{"id":"https://openalex.org/W4400599564","doi":"https://doi.org/10.1093/brain/awae231","title":"Epileptic activity on foramen ovale electrodes is associated with sleep and tau pathology in Alzheimer\u2019s disease","display_name":"Epileptic activity on foramen ovale electrodes is associated with sleep and tau pathology in Alzheimer\u2019s disease","publication_year":2024,"publication_date":"2024-07-10","ids":{"openalex":"https://openalex.org/W4400599564","doi":"https://doi.org/10.1093/brain/awae231","pmid":"https://pubmed.ncbi.nlm.nih.gov/38990981","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11788210"},"language":"en","primary_location":{"id":"doi:10.1093/brain/awae231","doi":"https://doi.org/10.1093/brain/awae231","is_oa":true,"landing_page_url":"https://doi.org/10.1093/brain/awae231","pdf_url":"https://academic.oup.com/brain/article-pdf/148/2/506/60967832/awae231.pdf","source":{"id":"https://openalex.org/S118357697","display_name":"Brain","issn_l":"0006-8950","issn":["0006-8950","1460-2156"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/brain/article-pdf/148/2/506/60967832/awae231.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081536011","display_name":"Astrid Devulder","orcid":"https://orcid.org/0000-0002-4652-2459","observed_orcids":["https://orcid.org/0000-0002-4652-2459"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Astrid Devulder","raw_affiliation_strings":["Department of Neurology, University Hospitals Leuven , Leuven 3000 ,","Laboratory for Epilepsy Research, KU Leuven Biomedical Sciences Group , Leuven 3000 ,"],"raw_orcid":"https://orcid.org/0000-0002-4652-2459","affiliations":[{"raw_affiliation_string":"Department of Neurology, University Hospitals Leuven , Leuven 3000 ,","institution_ids":["https://openalex.org/I2800231306"]},{"raw_affiliation_string":"Laboratory for Epilepsy Research, KU Leuven Biomedical Sciences Group , Leuven 3000 ,","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062099454","display_name":"Greet Vanderlinden","orcid":"https://orcid.org/0000-0002-5673-4121","observed_orcids":["https://orcid.org/0000-0002-5673-4121"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Greet Vanderlinden","raw_affiliation_strings":["Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven Biomedical Sciences Group , Leuven 3000 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven Biomedical Sciences Group , Leuven 3000 ,","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020826963","display_name":"Leen Van Langenhoven","orcid":"https://orcid.org/0009-0005-0499-7148","observed_orcids":["https://orcid.org/0009-0005-0499-7148"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Leen Van Langenhoven","raw_affiliation_strings":["Leuven Biostatistics and Statistical Bioinformatics Centre (L-BioStat), KU Leuven Biomedical Sciences Group , Leuven 3000 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leuven Biostatistics and Statistical Bioinformatics Centre (L-BioStat), KU Leuven Biomedical Sciences Group , Leuven 3000 ,","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024646128","display_name":"Dries Testelmans","orcid":"https://orcid.org/0000-0001-7303-9799","observed_orcids":["https://orcid.org/0000-0001-7303-9799"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Dries Testelmans","raw_affiliation_strings":["Department of Pulmonary Diseases, University Hospitals Leuven , Leuven 3000 ,","Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), KU Leuven Biomedical Sciences Group , Leuven 3000 ,"],"raw_orcid":"https://orcid.org/0000-0001-7303-9799","affiliations":[{"raw_affiliation_string":"Department of Pulmonary Diseases, University Hospitals Leuven , Leuven 3000 ,","institution_ids":["https://openalex.org/I2800231306"]},{"raw_affiliation_string":"Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), KU Leuven Biomedical Sciences Group , Leuven 3000 ,","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007577247","display_name":"Maarten J. A. Van Den Bossche","orcid":"https://orcid.org/0000-0002-2989-6600","observed_orcids":["https://orcid.org/0000-0002-2989-6600"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Maarten Van Den Bossche","raw_affiliation_strings":["Department of Geriatric Psychiatry, KUL University Psychiatric Center (UPC) KU Leuven , Leuven 3000 ,","Neuropsychiatry, Department of Neurosciences, Leuven Brain Institute, KU Leuven Biomedical Sciences Group , Leuven 3000 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatric Psychiatry, KUL University Psychiatric Center (UPC) KU Leuven , Leuven 3000 ,","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Neuropsychiatry, Department of Neurosciences, Leuven Brain Institute, KU Leuven