{"id":"https://openalex.org/W4400580910","doi":"https://doi.org/10.1093/toxsci/kfae090","title":"Insights into brominated flame retardant neurotoxicity: mechanisms of hippocampal neural cell death and brain region-specific transcriptomic shifts in mice","display_name":"Insights into brominated flame retardant neurotoxicity: mechanisms of hippocampal neural cell death and brain region-specific transcriptomic shifts in mice","publication_year":2024,"publication_date":"2024-07-12","ids":{"openalex":"https://openalex.org/W4400580910","doi":"https://doi.org/10.1093/toxsci/kfae090","pmid":"https://pubmed.ncbi.nlm.nih.gov/38995820"},"language":"en","primary_location":{"id":"doi:10.1093/toxsci/kfae090","doi":"https://doi.org/10.1093/toxsci/kfae090","is_oa":true,"landing_page_url":"https://doi.org/10.1093/toxsci/kfae090","pdf_url":"https://academic.oup.com/toxsci/advance-article-pdf/doi/10.1093/toxsci/kfae090/58530642/kfae090.pdf","source":{"id":"https://openalex.org/S186282544","display_name":"Toxicological Sciences","issn_l":"1096-0929","issn":["1096-0929","1096-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicological Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/toxsci/advance-article-pdf/doi/10.1093/toxsci/kfae090/58530642/kfae090.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Naomi E Kramer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naomi E Kramer","raw_affiliation_strings":["Department of Pharmaceutical and Biomedical Sciences, University of Georgia , Athens, GA 30602,","Interdisciplinary Toxicology Program, University of Georgia , Athens, GA 30602,","Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, GA 30602, USA","Interdisciplinary Toxicology Program, University of Georgia, Athens, GA 30602, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical and Biomedical Sciences, University of Georgia , Athens, GA 30602,","institution_ids":["https://openalex.org/I165733156"]},{"raw_affiliation_string":"Interdisciplinary Toxicology Program, University of Georgia , Athens, GA 30602,","institution_ids":["https://openalex.org/I165733156"]},{"raw_affiliation_string":"Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, GA 30602, USA","institution_ids":["https://openalex.org/I165733156"]},{"raw_affiliation_string":"Interdisciplinary Toxicology Program, University of Georgia, Athens, GA 30602, USA","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104423262","display_name":"Courtney E Fillmore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12311892","display_name":"Eugene Applebaum College of Pharmacy and Health Sciences","ror":"https://ror.org/0222p1e69","country_code":"US","type":"education","lineage":["https://openalex.org/I12311892"]},{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Courtney E Fillmore","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University , Detroit, MI 48201,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University , Detroit, MI 48201,","institution_ids":["https://openalex.org/I12311892","https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094040664","display_name":"Elizabeth G. Slane","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12311892","display_name":"Eugene Applebaum College of Pharmacy and Health Sciences","ror":"https://ror.org/0222p1e69","country_code":"US","type":"education","lineage":["https://openalex.org/I12311892"]},{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth G Slane","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University , Detroit, MI 48201,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University , Detroit, MI 48201,","institution_ids":["https://openalex.org/I12311892","https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040982083","display_name":"Lillie Marie A. Barnett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lillie M A Barnett","raw_affiliation_strings":["Interdisciplinary Toxicology Program, University of Georgia , Athens, GA 30602,","Interdisciplinary Toxicology Program, University of Georgia, Athens, GA 30602, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdisciplinary Toxicology Program, University of Georgia , Athens, GA 30602,","institution_ids":["https://openalex.org/I165733156"]},{"raw_affiliation_string":"Interdisciplinary Toxicology Program, University of Georgia, Athens, GA 30602, USA","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027521470","display_name":"John J. Wagner","orcid":"https://orcid.org/0000-0002-2552-3727","observed_orcids":["https://orcid.org/0000-0002-2552-3727"]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John J Wagner","raw_affiliation_strings":["Department of Physiology and Pharmacology, University of Georgia , Athens, GA 30602,","Interdisciplinary Toxicology Program, University of Georgia , Athens, GA 30602,","Department of Physiology and Pharmacology, University of Georgia, Athens GA 30602, USA","Interdisciplinary Toxicology Program, University of Georgia, Athens, GA 