{"id":"https://openalex.org/W4400623116","doi":"https://doi.org/10.21608/bvmj.2024.279991.1802","title":"A potential therapeutic impact of Gallic acid in a rat model of hepatocarcinogenesis through inhibition of cell proliferation and oncogenic miRNA-221 and induction of apoptosis by Nrf-2 /Bcl-2/TGF- \u03b21 signaling pathways","display_name":"A potential therapeutic impact of Gallic acid in a rat model of hepatocarcinogenesis through inhibition of cell proliferation and oncogenic miRNA-221 and induction of apoptosis by Nrf-2 /Bcl-2/TGF- \u03b21 signaling pathways","publication_year":2024,"publication_date":"2024-07-01","ids":{"openalex":"https://openalex.org/W4400623116","doi":"https://doi.org/10.21608/bvmj.2024.279991.1802"},"language":"en","primary_location":{"id":"doi:10.21608/bvmj.2024.279991.1802","doi":"https://doi.org/10.21608/bvmj.2024.279991.1802","is_oa":true,"landing_page_url":"https://doi.org/10.21608/bvmj.2024.279991.1802","pdf_url":"https://bvmj.journals.ekb.eg/article_365592_ab7163fa1923a32eab9a1253cd1af718.pdf","source":{"id":"https://openalex.org/S4210220379","display_name":"Benha Veterinary Medical Journal","issn_l":"1110-6581","issn":["1110-6581","2974-4806"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4323237894","host_organization_name":"Egypts Presidential Specialized Council for Education and Scientific Research","host_organization_lineage":["https://openalex.org/P4323237894"],"host_organization_lineage_names":["Egypts Presidential Specialized Council for Education and Scientific Research"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Benha Veterinary Medical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bvmj.journals.ekb.eg/article_365592_ab7163fa1923a32eab9a1253cd1af718.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104532041","display_name":"A\u02bclaa El-Sayed Al-Semelawy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I207547235","display_name":"Benha University","ror":"https://ror.org/03tn5ee41","country_code":"EG","type":"education","lineage":["https://openalex.org/I207547235"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"A\u02bclaa El-Sayed Al-Semelawy","raw_affiliation_strings":["Department of Biochemistry and molecular biology, Faculty of Veterinary Medicine, Benha University, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and molecular biology, Faculty of Veterinary Medicine, Benha University, Egypt","institution_ids":["https://openalex.org/I207547235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032807613","display_name":"Samy Aziza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I207547235","display_name":"Benha University","ror":"https://ror.org/03tn5ee41","country_code":"EG","type":"education","lineage":["https://openalex.org/I207547235"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Samy Ali Aziza","raw_affiliation_strings":["Department of Biochemistry and molecular biology, Faculty of Veterinary Medicine, Benha University, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and molecular biology, Faculty of Veterinary Medicine, Benha University, Egypt","institution_ids":["https://openalex.org/I207547235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062336005","display_name":"Hussein Abd Elmaksoud","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I207547235","display_name":"Benha University","ror":"https://ror.org/03tn5ee41","country_code":"EG","type":"education","lineage":["https://openalex.org/I207547235"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Hussein Abd El-Maksoud","raw_affiliation_strings":["Department of Biochemistry and molecular biology, Faculty of Veterinary Medicine, Benha University, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and molecular biology, Faculty of Veterinary Medicine, Benha University, Egypt","institution_ids":["https://openalex.org/I207547235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023432717","display_name":"Yakout A. Elsenosi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I207547235","display_name":"Benha University","ror":"https://ror.org/03tn5ee41","country_code":"EG","type":"education","lineage":["https://openalex.org/I207547235"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Yakout A EL-Senosi","raw_affiliation_strings":["Department of Biochemistry and molecular biology, Faculty of Veterinary Medicine, Benha University, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and molecular biology, Faculty of Veterinary Medicine, Benha University, Egypt","institution_ids":["https://openalex.org/I207547235"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010432669","display_name":"Afaf Desouky Abdel Magid","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I207547235","display_name":"Benha University","ror":"https://ror.org/03tn5ee41","country_code":"EG","type":"education","lineage":["https://openalex.org/I207547235"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Afaf Desoky Abel Magid","raw_affiliation_strings":["Department of Biochemistry and molecular