Biomedical Sciences Group , Leuven 3000 ,","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037642793","display_name":"Fran\u00e7ois\u2010Laurent De Winter","orcid":"https://orcid.org/0000-0001-7753-3575","observed_orcids":["https://orcid.org/0000-0001-7753-3575"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Fran\u00e7ois-Laurent De Winter","raw_affiliation_strings":["Department of Geriatric Psychiatry, KUL University Psychiatric Center (UPC) KU Leuven , Leuven 3000 ,","Neuropsychiatry, Department of Neurosciences, Leuven Brain Institute, KU Leuven Biomedical Sciences Group , Leuven 3000 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatric Psychiatry, KUL University Psychiatric Center (UPC) KU Leuven , Leuven 3000 ,","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Neuropsychiatry, Department of Neurosciences, Leuven Brain Institute, KU Leuven Biomedical Sciences Group , Leuven 3000 ,","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073952660","display_name":"Mathieu Vandenbulcke","orcid":"https://orcid.org/0000-0001-9765-1499","observed_orcids":["https://orcid.org/0000-0001-9765-1499"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Mathieu Vandenbulcke","raw_affiliation_strings":["Department of Geriatric Psychiatry, KUL University Psychiatric Center (UPC) KU Leuven , Leuven 3000 ,","Neuropsychiatry, Department of Neurosciences, Leuven Brain Institute, KU Leuven Biomedical Sciences Group , Leuven 3000 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatric Psychiatry, KUL University Psychiatric Center (UPC) KU Leuven , Leuven 3000 ,","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Neuropsychiatry, Department of Neurosciences, Leuven Brain Institute, KU Leuven Biomedical Sciences Group , Leuven 3000 ,","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071341444","display_name":"Rik R. Vandenberghe","orcid":"https://orcid.org/0000-0001-6237-2502","observed_orcids":["https://orcid.org/0000-0001-6237-2502"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Rik Vandenberghe","raw_affiliation_strings":["Department of Neurology, University Hospitals Leuven , Leuven 3000 ,","Laboratory for Cognitive Neurology, KU Leuven Biomedical Sciences Group , Leuven 3000 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University Hospitals Leuven , Leuven 3000 ,","institution_ids":["https://openalex.org/I2800231306"]},{"raw_affiliation_string":"Laboratory for Cognitive Neurology, KU Leuven Biomedical Sciences Group , Leuven 3000 ,","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028975858","display_name":"Tom Theys","orcid":"https://orcid.org/0000-0001-7595-3234","observed_orcids":["https://orcid.org/0000-0001-7595-3234"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Tom Theys","raw_affiliation_strings":["Department of Neurosurgery, University Hospitals Leuven , Leuven 3000 ,","Research Group Experimental Neurosurgery and Neuroanatomy, KU Leuven Biomedical Sciences Group , Leuven 3000 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University Hospitals Leuven , Leuven 3000 ,","institution_ids":["https://openalex.org/I2800231306"]},{"raw_affiliation_string":"Research Group Experimental Neurosurgery and Neuroanatomy, KU Leuven Biomedical Sciences Group , Leuven 3000 ,","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081304921","display_name":"Koen Van Laere","orcid":"https://orcid.org/0000-0001-5200-7245","observed_orcids":["https://orcid.org/0000-0001-5200-7245"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Koen Van Laere","raw_affiliation_strings":["Division of Nuclear Medicine, University Hospitals Leuven , Leuven 3000 ,","Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven Biomedical Sciences Group , Leuven 3000 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nuclear Medicine, University Hospitals Leuven , Leuven 3000 ,","institution_ids":["https://openalex.org/I2800231306"]},{"raw_affiliation_string":"Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven Biomedical Sciences Group , Leuven 3000 ,","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059287667","display_name":"Wim Van Paesschen","orcid":"https://orcid.org/0000-0002-8535-1699","observed_orcids":["https://orcid.org/0000-0002-8535-1699"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Wim Van Paesschen","raw_affiliation_strings":["Department of Neurology, University Hospitals Leuven , Leuven 3000 ,","Laboratory for Epilepsy Research, KU Leuven Biomedical Sciences Group , Leuven 3000 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University Hospitals Leuven , Leuven 3000 ,","institution_ids":["https://openalex.org/I2800231306"]},{"raw_affiliation_string":"Laboratory for Epilepsy Research, KU