30602, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, University of Georgia , Athens, GA 30602,","institution_ids":["https://openalex.org/I165733156"]},{"raw_affiliation_string":"Interdisciplinary Toxicology Program, University of Georgia , Athens, GA 30602,","institution_ids":["https://openalex.org/I165733156"]},{"raw_affiliation_string":"Department of Physiology and Pharmacology, University of Georgia, Athens GA 30602, USA","institution_ids":["https://openalex.org/I165733156"]},{"raw_affiliation_string":"Interdisciplinary Toxicology Program, University of Georgia, Athens, GA 30602, USA","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033980467","display_name":"Brian S. Cummings","orcid":"https://orcid.org/0000-0001-5388-9390","observed_orcids":["https://orcid.org/0000-0001-5388-9390"]},"institutions":[{"id":"https://openalex.org/I12311892","display_name":"Eugene Applebaum College of Pharmacy and Health Sciences","ror":"https://ror.org/0222p1e69","country_code":"US","type":"education","lineage":["https://openalex.org/I12311892"]},{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]},{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Brian S Cummings","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University , Detroit, MI 48201,","Department of Pharmaceutical and Biomedical Sciences, University of Georgia , Athens, GA 30602,","Interdisciplinary Toxicology Program, University of Georgia , Athens, GA 30602,","Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, GA 30602, USA","Interdisciplinary Toxicology Program, University of Georgia, Athens, GA 30602, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University , Detroit, MI 48201,","institution_ids":["https://openalex.org/I12311892","https://openalex.org/I185443292"]},{"raw_affiliation_string":"Department of Pharmaceutical and Biomedical Sciences, University of Georgia , Athens, GA 30602,","institution_ids":["https://openalex.org/I165733156"]},{"raw_affiliation_string":"Interdisciplinary Toxicology Program, University of Georgia , Athens, GA 30602,","institution_ids":["https://openalex.org/I165733156"]},{"raw_affiliation_string":"Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, GA 30602, USA","institution_ids":["https://openalex.org/I165733156"]},{"raw_affiliation_string":"Interdisciplinary Toxicology Program, University of Georgia, Athens, GA 30602, USA","institution_ids":["https://openalex.org/I165733156"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5033980467"],"corresponding_institution_ids":["https://openalex.org/I12311892","https://openalex.org/I165733156","https://openalex.org/I185443292"],"apc_list":{"value":4858,"currency":"USD","value_usd":4858},"apc_paid":null,"fwci":0.7057,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.60910595,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"201","issue":"2","first_page":"282","last_page":"299"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11869","display_name":"Per- and polyfluoroalkyl substances research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11360","display_name":"Flame retardant materials and properties","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2507","display_name":"Polymers and Plastics"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brominated-flame-retardants","display_name":"brominated flame retardants","score":1.0},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.871999979019165},{"id":"https://openalex.org/keywords/hippocampal-cell-death","display_name":"hippocampal cell death","score":0.7429999709129333},{"id":"https://openalex.org/keywords/hexabromocyclododecane","display_name":"hexabromocyclododecane","score":0.984000027179718},{"id":"https://openalex.org/keywords/tetrabromobisphenol-a","display_name":"tetrabromobisphenol A","score":0.9350000023841858},{"id":"https://openalex.org/keywords/bde-47","display_name":"BDE-47","score":0.9710000157356262},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.8870000243186951},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.890999972820282},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.8669999837875366},{"id":"https://openalex.org/keywords/snap29","display_name":"SNAP29","score":0.6980000138282776},{"id":"https://openalex.org/keywords/vesicular-trafficking","display_name":"vesicle trafficking","score":0.902999997138977},{"id":"https://openalex.org/keywords/dorsal-striatum","display_name":"dorsal striatum","score":0.9120000004768372},{"id":"https://openalex.org/keywords/frontal-cortex","display_name":"frontal cortex","score":0.996999979019165},{"id":"https://openalex.org/keywords/ht22-cells","display_name":"HT22 