{"id":"https://openalex.org/W4400623925","doi":"https://doi.org/10.1016/j.csbj.2024.07.012","title":"Systematic data analysis pipeline for quantitative morphological cell phenotyping","display_name":"Systematic data analysis pipeline for quantitative morphological cell phenotyping","publication_year":2024,"publication_date":"2024-07-14","ids":{"openalex":"https://openalex.org/W4400623925","doi":"https://doi.org/10.1016/j.csbj.2024.07.012","pmid":"https://pubmed.ncbi.nlm.nih.gov/39104709","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11298594"},"language":"en","primary_location":{"id":"doi:10.1016/j.csbj.2024.07.012","doi":"https://doi.org/10.1016/j.csbj.2024.07.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.csbj.2024.07.012","pdf_url":null,"source":{"id":"https://openalex.org/S2764539591","display_name":"Computational and Structural Biotechnology Journal","issn_l":"2001-0370","issn":["2001-0370"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Structural Biotechnology Journal","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.csbj.2024.07.012","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074620623","display_name":"Farzan Ghanegolmohammadi","orcid":"https://orcid.org/0000-0001-5217-0878","observed_orcids":["https://orcid.org/0000-0001-5217-0878"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP","US"],"is_corresponding":true,"raw_author_name":"Farzan Ghanegolmohammadi","raw_affiliation_strings":["Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA","Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mohammad Eslami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1287163989","display_name":"Massachusetts Eye and Ear Infirmary","ror":"https://ror.org/04g3dn724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1287163989"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohammad Eslami","raw_affiliation_strings":["Harvard Ophthalmology AI Lab, Schepen\u2019s Eye Research Institute of Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Ophthalmology AI Lab, Schepen\u2019s Eye Research Institute of Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, USA","institution_ids":["https://openalex.org/I1287163989","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060486921","display_name":"Yoshikazu Ohya","orcid":"https://orcid.org/0000-0003-0837-1239","observed_orcids":["https://orcid.org/0000-0003-0837-1239"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yoshikazu Ohya","raw_affiliation_strings":["Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5060486921","https://openalex.org/A5074620623"],"corresponding_institution_ids":["https://openalex.org/I63966007","https://openalex.org/I74801974"],"apc_list":{"value":3230,"currency":"USD","value_usd":3230},"apc_paid":{"value":3230,"currency":"USD","value_usd":3230},"fwci":0.1079,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.10216718,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"23","issue":null,"first_page":"2949","last_page":"2962"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12536","display_name":"Topological and Geometric Data Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-morphology","display_name":"cell morphology","score":0.8569999933242798},{"id":"https://openalex.org/keywords/image-based-phenotyping","display_name":"image-based phenotyping","score":0.7020000219345093},{"id":"https://openalex.org/keywords/data-analysis-pipeline","display_name":"data analysis pipeline","score":0.7670000195503235},{"id":"https://openalex.org/keywords/phenome","display_name":"phenome","score":0.4860000014305115},{"id":"https://openalex.org/keywords/r-package","display_name":"R package","score":0.7799999713897705}],"concepts":[{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.6733605265617371},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6653309464454651},{"id":"https://openalex.org/C153083717","wikidata":"https://www.wikidata.org/wiki/Q6535263","display_name":"Leverage (statistics)","level":2,"score":0.6535742282867432},{"id":"https://openalex.org/C165696696","wikidata":"https://www.wikidata.org/wiki/Q11287","display_name":"Exploit","level":2,"score":0.6478767395019531},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.5713233351707458},{"id":"https://openalex.org/C43521106","wikidata":"https://www.wikidata.org/wiki/Q2165493","display_name":"Pipeline (software)","level":2,"score":0.5361008644104004},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.44651874899864197},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3596336245536804},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.25542545318603516},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.08402490615844727},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07494661211967468},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.csbj.2024.07.012","doi":"https://doi.org/10.1016/j.csbj.2024.07.