{"id":"https://openalex.org/W4400548263","doi":"https://doi.org/10.1038/s41598-024-67108-4","title":"Serum microRNAs as new biomarkers for detecting subclinical hemolysis in the nonacute phase of G6PD deficiency","display_name":"Serum microRNAs as new biomarkers for detecting subclinical hemolysis in the nonacute phase of G6PD deficiency","publication_year":2024,"publication_date":"2024-07-11","ids":{"openalex":"https://openalex.org/W4400548263","doi":"https://doi.org/10.1038/s41598-024-67108-4","pmid":"https://pubmed.ncbi.nlm.nih.gov/38992151","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11239928"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-024-67108-4","doi":"https://doi.org/10.1038/s41598-024-67108-4","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1038/s41598-024-67108-4","pdf_url":null,"source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1038/s41598-024-67108-4","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061561320","display_name":"Kanyarat Boonpeng","orcid":"https://orcid.org/0000-0003-1250-8568","observed_orcids":["https://orcid.org/0000-0003-1250-8568"]},"institutions":[{"id":"https://openalex.org/I158708052","display_name":"Chulalongkorn University","ror":"https://ror.org/028wp3y58","country_code":"TH","type":"education","lineage":["https://openalex.org/I158708052"]},{"id":"https://openalex.org/I79072001","display_name":"International University of Health and Welfare","ror":"https://ror.org/053d3tv41","country_code":"JP","type":"education","lineage":["https://openalex.org/I79072001"]}],"countries":["JP","TH"],"is_corresponding":false,"raw_author_name":"Kanyarat Boonpeng","raw_affiliation_strings":["Graduate School, Department of Medical Technology and Sciences, International University of Health and Welfare, 137-1 Enokizu, Okawa, 831-8501, Japan","Program in Clinical Hematology Sciences, Department of Clinical Microscopy, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School, Department of Medical Technology and Sciences, International University of Health and Welfare, 137-1 Enokizu, Okawa, 831-8501, Japan","institution_ids":["https://openalex.org/I79072001"]},{"raw_affiliation_string":"Program in Clinical Hematology Sciences, Department of Clinical Microscopy, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand","institution_ids":["https://openalex.org/I158708052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039799977","display_name":"Tatsuki Shibuta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79072001","display_name":"International University of Health and Welfare","ror":"https://ror.org/053d3tv41","country_code":"JP","type":"education","lineage":["https://openalex.org/I79072001"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsuki Shibuta","raw_affiliation_strings":["Graduate School, Department of Medical Technology and Sciences, International University of Health and Welfare, 137-1 Enokizu, Okawa, 831-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School, Department of Medical Technology and Sciences, International University of Health and Welfare, 137-1 Enokizu, Okawa, 831-8501, Japan","institution_ids":["https://openalex.org/I79072001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042942360","display_name":"Yoshitaka Hirooka","orcid":"https://orcid.org/0000-0002-5330-6893","observed_orcids":["https://orcid.org/0000-0002-5330-6893"]},"institutions":[{"id":"https://openalex.org/I79072001","display_name":"International University of Health and Welfare","ror":"https://ror.org/053d3tv41","country_code":"JP","type":"education","lineage":["https://openalex.org/I79072001"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshitaka Hirooka","raw_affiliation_strings":["Graduate School, Department of Medical Technology and Sciences, International University of Health and Welfare, 137-1 Enokizu, Okawa, 831-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School, Department of Medical Technology and Sciences, International University of Health and Welfare, 137-1 Enokizu, Okawa, 831-8501, Japan","institution_ids":["https://openalex.org/I79072001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049606584","display_name":"Kasem Kulkeaw","orcid":"https://orcid.org/0000-0002-6652-9244","observed_orcids":["https://orcid.org/0000-0002-6652-9244"]},"institutions":[{"id":"https://openalex.org/I1332387789","display_name":"Siriraj Hospital","ror":"https://ror.org/0331zs648","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I1332387789"]},{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Kasem Kulkeaw","raw_affiliation_strings":["Siriraj Integrative Center for Neglected Parasitic Diseases, Department