cells","score":0.890999972820282},{"id":"https://openalex.org/keywords/3-methyladenine","display_name":"3-methyladenine","score":0.8980000019073486}],"concepts":[{"id":"https://openalex.org/C2780542059","wikidata":"https://www.wikidata.org/wiki/Q420301","display_name":"Hexabromocyclododecane","level":3,"score":0.6939209699630737},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5517327189445496},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.5442819595336914},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.5161174535751343},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4765898883342743},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.4752733111381531},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4750511646270752},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40023714303970337},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.22150307893753052},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.20243936777114868},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19672217965126038},{"id":"https://openalex.org/C205474432","wikidata":"https://www.wikidata.org/wiki/Q1354051","display_name":"Fire retardant","level":2,"score":0.16185703873634338},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.10999792814254761},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005411","descriptor_name":"Flame Retardants","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006842","descriptor_name":"Hydrocarbons, Brominated","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011075","descriptor_name":"Polybrominated Biphenyls","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020258","descriptor_name":"Neurotoxicity Syndromes","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D020258","descriptor_name":"Neurotoxicity Syndromes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020258","descriptor_name":"Neurotoxicity Syndromes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055768","descriptor_name":"Halogenated Diphenyl Ethers","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/toxsci/kfae090","doi":"https://doi.org/10.1093/toxsci/kfae090","is_oa":true,"landing_page_url":"https://doi.org/10.1093/toxsci/kfae090","pdf_url":"https://academic.oup.com/toxsci/advance-article-pdf/doi/10.1093/toxsci/kfae090/58530642/kfae090.pdf","source":{"id":"https://openalex.org/S186282544","display_name":"Toxicological Sciences","issn_l":"1096-0929","issn":["1096-0929","1096-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicological Sciences","raw_type":"journal-article"},{"id":"pmid:38995820","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38995820","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicological sciences : an official journal of the Society of Toxicology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/toxsci/kfae090","doi":"https://doi.org/10.1093/toxsci/kfae090","is_oa":true,"landing_page_url":"https://doi.org/10.1093/toxsci/kfae090","pdf_url":"https://academic.oup.com/toxsci/advance-article-pdf/doi/10.1093/toxsci/kfae090/58530642/kfae090.pdf","source":{"id":"https://openalex.org/S186282544","display_name":"Toxicological Sciences","issn_l":"1096-0929","issn":["1096-0929","1096-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicological Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7599999904632568}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4400580910.pdf","grobid_xml":"https://content.openalex.org/works/W4400580910.grobid-xml"},"referenced_works_count":86,"referenced_works":["https://openalex.org/W115538672","https://openalex.org/W803678408","https://openalex.org/W1243475629","https://openalex.org/W1537800061","https://openalex.org/W1560020441","https://openalex.org/W1617495083","https://openalex.org/W1883584254","https://openalex.org/W1920097203","https://openalex.org/W1974319047","https://openalex.org/W1977083155","https://openalex.org/W1979359901","https://openalex.org/W1997235708","https://openalex.org/W2003743209","https://openalex.org/W2029026381","https://openalex.org/W2030066250","https://openalex.org/W2036594407","https://openalex.org/W2036897871","https://openalex.org/W2042896209","https://openalex.org/W2045227278","https://openalex.org/W2051005796","https://openalex.org/W2053003157","https://openalex.org/W2066088304","https://openalex.org/W2067556951","https://openalex.org/W2069787673","https://openalex.org/W2070050178","https://openalex.org/W2075748018","https://openalex.org/W2083693788","https://openalex.org/W2085099837","https://openalex.org/W2086223566","https://openalex.org/W2101582633","https://openalex.org/W2103379588","https://openalex.org/W2104992683","https://openalex.org/W2113571738","https://openalex.org/W2128816326","https://openalex.org/W2137586531","https://openalex.org/W2138207763","https://openalex.org/W2148357765","https://openalex.org/W2152248981","https://openalex.org/W2157660552","https://openalex.org/W2161467578","https://openalex.org/W2165080592","https://openalex.org/W2169603142","https://openalex.org/W2179438025","https://openalex.org/W2273340604","https://openalex.org/W2345356016","https://openalex.org/W2415781557","https://openalex.org/W2469425187","https://openalex.org/W2583470687","https://openalex.org/W2615569167","https://openalex.org/W2617495579","https://openalex.org/W2621147070","https://openalex.org/W2743038351","https://