{"id":"https://openalex.org/W4400623463","doi":"https://doi.org/10.1016/j.ajoint.2024.100054","title":"3-year safety and efficacy results of PreserFlo\u2122 Microshunt in glaucoma patients: A multicentre European cohort study","display_name":"3-year safety and efficacy results of PreserFlo\u2122 Microshunt in glaucoma patients: A multicentre European cohort study","publication_year":2024,"publication_date":"2024-07-14","ids":{"openalex":"https://openalex.org/W4400623463","doi":"https://doi.org/10.1016/j.ajoint.2024.100054"},"language":"en","primary_location":{"id":"doi:10.1016/j.ajoint.2024.100054","doi":"https://doi.org/10.1016/j.ajoint.2024.100054","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ajoint.2024.100054","pdf_url":null,"source":{"id":"https://openalex.org/S5407036997","display_name":"AJO International","issn_l":"2950-2535","issn":["2950-2535"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AJO International","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.ajoint.2024.100054","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007696372","display_name":"Karl Mercieca","orcid":"https://orcid.org/0000-0002-2960-8090","observed_orcids":["https://orcid.org/0000-0002-2960-8090"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I2801704036","display_name":"Manchester Royal Eye Hospital","ror":"https://ror.org/04xtpk854","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801704036","https://openalex.org/I4210092852","https://openalex.org/I4210166818"]}],"countries":["DE","GB"],"is_corresponding":false,"raw_author_name":"Karl Mercieca","raw_affiliation_strings":["Department of Ophthalmology, University of Bonn, Bonn, Germany","Manchester Royal Eye Hospital, Manchester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"Manchester Royal Eye Hospital, Manchester, United Kingdom","institution_ids":["https://openalex.org/I2801704036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011561696","display_name":"Raj Bhayani","orcid":"https://orcid.org/0000-0003-2003-5895","observed_orcids":["https://orcid.org/0000-0003-2003-5895"]},"institutions":[{"id":"https://openalex.org/I2801704036","display_name":"Manchester Royal Eye Hospital","ror":"https://ror.org/04xtpk854","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801704036","https://openalex.org/I4210092852","https://openalex.org/I4210166818"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Raj Bhayani","raw_affiliation_strings":["Manchester Royal Eye Hospital, Manchester, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0003-2003-5895","affiliations":[{"raw_affiliation_string":"Manchester Royal Eye Hospital, Manchester, United Kingdom","institution_ids":["https://openalex.org/I2801704036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003345723","display_name":"Jos\u00e9 Mar\u00eda Mart\u00ednez-de-la-Casa","orcid":"https://orcid.org/0000-0001-9441-0542","observed_orcids":["https://orcid.org/0000-0001-9441-0542"]},"institutions":[{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]},{"id":"https://openalex.org/I2961216182","display_name":"Hospital Cl\u00ednico San Carlos","ror":"https://ror.org/04d0ybj29","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2961216182","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jose Maria Martinez-de-la-Casa","raw_affiliation_strings":["Hospital Clinico San Carlos. Universidad Complutense. Madrid, Spain"],"raw_orcid":"https://orcid.org/0000-0001-9441-0542","affiliations":[{"raw_affiliation_string":"Hospital Clinico San Carlos. Universidad Complutense. Madrid, Spain","institution_ids":["https://openalex.org/I121748325","https://openalex.org/I2961216182"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085804289","display_name":"Michele Figus","orcid":"https://orcid.org/0000-0003-2243-9033","observed_orcids":["https://orcid.org/0000-0003-2243-9033","https://orcid.org/0000-0003-3211-3344"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Michele Figus","raw_affiliation_strings":["Department of Surgical, Medical, Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical, Medical, Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024163444","display_name":"Karsten Klabe","orcid":"https://orcid.org/0000-0002-4443-640X","observed_orcids":["https://orcid.org/0000-0002-4443-640X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karsten Klabe","raw_affiliation_strings":["Breyer Kaymak Klabe Augenchirurgie, Duesseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breyer Kaymak Klabe Augenchirurgie, Duesseldorf, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028984179","display_name":"Alessandro Rabiolo","orcid":"https://orcid.org/0000-0002-7772-5929","observed_orcids":["https://orcid.org/0000-0002-7772-5929"]},"institutions":[{"id":"https://openalex.org/I123338534","display_name":"Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro\u201d","ror":"https://ror.org/04387x656","country_code":"IT","type":"education","lineage":["https://openalex.org/I123338534"]},{"id":"https://openalex.org/I4210119436","display_name":"Azienda