{"id":"https://openalex.org/W4400568934","doi":"https://doi.org/10.1002/ctd2.329","title":"Gastric cancer detection based on cell\u2010free DNA in blood: A systematic review and meta\u2010analysis","display_name":"Gastric cancer detection based on cell\u2010free DNA in blood: A systematic review and meta\u2010analysis","publication_year":2024,"publication_date":"2024-07-10","ids":{"openalex":"https://openalex.org/W4400568934","doi":"https://doi.org/10.1002/ctd2.329"},"language":"en","primary_location":{"id":"doi:10.1002/ctd2.329","doi":"https://doi.org/10.1002/ctd2.329","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ctd2.329","pdf_url":null,"source":{"id":"https://openalex.org/S4210181638","display_name":"Clinical and Translational Discovery","issn_l":"2768-0622","issn":["2768-0622"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Discovery","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1002/ctd2.329","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060977752","display_name":"Mona Wang","orcid":"https://orcid.org/0009-0005-8019-1461","observed_orcids":["https://orcid.org/0009-0005-8019-1461"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["CN","DE"],"is_corresponding":false,"raw_author_name":"Mona Wang","raw_affiliation_strings":["PYLOTUM Key Joint Laboratory for Upper GI Cancer Peking University Cancer Hospital & Institute Beijing China","PYLOTUM Key Joint Laboratory for Upper GI Cancer, Technical University of Munich, Munich, Germany","TUM School of Medicine and Health, Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Munich, Germany"],"raw_orcid":"https://orcid.org/0009-0005-8019-1461","affiliations":[{"raw_affiliation_string":"PYLOTUM Key Joint Laboratory for Upper GI Cancer Peking University Cancer Hospital & Institute Beijing China","institution_ids":["https://openalex.org/I4210093964"]},{"raw_affiliation_string":"PYLOTUM Key Joint Laboratory for Upper GI Cancer, Technical University of Munich, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"TUM School of Medicine and Health, Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059694740","display_name":"Xiaohan Fan","orcid":"https://orcid.org/0000-0003-2325-3839","observed_orcids":["https://orcid.org/0000-0003-2325-3839"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]},{"id":"https://openalex.org/I4210130930","display_name":"Peking University First Hospital","ror":"https://ror.org/02z1vqm45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210130930"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["CN","DE"],"is_corresponding":false,"raw_author_name":"Xiaohan Fan","raw_affiliation_strings":["Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Cancer Epidemiology Peking University Cancer Hospital & Institute Beijing China","PYLOTUM Key Joint Laboratory for Upper GI Cancer Peking University Cancer Hospital & Institute Beijing China","PYLOTUM Key Joint Laboratory for Upper GI Cancer, Technical University of Munich, Munich, Germany","Scientific Research Department, Peking University First Hospital, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Cancer Epidemiology Peking University Cancer Hospital & Institute Beijing China","institution_ids":["https://openalex.org/I4210093964"]},{"raw_affiliation_string":"PYLOTUM Key Joint Laboratory for Upper GI Cancer Peking University Cancer Hospital & Institute Beijing China","institution_ids":["https://openalex.org/I4210093964"]},{"raw_affiliation_string":"PYLOTUM Key Joint Laboratory for Upper GI Cancer, Technical University of Munich, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Scientific Research Department, Peking University First Hospital, Beijing, China","institution_ids":["https://openalex.org/I4210130930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101899424","display_name":"Boyang Huang","orcid":"https://orcid.org/0009-0004-0467-0869","observed_orcids":["https://orcid.org/0009-0004-0467-0869","https://orcid.org/0000-0002-2077-608X"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["CN","DE"],"is_corresponding":false,"raw_author_name":"Boyang Huang","raw_affiliation_strings":["PYLOTUM Key Joint Laboratory for Upper GI Cancer Peking University Cancer Hospital & Institute Beijing China","PYLOTUM Key Joint Laboratory for Upper GI Cancer, Technical University of Munich, Munich, Germany","TUM School of Medicine and Health, Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PYLOTUM Key Joint Laboratory for Upper GI Cancer Peking University Cancer Hospital & Institute Beijing China","institution_ids":["https://openalex.org/I4210093964"]},{"raw_affiliation_string":"PYLOTUM Key Joint Laboratory for Upper GI Cancer, Technical University