openalex.org/W2747147878","https://openalex.org/W2763703940","https://openalex.org/W2768319432","https://openalex.org/W2803179488","https://openalex.org/W2906602807","https://openalex.org/W2928665623","https://openalex.org/W2944447368","https://openalex.org/W2946400355","https://openalex.org/W2951470165","https://openalex.org/W2951990413","https://openalex.org/W2955500279","https://openalex.org/W2957848130","https://openalex.org/W2990736321","https://openalex.org/W2991178209","https://openalex.org/W2997053648","https://openalex.org/W3000260620","https://openalex.org/W3013353708","https://openalex.org/W3014019516","https://openalex.org/W3033632802","https://openalex.org/W3043204472","https://openalex.org/W3069274510","https://openalex.org/W3114969297","https://openalex.org/W3124330079","https://openalex.org/W3145969289","https://openalex.org/W3158043581","https://openalex.org/W3191078927","https://openalex.org/W4211019701","https://openalex.org/W4213444618","https://openalex.org/W4226051960","https://openalex.org/W4229875191","https://openalex.org/W4291020742","https://openalex.org/W4297474373","https://openalex.org/W4313367944","https://openalex.org/W4383621583"],"related_works":["https://openalex.org/W4377020906","https://openalex.org/W3168219275","https://openalex.org/W763610814","https://openalex.org/W7099511914","https://openalex.org/W4291020742","https://openalex.org/W2030066250","https://openalex.org/W3200562133","https://openalex.org/W3016402342","https://openalex.org/W3043520316","https://openalex.org/W2396289202"],"abstract_inverted_index":{"Brominated":[0],"flame":[1,85],"retardants":[2],"(BFRs)":[3],"reduce":[4],"flammability":[5],"in":[6,24,39,53,67,101,112,117,226,236,244,257,260,273,279],"a":[7],"wide":[8],"range":[9],"of":[10,60,75,79,131,188,199,277],"products":[11],"including":[12,37,87],"electronics,":[13],"carpets,":[14],"and":[15,41,56,72,104,107,115,126,148,157,173,176,211,218,262,270],"paint,":[16],"but":[17,232],"leach":[18],"into":[19],"the":[20,46,58,68,179,208,216,237,245,274],"environment":[21],"to":[22,83],"result":[23],"continuous,":[25],"population-level":[26],"exposure.":[27],"Epidemiology":[28],"studies":[29],"have":[30],"correlated":[31],"BFR":[32,152,168],"exposure":[33,63,153,169],"with":[34,178,204,215],"neurological":[35],"problems,":[36],"alterations":[38,111],"learning":[40],"memory.":[42],"This":[43],"study":[44],"investigated":[45],"molecular":[47],"mechanisms":[48],"mediating":[49,161,201],"BFR-induced":[50],"cell":[51,113,140,227],"death":[52,228],"hippocampal":[54],"cells":[55,82,259],"clarified":[57],"impact":[59,206],"hexabromocyclododecane":[61],"(HBCD)":[62],"on":[64,207],"gene":[65],"transcription":[66],"hippocampus,":[69],"dorsal":[70,212,217,246],"striatum,":[71],"frontal":[73,209],"cortex":[74,210],"male":[76,195],"mice.":[77],"Exposure":[78],"hippocampus-derived":[80],"HT-22":[81],"various":[84],"retardants,":[86],"tetrabromobisphenol-A":[88],"(current":[89],"use),":[90],"HBCD":[91,156],"(phasing":[92],"out),":[93],"or":[94,229],"2,2',4,4'-tetrabromodiphenyl":[95],"ether":[96],"(BDE-47,":[97],"phased":[98],"out)":[99],"resulted":[100],"time,":[102],"concentration,":[103],"chemical-dependent":[105,255],"cellular":[106],"nuclear":[108,133],"morphology":[109],"alterations,":[110],"cycle":[114],"increases":[116,225,235],"annexin":[118],"V":[119],"staining.":[120],"All":[121],"3":[122],"BFRs":[123,252,266],"increased":[124,170],"p53":[125,132],"p21":[127],"expression;":[128],"however,":[129],"inhibition":[130],"translocation":[134],"using":[135],"pifthrin-\u03b1":[136],"did":[137,233],"not":[138],"decrease":[139],"death.":[141],"Transcriptomic":[142,186],"analysis":[143,222],"upon":[144],"low":[145],"(10":[146,150],"nM)":[147],"cytotoxic":[149],"\u03bcM)":[151],"indicated":[154],"that":[155,167,251,265],"BDE-47":[158],"altered":[159],"genes":[160,200],"autophagy-related":[162],"pathways.":[163],"Further":[164],"evaluation":[165],"showed":[166],"LC3-II":[171],"conversion":[172],"autophagosome/autolysosome":[174],"formation,":[175],"co-exposure":[177],"autophagy":[180,230,256],"inhibitor":[181],"3-methyladenine":[182],"(3-MA)":[183],"attenuated":[184],"cytotoxicity.":[185],"assessment":[187],"select":[189],"brain":[190,275],"regions":[191],"from":[192],"subchronically":[193],"HBCD-exposed":[194],"mice":[196],"demonstrated":[197,223],"alteration":[198],"vesicular":[202,280],"transport,":[203],"greater":[205],"striatum":[213],"compared":[214],"ventral":[219],"hippocampus.":[220,247],"Immunoblot":[221],"no":[224],"markers,":[231],"demonstrate":[234,250],"SNARE":[238],"binding":[239],"complex":[240],"protein":[241,271],"SNAP29,":[242],"specifically":[243],"These":[248],"data":[249],"can":[253],"induce":[254,267],"neural":[258],"vitro":[261],"provide":[263],"evidence":[264],"region-specific":[268],"transcriptomic":[269],"expression":[272],"suggestive":[276],"changes":[278],"trafficking.":[281]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-07-13T00:00:00"}