of Parasitology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2, Wanglang Road, Bangkok Noi, Bangkok, 10700, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Siriraj Integrative Center for Neglected Parasitic Diseases, Department of Parasitology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2, Wanglang Road, Bangkok Noi, Bangkok, 10700, Thailand","institution_ids":["https://openalex.org/I1332387789","https://openalex.org/I25399158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051112813","display_name":"Duangdao Palasuwan","orcid":"https://orcid.org/0000-0003-3946-071X","observed_orcids":["https://orcid.org/0000-0003-3946-071X"]},"institutions":[{"id":"https://openalex.org/I158708052","display_name":"Chulalongkorn University","ror":"https://ror.org/028wp3y58","country_code":"TH","type":"education","lineage":["https://openalex.org/I158708052"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Duangdao Palasuwan","raw_affiliation_strings":["Oxidation in Red Cell Disorders Research Unit, Department of Clinical Microscopy, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand. nantadao@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oxidation in Red Cell Disorders Research Unit, Department of Clinical Microscopy, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand. nantadao@gmail.com","institution_ids":["https://openalex.org/I158708052"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084137822","display_name":"Tsukuru Umemura","orcid":"https://orcid.org/0000-0003-1187-3248","observed_orcids":["https://orcid.org/0000-0003-1187-3248"]},"institutions":[{"id":"https://openalex.org/I4405284961","display_name":"Takagi Hospital","ror":"https://ror.org/04hdnvg05","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405284961"]},{"id":"https://openalex.org/I79072001","display_name":"International University of Health and Welfare","ror":"https://ror.org/053d3tv41","country_code":"JP","type":"education","lineage":["https://openalex.org/I79072001"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Tsukuru Umemura","raw_affiliation_strings":["Clinical Laboratory, Kouhoukai Takagi Hospital, 141-11 Sakemi, Okawa, 831-0016, Japan. umemura@iuhw.ac.jp","Graduate School, Department of Medical Technology and Sciences, International University of Health and Welfare, 137-1 Enokizu, Okawa, 831-8501, Japan. umemura@iuhw.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Laboratory, Kouhoukai Takagi Hospital, 141-11 Sakemi, Okawa, 831-0016, Japan. umemura@iuhw.ac.jp","institution_ids":["https://openalex.org/I4405284961"]},{"raw_affiliation_string":"Graduate School, Department of Medical Technology and Sciences, International University of Health and Welfare, 137-1 Enokizu, Okawa, 831-8501, Japan. umemura@iuhw.ac.jp","institution_ids":["https://openalex.org/I79072001"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5051112813","https://openalex.org/A5084137822"],"corresponding_institution_ids":["https://openalex.org/I158708052","https://openalex.org/I4405284961","https://openalex.org/I79072001"],"apc_list":{"value":2590,"currency":"USD","value_usd":2590},"apc_paid":{"value":2590,"currency":"USD","value_usd":2590},"fwci":2.0216,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.85857355,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"14","issue":"1","first_page":"16029","last_page":"16029"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12068","display_name":"Neonatal Health and Biochemistry","score":0.8148999810218811,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12068","display_name":"Neonatal Health and Biochemistry","score":0.8148999810218811,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.07900000363588333,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.05490000173449516,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/g6pd-deficiency","display_name":"glucose-6-phosphate dehydrogenase deficiency","score":0.9810000061988831},{"id":"https://openalex.org/keywords/serum-mirna","display_name":"serum microRNA","score":0.9449999928474426},{"id":"https://openalex.org/keywords/mir-451a","display_name":"miR-451a","score":0.8930000066757202},{"id":"https://openalex.org/keywords/mir-16","display_name":"miR-16","score":1.0},{"id":"https://openalex.org/keywords/mir-155","display_name":"miR-155","score":1.0},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7910000085830688},{"id":"https://openalex.org/keywords/hemolytic-anemia","display_name":"hemolytic anemia","score":0.8920000195503235}],"concepts":[{"id":"https://openalex.org/C2779902561","wikidata":"https://www.wikidata.org/wiki/Q471706","display_name":"Hemolysis","level":2,"score":0.9477804899215698},{"id":"https://openalex.org/C113280763","wikidata":"https://www.wikidata.org/wiki/Q2326546","display_name":"Subclinical