{"id":"https://openalex.org/W4400607828","doi":"https://doi.org/10.1101/2024.07.09.602634","title":"Serum amyloid A3 deficiency modulates aortic immune composition and attenuates murine atherosclerosis progression","display_name":"Serum amyloid A3 deficiency modulates aortic immune composition and attenuates murine atherosclerosis progression","publication_year":2024,"publication_date":"2024-07-13","ids":{"openalex":"https://openalex.org/W4400607828","doi":"https://doi.org/10.1101/2024.07.09.602634"},"language":"en","primary_location":{"id":"doi:10.1101/2024.07.09.602634","doi":"https://doi.org/10.1101/2024.07.09.602634","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.07.09.602634","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.1101/2024.07.09.602634","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112873285","display_name":"Tzu-Yin Chou","orcid":"https://orcid.org/0009-0009-9627-1596","observed_orcids":["https://orcid.org/0009-0009-9627-1596"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Tzu-Yin Chou","raw_affiliation_strings":["Department of Biochemical Science and Technology, National Taiwan University, Taipei 10617, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemical Science and Technology, National Taiwan University, Taipei 10617, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yu-Zhen Ye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu-Zhen Ye","raw_affiliation_strings":["Department of Biochemical Science and Technology, National Taiwan University, Taipei 10617, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemical Science and Technology, National Taiwan University, Taipei 10617, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106038892","display_name":"Chia-Jung Lien","orcid":"https://orcid.org/0009-0008-1783-2723","observed_orcids":["https://orcid.org/0009-0008-1783-2723"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chia-Jung Lien","raw_affiliation_strings":["Department of Biochemical Science and Technology, National Taiwan University, Taipei 10617, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemical Science and Technology, National Taiwan University, Taipei 10617, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jui-Chun Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jui-Chun Wang","raw_affiliation_strings":["Department of Biochemical Science and Technology, National Taiwan University, Taipei 10617, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemical Science and Technology, National Taiwan University, Taipei 10617, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023193998","display_name":"Chen-Hsuan Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chen-Hsuan Yang","raw_affiliation_strings":["Department of Biochemical Science and Technology, National Taiwan University, Taipei 10617, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemical Science and Technology, National Taiwan University, Taipei 10617, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040088125","display_name":"Yen-Ting Chen","orcid":"https://orcid.org/0000-0001-7948-2775","observed_orcids":["https://orcid.org/0000-0001-7948-2775"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yen-Ting Chen","raw_affiliation_strings":["Department of Biochemical Science and Technology, National Taiwan University, Taipei 10617, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemical Science and Technology, National Taiwan University, Taipei 10617, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072202932","display_name":"Pei-An Chao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Pei-An Chao","raw_affiliation_strings":["Department of Biochemical Science and Technology, National Taiwan University, Taipei 10617, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemical Science and Technology, National Taiwan University, Taipei 10617, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045905668","display_name":"Jian-Da Lin","orcid":"https://orcid.org/0000-0003-3697-4766","observed_orcids":["https://orcid.org/0000-0003-3697-4766"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Jian-Da Lin","raw_affiliation_strings":["Department of Biochemical Science and Technology, National Taiwan University, Taipei 10617, Taiwan"],"raw_orcid":"https://orcid.org/0000-0003-3697-4766","affiliations":[{"raw_affiliation_string":"Department of Biochemical Science and Technology, National Taiwan University, Taipei 