biology, Faculty of Veterinary Medicine, Benha University, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and molecular biology, Faculty of Veterinary Medicine, Benha University, Egypt","institution_ids":["https://openalex.org/I207547235"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I207547235"],"apc_list":null,"apc_paid":null,"fwci":0.1725,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.42330029,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"46","issue":"2","first_page":"13","last_page":"18"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.29350000619888306,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.29350000619888306,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14135","display_name":"Cancer and biochemical research","score":0.1428000032901764,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.10480000078678131,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gallic-acid","display_name":"gallic acid","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9769999980926514},{"id":"https://openalex.org/keywords/hepatocarcinogenesis","display_name":"hepatocarcinogenesis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/diethylnitrosamine","display_name":"diethylnitrosamine","score":0.9229999780654907},{"id":"https://openalex.org/keywords/carbon-tetrachloride","display_name":"carbon tetrachloride","score":0.9829999804496765},{"id":"https://openalex.org/keywords/mir-221","display_name":"miR-221","score":0.7860000133514404},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.8849999904632568},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":1.0},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.972000002861023},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8360000252723694},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.8949999809265137},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8619999885559082},{"id":"https://openalex.org/keywords/liver-enzymes","display_name":"liver enzymes","score":0.578000009059906},{"id":"https://openalex.org/keywords/polyphenols","display_name":"polyphenols","score":0.7239999771118164},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.5120000243186951}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7185823917388916},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6807299852371216},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6408615112304688},{"id":"https://openalex.org/C2778362808","wikidata":"https://www.wikidata.org/wiki/Q375837","display_name":"Gallic acid","level":3,"score":0.5999827980995178},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.578815758228302},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5282974243164062},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.458077609539032},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4145125150680542},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3441340923309326},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3358369469642639},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19214466214179993},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09937405586242676},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.21608/bvmj.2024.279991.1802","doi":"https://doi.org/10.21608/bvmj.2024.279991.1802","is_oa":true,"landing_page_url":"https://doi.org/10.21608/bvmj.2024.279991.1802","pdf_url":"https://bvmj.journals.ekb.eg/article_365592_ab7163fa1923a32eab9a1253cd1af718.pdf","source":{"id":"https://openalex.org/S4210220379","display_name":"Benha Veterinary Medical Journal","issn_l":"1110-6581","issn":["1110-6581","2974-4806"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4323237894","host_organization_name":"Egypts Presidential Specialized Council for Education and Scientific Research","host_organization_lineage":["https://openalex.org/P4323237894"],"host_organization_lineage_names":["Egypts Presidential Specialized Council for Education and Scientific Research"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Benha Veterinary Medical Journal","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:b225114fa61d4b8294f6b29f5cab4d45","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/b225114fa61d4b8294f6b29f5cab4d45","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Benha Veterinary Medical Journal, Vol 46, Iss 2, Pp 13-18 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.21608/bvmj.2024.279991.1802","doi":"https://doi.org/10.21608/bvmj.2024.279991.1802","is_oa":true,"landing_page_url":"https://doi.org/10.21608/bvmj.2024.279991.1802","pdf_url":"https://bvmj.journals.ekb.eg/article_365592_ab7163fa1923a32eab9a1253cd1af718.pdf","source":{"id":"https://openalex.org/S4210220379","display_name":"Benha Veterinary Medical Journal","issn_l":"1110-6581","issn":["1110-6581","2974-4806"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4323237894","host_organization_name":"Egypts Presidential Specialized Council for Education and Scientific Research","host_organization_lineage":["https://openalex.org/P4323237894"],"host_organization_lineage_names":["Egypts Presidential Specialized Council for Education and Scientific Research"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Benha Veterinary Medical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4400623116.pdf","grobid_xml":"https://content.openalex.org/works/W4400623116.