of Munich, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"TUM School of Medicine and Health, Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080681893","display_name":"Kai\u2010Feng Pan","orcid":"https://orcid.org/0000-0002-3680-3126","observed_orcids":["https://orcid.org/0000-0002-3680-3126"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["CN","DE"],"is_corresponding":false,"raw_author_name":"Kaifeng Pan","raw_affiliation_strings":["PYLOTUM Key Joint Laboratory for Upper GI Cancer Peking University Cancer Hospital & Institute Beijing China","PYLOTUM Key Joint Laboratory for Upper GI Cancer, Technical University of Munich, Munich, Germany","State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute, Beijing, China. Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PYLOTUM Key Joint Laboratory for Upper GI Cancer Peking University Cancer Hospital & Institute Beijing China","institution_ids":["https://openalex.org/I4210093964"]},{"raw_affiliation_string":"PYLOTUM Key Joint Laboratory for Upper GI Cancer, Technical University of Munich, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute, Beijing, China. Beijing China","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027763220","display_name":"Markus Gerhard","orcid":"https://orcid.org/0000-0001-9110-3950","observed_orcids":["https://orcid.org/0000-0001-9110-3950"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["CN","DE"],"is_corresponding":false,"raw_author_name":"Markus Gerhard","raw_affiliation_strings":["PYLOTUM Key Joint Laboratory for Upper GI Cancer Peking University Cancer Hospital & Institute Beijing China","PYLOTUM Key Joint Laboratory for Upper GI Cancer, Technical University of Munich, Munich, Germany","TUM School of Medicine and Health, Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PYLOTUM Key Joint Laboratory for Upper GI Cancer Peking University Cancer Hospital & Institute Beijing China","institution_ids":["https://openalex.org/I4210093964"]},{"raw_affiliation_string":"PYLOTUM Key Joint Laboratory for Upper GI Cancer, Technical University of Munich, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"TUM School of Medicine and Health, Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039847078","display_name":"Raquel Mej\u00edas\u2010Luque","orcid":"https://orcid.org/0000-0002-4602-4927","observed_orcids":["https://orcid.org/0000-0002-4602-4927"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["CN","DE"],"is_corresponding":true,"raw_author_name":"Raquel Mej\u00edas\u2010Luque","raw_affiliation_strings":["PYLOTUM Key Joint Laboratory for Upper GI Cancer Peking University Cancer Hospital & Institute Beijing China","PYLOTUM Key Joint Laboratory for Upper GI Cancer, Technical University of Munich, Munich, Germany","TUM School of Medicine and Health, Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PYLOTUM Key Joint Laboratory for Upper GI Cancer Peking University Cancer Hospital & Institute Beijing China","institution_ids":["https://openalex.org/I4210093964"]},{"raw_affiliation_string":"PYLOTUM Key Joint Laboratory for Upper GI Cancer, Technical University of Munich, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"TUM School of Medicine and Health, Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5117634646","display_name":"Yang Zhang","orcid":"https://orcid.org/0000-0002-9081-0802","observed_orcids":["https://orcid.org/0000-0002-9081-0802"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["CN","DE"],"is_corresponding":true,"raw_author_name":"Yang Zhang","raw_affiliation_strings":["Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Cancer Epidemiology Peking University Cancer Hospital & Institute Beijing China","PYLOTUM Key Joint Laboratory for Upper GI Cancer Peking University Cancer Hospital & Institute Beijing China","PYLOTUM Key Joint Laboratory for Upper GI Cancer, Technical University of Munich, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Cancer Epidemiology Peking University Cancer Hospital & Institute Beijing China","institution_ids":["https://openalex.org/I4210093964"]},{"raw_affiliation_string":"PYLOTUM Key Joint Laboratory for Upper GI Cancer Peking University Cancer Hospital & Institute Beijing China","institution_ids":["https://openalex.org/I4210093964"]},{"raw_affiliation_string":"PYLOTUM Key Joint Laboratory for Upper GI Cancer, Technical University of