10617, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5045905668"],"corresponding_institution_ids":["https://openalex.org/I16733864"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serum-amyloid-a3","display_name":"serum amyloid A3","score":0.9879999756813049},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9049999713897705},{"id":"https://openalex.org/keywords/trem2","display_name":"TREM2","score":0.5120000243186951},{"id":"https://openalex.org/keywords/gpnmb","display_name":"GPNMB","score":0.7580000162124634},{"id":"https://openalex.org/keywords/osteopontin","display_name":"osteopontin","score":0.5950000286102295},{"id":"https://openalex.org/keywords/cholesterol-metabolism","display_name":"cholesterol metabolism","score":0.6320000290870667},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.734000027179718},{"id":"https://openalex.org/keywords/plaque-progression","display_name":"plaque progression","score":0.6850000023841858},{"id":"https://openalex.org/keywords/anti-inflammatory-macrophages","display_name":"anti-inflammatory macrophages","score":0.7649999856948853}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7142038345336914},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5676773190498352},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.521319568157196},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4404246211051941},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41614818572998047},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2842732071876526},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2721473276615143},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2024.07.09.602634","doi":"https://doi.org/10.1101/2024.07.09.602634","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.07.09.602634","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2024.07.09.602634","doi":"https://doi.org/10.1101/2024.07.09.602634","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.07.09.602634","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9907000064849854}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":123,"referenced_works":["https://openalex.org/W130824192","https://openalex.org/W147019719","https://openalex.org/W1507364611","https://openalex.org/W1568265476","https://openalex.org/W1894325834","https://openalex.org/W1968960234","https://openalex.org/W1980886700","https://openalex.org/W1986182250","https://openalex.org/W1987774046","https://openalex.org/W1995461730","https://openalex.org/W2003893081","https://openalex.org/W2010044292","https://openalex.org/W2017763556","https://openalex.org/W2021595534","https://openalex.org/W2021974115","https://openalex.org/W2023165771","https://openalex.org/W2034233204","https://openalex.org/W2035618305","https://openalex.org/W2047964740","https://openalex.org/W2056386675","https://openalex.org/W2063645354","https://openalex.org/W2066223184","https://openalex.org/W2087023256","https://openalex.org/W2090377375","https://openalex.org/W2096488601","https://openalex.org/W2098728736","https://openalex.org/W2106129084","https://openalex.org/W2111764884","https://openalex.org/W2117304506","https://openalex.org/W2129214570","https://openalex.org/W2130073289","https://openalex.org/W2133950776","https://openalex.org/W2140380746","https://openalex.org/W2182520417","https://openalex.org/W2242760558","https://openalex.org/W2259285103","https://openalex.org/W2299317792","https://openalex.org/W2525947787","https://openalex.org/W2560291684","https://openalex.org/W2593749270","https://openalex.org/W2596229447","https://openalex.org/W2621428836","https://openalex.org/W2622647307","https://openalex.org/W2755010202","https://openalex.org/W2759646346","https://openalex.org/W2770404658","https://openalex.org/W2792855672","https://openalex.org/W2883316251","https://openalex.org/W2889269713","https://openalex.org/W2890365959","https://openalex.org/W2891644675","https://openalex.org/W2900494132","https://openalex.org/W2907514116","https://openalex.org/W2913705661","https://openalex.org/W2916672270","https://openalex.org/W2936100272","https://openalex.org/W2945777288","https://openalex.org/W2949177718","https://openalex.org/W2967248220","https://openalex.org/W2970950953","https://openalex.org/W2982665975","https://openalex.org/W2988988674","https://openalex.org/W2992966803","https://openalex.org/W2994849646","https://openalex.org/W3004159905","https://openalex.org/W3005864097","https://openalex.org/W3012983129","https://openalex.org/W3014655051","https://openalex.org/W3031817190","https://openalex.org/W3082526716","https://openalex.org/W3088551053","https://openalex.org/W3096633873","https://openalex.org/W3127743346","https://openalex.org/W3132661792","https://openalex.org/W3133537018","https://openalex.org/W3137491405","https://openalex.org/W3145037845","https://openalex.org/W3162634027","https://openalex.org/W3164692211","https://openalex.org/W3175752499","https://openalex.org/W3180599331","https://openalex.org/W3197668690","https://openalex.org/W3202565215","https://openalex.org/W3202776049","https://openalex.org/W3214523816","https://openalex.org/W4200112535","https://openalex.org/W4205145157","https://openalex.org/W4206582106","https://openalex.org/W4206907877","https://openalex.org/W4211134725","https://openalex.org/W4220966948","https://openalex.org/W4221057998","https://openalex.org/W4221123198","https://openalex.org/W4223902443","https://openalex.org/W4223976069","https://openalex.org/W4224226256","https://openalex.org/W4224277525","https://openalex.org/W4224315232","https://openalex.org/W4225150594","https://openalex.org/W4226148121","https://openalex.org/W4281392273","https://openalex.org/W4283774666","https://openalex.org/W4290034635","https://openalex.org/W4291997190","https://openalex.org/W4306392348","https://openalex.org/W4315779391","https://openalex.org/W4317433962","https://openalex.org/W4319018618","https://openalex.org/W4321178799","https://openalex.org/W4361277983","https://openalex.org/W4379053616","https://openalex.org/W4380995142","https://openalex.org/W4385271312","https://openalex.org/W4385631321","https://openalex.org/W4386640101","https://openalex.org/W4387458629","https://openalex.org/W4387806924","https://openalex.org/W4388569149","https://openalex.org/W4389378610","https://openalex.org/W4390227705","https://openalex.org/W4391841707","https://openalex.org/W4392653593","https://openalex.org/W4396588628"],"related_works":["https://openalex.org/W4401628955","https://openalex.org/W3137491405","https://openalex.org/W2770404658","https://openalex.org/W7033559718","https://openalex.org/W2922430092","https://openalex.org/W2167476523","https://openalex.org/W4234784065","https://openalex.org/W147019719","https://openalex.org/W2123667269","https://openalex.org/W7166549269"],"abstract_inverted_index":{"Abstract":[0],"Atherosclerosis":[1],"is":[2],"a":[3,64,71,169],"growing":[4],"concern":[5],"in":[6,79,103,114,146,161],"developed":[7,90],"nations,":[8],"necessitating":[9],"the":[10,126,142],"identification":[11],"of":[12,38,172],"therapeutic":[13],"targets":[14],"for":[15],"advancing":[16],"personalized":[17],"medicine.":[18],"Serum":[19],"amyloid":[20],"A3":[21],"(":[22,46],"Saa3":[23,45,47,84,87,116,147,167],")":[24,49],"has":[25],"been":[26],"linked":[27],"to":[28,150],"accelerated":[29],"plaque":[30,52],"progression":[31],"by":[32,54,131],"affecting":[33],"cholesterol":[34,156],"metabolism":[35,157],"and":[36,83,96,122,125,137,158],"modulation":[37],"inflammation.":[39],"We":[40],"hypothesize":[41],"that":[42,176],"knocking":[43],"out":[44],"\u2212/\u2212":[48,85,88,117,148],"could":[50],"mitigate":[51],"development":[53],"regulating":[55],"aortic":[56,104,110,173],"immune":[57,105,174],"cell":[58,106],"compositions":[59],"during":[60],"atherosclerosis":[61,69,178],"progression.":[62,179],"Using":[63],"murine":[65],"model,":[66],"we":[67],"induced":[68],"via":[70],"gain-of-function":[72],"mutant":[73],"PCSK9-encoding":[74],"adeno-associated":[75],"viral":[76],"vector":[77],"(AAVmPCSK9)":[78],"female":[80],"wild-type":[81],"(WT)":[82],"mice.":[86,152],"mice":[89,118],"smaller":[91],"plaques":[92],"than":[93],"WT":[94,151],"mice,":[95],"single-cell":[97],"RNA":[98],"sequencing":[99],"revealed":[100],"significant":[101],"differences":[102],"populations,":[107],"particularly":[108],"among":[109],"macrophages.":[111,163],"Aortic":[112],"macrophages":[113,145],"atherosclerotic":[115],"represent":[119],"an":[120],"anti-inflammatory":[121],"tissue-repairing":[123],"phenotype":[124],"Trem2":[127],"hi":[128],"macrophages,":[129],"characterized":[130],"high":[132],"Gpnmb":[133],",":[134,136],"Lpl":[135],"Spp1":[138],"expressions,":[139],"predominated":[140],"over":[141],"typical":[143],"foamy":[144,162],"compared":[149],"Notably,":[153],"SAA3":[154],"regulates":[155],"inflammatory":[159],"responses":[160],"Our":[164],"study":[165],"highlights":[166],"as":[168],"key":[170],"modulator":[171],"cells":[175],"impact":[177]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2024-07-14T00:00:00"}