Leuven Biomedical Sciences Group , Leuven 3000 ,","institution_ids":["https://openalex.org/I99464096"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5081536011"],"corresponding_institution_ids":["https://openalex.org/I2800231306","https://openalex.org/I99464096"],"apc_list":{"value":4562,"currency":"GBP","value_usd":5831},"apc_paid":{"value":4562,"currency":"GBP","value_usd":5831},"fwci":4.9342,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.96460655,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"148","issue":"2","first_page":"506","last_page":"520"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.48489999771118164,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.48489999771118164,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.2953999936580658,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.11739999800920486,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.972000002861023},{"id":"https://openalex.org/keywords/interictal-epileptiform-discharges","display_name":"interictal epileptiform discharges","score":0.8889999985694885},{"id":"https://openalex.org/keywords/foramen-ovale-electrodes","display_name":"foramen ovale electrodes","score":0.8519999980926514},{"id":"https://openalex.org/keywords/intracranial-eeg","display_name":"intracranial EEG","score":0.843999981880188},{"id":"https://openalex.org/keywords/sleep","display_name":"sleep","score":0.5180000066757202},{"id":"https://openalex.org/keywords/slow-wave-sleep","display_name":"slow-wave sleep","score":0.8399999737739563},{"id":"https://openalex.org/keywords/nrem-sleep","display_name":"NREM sleep","score":0.7860000133514404},{"id":"https://openalex.org/keywords/tau-pathology","display_name":"tau pathology","score":0.7300000190734863},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.7139999866485596},{"id":"https://openalex.org/keywords/focal-seizures","display_name":"focal seizures","score":0.6010000109672546},{"id":"https://openalex.org/keywords/neuronal-hyperexcitability","display_name":"neuronal hyperexcitability","score":0.6679999828338623}],"concepts":[{"id":"https://openalex.org/C3017833866","wikidata":"https://www.wikidata.org/wiki/Q2397106","display_name":"Tau pathology","level":4,"score":0.5278586745262146},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5260106325149536},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5197474956512451},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4848812520503998},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.47821804881095886},{"id":"https://openalex.org/C2779987240","wikidata":"https://www.wikidata.org/wiki/Q767116","display_name":"Foramen ovale (heart)","level":4,"score":0.4549001455307007},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4321586489677429},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.41264989972114563},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3109101355075836},{"id":"https://openalex.org/C2776893843","wikidata":"https://www.wikidata.org/wiki/Q757749","display_name":"Patent foramen ovale","level":3,"score":0.2619789242744446},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.16133132576942444},{"id":"https://openalex.org/C2778541695","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Migraine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012890","descriptor_name":"Sleep","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017286","descriptor_name":"Polysomnography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054085","descriptor_name":"Foramen Ovale","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/brain/awae231","doi":"https://doi.org/10.1093/brain/awae231","is_oa":true,"landing_page_url":"https://doi.org/10.1093/brain/awae231","pdf_url":"https://academic.oup.com/brain/article-pdf/148/2/506/60967832/awae231.pdf","source":{"id":"https://openalex.org/S118357697","display_name":"Brain","issn_l":"0006-8950","issn":["0006-8950","1460-2156"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11788210","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11788210","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11788210/pdf/awae231.