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.csbj.2024.07.012","pdf_url":null,"source":{"id":"https://openalex.org/S2764539591","display_name":"Computational and Structural Biotechnology Journal","issn_l":"2001-0370","issn":["2001-0370"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Structural Biotechnology Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11298594","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11298594","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comput Struct Biotechnol J","raw_type":"Text"},{"id":"pmid:39104709","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39104709","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and structural biotechnology journal","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:a973de94a30c4195bc13924a47b6dad4","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/a973de94a30c4195bc13924a47b6dad4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 2949-2962 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.csbj.2024.07.012","doi":"https://doi.org/10.1016/j.csbj.2024.07.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.csbj.2024.07.012","pdf_url":null,"source":{"id":"https://openalex.org/S2764539591","display_name":"Computational and Structural Biotechnology Journal","issn_l":"2001-0370","issn":["2001-0370"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Structural Biotechnology Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3629132187","display_name":null,"funder_award_id":"160693","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G4214894355","display_name":"Morphological profiling system for development of  antifungal agensts","funder_award_id":"23K23483","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5806612612","display_name":null,"funder_award_id":"19H03205","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G8368145296","display_name":null,"funder_award_id":"22H02216","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"}],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":170,"referenced_works":["https://openalex.org/W429766147","https://openalex.org/W830547093","https://openalex.org/W1185588434","https://openalex.org/W1505191356","https://openalex.org/W1507444366","https://openalex.org/W1854781589","https://openalex.org/W1897592488","https://openalex.org/W1967220526","https://openalex.org/W1970480709","https://openalex.org/W1974934611","https://openalex.org/W1987012261","https://openalex.org/W1989227183","https://openalex.org/W1991883934","https://openalex.org/W1993669821","https://openalex.org/W1995054497","https://openalex.org/W2007953826","https://openalex.org/W2008750507","https://openalex.org/W2008985174","https://openalex.org/W2013324041","https://openalex.org/W2018881990","https://openalex.org/W2026433130","https://openalex.org/W2028201091","https://openalex.org/W2028393439","https://openalex.org/W2028713366","https://openalex.org/W2029918259","https://openalex.org/W2030565979","https://openalex.org/W2032228873","https://openalex.org/W2045443942","https://openalex.org/W2056344676","https://openalex.org/W2065455422","https://openalex.org/W2075744820","https://openalex.org/W2083042078","https://openalex.org/W2086243224","https://openalex.org/W2098009642","https://openalex.org/W2113057727","https://openalex.org/W2114116884","https://openalex.org/W2119387367","https://openalex.org/W2120865735","https://openalex.org/W2121469024","https://openalex.org/W2129003022","https://openalex.org/W2129249398","https://openalex.org/W2133422502","https://openalex.org/W2141386558","https://openalex.org/W2148561513","https://openalex.org/W2150091347","https://openalex.org/W2151385152","https://openalex.org/W2153124993","https://openalex.org/W2155182770","https://openalex.org/W2157150618","https://openalex.org/W2160676466","https://openalex.org/W2162424885","https://openalex.org/W2169818143","https://openalex.org/W2171033594","https://openalex.org/W2271268216","https://openalex.org/W2274879598","https://openalex.org/W2302501749","https://openalex.org/W2307267906","https://openalex.org/W2337223972","https://openalex.org/W2340102874","https://openalex.org/W2405306759","https://openalex.org/W2480007569","https://openalex.org/W2487810004","https://openalex.org/W2515544675","https://openalex.org/W2519132385","https://openalex.org/W2554938200","https://openalex.org/W2591514928","https://openalex.org/W2597357676","https://openalex.org/W2601742850","https://openalex.org/W2606209624","https://openalex.org/W2611138580","https://openalex.org/W2619710464","https://openalex.org/W2626606138","https://openalex.org/W2641905542","https://openalex.org/W2720581846","https://openalex.org/W2744556021","https://openalex.org/W2744947029","https://openalex.org/W2751625431","https://openalex.org/W2790119933","https://openalex.org/W2790179710","https://openalex.org/W2794301983","https://openalex.org/W2798127115","https://openalex.org/W2804323293","https://openalex.org/W2807422051","https://openalex.org/W2808795808","https://openalex.org/W2883282742","https://openalex.org/W2883847292","https://openalex.org/W2884682196","https://openalex.org/W2888971284","https://openalex.org/W2900936384","https://openalex.org/W2905502540","https://openalex.org/W2912397168","