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1904889669","https://openalex.org/W1966537844","https://openalex.org/W1971152759","https://openalex.org/W1983734516","https://openalex.org/W1994682335","https://openalex.org/W2032986261","https://openalex.org/W2074705421","https://openalex.org/W2095144785","https://openalex.org/W2127215985","https://openalex.org/W2161163389","https://openalex.org/W2167001925","https://openalex.org/W2170097870","https://openalex.org/W2186703523","https://openalex.org/W2343177674","https://openalex.org/W2611688197","https://openalex.org/W2625594257","https://openalex.org/W2784418525","https://openalex.org/W2886513383","https://openalex.org/W2902228088","https://openalex.org/W2924655145","https://openalex.org/W2948290002","https://openalex.org/W2969325008","https://openalex.org/W2978070590","https://openalex.org/W2983258509","https://openalex.org/W2998196333","https://openalex.org/W3015825368","https://openalex.org/W3041535380","https://openalex.org/W3102491904","https://openalex.org/W3121393256","https://openalex.org/W3121580697","https://openalex.org/W3136275197","https://openalex.org/W4224434422","https://openalex.org/W4284713557","https://openalex.org/W4296832508","https://openalex.org/W4309807618","https://openalex.org/W4379986459","https://openalex.org/W4385366803","https://openalex.org/W4388904230"],"related_works":["https://openalex.org/W2625594257","https://openalex.org/W2024184602","https://openalex.org/W4395693230","https://openalex.org/W2541410040","https://openalex.org/W3201685527","https://openalex.org/W1854592836","https://openalex.org/W4389025158","https://openalex.org/W2998196333","https://openalex.org/W4395692920","https://openalex.org/W2392511698"],"abstract_inverted_index":{"Hepatocellular":[0],"carcinoma":[1],"(HCC)":[2],"is":[3,25,49],"still":[4],"a":[5,61,81,137,229],"main":[6],"cause":[7],"of":[8,20,46,58,64,112,139,177,184,206,211],"fatality":[9],"for":[10,161],"individuals":[11],"with":[12,115,151,174,204],"chronic":[13],"liver":[14,170,223,234],"illnesses,":[15],"according":[16],"to":[17,50,125],"statistical":[18],"analyses":[19],"cancer.":[21],"Gallic":[22],"acid":[23],"(GA)":[24],"among":[26],"the":[27,44,52,127],"most":[28],"probable":[29],"polyphenols":[30],"which":[31],"possess":[32],"several":[33],"pharmacological":[34],"effects":[35],"as":[36,80],"antioxidant,":[37],"anti-Inflammatory,":[38],"apoptotic":[39],"and":[40,55,131,159,172,179,181,199,209,214,227,240],"antitumor":[41],"activities.":[42],"Therefore,":[43],"objective":[45],"this":[47],"study":[48],"evaluate":[51],"potential":[53],"therapeutic":[54,231],"anti-cancerous":[56],"effect":[57],"GA":[59,152,191,221],"on":[60],"rat":[62],"model":[63],"HCC.":[65],"Thirty":[66],"rats":[67,105],"were":[68,106,134],"segregated":[69],"equally":[70],"into":[71],"three":[72],"groups.":[73],"G1":[74],"(Normal":[75],"control):":[76],"Rats":[77],"given":[78,107,157],"saline":[79],"vehicle.":[82],"G2:":[83],"(HCC":[84],"non":[85],"-treated)":[86],"HCC":[87,148],"was":[88],"induced":[89],"via":[90],"utilizing":[91],"diethylnitrosamine":[92],"(DEN)":[93],"injection":[94],"(200":[95],"mg/kg":[96,154],"b.wt)":[97,123],"intraperitoneal,":[98],"then":[99],"two":[100],"weeks":[101,146],"after":[102,136,147],"DEN":[103,130],"injection,":[104],"3":[108,186,216],"weekly":[109],"successive":[110],"doses":[111],"CCl4":[113,132],"diluted":[114],"corn":[116],"oil":[117],"at":[118],"1:1":[119],"proportion":[120],"(3":[121],"ml/kg":[122],"orally":[124,158],"boost":[126],"carcinogenic":[128],"impact.":[129],"administrations":[133],"repeated":[135],"period":[138],"5":[140],"weeks.":[141,163],"G3:":[142],"(HCC+GA":[143],"treated):":[144],"15":[145],"induction,":[149],"treatment":[150,192],"(100":[153],"b.":[155],"wt.)":[156],"continued":[160],"six":[162],"The":[164],"results":[165],"showed":[166],"significant":[167,194],"upregulations":[168],"in":[169,188,196],"microRNA-221":[171,208],"TGF-\u03b21,":[173,207],"obvious":[175],"down-regulation":[176],"(Nrf2":[178],"Bcl-2)":[180],"insignificant":[182],"downregulation":[183,205],"caspase":[185,215],"gene":[187,217],"HCC-induced":[189],"rats.":[190],"exhibited":[193],"decline":[195],"ALT,":[197],"AST":[198],"ALP":[200],"hepatic":[201],"enzyme":[202],"markers":[203],"upregulation":[210],"Nrf2,":[212],"Bcl-2":[213],"expression.":[218],"In":[219],"conclusion,":[220],"reduces":[222],"preneoplastic":[224],"lesions":[225],"development":[226],"has":[228],"helpful":[230],"impact":[232],"against":[233],"cancer,":[235],"inhibiting":[236],"growth":[237],"promoting":[238],"oncogene":[239],"increasing":[241],"apoptosis.":[242]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2024-07-15T00:00:00"}