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain","raw_type":"Text"},{"id":"pmid:38990981","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38990981","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain : a journal of neurology","raw_type":"Journal Article"},{"id":"pmh:oai:lirias2repo.kuleuven.be:20.500.12942/745972","doi":null,"is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/20.500.12942/745972","pdf_url":"https://lirias.kuleuven.be/retrieve/f01cd2c0-153e-4827-b1a6-f96105e1675e","source":{"id":"https://openalex.org/S7407055369","display_name":"Lirias","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brain, vol. 148 (2), (506-520)","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1093/brain/awae231","doi":"https://doi.org/10.1093/brain/awae231","is_oa":true,"landing_page_url":"https://doi.org/10.1093/brain/awae231","pdf_url":"https://academic.oup.com/brain/article-pdf/148/2/506/60967832/awae231.pdf","source":{"id":"https://openalex.org/S118357697","display_name":"Brain","issn_l":"0006-8950","issn":["0006-8950","1460-2156"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[{"id":"https://openalex.org/G1599736970","display_name":null,"funder_award_id":"C24/18/097","funder_id":"https://openalex.org/F4320322308","funder_display_name":"KU Leuven"},{"id":"https://openalex.org/G7653564592","display_name":null,"funder_award_id":"C24/18/097","funder_id":"https://openalex.org/F4320335227","funder_display_name":"Bijzonder Onderzoeksfonds UGent"}],"funders":[{"id":"https://openalex.org/F4320322308","display_name":"KU Leuven","ror":"https://ror.org/05f950310"},{"id":"https://openalex.org/F4320335227","display_name":"Bijzonder Onderzoeksfonds UGent","ror":"https://ror.org/00cv9y106"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4400599564.pdf","grobid_xml":"https://content.openalex.org/works/W4400599564.grobid-xml"},"referenced_works_count":97,"referenced_works":["https://openalex.org/W1577819345","https://openalex.org/W1607924132","https://openalex.org/W1968937229","https://openalex.org/W1970910654","https://openalex.org/W1971331023","https://openalex.org/W1976588532","https://openalex.org/W1992681087","https://openalex.org/W1992999217","https://openalex.org/W1993571512","https://openalex.org/W1995214797","https://openalex.org/W1996802297","https://openalex.org/W2015603515","https://openalex.org/W2018149936","https://openalex.org/W2022796423","https://openalex.org/W2026802237","https://openalex.org/W2035466313","https://openalex.org/W2038134523","https://openalex.org/W2052806196","https://openalex.org/W2068877613","https://openalex.org/W2070724678","https://openalex.org/W2076327464","https://openalex.org/W2082429191","https://openalex.org/W2084136428","https://openalex.org/W2085810240","https://openalex.org/W2115017507","https://openalex.org/W2122213698","https://openalex.org/W2139881480","https://openalex.org/W2150471812","https://openalex.org/W2160311930","https://openalex.org/W2161166547","https://openalex.org/W2320560376","https://openalex.org/W2343799156","https://openalex.org/W2410744428","https://openalex.org/W2412332240","https://openalex.org/W2440154114","https://openalex.org/W2472346278","https://openalex.org/W2472395506","https://openalex.org/W2474977510","https://openalex.org/W2486635298","https://openalex.org/W2491434204","https://openalex.org/W2513581974","https://openalex.org/W2518174992","https://openalex.org/W2527558243","https://openalex.org/W2533786560","https://openalex.org/W2549366107","https://openalex.org/W2553360915","https://openalex.org/W2563603498","https://openalex.org/W2573597225","https://openalex.org/W2579604288","https://openalex.org/W2582524520","https://openalex.org/W2610741017","https://openalex.org/W2735226312","https://openalex.org/W2735688622","https://openalex.org/W2763470121","https://openalex.org/W2792305910","https://openalex.org/W2797347068","https://openalex.org/W2798054687","https://openalex.org/W2840024223","https://openalex.org/W2884721824","https://openalex.org/W2910774779","https://openalex.org/W2951101464","https://openalex.org/W2991295865","https://openalex.org/W2994889552","https://openalex.org/W3000313970","https://openalex.org/W3014925152","https://openalex.org/W3015286476","https://openalex.org/W3020080361","https://openalex.org/W3030476832","https://openalex.org/W3031624751","https://openalex.org/W3040701896","https://openalex.org/W3046988908","https://openalex.org/W3080427999","https://openalex.org/W3081507804","https://openalex.org/W3082341480","https://openalex.org/W3088845489","https://openalex.org/W3121468319","https://openalex.org/W3151084972","https://openalex.org/W3157186248","https://openalex.org/W3163306446","https://openalex.org/W3167249883","https://openalex.org/W3198271209","https://openalex.org/W3202631805","https://openalex.org/W3205368504","https://openalex.org/W3211433075","https://openalex.org/W4200151549","https://openalex.org/W4200163037","https://openalex.org/W4206957055","https://openalex.org/W4211016192","https://openalex.org/W4224224537","https://openalex.org/W4225154043","https://openalex.org/W4225299985","https://openalex.org/W4307198180","https://openalex.org/W4367315954","https://openalex.org/W4386814392","https://openalex.org/W4388579116","https://openalex.org