infection","level":2,"score":0.7187067866325378},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.677485466003418},{"id":"https://openalex.org/C2778119762","wikidata":"https://www.wikidata.org/wiki/Q848343","display_name":"Glucose-6-phosphate dehydrogenase deficiency","level":2,"score":0.6335293650627136},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.601693868637085},{"id":"https://openalex.org/C2908811589","wikidata":"https://www.wikidata.org/wiki/Q848343","display_name":"Glucosephosphate Dehydrogenase Deficiency","level":5,"score":0.5798100829124451},{"id":"https://openalex.org/C2910801743","wikidata":"https://www.wikidata.org/wiki/Q471706","display_name":"Haemolysis","level":2,"score":0.563895583152771},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.49117204546928406},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.4661971628665924},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4460834860801697},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40444082021713257},{"id":"https://openalex.org/C2780196906","wikidata":"https://www.wikidata.org/wiki/Q421793","display_name":"Glucose-6-phosphate dehydrogenase","level":4,"score":0.28143322467803955},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17879605293273926},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15399405360221863},{"id":"https://openalex.org/C2776317432","wikidata":"https://www.wikidata.org/wiki/Q412547","display_name":"Dehydrogenase","level":3,"score":0.147051602602005},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09848996996879578},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0937117338180542},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08841255307197571}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005954","descriptor_name":"Glucosephosphate Dehydrogenase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005954","descriptor_name":"Glucosephosphate Dehydrogenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005955","descriptor_name":"Glucosephosphate Dehydrogenase Deficiency","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005955","descriptor_name":"Glucosephosphate Dehydrogenase Deficiency","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D005955","descriptor_name":"Glucosephosphate Dehydrogenase Deficiency","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1038/s41598-024-67108-4","doi":"https://doi.org/10.1038/s41598-024-67108-4","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1038/s41598-024-67108-4","pdf_url":null,"source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11239928","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11239928","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11239928/pdf/41598_2024_Article_67108.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:38992151","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38992151","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:2fd747ff5e4e45da902b22f9e3a0c878","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2fd747ff5e4e45da902b22f9e3a0c878","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)","raw_type":"article"},{"id":"doi:10.60692/jm2a2-3eb87","doi":"https://doi.org/10.60692/jm2a2-3eb87","is_oa":true,"landing_page_url":"https://doi.org/10.60692/jm2a2-3eb87","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/mhg6w-69y07","doi":"https://doi.org/10.60692/mhg6w-69y07","is_oa":true,"landing_page_url":"https://doi.org/10.60692/mhg6w-69y07","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1038/s41598-024-67108-4","doi":"https://doi.org/10.1038/s41598-024-67108-4","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1038/s41598-024-67108-4","pdf_url":null,"source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2224666635","display_name":"Development of an early diagnosis of vascular endothelial cell injury in lifestyle-related diseases using highly sensitive extracellular vesicle analysis.","funder_award_id":"24K14796","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5084229955","display_name":null,"funder_award_id":"PHD/0116/2560","funder_id":"https://openalex.org/F4320327548","funder_display_name":"Royal Golden Jubilee (RGJ) Ph.D. Programme"}],"funders":[{"id":"https://openalex.org/F4320321557","display_name":"Chulalongkorn University","ror":"https://ror.org/028wp3y58"},{"id":"https://openalex.org/F4320322817","display_name":"National Research Council of Thailand","ror":"https://ror.org/018wfhg78"},{"id":"https://openalex.org/F4320327548","display_name":"Royal