salt":[35],"(NS;":[37],"0.49%":[38],"NaCl)":[39,43],"or":[40,83],"HS":[41,214,237],"(4%":[42],"for":[44],"2":[45],"weeks.":[46],"was":[49,105,119,133],"assessed":[50],"by":[51,121,234],"measuring":[52],"L-NAME":[53],"induced":[54],"vasoconstriction":[55],"of":[56,88,123,144,152,160,182],"afferent":[58,116],"arteriole":[59],"using":[60],"blood":[62,75,154],"perfused":[63,73],"juxtamedullary":[64],"nephron":[65],"(JMN)":[66],"preparation.":[67],"In":[68],"this":[69],"preparation,":[70],"kidneys":[71],"with":[74,97,125,128,194],"from":[76,167],"donor":[78,155,163],"rat":[79],"on":[80],"matching":[82],"different":[84],"donor.":[91],"Kidney":[92],"isolated":[96],"magnetic":[98],"activated":[99],"cell":[100],"sorting":[101],"and":[102,164,198],"HDAC1":[103,124,131,217],"activity":[104,132],"measured.":[106],"RESULTS:":[107],"found":[109,141],"HS-induced":[110],"impaired":[111,175],"arteriole.":[117],"This":[118,178,225],"restored":[120,207],"inhibition":[122],"MS-275.":[126],"Consistent":[127],"these":[129],"findings,":[130],"increased":[134],"cells.":[138],"further":[140],"loss":[143],"be":[147,171],"dependent":[148],"upon":[149],"rather":[156],"than":[157],"plasma":[166],"HS-fed":[168],"sufficient":[172],"induce":[174],"signaling.":[177,209,224,243],"indicates":[179],"presence":[181],"humoral":[184],"factor":[185],"we":[186],"termed":[187],"plasma-derived":[188],"dysfunction":[190],"mediator":[191],"(PDEM).":[192],"Pretreatment":[193],"antioxidants,":[196],"PEG-SOD":[197],"PEG-catalase,":[199],"as":[200,202],"well":[201],"NOS":[204],"cofactor,":[205],"tetrahydrobiopterin,":[206],"CONCLUSION:":[210],"conclude":[212],"activates":[215],"PDEM":[219],"leading":[220],"decreased":[222],"study":[226],"provides":[227],"novel":[228],"insights":[229],"into":[230],"molecular":[232],"mechanisms":[233],"which":[235],"decreases":[238],"renal":[239]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2024-07-16T00:00:00"}