Ospedaliero Universitaria Maggiore della Carita","ror":"https://ror.org/02gp92p70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210119436"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandro Rabiolo","raw_affiliation_strings":["Department of Health Sciences, Universit\u00e0 del Piemonte Orientale \u201cAmedeo, Avogadro\u201d, Novara, Italy","Department of Ophthalmology, University Hospital Maggiore della Carit\u00e0, Novara, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences, Universit\u00e0 del Piemonte Orientale \u201cAmedeo, Avogadro\u201d, Novara, Italy","institution_ids":["https://openalex.org/I123338534"]},{"raw_affiliation_string":"Department of Ophthalmology, University Hospital Maggiore della Carit\u00e0, Novara, Italy","institution_ids":["https://openalex.org/I4210119436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054531813","display_name":"Constance Weber","orcid":"https://orcid.org/0000-0002-9714-2851","observed_orcids":["https://orcid.org/0000-0002-9714-2851"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Constance Weber","raw_affiliation_strings":["Department of Ophthalmology, University of Bonn, Bonn, Germany"],"raw_orcid":"https://orcid.org/0000-0002-9714-2851","affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5054531813"],"corresponding_institution_ids":["https://openalex.org/I135140700"],"apc_list":{"value":1800,"currency":"USD","value_usd":1800},"apc_paid":{"value":1800,"currency":"USD","value_usd":1800},"fwci":2.1589,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.84640542,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":"1","issue":"3","first_page":"100054","last_page":"100054"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11291","display_name":"Intraocular Surgery and Lenses","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/preserflo-microshunt","display_name":"PreserFlo MicroShunt","score":0.9570000171661377},{"id":"https://openalex.org/keywords/glaucoma-surgery","display_name":"glaucoma surgery","score":0.8830000162124634},{"id":"https://openalex.org/keywords/microshunt","display_name":"microshunt","score":0.7239999771118164},{"id":"https://openalex.org/keywords/intraocular-pressure-reduction","display_name":"intraocular pressure reduction","score":0.8949999809265137},{"id":"https://openalex.org/keywords/surgical-success-rate","display_name":"surgical success rate","score":0.7440000176429749},{"id":"https://openalex.org/keywords/postoperative-complications","display_name":"postoperative complications","score":0.6869999766349792},{"id":"https://openalex.org/keywords/intraocular-pressure-lowering-agents","display_name":"intraocular pressure-lowering agents","score":0.7070000171661377},{"id":"https://openalex.org/keywords/bleb-needling","display_name":"bleb needling","score":0.7559999823570251},{"id":"https://openalex.org/keywords/trabeculectomy","display_name":"trabeculectomy","score":0.8399999737739563},{"id":"https://openalex.org/keywords/glaucoma-drainage-devices","display_name":"glaucoma drainage devices","score":0.8820000290870667},{"id":"https://openalex.org/keywords/corneal-decompensation","display_name":"corneal decompensation","score":0.7670000195503235},{"id":"https://openalex.org/keywords/conjunctival-erosion","display_name":"conjunctival erosion","score":0.7630000114440918},{"id":"https://openalex.org/keywords/postoperative-uveitis","display_name":"postoperative uveitis","score":0.8859999775886536}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9618688821792603},{"id":"https://openalex.org/C2781092963","wikidata":"https://www.wikidata.org/wiki/Q650050","display_name":"Intraocular pressure","level":2,"score":0.676314115524292},{"id":"https://openalex.org/C2776508836","wikidata":"https://www.wikidata.org/wiki/Q5567290","display_name":"Glaucoma medication","level":3,"score":0.6643134355545044},{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.6553125381469727},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.5866178870201111},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.5559902191162109},{"id":"https://openalex.org/C2776766258","wikidata":"https://www.wikidata.org/wiki/Q5567291","display_name":"Glaucoma surgery","level":3,"score":0.5495437979698181},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5221417546272278},{"id":"https://openalex.org/C2777824320","wikidata":"https://www.wikidata.org/wiki/Q3177088","display_name":"Trabeculectomy","level":3,"score":0.5132827758789062},{"id":"https://openalex.org/C2778257484","wikidata":"https://www.wikidata.org/wiki/Q555066","display_name":"Visual acuity","level":2,"score":0.5067065358161926},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.47198253870010376},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07236716151237488}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ajoint.2024.100054","doi":"https://doi.org/10.1016/j.ajoint.2024.100054","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ajoint.2024.100054","pdf_url":null,"source":{"id":"https://openalex.org/S5407036997","display_name":"AJO