Munich, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5039847078","https://openalex.org/A5117634646"],"corresponding_institution_ids":["https://openalex.org/I4210093964","https://openalex.org/I62916508"],"apc_list":{"value":2420,"currency":"USD","value_usd":2420},"apc_paid":{"value":2420,"currency":"USD","value_usd":2420},"fwci":0.0373,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.03844042,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"4","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9146000146865845,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9146000146865845,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.03530000150203705,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":1.0},{"id":"https://openalex.org/keywords/cell-free-dna","display_name":"cell-free DNA","score":0.8360000252723694},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.7609999775886536},{"id":"https://openalex.org/keywords/early-cancer-detection","display_name":"early cancer detection","score":0.8180000185966492},{"id":"https://openalex.org/keywords/tumor-screening","display_name":"cancer screening","score":0.828000009059906},{"id":"https://openalex.org/keywords/cfdna-concentration","display_name":"cfDNA concentration","score":0.7990000247955322},{"id":"https://openalex.org/keywords/dna-methylation-markers","display_name":"DNA methylation biomarkers","score":0.8659999966621399},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.7519999742507935},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"diagnostic accuracy","score":0.8830000162124634},{"id":"https://openalex.org/keywords/minimally-invasive-diagnostics","display_name":"minimally invasive diagnosis","score":0.7509999871253967}],"concepts":[{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.8223630785942078},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.6703857779502869},{"id":"https://openalex.org/C2776478404","wikidata":"https://www.wikidata.org/wiki/Q1105187","display_name":"Cochrane Library","level":3,"score":0.6272357106208801},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5790917277336121},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5703021287918091},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5070068836212158},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.5008277893066406},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.48410165309906006},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44790905714035034},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.42479246854782104},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.424124538898468},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.3796725869178772},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32140883803367615},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.209692120552063},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09520286321640015},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08673357963562012},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1002/ctd2.329","doi":"https://doi.org/10.1002/ctd2.329","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ctd2.329","pdf_url":null,"source":{"id":"https://openalex.org/S4210181638","display_name":"Clinical and Translational Discovery","issn_l":"2768-0622","issn":["2768-0622"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Discovery","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:1d509c8ca41849c99ce2b326dee93e3d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1d509c8ca41849c99ce2b326dee93e3d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical and Translational Discovery, Vol 4, Iss 4, Pp n/a-n/a (2024)","raw_type":"article"},{"id":"pmh:oai:mediatum.ub.tum.de:node/1761429","doi":null,"is_oa":true,"landing_page_url":"https://mediatum.ub.tum.de/1761429","pdf_url":null,"source":{"id":"https://openalex.org/S4306400453","display_name":"mediaTUM \u2013 the media and publications repository of the Technical University Munich (Technical University Munich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62916508","host_organization_name":"Technical University of Munich","host_organization_lineage":["https://openalex.org/I62916508"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/ctd2.329","doi":"https://doi.org/10.1002/ctd2.329","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ctd2.329","pdf_url":null,"source":{"id":"https://openalex.org/S4210181638","display_name":"Clinical and Translational Discovery","issn_l":"2768-0622","issn":["2768-0622"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Discovery","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[{"id":"https://openalex.org/G5301159991","display_name":null,"funder_award_id":"81861138041","funder_id":"https://openalex.org/F4320336809","funder_display_name":"Joint Fund to Promote Cross-Straits Scientific and Technological Cooperation"},{"id":"https://openalex.org/G5515251136","display_name":null,"funder_award_id":"GE 