Golden Jubilee (RGJ) Ph.D. Programme","ror":"https://ror.org/05fp08r12"},{"id":"https://openalex.org/F4320329659","display_name":"Thailand Science Research and Innovation","ror":"https://ror.org/000025p04"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W104039999","https://openalex.org/W178965487","https://openalex.org/W1494052777","https://openalex.org/W1602542425","https://openalex.org/W1732724144","https://openalex.org/W1964753012","https://openalex.org/W1992052556","https://openalex.org/W1997424007","https://openalex.org/W2004045031","https://openalex.org/W2005645711","https://openalex.org/W2006247279","https://openalex.org/W2012913468","https://openalex.org/W2014974499","https://openalex.org/W2028188785","https://openalex.org/W2039831000","https://openalex.org/W2045942033","https://openalex.org/W2048569126","https://openalex.org/W2064456174","https://openalex.org/W2076211938","https://openalex.org/W2088888368","https://openalex.org/W2102111081","https://openalex.org/W2125939997","https://openalex.org/W2134912780","https://openalex.org/W2140775205","https://openalex.org/W2164940259","https://openalex.org/W2179912193","https://openalex.org/W2264055547","https://openalex.org/W2334927984","https://openalex.org/W2338153498","https://openalex.org/W2560259923","https://openalex.org/W2600362526","https://openalex.org/W2781635256","https://openalex.org/W2783260103","https://openalex.org/W2789933043","https://openalex.org/W2791721399","https://openalex.org/W2792484833","https://openalex.org/W2796422903","https://openalex.org/W2920890178","https://openalex.org/W2953720052","https://openalex.org/W2973473087","https://openalex.org/W2996741941","https://openalex.org/W3036204163","https://openalex.org/W3156905371","https://openalex.org/W3158558612","https://openalex.org/W3199004539","https://openalex.org/W3207117426","https://openalex.org/W3211116320","https://openalex.org/W4255911495","https://openalex.org/W4293679384","https://openalex.org/W4298337257","https://openalex.org/W4300670732","https://openalex.org/W4303968930","https://openalex.org/W4321331893"],"related_works":["https://openalex.org/W2184417045","https://openalex.org/W2074089397","https://openalex.org/W4297581364","https://openalex.org/W7160832168","https://openalex.org/W2327194754","https://openalex.org/W4414740536","https://openalex.org/W2998351594","https://openalex.org/W3024022691","https://openalex.org/W3211116320","https://openalex.org/W1599755643"],"abstract_inverted_index":{"Glucose-6-phosphate":[0],"dehydrogenase":[1],"(G6PD)":[2],"deficiency":[3,15,59,100],"is":[4,64],"one":[5],"of":[6,51,57,75,87,124,143,146,178,197],"the":[7,55,73,84,108,118,122,175,194],"most":[8],"common":[9],"enzymopathies":[10],"worldwide.":[11],"Patients":[12,90],"with":[13,91,135],"G6PD":[14,58,88,95,103,137,179,198],"are":[16],"usually":[17],"asymptomatic":[18],"throughout":[19],"their":[20],"life":[21],"but":[22],"can":[23,42,184],"develop":[24],"acute":[25],"hemolysis":[26,82,113,192],"after":[27],"exposure":[28],"to":[29,71,155,190],"free":[30],"radicals":[31],"or":[32,93],"certain":[33],"medications.":[34],"Several":[35],"studies":[36],"have":[37],"shown":[38],"that":[39,163],"serum":[40,76,125],"miRNAs":[41,77,148,166,183],"be":[43,185],"used":[44],"as":[45,78,169,187],"prognostic":[46],"biomarkers":[47,79,171,189],"in":[48,83,107,117,133,174,193],"various":[49],"types":[50],"hemolytic":[52],"anemias.":[53],"However,":[54],"impact":[56],"on":[60],"circulating":[61],"miRNA":[62],"profiles":[63],"largely":[65],"unknown.":[66],"The":[67,111],"present":[68,109],"study":[69],"aimed":[70],"assess":[72],"use":[74],"for":[80,172],"detecting":[81],"nonacute":[85,195],"phase":[86,177,196],"deficiency.":[89,138,180,199],"severe":[92,136],"moderate":[94],"Viangchan":[96],"(871G":[97],">":[98],"A)":[99],"and":[101,128,151],"normal":[102,116],"patients":[104,134,173],"were":[105,115,130],"enrolled":[106],"study.":[110],"biochemical":[112],"indices":[114],"three":[119,147,165],"groups,":[120],"while":[121],"levels":[123],"miR-451a,":[126],"miR-16,":[127,150],"miR-155":[129],"significantly":[131],"increased":[132],"In":[139,181],"addition,":[140],"3D":[141],"analysis":[142],"a":[144],"set":[145],"(miR-451a,":[149],"miR-155)":[152],"was":[153],"able":[154],"differentiate":[156],"G6PD-deficient":[157],"individuals":[158],"from":[159],"healthy":[160],"individuals,":[161],"suggesting":[162],"these":[164],"may":[167],"serve":[168],"potential":[170],"nonhemolytic":[176],"conclusion,":[182],"utilized":[186],"additional":[188],"detect":[191]},"counts_by_year":[{"year":2026,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-07-12T00:00:00"}