International","issn_l":"2950-2535","issn":["2950-2535"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AJO International","raw_type":"journal-article"},{"id":"pmh:oai:arpi.unipi.it:11568/1263771","doi":null,"is_oa":true,"landing_page_url":"https://www.sciencedirect.com/science/article/pii/S2950253524000546","pdf_url":null,"source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.ajoint.2024.100054","doi":"https://doi.org/10.1016/j.ajoint.2024.100054","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ajoint.2024.100054","pdf_url":null,"source":{"id":"https://openalex.org/S5407036997","display_name":"AJO International","issn_l":"2950-2535","issn":["2950-2535"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AJO International","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W2057266151","https://openalex.org/W2422961891","https://openalex.org/W2921734131","https://openalex.org/W2976836687","https://openalex.org/W3084961025","https://openalex.org/W3093526443","https://openalex.org/W3151383780","https://openalex.org/W3159790797","https://openalex.org/W3178660839","https://openalex.org/W3183386760","https://openalex.org/W3198558612","https://openalex.org/W4220934208","https://openalex.org/W4288059581","https://openalex.org/W4313379657","https://openalex.org/W4363649756","https://openalex.org/W4380875565","https://openalex.org/W4388788465","https://openalex.org/W6848786292","https://openalex.org/W6852370643","https://openalex.org/W7075608670"],"related_works":["https://openalex.org/W4220697284","https://openalex.org/W4400937608","https://openalex.org/W7125607838","https://openalex.org/W4220934208","https://openalex.org/W4412780198","https://openalex.org/W4406549744","https://openalex.org/W4407405545","https://openalex.org/W4311185926","https://openalex.org/W7122627246","https://openalex.org/W4312080689"],"abstract_inverted_index":{"To":[0],"report":[1],"three-year":[2],"outcomes":[3,37],"of":[4,18,52,134,143],"a":[5,141,169,177,193,201,217,225,229,235,257],"multicenter":[6],"cohort":[7,14],"undergoing":[8,24],"Preserflo":[9],"Microshunt":[10],"surgery":[11,255],"(PFMS).":[12],"Retrospective":[13,16],"study":[15],"review":[17],"100":[19,50],"consecutive":[20],"eyes":[21,51,157,167,175,179,189,198,233],"(91":[22],"patients)":[23],"PFMS":[25,184,254],"from":[26,127,146],"four":[27],"tertiary-referral":[28],"glaucoma":[29,162,170],"centers.":[30],"Primary":[31],"outcome":[32],"were":[33,55,65,250],"success":[34,60],"rates.":[35],"Secondary":[36],"included:":[38],"intraocular":[39],"pressure":[40],"(IOP),":[41],"best-corrected":[42],"visual":[43],"acuity,":[44],"medication,":[45],"complications":[46],"and":[47,58,70,84,98,108,113,173,196,215,244,259,265],"postoperative":[48,236],"interventions.":[49],"91":[53],"patients":[54],"included.":[56],"Qualified":[57],"complete":[59],"rates":[61],"(95":[62],"%":[63,67,72,81,86,95,100,110,115],"CI)":[64],"80":[66],"(72\u201387":[68],"%)":[69,74,83,88,97,102,112,117,136,159,191,200],"56":[71],"(47\u201365":[73],"for":[75,89,103,118,262],"Criterion":[76,90,104,119],"A":[77],"(IOP\u226421":[78],"mmHg),":[79,93],"75":[80],"(67\u201383":[82],"55":[85],"(46\u201365":[87],"B":[91],"(IOP\u226418":[92],"44":[94],"(31\u201350":[96],"39":[99],"(30\u201349":[101],"C":[105],"(IOP\u226415":[106],"mmHg)":[107,122],"10":[109,114],"(5\u201316":[111,116],"D":[120],"(IOP\u226412":[121],"respectively.":[123],"Mean":[124],"IOP":[125,264],"decreased":[126],"23.8":[128],"mmHg":[129,132],"to":[130,151],"14.1":[131],"(reduction":[133],"35.3":[135],"after":[137,183,219],"36":[138],"months":[139],"with":[140,241],"reduction":[142],"IOP-lowering":[144],"agents":[145],"2.52":[147],"(0":[148,153],"\u2013":[149,154],"4)":[150],"0.69":[152],"3).":[155],"7":[156],"(7":[158],"needed":[160],"additional":[161,181],"surgery.":[163,231],"Of":[164,186],"these,":[165,187],"3":[166],"underwent":[168,192,216],"drainage":[171],"device":[172],"4":[174],"had":[176,224],"trabeculectomy.36":[178],"received":[180],"procedures":[182],"implantation.":[185],"14":[188],"(14":[190],"surgical":[194],"revision":[195,230],"12":[197],"(12":[199],"bleb":[202],"needling":[203],"procedure.":[204],"The":[205],"complication":[206],"rate":[207],"was":[208,239],"low:":[209],"1":[210,222],"eye":[211,223],"developed":[212,234],"corneal":[213],"decompensation":[214],"DMEK":[218],"24":[220],"months.":[221],"conjunctival":[226],"erosion":[227],"requiring":[228],"2":[232],"uveitis":[237],"that":[238],"treated":[240],"topical":[242],"steroids":[243],"resolved":[245],"without":[246],"further":[247],"damage.":[248],"There":[249],"no":[251],"hypotony-related":[252],"complications.":[253],"is":[256],"safe":[258],"effective":[260],"procedure":[261],"reducing":[263],"pressure-lowering":[266],"therapy.":[267]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-07-15T00:00:00"}