2042_13\u20101","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320336809","display_name":"Joint Fund to Promote Cross-Straits Scientific and Technological Cooperation","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1849446486","https://openalex.org/W2003019456","https://openalex.org/W2055539669","https://openalex.org/W2057741550","https://openalex.org/W2067963606","https://openalex.org/W2093715546","https://openalex.org/W2107638293","https://openalex.org/W2140151329","https://openalex.org/W2179608879","https://openalex.org/W2216019077","https://openalex.org/W2284296152","https://openalex.org/W2578418759","https://openalex.org/W2608738563","https://openalex.org/W2747939174","https://openalex.org/W2783674487","https://openalex.org/W2790011499","https://openalex.org/W2883303482","https://openalex.org/W2890545987","https://openalex.org/W2897177558","https://openalex.org/W2917102036","https://openalex.org/W2944752144","https://openalex.org/W2947989913","https://openalex.org/W2950682268","https://openalex.org/W3013591901","https://openalex.org/W3013647689","https://openalex.org/W3044049599","https://openalex.org/W3102998479","https://openalex.org/W3128646645","https://openalex.org/W3196756026","https://openalex.org/W3207824529","https://openalex.org/W3213673750","https://openalex.org/W4205532841","https://openalex.org/W4225308808","https://openalex.org/W4315754639","https://openalex.org/W4387661052"],"related_works":["https://openalex.org/W4410816446","https://openalex.org/W4393905367","https://openalex.org/W4400931927","https://openalex.org/W3096131146","https://openalex.org/W2981318739","https://openalex.org/W4394741347","https://openalex.org/W2216019077","https://openalex.org/W4386888628","https://openalex.org/W3106552829","https://openalex.org/W2341114501"],"abstract_inverted_index":{"Abstract":[0],"Objective":[1],"Screening":[2],"and":[3,29,52,71,89,148,170,183,186,193,206],"early":[4,222],"diagnosis":[5],"of":[6,34,46,59,67,80,87,105,116,126,154,167,203],"gastric":[7],"cancer":[8],"(GC)":[9],"are":[10],"crucial":[11],"for":[12,44,62,92,101,220],"improved":[13],"prognosis.":[14],"However,":[15],"gastroscopic":[16],"screening":[17,45],"is":[18],"not":[19],"feasible":[20],"in":[21,135],"large":[22],"populations":[23],"due":[24],"to":[25,112],"its":[26],"high":[27],"cost":[28],"invasive":[30],"nature.":[31],"The":[32,98],"detection":[33,66],"circulating":[35],"cell\u2010free":[36],"DNA":[37],"(cfDNA)":[38],"provides":[39],"an":[40],"attractive":[41],"minimally\u2010invasive":[42],"alternative":[43],"GC.":[47],"In":[48],"this":[49,136],"systematic":[50,78],"review":[51],"meta\u2010analysis,":[53,137],"we":[54],"evaluate":[55,113],"the":[56,65,102,114,165,173,187,200],"diagnostic":[57,218],"value":[58,219],"cfDNA\u2010based":[60,215],"markers":[61],"GC,":[63,172],"including":[64],"total":[68,125],"concentration,":[69,142],"mutations,":[70],"methylation":[72,146],"alterations.":[73],"Methods":[74],"We":[75],"performed":[76],"a":[77],"search":[79],"four":[81],"literature":[82],"databases":[83],"(PubMed,":[84],"Embase,":[85],"Web":[86],"Science,":[88],"Cochrane":[90],"Library)":[91],"articles":[93,129],"published":[94],"before":[95],"November":[96],"2022.":[97],"revised":[99],"tool":[100],"Quality":[103],"Assessment":[104],"Diagnostic":[106],"Accuracy":[107],"Studies":[108],"(QUADAS\u20102)":[109],"was":[110],"used":[111],"quality":[115],"included":[117,134],"studies.":[118],"PROSPERO":[119],"registration":[120],"number:":[121],"CRD42021210830.":[122],"Results":[123],"A":[124],"15":[127],"original":[128],"involving":[130],"2849":[131],"individuals":[132],"were":[133,180,190],"comprising":[138],"five":[139],"studies":[140,144],"on":[141,145,151],"nine":[143],"alterations,":[147],"one":[149],"study":[150],"mutation":[152],"biomarkers":[153,216],"cfDNA.":[155],"Among":[156],"these":[157],"studies,":[158],"seven":[159],"selected":[160],"early\u2010stage":[161,171],"GC":[162,221],"subjects.":[163],"For":[164],"diagnoses":[166],"overall":[168],"stages":[169],"pooled":[174,188],"sensitivities":[175],"with":[176,196],"95%":[177],"confidence":[178],"interval":[179],"0.74":[181],"(0.66\u20130.82)":[182],"0.64":[184],"(0.51\u20130.76),":[185],"specificities":[189],"0.92":[191],"(0.84\u20130.96)":[192],"0.94":[194],"(0.87\u20130.98)":[195],"summary":[197],"areas":[198],"under":[199],"curve":[201],"(SAUCs)":[202],"0.89":[204],"(0.86\u20130.91)":[205],"0.86":[207],"(0.83\u20130.89),":[208],"respectively.":[209],"Conclusions":[210],"This":[211],"meta\u2010analysis":[212],"suggests":[213],"that":[214],"show":[217],"detection.":[223]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-07-12T00:00:00"}