https://openalex.org/W2913401199","https://openalex.org/W2919670103","https://openalex.org/W2921558168","https://openalex.org/W2945047129","https://openalex.org/W2946901414","https://openalex.org/W2947544550","https://openalex.org/W2948301682","https://openalex.org/W2949493305","https://openalex.org/W2949812970","https://openalex.org/W2951934944","https://openalex.org/W2952860256","https://openalex.org/W2961081293","https://openalex.org/W2963352985","https://openalex.org/W2963995738","https://openalex.org/W2969790209","https://openalex.org/W2979345840","https://openalex.org/W2980998394","https://openalex.org/W2995276890","https://openalex.org/W2997412521","https://openalex.org/W3001425747","https://openalex.org/W3001767870","https://openalex.org/W3002429172","https://openalex.org/W3004305487","https://openalex.org/W3006268927","https://openalex.org/W3011417339","https://openalex.org/W3018475622","https://openalex.org/W3022107493","https://openalex.org/W3022710784","https://openalex.org/W3028077246","https://openalex.org/W3033098366","https://openalex.org/W3033330793","https://openalex.org/W3040727891","https://openalex.org/W3047346587","https://openalex.org/W3081688559","https://openalex.org/W3089090082","https://openalex.org/W3111149356","https://openalex.org/W3111521801","https://openalex.org/W3113917069","https://openalex.org/W3114735211","https://openalex.org/W3120224790","https://openalex.org/W3154324864","https://openalex.org/W3156643147","https://openalex.org/W3164147211","https://openalex.org/W3165664581","https://openalex.org/W3196897371","https://openalex.org/W3198262548","https://openalex.org/W3200545451","https://openalex.org/W3200707343","https://openalex.org/W3204438512","https://openalex.org/W3205462323","https://openalex.org/W3209439628","https://openalex.org/W3213856518","https://openalex.org/W3215159356","https://openalex.org/W4200123036","https://openalex.org/W4200370303","https://openalex.org/W4205944092","https://openalex.org/W4206511670","https://openalex.org/W4213078347","https://openalex.org/W4221000278","https://openalex.org/W4221040719","https://openalex.org/W4225152629","https://openalex.org/W4307725221","https://openalex.org/W4307989778","https://openalex.org/W4317437838","https://openalex.org/W4322704678","https://openalex.org/W4362521490","https://openalex.org/W4380985766","https://openalex.org/W4387077581","https://openalex.org/W4387575764","https://openalex.org/W4389555445","https://openalex.org/W4390595612","https://openalex.org/W4390636599","https://openalex.org/W4390880427","https://openalex.org/W4391429075","https://openalex.org/W4391993840","https://openalex.org/W4393166444","https://openalex.org/W4393526464","https://openalex.org/W4406844141","https://openalex.org/W6774508477"],"related_works":["https://openalex.org/W2751625431","https://openalex.org/W2107554012","https://openalex.org/W1975787005","https://openalex.org/W4410417241","https://openalex.org/W2265528979","https://openalex.org/W2563304727","https://openalex.org/W3129581169","https://openalex.org/W4327552158","https://openalex.org/W7130502283","https://openalex.org/W3178827911"],"abstract_inverted_index":{"Quantitative":[0],"morphological":[1,11,62],"phenotyping":[2],"(QMP)":[3],"is":[4,52],"an":[5],"image-based":[6],"method":[7],"used":[8],"to":[9,27,34,40,70,127,138,143],"capture":[10],"features":[12],"at":[13],"both":[14],"the":[15,72,81,93,103,129],"cellular":[16,61],"and":[17,30,99,106,135],"population":[18],"level.":[19],"Its":[20],"interdisciplinary":[21],"nature,":[22],"spanning":[23],"from":[24],"data":[25],"collection":[26],"result":[28],"analysis":[29],"interpretation,":[31],"can":[32,58],"lead":[33],"uncertainties,":[35],"particularly":[36],"among":[37],"those":[38],"new":[39],"this":[41],"actively":[42],"growing":[43],"field.":[44],"High":[45],"analytical":[46],"specificity":[47],"for":[48,108,122,131],"a":[49,67,76,85],"typical":[50,86],"QMP":[51,73],"achieved":[53],"through":[54],"sophisticated":[55],"approaches":[56],"that":[57],"leverage":[59],"subtle":[60],"changes.":[63],"Here,":[64],"we":[65,79,91],"outline":[66],"systematic":[68],"workflow":[69],"refine":[71],"methodology.":[74],"For":[75],"practical":[77],"review,":[78],"describe":[80],"main":[82],"steps":[83],"of":[84,141],"QMP;":[87],"in":[88],"each":[89],"step,":[90],"discuss":[92],"available":[94],"methods,":[95],"their":[96],"applications,":[97],"advantages,":[98],"disadvantages,":[100],"along":[101],"with":[102,146],"R":[104],"functions":[105],"packages":[107],"easy":[109],"implementation.":[110],"This":[111],"review":[112],"does":[113],"not":[114],"cover":[115],"theoretical":[116],"backgrounds,":[117],"but":[118],"provides":[119],"several":[120],"references":[121],"interested":[123],"researchers.":[124],"It":[125],"aims":[126],"broaden":[128],"horizons":[130],"future":[132],"phenome":[133],"studies":[134],"demonstrate":[136],"how":[137],"exploit":[139],"years":[140],"endeavors":[142],"achieve":[144],"more":[145],"less.":[147]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2024-07-15T00:00:00"}