/W4388597456","https://openalex.org/W4389687993"],"related_works":["https://openalex.org/W7018458320","https://openalex.org/W4388597456","https://openalex.org/W2610741017","https://openalex.org/W4405552875","https://openalex.org/W4389441817","https://openalex.org/W2546552801","https://openalex.org/W4379279974","https://openalex.org/W4390199486","https://openalex.org/W4390200001","https://openalex.org/W2981278673"],"abstract_inverted_index":{"Both":[0],"sleep":[1,33,300,305,312,324,331,341],"alterations":[2],"and":[3,13,16,34,63,66,81,87,140,167,183,220,283,303,316,322,360,393],"epileptiform":[4,117,162,240,391],"activity":[5,118,171,224,392],"are":[6,17],"associated":[7,252,362],"with":[8,85,363],"the":[9,39,46,75,100,243,254,269,273,278,336,364],"accumulation":[10],"of":[11,41,78,108,150,185,239,245,261,268,328],"amyloid-\u03b2":[12],"tau":[14,69,394],"pathology":[15,44,395],"currently":[18],"investigated":[19],"for":[20,99,277],"potential":[21],"therapeutic":[22],"interventions":[23],"in":[24,71,74,82,126,146,180,228,258,335,339,396],"Alzheimer's":[25,42,79,92,397],"disease.":[26,398],"However,":[27],"a":[28,106,109,121,127,147,237,265,386],"bidirectional":[29],"intertwining":[30],"relationship":[31],"between":[32,160,389],"neuronal":[35],"hyperexcitability":[36],"might":[37],"modulate":[38],"effects":[40],"disease":[43,80],"on":[45,120,177,190,201,225,247,291],"corresponding":[47],"associations.":[48],"To":[49],"investigate":[50],"this,":[51],"we":[52],"performed":[53],"multiple":[54],"day":[55],"simultaneous":[56],"foramen":[57],"ovale":[58],"(FO)":[59],"plus":[60],"scalp":[61,123,191,207,232],"EEG":[62,124,208],"polysomnography":[64,165],"recordings":[65],"acquired":[67],"18F-MK6240":[68,134,168,255,270],"PET-MR":[70],"three":[72],"patients":[73,84,182],"prodromal":[76],"stage":[77,342],"two":[83,196],"mild":[86],"moderate":[88],"dementia":[89],"due":[90],"to":[91,157,253],"disease,":[93],"respectively.":[94],"As":[95],"an":[96],"eligibility":[97],"criterion":[98],"present":[101,176],"study,":[102],"subjects":[103],"either":[104],"had":[105],"history":[107],"recent":[110],"seizure":[111],"(n":[112,130],"=":[113,131,281,288,346,350,354,358,368,373,380],"2)":[114],"or":[115,375],"subclinical":[116],"(SEA)":[119],"previous":[122],"taken":[125],"research":[128],"context":[129],"3).":[132],"The":[133,326],"standard":[135],"uptake":[136],"value":[137],"ratio":[138],"(SUVR)":[139],"asymmetry":[141,267],"index":[142,366,371,378],"(AI)":[143],"were":[144,155,187,199,294],"calculated":[145],"priori-defined":[148],"volumes":[149,260],"interest.":[151],"Linear":[152],"mixed-effects":[153],"models":[154],"used":[156],"study":[158],"associations":[159],"interictal":[161],"discharges":[163,219],"(IEDs),":[164],"parameters":[166],"SUVR.":[169],"Epileptiform":[170],"was":[172,250,264,332],"bilateral":[173],"but":[174],"asymmetrically":[175],"FO":[178,202,226],"electrodes":[179,227,235,249,293],"all":[181],"\u226595%":[184],"IEDs":[186,246,290,329],"not":[188,251,333,361],"visible":[189],"EEG.":[192],"In":[193],"one":[194],"patient,":[195],"focal":[197],"seizures":[198],"detected":[200],"electrodes,":[203],"both":[204],"without":[205],"visual":[206],"correlate.":[209],"We":[210],"observed":[211],"lateralized":[212,221],"periodic":[213],"discharges,":[214],"brief":[215],"potentially":[216],"ictal":[217],"rhythmic":[218,222],"delta":[223],"four":[229],"patients.":[230],"Unlike":[231],"EEG,":[233],"intracranial":[234,248,292],"showed":[236],"lateralization":[238],"activity.":[241],"Although":[242],"amount":[244],"SUVR":[256],"binding":[257,271],"different":[259],"interest,":[262],"there":[263],"congruent":[266],"towards":[272],"most":[274,295],"epileptic":[275],"hemisphere":[276],"mesial":[279],"(P":[280,287,345,349,353,357,367,372,379],"0.007)":[282],"lateral":[284],"temporal":[285],"cortex":[286],"0.006).":[289],"abundant":[296],"during":[297,319,330],"slow":[298],"wave":[299],"(SWS)":[301],"(92/h)":[302],"non-REM":[304,311],"2":[306],"(N2,":[307],"81/h),":[308],"followed":[309],"by":[310],"1":[313],"(N1,":[314],"33/h)":[315],"least":[317],"frequent":[318],"wakefulness":[320],"(17/h)":[321],"REM":[323],"(9/h).":[325],"extent":[327],"reflected":[334],"relative":[337],"time":[338],"each":[340],"spent":[343],"[REM%":[344],"0.415),":[347],"N1%":[348],"0.668),":[351],"N2%":[352],"0.442),":[355],"SWS%":[356],"0.988)],":[359],"arousal":[365],"0.317),":[369],"apnoea-hypopnoea":[370],"0.846)":[374],"oxygen":[376],"desaturation":[377],"0.746).":[381],"Together,":[382],"our":[383],"observations":[384],"suggest":[385],"multi-directional":[387],"interaction":[388],"sleep,":[390]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2024-07-13T00:00:00"}
